The cell biology of polycystic kidney disease

Prospects for mTOR Inhibitor Use in Patients with Polycystic Kidney Disease and Hamartomatous Diseases

(2010) V. E. Torres et al.   Clinical Journal of the American Society of Nephrology

Randomized Clinical Trial of Long-Acting Somatostatin for Autosomal Dominant Polycystic Kidney and Liver Disease

(2010) M. C. Hogan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Inhibition of glucosylceramide accumulation results in effective blockade of polycystic kidney disease in mouse models

(2010) Thomas A Natoli et al.   NATURE MEDICINE

Polycystins and renovascular mechanosensory transduction

(2010) Amanda Patel et al.   Nature Reviews Nephrology

Sirolimus and Kidney Growth in Autosomal Dominant Polycystic Kidney Disease

(2010) Andreas L. Serra et al.   NEW ENGLAND JOURNAL OF MEDICINE

Everolimus in Patients with Autosomal Dominant Polycystic Kidney Disease

(2010) Gerd Walz et al.   NEW ENGLAND JOURNAL OF MEDICINE

Carboxy Terminal Tail of Polycystin-1 Regulates Localization of TSC2 to Repress mTOR

(2010) Ruhee Dere et al.   PLoS One

Effect of Pioglitazone on Survival and Renal Function in a Mouse Model of Polycystic Kidney Disease

(2009) K.L. Raphael et al.   AMERICAN JOURNAL OF NEPHROLOGY

Pkd2 Dosage Influences Cellular Repair Responses following Ischemia-Reperfusion Injury

(2009) Sony Prasad et al.   AMERICAN JOURNAL OF PATHOLOGY

Polycystins and Primary Cilia: Primers for Cell Cycle Progression

(2009) Jing Zhou   Annual Review of Physiology

Advances in the pathogenesis and treatment of polycystic kidney disease

(2009) Vishal Patel et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Toxic tubular injury in kidneys from Pkd1-deletion mice accelerates cystogenesis accompanied by dysregulated planar cell polarity and canonical Wnt signaling pathways

(2009) H. Happe et al.   HUMAN MOLECULAR GENETICS

Renal injury is a third hit promoting rapid development of adult polycystic kidney disease

(2009) Ayumi Takakura et al.   HUMAN MOLECULAR GENETICS

Systems biology of autosomal dominant polycystic kidney disease (ADPKD): computational identification of gene expression pathways and integrated regulatory networks

(2009) Xuewen Song et al.   HUMAN MOLECULAR GENETICS

Polycystin-1 Interacts with Inositol 1,4,5-Trisphosphate Receptor to Modulate Intracellular Ca2+Signaling with Implications for Polycystic Kidney Disease

(2009) Yun Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Polycystin-1 C-terminal Cleavage Is Modulated by Polycystin-2 Expression

(2009) Claudia A. Bertuccio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Homophilic and heterophilic polycystin 1 interactions regulate E-cadherin recruitment and junction assembly in MDCK cells

(2009) A. J. Streets et al.   JOURNAL OF CELL SCIENCE

Pkd1 Haploinsufficiency Increases Renal Damage and Induces Microcyst Formation following Ischemia/Reperfusion

(2009) A. P. Bastos et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Loss of Oriented Cell Division Does not Initiate Cyst Formation

(2009) S. Nishio et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Characterization of PKD Protein-Positive Exosome-Like Vesicles

(2009) M. C. Hogan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Conditional Mutation of Pkd2 Causes Cystogenesis and Upregulates  -Catenin

(2009) I. Kim et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Incompletely penetrant PKD1 alleles suggest a role for gene dosage in cyst initiation in polycystic kidney disease

(2009) Sandro Rossetti et al.   KIDNEY INTERNATIONAL

Cyclic nucleotide signaling in polycystic kidney disease

(2009) Xiaofang Wang et al.   KIDNEY INTERNATIONAL

Polycystin-1 Regulates Extracellular Signal-Regulated Kinase-Dependent Phosphorylation of Tuberin To Control Cell Size through mTOR and Its Downstream Effectors S6K and 4EBP1

(2009) G. Distefano et al.   MOLECULAR AND CELLULAR BIOLOGY

Long-term rapamycin therapy in the Han:SPRD rat model of polycystic kidney disease (PKD)

(2009) I. Zafar et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Structural and molecular basis of the assembly of the TRPP2/PKD1 complex

(2009) Yong Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polycystic Kidney Disease

(2008) Peter C. Harris et al.   Annual Review of Medicine

The TSC1–TSC2 complex: a molecular switchboard controlling cell growth

(2008) Jingxiang Huang et al.   BIOCHEMICAL JOURNAL

Role of Vasopressin Antagonists

(2008) V. E. Torres   Clinical Journal of the American Society of Nephrology

Acute kidney injury and aberrant planar cell polarity induce cyst formation in mice lacking renal cilia

(2008) Vishal Patel et al.   HUMAN MOLECULAR GENETICS

Polycystin-1 C-terminal tail associates with β-catenin and inhibits canonical Wnt signaling

(2008) Mark Lal et al.   HUMAN MOLECULAR GENETICS

Polycystin-2 down-regulates cell proliferation via promoting PERK-dependent phosphorylation of eIF2α

(2008) Genqing Liang et al.   HUMAN MOLECULAR GENETICS

Domain Mapping of the Polycystin-2 C-terminal Tail Usingde NovoMolecular Modeling and Biophysical Analysis

(2008) Andjelka Ćelić et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pkd1 Inactivation Induced in Adulthood Produces Focal Cystic Disease

(2008) A. Takakura et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Small-Molecule CFTR Inhibitors Slow Cyst Growth in Polycystic Kidney Disease

(2008) B. Yang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Triptolide Reduces Cystogenesis in a Model of ADPKD

(2008) S. J. Leuenroth et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

KCa3.1 potassium channels are critical for cAMP-dependent chloride secretion and cyst growth in autosomal-dominant polycystic kidney disease

(2008) Mamdouh Albaqumi et al.   KIDNEY INTERNATIONAL