A sesquiterpene lactone antrocin from Antrodia camphorata negatively modulates JAK2/STAT3 signaling via microRNA let-7c and induces apoptosis in lung cancer cells

Expression and Clinical Significance of STAT3, P-STAT3, and VEGF-C in Small Cell Lung Cancer

(2012) Xue Zhao et al.   Asian Pacific Journal of Cancer Prevention

JAK2-related pathway induces acquired erlotinib resistance in lung cancer cells harboring an epidermal growth factor receptor-activating mutation

(2012) Daijiro Harada et al.   CANCER SCIENCE

Genomic Landscape of Non-Small Cell Lung Cancer in Smokers and Never-Smokers

(2012) Ramaswamy Govindan et al.   CELL

JAK/STAT signal pathway activation promotes progression and survival of human oesophageal squamous cell carcinoma

(2012) Zhenbing You et al.   Clinical & Translational Oncology

Let-7 Expression Is a Significant Determinant of Response to Chemotherapy through the Regulation of IL-6/STAT3 Pathway in Esophageal Squamous Cell Carcinoma

(2012) K. Sugimura et al.   CLINICAL CANCER RESEARCH

Quercetin abrogates IL-6/STAT3 signaling and inhibits glioblastoma cell line growth and migration

(2012) Jonathan Michaud-Levesque et al.   EXPERIMENTAL CELL RESEARCH

Diet-derived polyphenols inhibit angiogenesis by modulating the interleukin-6/STAT3 pathway

(2012) Sylvie Lamy et al.   EXPERIMENTAL CELL RESEARCH

JAK2 inhibitors in the treatment of myeloproliferative neoplasms

(2012) Raoul Tibes et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

(−)-Epigallocatechin Gallate Induces Fas/CD95-Mediated Apoptosis through Inhibiting Constitutive and IL-6-Induced JAK/STAT3 Signaling in Head and Neck Squamous Cell Carcinoma Cells

(2012) Hui-Yi Lin et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Targeting the Interleukin-6/Jak/Stat Pathway in Human Malignancies

(2012) Pasquale Sansone et al.   JOURNAL OF CLINICAL ONCOLOGY

Targeting Stat3 Induces Senescence in Tumor Cells and Elicits Prophylactic and Therapeutic Immune Responses against Breast Cancer Growth Mediated by NK Cells and CD4+ T Cells

(2012) M. Tkach et al.   JOURNAL OF IMMUNOLOGY

Novel synthetic derivatives of the natural product berbamine inhibit Jak2/Stat3 signaling and induce apoptosis of human melanoma cells

(2012) Sangkil Nam et al.   Molecular Oncology

Signal transducer and activator of transcription 3 promotes angiogenesis and drives malignant progression in glioma

(2012) Tiffany A. Doucette et al.   NEURO-ONCOLOGY

STAT3 Is Activated by JAK2 Independent of Key Oncogenic Driver Mutations in Non-Small Cell Lung Carcinoma

(2012) Brendan D. Looyenga et al.   PLoS One

Curcumin Blocks Small Cell Lung Cancer Cells Migration, Invasion, Angiogenesis, Cell Cycle and Neoplasia through Janus Kinase-STAT3 Signalling Pathway

(2012) Cheng-Liang Yang et al.   PLoS One

Orally bioavailable small-molecule inhibitor of transcription factor Stat3 regresses human breast and lung cancer xenografts

(2012) X. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

JAK2 the future: therapeutic strategies for JAK-dependent malignancies

(2012) Lindsay M. LaFave et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Perspectives on Sesquiterpene Lactones in Inflammation and Cancer

(2011) Irmgard Merfort   CURRENT DRUG TARGETS

Small Molecule Inhibitors of STAT3 for Cancer Therapy

(2011) M. Zhao et al.   CURRENT MEDICINAL CHEMISTRY

Total Syntheses of Drimane-Type Sesquiterpenoids Enabled by a Gold-Catalyzed Tandem Reaction

(2011) Hang Shi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Inhibition of JAK2 Signaling by TG101209 Enhances Radiotherapy in Lung Cancer Models

(2011) Yunguang Sun et al.   Journal of Thoracic Oncology

Knockdown of stat3 expression by RNAi inhibits in vitro growth of human ovarian cancer

(2011) Shu-Hua Zhao et al.   Radiology and Oncology

Identification of Antrocin from Antrodia camphorata as a Selective and Novel Class of Small Molecule Inhibitor of Akt/mTOR Signaling in Metastatic Breast Cancer MDA-MB-231 Cells

(2010) Yerra Koteswara Rao et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Overexpression of STAT3 Potentiates Growth, Survival, and Radioresistance of Non-Small-Cell Lung Cancer (NSCLC) cells

(2010) Zhen-Jie Yin et al.   JOURNAL OF SURGICAL RESEARCH

Reciprocal Regulation of c-Src and STAT3 in Non-Small Cell Lung Cancer

(2009) L. A. Byers et al.   CLINICAL CANCER RESEARCH

Dangerous liaisons: STAT3 and NF-κB collaboration and crosstalk in cancer

(2009) Sergei I. Grivennikov et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Review of Pharmacological Effects ofAntrodia camphorataand Its Bioactive Compounds

(2009) Madamanchi Geethangili et al.   Evidence-based Complementary and Alternative Medicine

Lung Cancer

(2008) Roy S. Herbst et al.   NEW ENGLAND JOURNAL OF MEDICINE

Suppression of non-small cell lung tumor development by the let-7 microRNA family

(2008) M. S. Kumar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA