Novel NEK8 Mutations Cause Severe Syndromic Renal Cystic Dysplasia through YAP Dysregulation

Nephronophthisis and related syndromes

(2015) Matthias T.F. Wolf   CURRENT OPINION IN PEDIATRICS

Control of tissue growth by Yap relies on cell density and F-actin in zebrafish fin regeneration

(2015) R. Mateus et al.   DEVELOPMENT

Atypical protein kinase C induces cell transformation by disrupting Hippo/Yap signaling

(2015) Andrew Archibald et al.   MOLECULAR BIOLOGY OF THE CELL

TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors

(2015) Inês Cebola et al.   NATURE CELL BIOLOGY

ANKS6 is the critical activator of NEK8 kinase in embryonic situs determination and organ patterning

(2015) Peter G. Czarnecki et al.   Nature Communications

Actin remodelling factors control ciliogenesis by regulating YAP/TAZ activity and vesicle trafficking

(2015) Jongshin Kim et al.   Nature Communications

Mutations of CEP83 Cause Infantile Nephronophthisis and Intellectual Disability

(2014) Marion Failler et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Hippo Pathway Activity Influences Liver Cell Fate

(2014) Dean Yimlamai et al.   CELL

The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease

(2014) X. Varelas   DEVELOPMENT

3D spheroid model of mIMCD3 cells for studying ciliopathies and renal epithelial disorders

(2014) Rachel H Giles et al.   Nature Protocols

The Biology of YAP/TAZ: Hippo Signaling and Beyond

(2014) Stefano Piccolo et al.   PHYSIOLOGICAL REVIEWS

Defects in the IFT-B Component IFT172 Cause Jeune and Mainzer-Saldino Syndromes in Humans

(2013) Jan Halbritter et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Emerging roles of TEAD transcription factors and its coactivators in cancers

(2013) Ajaybabu V. Pobbati et al.   CANCER BIOLOGY & THERAPY

Hepatocyte nuclear factor 1  controls nephron tubular development

(2013) F. Massa et al.   DEVELOPMENT

HNF1B controls proximal-intermediate nephron segment identity in vertebrates by regulating Notch signalling components and Irx1/2

(2013) C. Heliot et al.   DEVELOPMENT

Yes-Associated Protein Up-regulates Jagged-1 and Activates the NOTCH Pathway in Human Hepatocellular Carcinoma

(2013) Darjus Felix Tschaharganeh et al.   GASTROENTEROLOGY

The Hippo pathway: regulators and regulations

(2013) F.-X. Yu et al.   GENES & DEVELOPMENT

Mutations in NEK8 link multiple organ dysplasia with altered Hippo signalling and increased c-MYC expression

(2013) Valeska Frank et al.   HUMAN MOLECULAR GENETICS

A HomozygousPDE6DMutation in Joubert Syndrome Impairs Targeting of Farnesylated INPP5E Protein to the Primary Cilium

(2013) Sophie Thomas et al.   HUMAN MUTATION

NEK8 Links the ATR-Regulated Replication Stress Response and S Phase CDK Activity to Renal Ciliopathies

(2013) Hyo Jei Claudia Choi et al.   MOLECULAR CELL

ANKS6 is a central component of a nephronophthisis module linking NEK8 to INVS and NPHP3

(2013) Sylvia Hoff et al.   NATURE GENETICS

Yap- and Cdc42-Dependent Nephrogenesis and Morphogenesis during Mouse Kidney Development

(2013) Antoine Reginensi et al.   PLoS Genetics

CCN2: a master regulator of the genesis of bone and cartilage

(2013) Masaharu Takigawa   Journal of Cell Communication and Signaling

Clinical spectrum and pathogenesis of nephronophthisis

(2012) Thomas Benzing et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

The ciliary protein Nek8/Nphp9 acts downstream of Inv/Nphp2 during pronephros morphogenesis and left-right establishment in zebrafish

(2012) Hajime Fukui et al.   FEBS LETTERS

Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP

(2012) Y. Liu-Chittenden et al.   GENES & DEVELOPMENT

The ciliopathy disease protein NPHP9 promotes nuclear delivery and activation of the oncogenic transcriptional regulator TAZ

(2012) Sandra Habbig et al.   HUMAN MOLECULAR GENETICS

Cell cycle regulation by the NEK family of protein kinases

(2012) A. M. Fry et al.   JOURNAL OF CELL SCIENCE

Loss of the Ciliary Kinase Nek8 Causes Left-Right Asymmetry Defects

(2012) D. K. Manning et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Current insights into renal ciliopathies: what can genetics teach us?

(2012) Heleen H. Arts et al.   PEDIATRIC NEPHROLOGY

Association of INVS (NPHP2) mutation in an adolescent exhibiting nephronophthisis (NPH) and complete situs inversus

(2011) M. Okada et al.   CLINICAL NEPHROLOGY

The Nek8 protein kinase, mutated in the human cystic kidney disease nephronophthisis, is both activated and degraded during ciliogenesis

(2011) Detina Zalli et al.   HUMAN MOLECULAR GENETICS

NPHP4, a cilia-associated protein, negatively regulates the Hippo pathway

(2011) Sandra Habbig et al.   JOURNAL OF CELL BIOLOGY

Hippo Pathway Inhibits Wnt Signaling to Restrain Cardiomyocyte Proliferation and Heart Size

(2011) T. Heallen et al.   SCIENCE

The Crumbs Complex Couples Cell Density Sensing to Hippo-Dependent Control of the TGF-β-SMAD Pathway

(2010) Xaralabos Varelas et al.   DEVELOPMENTAL CELL

Lipocalin 2 is essential for chronic kidney disease progression in mice and humans

(2010) Amandine Viau et al.   JOURNAL OF CLINICAL INVESTIGATION

Renal cystic dysplasia, paucity of bile ducts, situs inversus, bowing of the femora in two siblings in the Reunion Island: a ciliopathy?

(2009) Jean-Luc Alessandri et al.   CLINICAL DYSMORPHOLOGY

Mutations of NPHP2 and NPHP3 in infantile nephronophthisis

(2009) Kálmán Tory et al.   KIDNEY INTERNATIONAL

Scribble participates in Hippo signaling and is required for normal zebrafish pronephros development

(2009) K. Skouloudaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of Nephrocystin-3 Function Can Cause Embryonic Lethality, Meckel-Gruber-like Syndrome, Situs Inversus, and Renal-Hepatic-Pancreatic Dysplasia

(2008) Carsten Bergmann et al.   AMERICAN JOURNAL OF HUMAN GENETICS

NEK8 Mutations Affect Ciliary and Centrosomal Localization and May Cause Nephronophthisis

(2008) E. A. Otto et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY