Alantolactone induces apoptosis, promotes STAT3 glutathionylation and enhances chemosensitivity of A549 lung adenocarcinoma cells to doxorubicin via oxidative stress

Excessive Reactive Oxygen Species and Exotic DNA Lesions as an Exploitable Liability

(2016) Safnas F. AbdulSalam et al.   BIOCHEMISTRY

Cyclosporine A sensitizes human non-small cell lung cancer cells to gefitinib through inhibition of STAT3

(2016) Jiawei Shou et al.   CANCER LETTERS

Nitric oxide and reactive oxygen species: Clues to target oxidative damage repair defective breast cancers

(2016) Veena Somasundaram et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Adjuvant Therapy of Resected Non-small Cell Lung Cancer: can We Move Forward?

(2016) Lucio Buffoni et al.   CURRENT TREATMENT OPTIONS IN ONCOLOGY

Suppression of StarD7 promotes endoplasmic reticulum stress and induces ROS production

(2016) Jésica Flores-Martín et al.   FREE RADICAL BIOLOGY AND MEDICINE

Methylglyoxal induces cell death through endoplasmic reticulum stress-associated ROS production and mitochondrial dysfunction

(2016) Chi-Ming Chan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Vitamin D Enhances the Efficacy of Irinotecan through miR-627-Mediated Inhibition of Intratumoral Drug Metabolism

(2016) M. Sun et al.   MOLECULAR CANCER THERAPEUTICS

Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors

(2016) Yong Jia et al.   NATURE

Picoliter-Droplet Digital Polymerase Chain Reaction-Based Analysis of Cell-Free Plasma DNA to Assess EGFR Mutations in Lung Adenocarcinoma That Confer Resistance to Tyrosine-Kinase Inhibitors

(2016) Y. Seki et al.   ONCOLOGIST

Triggering apoptosis in cancer cells with an analogue of cribrostatin 6 that elevates intracellular ROS

(2016) D. J. Asby et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

TetraMabs: simultaneous targeting of four oncogenic receptor tyrosine kinases for tumor growth inhibition in heterogeneous tumor cell populations

(2016) Raffaella Castoldi et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Endoplasmic reticulum stress-mediated neuronal apoptosis by acrylamide exposure

(2016) Yuta Komoike et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The role and potential mechanisms of LncRNA-TATDN1 on metastasis and invasion of non-small cell lung cancer

(2016) Niu Zequn et al.   Oncotarget

Selective killing of gastric cancer cells by a small molecule via targeting TrxR1 and ROS-mediated ER stress activation

(2016) Weiqian Chen et al.   Oncotarget

Plumericin inhibits proliferation of vascular smooth muscle cells by blocking STAT3 signaling via S-glutathionylation

(2016) Elke H Heiss et al.   Scientific Reports

The Role of PIK3CA Mutations among Lung Adenocarcinoma Patients with Primary and Acquired Resistance to EGFR Tyrosine Kinase Inhibition

(2016) Shang-Gin Wu et al.   Scientific Reports

Structurally novel steroidal spirooxindole by241 potently inhibits tumor growth mainly through ROS-mediated mechanisms

(2016) Xiao-Jing Shi et al.   Scientific Reports

Berberine Increases Doxorubicin Sensitivity by Suppressing STAT3 in Lung Cancer

(2015) Ting Zhu et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Alantolactone induces G1 phase arrest and apoptosis of multiple myeloma cells and overcomes bortezomib resistance

(2015) Yao Yao et al.   APOPTOSIS

Alantolactone selectively suppresses STAT3 activation and exhibits potent anticancer activity in MDA-MB-231 cells

(2015) Jaemoo Chun et al.   CANCER LETTERS

Cinnamaldehyde Derivative (CB-PIC) Sensitizes Chemo-Resistant Cancer Cells to Drug-Induced Apoptosis via Suppression of MDR1 and its Upstream STAT3 and AKT Signalling

(2015) Jianzhong Xi et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Targeting Apoptosis and Multiple Signaling Pathways with Icariside II in Cancer Cells

(2015) Muhammad Khan et al.   International Journal of Biological Sciences

Continuous exposure of non-small cell lung cancer cells with wild-type EGFR to an inhibitor of EGFR tyrosine kinase induces chemoresistance by activating STAT3

(2015) JIE TANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Killing cancer with platycodin D through multiple mechanisms

(2015) Muhammad Khan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Mangosenone F, A Furanoxanthone fromGarciana mangostana, Induces Reactive Oxygen Species-Mediated Apoptosis in Lung Cancer Cells and Decreases Xenograft Tumor Growth

(2015) Kyung Hye Seo et al.   PHYTOTHERAPY RESEARCH

Brassinin inhibits STAT3 signaling pathway through modulation of PIAS-3 and SOCS-3 expression and sensitizes human lung cancer xenograft in nude mice to paclitaxel

(2015) Jong Hyun Lee et al.   Oncotarget

Gefitinib resistance resulted from STAT3-mediated Akt activation in lung cancer cells

(2015) Kai Wu et al.   Oncotarget

Recombinant viral capsid protein VP1 suppresses lung cancer metastasis by inhibiting COX-2/PGE2 and MIG-7

(2015) Ming-Yi Ho et al.   Oncotarget

Multiple regulation pathways and pivotal biological functions of STAT3 in cancer

(2015) Jie Yuan et al.   Scientific Reports

S-Glutathionylation at Cys328 and Cys542 Impairs STAT3 Phosphorylation

(2014) Elena Butturini et al.   ACS Chemical Biology

G226, a new epipolythiodioxopiperazine derivative, triggers DNA damage and apoptosis in human cancer cells in vitro via ROS generation

(2014) Peng-xing He et al.   ACTA PHARMACOLOGICA SINICA

Drug Resistance via Feedback Activation of Stat3 in Oncogene-Addicted Cancer Cells

(2014) Ho-June Lee et al.   CANCER CELL

Lung Cancer in China

(2013) Jun She et al.   CHEST

Mild oxidative stress induces S-glutathionylation of STAT3 and enhances chemosensitivity of tumoural cells to chemotherapeutic drugs

(2013) Elena Butturini et al.   FREE RADICAL BIOLOGY AND MEDICINE

Different roles of inducible nitric oxide synthase and cyclooxygenase-2 in carcinogenesis and metastasis of intrahepatic cholangiocarcinoma

(2012) Shinichi Aishima et al.   HUMAN PATHOLOGY

Isoalantolactone Induces Reactive Oxygen Species Mediated Apoptosis in Pancreatic Carcinoma PANC-1 Cells

(2012) Muhammad Khan et al.   International Journal of Biological Sciences

Alantolactone induces apoptosis in glioblastoma cells via GSH depletion, ROS generation, and mitochondrial dysfunction

(2012) Muhammad Khan et al.   IUBMB LIFE

Platycodin D Induces Reactive Oxygen Species–Mediated Apoptosis Signal–Regulating Kinase 1 Activation and Endoplasmic Reticulum Stress Response in Human Breast Cancer Cells

(2012) Ji Sun Yu et al.   JOURNAL OF MEDICINAL FOOD

Deactivation of Signal Transducer and Activator of Transcription 3 Reverses Chemotherapeutics Resistance of Leukemia Cells via Down-Regulating P-gp

(2011) Xulong Zhang et al.   PLoS One

Reactive oxygen species, cellular redox systems, and apoptosis

(2010) Magdalena L. Circu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Targeting STAT3 in cancer: how successful are we?

(2008) Peibin Yue et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS