Structural dynamics and energetics underlying allosteric inactivation of the cannabinoid receptor CB1

G Protein-coupled Receptor Kinases of the GRK4 Protein Subfamily Phosphorylate Inactive G Protein-coupled Receptors (GPCRs)

(2015) Lingyong Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conformational Selection and Equilibrium Governs the Ability of Retinals to Bind Opsin

(2014) Christopher T. Schafer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Visualization of arrestin recruitment by a G-protein-coupled receptor

(2014) Arun K. Shukla et al.   NATURE

Allosteric sodium in class A GPCR signaling

(2014) Vsevolod Katritch et al.   TRENDS IN BIOCHEMICAL SCIENCES

Ligand-specific endocytic dwell times control functional selectivity of the cannabinoid receptor 1

(2014) Jacqueline Flores-Otero et al.   Nature Communications

The Membrane Proximal Region of the Cannabinoid Receptor CB1 N-Terminus Can Allosterically Modulate Ligand Affinity

(2013) Jonathan F. Fay et al.   BIOCHEMISTRY

Real-time characterization of cannabinoid receptor 1 (CB1) allosteric modulators reveals novel mechanism of action

(2013) Erin E Cawston et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Dynamic Process of β2-Adrenergic Receptor Activation

(2013) Rie Nygaard et al.   CELL

Allosteric Modulation of a Cannabinoid G Protein-coupled Receptor

(2013) Derek M. Shore et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct Roles of β-Arrestin 1 and β-Arrestin 2 in ORG27569-induced Biased Signaling and Internalization of the Cannabinoid Receptor 1 (CB1)

(2013) Kwang H. Ahn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Constitutively Activating Mutation Alters the Dynamics and Energetics of a Key Conformational Change in a Ligand-free G Protein-coupled Receptor

(2013) Hisao Tsukamoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thermostabilization of the β1-Adrenergic Receptor Correlates with Increased Entropy of the Inactive State

(2013) Michiel J. M. Niesen et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Activation and allosteric modulation of a muscarinic acetylcholine receptor

(2013) Andrew C. Kruse et al.   NATURE

Emerging paradigms in GPCR allostery: implications for drug discovery

(2013) Denise Wootten et al.   NATURE REVIEWS DRUG DISCOVERY

Structural Features for Functional Selectivity at Serotonin Receptors

(2013) D. Wacker et al.   SCIENCE

Genetically Encoded Photo-cross-linkers Map the Binding Site of an Allosteric Drug on a G Protein-Coupled Receptor

(2012) Amy Grunbeck et al.   ACS Chemical Biology

Allosteric Modulator ORG27569 Induces CB1 Cannabinoid Receptor High Affinity Agonist Binding State, Receptor Internalization, and GiProtein-independent ERK1/2 Kinase Activation

(2012) Kwang H. Ahn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Key Agonist-induced Conformational Change in the Cannabinoid Receptor CB1 Is Blocked by the Allosteric Ligand Org 27569

(2012) Jonathan F. Fay et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural insights into biased G protein-coupled receptor signaling revealed by fluorescence spectroscopy

(2012) R. Rahmeh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biased Signaling Pathways in  2-Adrenergic Receptor Characterized by 19F-NMR

(2012) J. J. Liu et al.   SCIENCE

Conformational changes in the G protein Gs induced by the β2 adrenergic receptor

(2011) Ka Young Chung et al.   NATURE

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

Stabilized G protein binding site in the structure of constitutively active metarhodopsin-II

(2011) X. Deupi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conformational dynamics of helix 8 in the GPCR rhodopsin controls arrestin activation in the desensitization process

(2011) K. Kirchberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct Phosphorylation Sites on the  2-Adrenergic Receptor Establish a Barcode That Encodes Differential Functions of  -Arrestin

(2011) K. N. Nobles et al.   Science Signaling

Diversity and modularity of G protein-coupled receptor structures

(2011) Vsevolod Katritch et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Energy Landscapes as a Tool to Integrate GPCR Structure, Dynamics, and Function

(2010) Xavier Deupi et al.   PHYSIOLOGY

Highly conserved tyrosine stabilizes the active state of rhodopsin

(2010) J. A. Goncalves et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Magnitude of the Light-induced Conformational Change in Different Rhodopsins Correlates with Their Ability to Activate G Proteins

(2009) Hisao Tsukamoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Development and crystallization of a minimal thermostabilised G protein-coupled receptor

(2009) Tony Warne et al.   PROTEIN EXPRESSION AND PURIFICATION

Crystal structure of opsin in its G-protein-interacting conformation

(2008) Patrick Scheerer et al.   NATURE

High-resolution distance mapping in rhodopsin reveals the pattern of helix movement due to activation

(2008) C. Altenbach et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA