Functional Relationship between Leptin and Nitric Oxide in Metabolism

iNOS Gene Ablation Prevents Liver Fibrosis in Leptin-Deficient ob/ob Mice

(2019) Sara Becerril et al.   Genes

Physical activity and muscle–brain crosstalk

(2019) Bente Klarlund Pedersen   Nature Reviews Endocrinology

Targeted disruption of the iNOS gene improves adipose tissue inflammation and fibrosis in leptin-deficient ob/ob mice: role of tenascin C

(2018) S Becerril et al.   INTERNATIONAL JOURNAL OF OBESITY

Melanocortin 4 Receptor Pathway Dysfunction in Obesity: Patient Stratification Aimed at MC4R Agonist Treatment

(2018) Kristin L Ayers et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

MC4R agonism promotes durable weight loss in patients with leptin receptor deficiency

(2018) Karine Clément et al.   NATURE MEDICINE

The LepR-mediated leptin transport across brain barriers controls food reward

(2018) Alessandro Di Spiezio et al.   Molecular Metabolism

Leptin is a physiological regulator of skeletal muscle angiogenesis and is locally produced by PDGFRα and PDGFRβ expressing perivascular cells

(2018) Emmanuel Nwadozi et al.   ANGIOGENESIS

Blood Pressure in Healthy Humans Is Regulated by Neuronal NO SynthaseNovelty and Significance

(2017) Husain Shabeeh et al.   HYPERTENSION

Foxc2 coordinates inflammation and browning of white adipose by leptin-STAT3-PRDM16 signal in mice

(2017) L Gan et al.   INTERNATIONAL JOURNAL OF OBESITY

Leptin stimulates bone formation inob/obmice at doses having minimal impact on energy metabolism

(2017) Kenneth A Philbrick et al.   JOURNAL OF ENDOCRINOLOGY

The cellular and molecular bases of leptin and ghrelin resistance in obesity

(2017) Huxing Cui et al.   Nature Reviews Endocrinology

The glucoregulatory actions of leptin

(2017) Anna M. D'souza et al.   Molecular Metabolism

Crosstalk between adipokines and myokines in fat browning

(2016) A. Rodríguez et al.   Acta Physiologica

Leptin dose-dependently decreases atherosclerosis by attenuation of hypercholesterolemia and induction of adiponectin

(2016) Annett Hoffmann et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Sex-dependent regulation of hypothalamic neuropeptide Y-Y1 receptor gene expression in leptin treated obese (ob/ob) or lean mice

(2016) Paolo Mele et al.   BRAIN RESEARCH

Adipose Tissue Hypoxia, Inflammation, and Fibrosis in Obese Insulin-Sensitive and Obese Insulin-Resistant Subjects

(2016) Helen M. Lawler et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Revisiting the adipocyte: a model for integration of cytokine signaling in the regulation of energy metabolism

(2015) Amaia Rodríguez et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Nitrate enhances skeletal muscle fatty acid oxidation via a nitric oxide-cGMP-PPAR-mediated mechanism

(2015) Tom Ashmore et al.   BMC BIOLOGY

Leptin and Insulin Act on POMC Neurons to Promote the Browning of White Fat

(2015) Garron T. Dodd et al.   CELL

Interactions between cocoa flavanols and inorganic nitrate: Additive effects on endothelial function at achievable dietary amounts

(2015) Ana Rodriguez-Mateos et al.   FREE RADICAL BIOLOGY AND MEDICINE

Significance of nitric oxide synthases: Lessons from triple nitric oxide synthases null mice

(2015) Masato Tsutsui et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Dietary nitrite supplementation improves insulin resistance in type 2 diabetic KKAy mice

(2015) Kazuo Ohtake et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Leptin administration restores the altered adipose and hepatic expression of aquaglyceroporins improving the non-alcoholic fatty liver of ob/ob mice

(2015) Amaia Rodríguez et al.   Scientific Reports

Leptin Promotes Wound Healing in the Skin

(2015) Susumu Tadokoro et al.   PLoS One

FNDC5 could be regulated by leptin in adipose tissue

(2014) Carolina Gutierrez-Repiso et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Leptin administration activates irisin-induced myogenesis via nitric oxide-dependent mechanisms, but reduces its effect on subcutaneous fat browning in mice

(2014) A Rodríguez et al.   INTERNATIONAL JOURNAL OF OBESITY

Direct and indirect effects of leptin on adipocyte metabolism

(2013) Ruth B.S. Harris   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Leptin Stimulates Both Endothelin-1 and Nitric Oxide Activity in Lean Subjects But Not in Patients With Obesity-Related Metabolic Syndrome

(2013) Francesca Schinzari et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Leptin–cytokine crosstalk in breast cancer

(2013) Gale Newman et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Evidence for two types of brown adipose tissue in humans

(2013) Martin E Lidell et al.   NATURE MEDICINE

Leptin Potentiates Endothelium-Dependent Relaxation by Inducing Endothelial Expression of Neuronal NO Synthase

(2012) Sebastian Benkhoff et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Increased Tenascin C And Toll-Like Receptor 4 Levels in Visceral Adipose Tissue as a Link between Inflammation and Extracellular Matrix Remodeling in Obesity

(2012) Victoria Catalán et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Leptin is key to peroxynitrite-mediated oxidative stress and Kupffer cell activation in experimental non-alcoholic steatohepatitis

(2012) Saurabh Chatterjee et al.   JOURNAL OF HEPATOLOGY

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

Leptin action through hypothalamic nitric oxide synthase-1–expressing neurons controls energy balance

(2012) Rebecca L Leshan et al.   NATURE MEDICINE

Transcriptional analysis of brown adipose tissue in leptin-deficient mice lacking inducible nitric oxide synthase: evidence of the role of Med1 in energy balance

(2012) Sara Becerril et al.   PHYSIOLOGICAL GENOMICS

Leptin Reduces the Expression and Increases the Phosphorylation of the Negative Regulators of GLUT4 Traffic TBC1D1 and TBC1D4 in Muscle of ob/ob Mice

(2012) Neira Sáinz et al.   PLoS One

Dietary Inorganic Nitrate Improves Mitochondrial Efficiency in Humans

(2011) Filip J. Larsen et al.   Cell Metabolism

Vascular Endothelial Growth Factor Receptor-2 Couples Cyclo-Oxygenase-2 with Pro-Angiogenic Actions of Leptin on Human Endothelial Cells

(2011) Elena Garonna et al.   PLoS One

Leptin Induces Phosphorylation of Neuronal Nitric Oxide Synthase in Defined Hypothalamic Neurons

(2010) Jose Donato et al.   ENDOCRINOLOGY

Leptin Inhibits the Proliferation of Vascular Smooth Muscle Cells Induced by Angiotensin II through Nitric Oxide-Dependent Mechanisms

(2010) Amaia Rodríguez et al.   MEDIATORS OF INFLAMMATION

Deletion of Inducible Nitric-Oxide Synthase in Leptin-Deficient Mice Improves Brown Adipose Tissue Function

(2010) Sara Becerril et al.   PLoS One

Angiogenesis, adipokines and breast cancer

(2009) Linda Vona-Davis et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Inhibitory Effects of Leptin on Pancreatic  -Cell Function

(2009) E. Tuduri et al.   DIABETES

Leptin Indirectly Regulates Gonadotropin-Releasing Hormone Neuronal Function

(2009) Janette H. Quennell et al.   ENDOCRINOLOGY

Involvement of serum vascular endothelial growth factor family members in the development of obesity in mice and humans☆

(2009) Javier Gómez-Ambrosi et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Role of arginine in superficial wound healing in man

(2009) I.B.J.G. Debats et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Leptin Administration Favors Muscle Mass Accretion by Decreasing FoxO3a and Increasing PGC-1α in ob/ob Mice

(2009) Neira Sáinz et al.   PLoS One

PRDM16: the interconvertible adipo-myocyte switch

(2009) Gema Frühbeck et al.   TRENDS IN CELL BIOLOGY

Insulin and leptin enhance human sperm motility, acrosome reaction and nitric oxide production

(2008) Fanuel Lampiao et al.   ASIAN JOURNAL OF ANDROLOGY

Ghrelin Induces Growth Hormone Secretion Via a Nitric Oxide /cGMP Signalling Pathway

(2008) F. Rodríguez-Pacheco et al.   JOURNAL OF NEUROENDOCRINOLOGY

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(2008) Peter Krasnov et al.   MOLECULAR MEDICINE