Strategies to improve drug development for sepsis

Mortality Related to Severe Sepsis and Septic Shock Among Critically Ill Patients in Australia and New Zealand, 2000-2012

(2014) Kirsi-Maija Kaukonen et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A Novel Drug for Treatment of Necrotizing Soft-Tissue Infections

(2014) Eileen M. Bulger et al.   JAMA Surgery

Chloroquine inhibits HMGB1 inflammatory signaling and protects mice from lethal sepsis

(2013) Minghua Yang et al.   BIOCHEMICAL PHARMACOLOGY

Computational Drug Repositioning: From Data to Therapeutics

(2013) M R Hurle et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Benchmarking the Incidence and Mortality of Severe Sepsis in the United States*

(2013) David F. Gaieski et al.   CRITICAL CARE MEDICINE

Antitumor Necrosis Factor Therapy Is Associated With Improved Survival in Clinical Sepsis Trials

(2013) Ping Qiu et al.   CRITICAL CARE MEDICINE

A Randomized, Double-Blind, Placebo-Controlled, Phase 2b Study to Evaluate the Safety and Efficacy of Recombinant Human Soluble Thrombomodulin, ART-123, in Patients With Sepsis and Suspected Disseminated Intravascular Coagulation*

(2013) Jean-Louis Vincent et al.   CRITICAL CARE MEDICINE

A Phase 2 Randomized, Double-Blind, Placebo–Controlled Study of the Safety and Efficacy of Talactoferrin in Patients With Severe Sepsis*

(2013) Kalpalatha Guntupalli et al.   CRITICAL CARE MEDICINE

Two Decades of Mortality Trends Among Patients With Severe Sepsis

(2013) Elizabeth K. Stevenson et al.   CRITICAL CARE MEDICINE

The multifunctional alarmin HMGB1 with roles in the pathophysiology of sepsis and cancer

(2013) Kerrilyn R Diener et al.   IMMUNOLOGY AND CELL BIOLOGY

Outcome of acute respiratory distress syndrome patients treated with extracorporeal membrane oxygenation and brought to a referral center

(2013) Antoine Roch et al.   INTENSIVE CARE MEDICINE

Effect of Eritoran, an Antagonist of MD2-TLR4, on Mortality in Patients With Severe Sepsis

(2013) Steven M. Opal et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Survival of septic adults compared with nonseptic adults receiving extracorporeal membrane oxygenation for cardiopulmonary failure: A propensity-matched analysis

(2013) Aristine Cheng et al.   JOURNAL OF CRITICAL CARE

Complement Factor B Is the Downstream Effector of TLRs and Plays an Important Role in a Mouse Model of Severe Sepsis

(2013) L. Zou et al.   JOURNAL OF IMMUNOLOGY

Aged Mice Are Unable To Mount an Effective Myeloid Response to Sepsis

(2013) D. C. Nacionales et al.   JOURNAL OF IMMUNOLOGY

A Peptide Antagonist of CD28 Signaling Attenuates Toxic Shock and Necrotizing Soft-Tissue Infection Induced by Streptococcus pyogenes

(2013) Girish Ramachandran et al.   JOURNAL OF INFECTIOUS DISEASES

Overcoming Current Limitations in Humanized Mouse Research

(2013) Michael A. Brehm et al.   JOURNAL OF INFECTIOUS DISEASES

Sepsis definitions: time for change

(2013) Jean-Louis Vincent et al.   LANCET

Procalcitonin as a diagnostic marker for sepsis: a systematic review and meta-analysis

(2013) Christina Wacker et al.   LANCET INFECTIOUS DISEASES

Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach

(2013) Richard S Hotchkiss et al.   LANCET INFECTIOUS DISEASES

Cytokines in Sepsis: Potent Immunoregulators and Potential Therapeutic Targets—An Updated View

(2013) Wibke Schulte et al.   MEDIATORS OF INFLAMMATION

Cold-inducible RNA-binding protein (CIRP) triggers inflammatory responses in hemorrhagic shock and sepsis

(2013) Xiaoling Qiang et al.   NATURE MEDICINE

Severe Sepsis and Septic Shock

(2013) Derek C. Angus et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pentraxin 3 (PTX3) Is Associated with Severe Sepsis and Fatal Disease in Emergency Room Patients with Suspected Infection: A Prospective Cohort Study

(2013) Raija Uusitalo-Seppälä et al.   PLoS One

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin 27 as a Sepsis Diagnostic Biomarker in Critically Ill Adults

(2013) Hector R. Wong et al.   SHOCK

Complete Activation of Autophagic Process Attenuates Liver Injury and Improves Survival in Septic Mice

(2013) Chih-Wen Lin et al.   SHOCK

Animal models of sepsis

(2013) Mitchell P Fink   Virulence

Glyburide Reduces Bacterial Dissemination in a Mouse Model of Melioidosis

(2013) Gavin C. K. W. Koh et al.   PLoS Neglected Tropical Diseases

The TFPI-2 Derived Peptide EDC34 Improves Outcome of Gram-Negative Sepsis

(2013) Praveen Papareddy et al.   PLoS Pathogens

Matrix metalloproteinase-8 as a potential drug target for the therapy of sepsis*

(2012) Mitchell P. Fink   CRITICAL CARE MEDICINE

Specific elevation of DcR3 in sera of sepsis patients and its potential role as a clinically important biomarker of sepsis

(2012) Sunghee Kim et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

Unstressing intemperate models: how cold stress undermines mouse modeling

(2012) Christopher L. Karp   JOURNAL OF EXPERIMENTAL MEDICINE

Current trends in inflammatory and immunomodulatory mediators in sepsis

(2012) M. Aziz et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Persistent cognitive impairment, hippocampal atrophy and EEG changes in sepsis survivors

(2012) Alexander Semmler et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Drotrecogin Alfa (Activated) in Adults with Septic Shock

(2012) V. Marco Ranieri et al.   NEW ENGLAND JOURNAL OF MEDICINE

Adaptive trial designs: a review of barriers and opportunities

(2012) John A Kairalla et al.   Trials

Preclinical Sepsis Models

(2012) Tom van der Poll   Surgical Infections

Scavenger Receptor Class A Plays a Central Role in Mediating Mortality and the Development of the Pro-Inflammatory Phenotype in Polymicrobial Sepsis

(2012) Tammy R. Ozment et al.   PLoS Pathogens

Recombinant Tissue Factor Pathway Inhibitor in Severe Community-acquired Pneumonia

(2011) Richard G. Wunderink et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Oxidative stress and mitochondrial dysfunction in sepsis

(2011) H.F. Galley   BRITISH JOURNAL OF ANAESTHESIA

Incidence of adrenal insufficiency and impact of corticosteroid supplementation in critically ill children with systemic inflammatory syndrome and vasopressor-dependent shock*

(2011) Kiran B. Hebbar et al.   CRITICAL CARE MEDICINE

A novel role for matrix metalloproteinase-8 in sepsis*

(2011) Patrick D. Solan et al.   CRITICAL CARE MEDICINE

Pharmacological Characterization of FE 202158, a Novel, Potent, Selective, and Short-Acting Peptidic Vasopressin V1a Receptor Full Agonist for the Treatment of Vasodilatory Hypotension

(2011) R. Laporte et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Functional Disability 5 Years after Acute Respiratory Distress Syndrome

(2011) Margaret S. Herridge et al.   NEW ENGLAND JOURNAL OF MEDICINE

Serum MMP-8, -9 and TIMP-1 in sepsis: High serum levels of MMP-8 and TIMP-1 are associated with fatal outcome in a multicentre, prospective cohort study. Hypothetical impact of tetracyclines

(2011) Anneli Lauhio et al.   PHARMACOLOGICAL RESEARCH

High Plasma Level of Long Pentraxin 3 (PTX3) Is Associated with Fatal Disease in Bacteremic Patients: A Prospective Cohort Study

(2011) Reetta Huttunen et al.   PLoS One

The pig: a model for human infectious diseases

(2011) François Meurens et al.   TRENDS IN MICROBIOLOGY

A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis*

(2010) Todd W. Rice et al.   CRITICAL CARE MEDICINE

Neutrophil CD64 expression as marker of bacterial infection: A systematic review and meta-analysis

(2010) Joan Cid et al.   JOURNAL OF INFECTION

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Granulocyte–Macrophage Colony-stimulating Factor to Reverse Sepsis-associated Immunosuppression

(2009) Christian Meisel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Analysis of binding site for the novel small-molecule TLR4 signal transduction inhibitor TAK-242 and its therapeutic effect on mouse sepsis model

(2009) K Takashima et al.   BRITISH JOURNAL OF PHARMACOLOGY

The effects of steroids during sepsis depend on dose and severity of illness: an updated meta-analysis

(2009) P.C. Minneci et al.   CLINICAL MICROBIOLOGY AND INFECTION

Adrenal Insufficiency in Septic Shock

(2009) Virginie Maxime et al.   CLINICS IN CHEST MEDICINE

The Pathophysiology of Septic Shock

(2009) O. Okorie Nduka et al.   CRITICAL CARE CLINICS

Animal Models of Sepsis

(2009) Sergio L. Zanotti-Cavazzoni et al.   CRITICAL CARE CLINICS

Efficacy and safety of a phospholipid emulsion (GR270773) in Gram-negative severe sepsis: Results of a phase II multicenter, randomized, placebo-controlled, dose-finding clinical trial

(2009) R Phillip Dellinger et al.   CRITICAL CARE MEDICINE

Phase 2 trial of eritoran tetrasodium (E5564), a Toll-like receptor 4 antagonist, in patients with severe sepsis*

(2009) Mark Tidswell et al.   CRITICAL CARE MEDICINE

Resilience to Bacterial Infection: Difference between Species Could Be Due to Proteins in Serum

(2009) H. Shaw Warren et al.   JOURNAL OF INFECTIOUS DISEASES

Sepsis-induced human lymphocyte apoptosis and cytokine production in “humanized” mice

(2009) Jacqueline Unsinger et al.   JOURNAL OF LEUKOCYTE BIOLOGY

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(2009) H Warren et al.   MOLECULAR MEDICINE

Predisposing Factors for Adrenal Insufficiency

(2009) Stefan R. Bornstein   NEW ENGLAND JOURNAL OF MEDICINE

AP214, an analogue of α-melanocyte-stimulating hormone, ameliorates sepsis-induced acute kidney injury and mortality

(2008) K. Doi et al.   KIDNEY INTERNATIONAL

Animal models of sepsis and its complications

(2008) Mitchell P. Fink   KIDNEY INTERNATIONAL

Hydrocortisone Therapy for Patients with Septic Shock

(2008) Charles L. Sprung et al.   NEW ENGLAND JOURNAL OF MEDICINE