Themis1 enhances T cell receptor signaling during thymocyte development by promoting Vav1 activity and Grb2 stability

An Epistatic Interaction betweenThemis1andVav1Modulates Regulatory T Cell Function and Inflammatory Bowel Disease Development

(2015) Christophe Pedros et al.   JOURNAL OF IMMUNOLOGY

A THEMIS:SHP1 complex promotes T-cell survival

(2014) W. Paster et al.   EMBO JOURNAL

Regulation of proximal T cell receptor signaling and tolerance induction by deubiquitinase Usp9X

(2014) Edwina Naik et al.   JOURNAL OF EXPERIMENTAL MEDICINE

T Cell-Positive Selection Uses Self-Ligand Binding Strength to Optimize Repertoire Recognition of Foreign Antigens

(2013) Judith N. Mandl et al.   IMMUNITY

GRB2-Mediated Recruitment of THEMIS to LAT Is Essential for Thymocyte Development

(2013) W. Paster et al.   JOURNAL OF IMMUNOLOGY

Themis sets the signal threshold for positive and negative selection in T-cell development

(2013) Guo Fu et al.   NATURE

Mechanism and function of Vav1 localisation in TCR signalling

(2012) Olga Ksionda et al.   JOURNAL OF CELL SCIENCE

Reduced TCR signaling potential impairs negative selection but does not result in autoimmune disease

(2012) SuJin Hwang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Interchangeability of Themis1 and Themis2 in Thymocyte Development Reveals Two Related Proteins with Conserved Molecular Function

(2012) R. Lesourne et al.   JOURNAL OF IMMUNOLOGY

T cell receptor signal strength in Tregand iNKT cell development demonstrated by a novel fluorescent reporter mouse

(2011) Amy E. Moran et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Global quantification of mammalian gene expression control

(2011) Björn Schwanhäusser et al.   NATURE

Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor

(2011) Nicolas Bisson et al.   NATURE BIOTECHNOLOGY

T Cell Receptor (TCR)-induced Tyrosine Phosphorylation Dynamics Identifies THEMIS as a New TCR Signalosome Component

(2010) Claudia Brockmeyer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SHP-1 in T Cells Limits the Production of CD8 Effector Cells without Impacting the Formation of Long-Lived Central Memory Cells

(2010) C. C. Fowler et al.   JOURNAL OF IMMUNOLOGY

Grb2 functions at the top of the T-cell antigen receptor-induced tyrosine kinase cascade to control thymic selection

(2010) I. K. Jang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Digital Signaling and Hysteresis Characterize Ras Activation in Lymphoid Cells

(2009) Jayajit Das et al.   CELL

The B-lymphoid Grb2 interaction code

(2009) Konstantin Neumann et al.   IMMUNOLOGICAL REVIEWS

A Novel Gene Essential for the Development of Single Positive Thymocytes

(2009) K. Kakugawa et al.   MOLECULAR AND CELLULAR BIOLOGY

Themis, a T cell–specific protein important for late thymocyte development

(2009) Renaud Lesourne et al.   NATURE IMMUNOLOGY

Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection

(2009) Andy L Johnson et al.   NATURE IMMUNOLOGY

Themis controls thymocyte selection through regulation of T cell antigen receptor–mediated signaling

(2009) Guo Fu et al.   NATURE IMMUNOLOGY

Gasp, a Grb2-associating protein, is critical for positive selection of thymocytes

(2009) M. S. Patrick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Function of the Nucleotide Exchange Activity of Vav1 in T Cell Development and Activation

(2009) A. Saveliev et al.   Science Signaling

Molecular Origin and Functional Consequences of Digital Signaling and Hysteresis During Ras Activation in Lymphocytes

(2009) A. K. Chakraborty et al.   Science Signaling