Gut microbiota-derived succinate: Friend or foe in human metabolic diseases?

Gut microbial metabolites in obesity, NAFLD and T2DM

(2019) Emanuel E. Canfora et al.   Nature Reviews Endocrinology

Parabacteroides distasonis Alleviates Obesity and Metabolic Dysfunctions via Production of Succinate and Secondary Bile Acids

(2019) Kai Wang et al.   Cell Reports

Regulation of leukocyte function by citric acid cycle intermediates

(2019) Naeem K. Patil et al.   JOURNAL OF LEUKOCYTE BIOLOGY

SUCNR1 controls an anti-inflammatory program in macrophages to regulate the metabolic response to obesity

(2019) Noelia Keiran et al.   NATURE IMMUNOLOGY

Deciphering the trophic interaction between Akkermansia muciniphila and the butyrogenic gut commensal Anaerostipes caccae using a metatranscriptomic approach

(2018) Loo Wee Chia et al.   ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY

Metformin ameliorates activation of hepatic stellate cells and hepatic fibrosis by succinate and GPR91 inhibition

(2018) Giang Nguyen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Macrophage-Derived Extracellular Succinate Licenses Neural Stem Cells to Suppress Chronic Neuroinflammation

(2018) Luca Peruzzotti-Jametti et al.   Cell Stem Cell

Human gut microbiome: hopes, threats and promises

(2018) Patrice D Cani   GUT

Multiple faces of succinate beyond metabolism in blood

(2018) Franco Grimolizzi et al.   HAEMATOLOGICA

Elevated circulating levels of succinate in human obesity are linked to specific gut microbiota

(2018) Carolina Serena et al.   ISME Journal

Activation of intestinal tuft cell-expressed Sucnr1 triggers type 2 immunity in the mouse small intestine

(2018) Weiwei Lei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiple faces of succinate beyond metabolism in blood

(2018) Franco Grimolizzi et al.   HAEMATOLOGICA

Krebs Cycle Reimagined: The Emerging Roles of Succinate and Itaconate as Signal Transducers

(2018) Michael P. Murphy et al.   CELL

Accumulation of succinate controls activation of adipose tissue thermogenesis

(2018) Evanna L. Mills et al.   NATURE

The Profile of Human Milk Metabolome, Cytokines, and Antibodies in Inflammatory Bowel Diseases Versus Healthy Mothers, and Potential Impact on the Newborn

(2018) Xuanyi Meng et al.   Journal of Crohns & Colitis

Succinate receptor mediates intestinal inflammation and fibrosis

(2018) Dulce C. Macias-Ceja et al.   Mucosal Immunology

The Role of Succinate in the Regulation of Intestinal Inflammation

(2018) Jessica Connors et al.   Nutrients

Probiotics, prebiotics, synbiotics and insulin sensitivity

(2017) Y. A. Kim et al.   NUTRITION RESEARCH REVIEWS

Neonatal acquisition of Clostridia species protects against colonization by bacterial pathogens

(2017) Yun-Gi Kim et al.   SCIENCE

Phascolarctobacterium faecium abundant colonization in human gastrointestinal tract

(2017) Feifan Wu et al.   Experimental and Therapeutic Medicine

Meta-Analysis of Fecal Microbiota and Metabolites in Experimental Colitic Mice during the Inflammatory and Healing Phases

(2017) Toshifumi Osaka et al.   Nutrients

Shaping the Metabolism of Intestinal Bacteroides Population through Diet to Improve Human Health

(2017) David Rios-Covian et al.   Frontiers in Microbiology

Receptor structure-based discovery of non-metabolite agonists for the succinate receptor GPR91

(2017) Mette Trauelsen et al.   Molecular Metabolism

GPR91 deficiency exacerbates allergic contact dermatitis while reducing arthritic disease in mice

(2016) T. Rubić-Schneider et al.   ALLERGY

Integration of target responsive hydrogel with cascaded enzymatic reactions and microfluidic paper-based analytic devices (µPADs) for point-of-care testing (POCT)

(2016) Tian Tian et al.   BIOSENSORS & BIOELECTRONICS

From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

(2016) Ara Koh et al.   CELL

GPR91: expanding the frontiers of Krebs cycle intermediates

(2016) Matheus de Castro Fonseca et al.   Cell Communication and Signaling

Formation of propionate and butyrate by the human colonic microbiota

(2016) Petra Louis et al.   ENVIRONMENTAL MICROBIOLOGY

GPR91 senses extracellular succinate released from inflammatory macrophages and exacerbates rheumatoid arthritis

(2016) Amanda Littlewood-Evans et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The microbiota in adaptive immune homeostasis and disease

(2016) Kenya Honda et al.   NATURE

Insight into SUCNR1 (GPR91) structure and function

(2016) Julie Gilissen et al.   PHARMACOLOGY & THERAPEUTICS

Mucosal Interactions between Genetics, Diet, and Microbiome in Inflammatory Bowel Disease

(2016) Abigail Basson et al.   Frontiers in Immunology

Dietary Fiber-Induced Improvement in Glucose Metabolism Is Associated with Increased Abundance of Prevotella

(2015) Petia Kovatcheva-Datchary et al.   Cell Metabolism

Microbial production of Propionic and Succinic acid from Sorbitol using Propionibacterium acidipropionici

(2015) Juliana C Duarte et al.   AMB Express

Antibiotic Treatment Affects Intestinal Permeability and Gut Microbial Composition in Wistar Rats Dependent on Antibiotic Class

(2015) Monica Vera-Lise Tulstrup et al.   PLoS One

Succinate causes pathological cardiomyocyte hypertrophy through GPR91 activation

(2014) Carla J Aguiar et al.   Cell Communication and Signaling

The Gut Commensal Bacteroides thetaiotaomicron Exacerbates Enteric Infection through Modification of the Metabolic Landscape

(2014) Meredith M. Curtis et al.   Cell Host & Microbe

Gut Microbiota-Produced Succinate Promotes C. difficile Infection after Antibiotic Treatment or Motility Disturbance

(2014) Jessica A. Ferreyra et al.   Cell Host & Microbe

The Treatment-Naive Microbiome in New-Onset Crohn’s Disease

(2014) Dirk Gevers et al.   Cell Host & Microbe

Targeted Disruption of theSUCNR1Metabolic Receptor Leads to Dichotomous Effects on Obesity

(2014) Kenneth J. McCreath et al.   DIABETES

Erratum: Phylogenetic distribution of three pathways for propionate production within the human gut microbiota

(2014) Nicole Reichardt et al.   ISME Journal

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

(2014) Edward T. Chouchani et al.   NATURE

Links between diet, gut microbiota composition and gut metabolism

(2014) Harry J. Flint et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Identifying Gut Microbe-Host Phenotype Relationships Using Combinatorial Communities in Gnotobiotic Mice

(2014) J. J. Faith et al.   Science Translational Medicine

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis

(2013) Robert A Koeth et al.   NATURE MEDICINE

The gut microbiota — masters of host development and physiology

(2013) Felix Sommer et al.   NATURE REVIEWS MICROBIOLOGY

Succinate Increases in the Vitreous Fluid of Patients With Active Proliferative Diabetic Retinopathy

(2012) Makiko Matsumoto et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

The gut anaerobe Faecalibacterium prausnitzii uses an extracellular electron shuttle to grow at oxic–anoxic interphases

(2012) M Tanweer Khan et al.   ISME Journal

Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment

(2012) Xochitl C Morgan et al.   GENOME BIOLOGY

The Succinate Receptor as a Novel Therapeutic Target for Oxidative and Metabolic Stress-Related Conditions

(2012) Ana Carolina Ariza et al.   Frontiers in Endocrinology

Characterization of Phascolarctobacterium succinatutens sp. nov., an Asaccharolytic, Succinate-Utilizing Bacterium Isolated from Human Feces

(2011) Yohei Watanabe et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Discovery of a potent and selective small molecule hGPR91 antagonist

(2011) Debnath Bhuniya et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Eating For Two: How Metabolism Establishes Interspecies Interactions in the Gut

(2011) Michael A. Fischbach et al.   Cell Host & Microbe

GC/MS-based profiling of amino acids and TCA cycle-related molecules in ulcerative colitis

(2011) Makoto Ooi et al.   INFLAMMATION RESEARCH

Unravelling the effects of the environment and host genotype on the gut microbiome

(2011) Aymé Spor et al.   NATURE REVIEWS MICROBIOLOGY

Linking Long-Term Dietary Patterns with Gut Microbial Enterotypes

(2011) G. D. Wu et al.   SCIENCE

Gut Microbiota in Human Adults with Type 2 Diabetes Differs from Non-Diabetic Adults

(2010) Nadja Larsen et al.   PLoS One

Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa

(2010) C. De Filippo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Paraprevotella clara gen. nov., sp. nov. and Paraprevotella xylaniphila sp. nov., members of the family 'Prevotellaceae' isolated from human faeces

(2009) M. Morotomi et al.   INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY

Alistipes indistinctus sp. nov. and Odoribacter laneus sp. nov., common members of the human intestinal microbiota isolated from faeces

(2009) F. Nagai et al.   INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY

The core gut microbiome, energy balance and obesity

(2009) Peter J. Turnbaugh et al.   JOURNAL OF PHYSIOLOGY-LONDON

Anatomical Profiling of G Protein-Coupled Receptor Expression

(2008) Jean B. Regard et al.   CELL

Dialister succinatiphilus sp. nov. and Barnesiella intestinihominis sp. nov., isolated from human faeces

(2008) M. Morotomi et al.   INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY

Succinate receptor GPR91 provides a direct link between high glucose levels and renin release in murine and rabbit kidney

(2008) Ildikó Toma et al.   JOURNAL OF CLINICAL INVESTIGATION

A core gut microbiome in obese and lean twins

(2008) Peter J. Turnbaugh et al.   NATURE

Triggering the succinate receptor GPR91 on dendritic cells enhances immunity

(2008) Tina Rubic et al.   NATURE IMMUNOLOGY