The costimulatory molecule CD226 signals through VAV1 to amplify TCR signals and promote IL-17 production by CD4+T cells

Precise Temporal Profiling of Signaling Complexes in Primary Cells Using SWATH Mass Spectrometry

(2017) Etienne Caron et al.   Cell Reports

Themis1 enhances T cell receptor signaling during thymocyte development by promoting Vav1 activity and Grb2 stability

(2016) Ekaterina Zvezdova et al.   Science Signaling

A Natural Variant of the T Cell Receptor-Signaling Molecule Vav1 Reduces Both Effector T Cell Functions and Susceptibility to Neuroinflammation

(2016) Sahar Kassem et al.   PLoS Genetics

Themis1 enhances T cell receptor signaling during thymocyte development by promoting Vav1 activity and Grb2 stability

(2016) Ekaterina Zvezdova et al.   Science Signaling

DNAM-1 controls NK cell activation via an ITT-like motif

(2015) Zhanguang Zhang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Increased CD226 Expression on CD8+T Cells Is Associated with Upregulated Cytokine Production and Endothelial Cell Injury in Patients with Systemic Sclerosis

(2015) Masahiro Ayano et al.   JOURNAL OF IMMUNOLOGY

Divergent Phenotypes of Human Regulatory T Cells Expressing the Receptors TIGIT and CD226

(2015) Christopher A. Fuhrman et al.   JOURNAL OF IMMUNOLOGY

ERK phosphorylation and miR-181a expression modulate activation of human memory TH17 cells

(2015) Federico Mele et al.   Nature Communications

DNAM-1 Expression Marks an Alternative Program of NK Cell Maturation

(2015) Ludovic Martinet et al.   Cell Reports

Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor–independent TCR signaling hub

(2014) Romain Roncagalli et al.   NATURE IMMUNOLOGY

ERK differentially regulates Th17- and Treg-cell development and contributes to the pathogenesis of colitis

(2013) Houpu Liu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The CD226/CD155 Interaction Regulates the Proinflammatory (Th1/Th17)/Anti-Inflammatory (Th2) Balance in Humans

(2013) E. Lozano et al.   JOURNAL OF IMMUNOLOGY

GRB2-Mediated Recruitment of THEMIS to LAT Is Essential for Thymocyte Development

(2013) W. Paster et al.   JOURNAL OF IMMUNOLOGY

CD226 Gly307Ser association with multiple autoimmune diseases: A meta-analysis

(2012) Zhi-Xin Qiu et al.   HUMAN IMMUNOLOGY

Complementary Phosphorylation Sites in the Adaptor Protein SLP-76 Promote Synergistic Activation of Natural Killer Cells

(2012) H. S. Kim et al.   Science Signaling

Cooperative interactions at the SLP-76 complex are critical for actin polymerization

(2010) Mira Barda-Saad et al.   EMBO JOURNAL

Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases

(2010) A. K. Maiti et al.   RHEUMATOLOGY

FCHo Proteins Are Nucleators of Clathrin-Mediated Endocytosis

(2010) W. M. Henne et al.   SCIENCE

SLAP, a regulator of immunoreceptor ubiquitination, signaling, and trafficking

(2009) Leonard L. Dragone et al.   IMMUNOLOGICAL REVIEWS

Vav Links the T Cell Antigen Receptor to the Actin Cytoskeleton and T Cell Activation Independently of Intrinsic Guanine Nucleotide Exchange Activity

(2009) Ana V. Miletic et al.   PLoS One

Function of the Nucleotide Exchange Activity of Vav1 in T Cell Development and Activation

(2009) A. Saveliev et al.   Science Signaling

CD226 Gly307Ser association with multiple autoimmune diseases

(2008) J P Hafler et al.   GENES AND IMMUNITY

Recent advances in the biology of WASP and WIP

(2008) Narayanaswamy Ramesh et al.   IMMUNOLOGIC RESEARCH

DNAM-1 promotes activation of cytotoxic lymphocytes by nonprofessional antigen-presenting cells and tumors

(2008) Susan Gilfillan et al.   JOURNAL OF EXPERIMENTAL MEDICINE