Allosteric Modulation of a Cannabinoid G Protein-coupled Receptor

Distinct Roles of β-Arrestin 1 and β-Arrestin 2 in ORG27569-induced Biased Signaling and Internalization of the Cannabinoid Receptor 1 (CB1)

(2013) Kwang H. Ahn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of the second and third extracellular loops of the adenosine A1 receptor in activation and allosteric modulation

(2012) M.C. Peeters et al.   BIOCHEMICAL PHARMACOLOGY

Emerging opportunities for allosteric modulation of G-protein coupled receptors

(2012) Ching-I. Anderson Wang et al.   BIOCHEMICAL PHARMACOLOGY

Allosteric Modulator ORG27569 Induces CB1 Cannabinoid Receptor High Affinity Agonist Binding State, Receptor Internalization, and GiProtein-independent ERK1/2 Kinase Activation

(2012) Kwang H. Ahn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Long Range Effect of Mutations on Specific Conformational Changes in the Extracellular Loop 2 of Angiotensin II Type 1 Receptor

(2012) Hamiyet Unal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Key Agonist-induced Conformational Change in the Cannabinoid Receptor CB1 Is Blocked by the Allosteric Ligand Org 27569

(2012) Jonathan F. Fay et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Indole-2-carboxamides as Allosteric Modulators of the Cannabinoid CB1 Receptor

(2012) Francesco Piscitelli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Crystal Structure of a Lipid G Protein-Coupled Receptor

(2012) M. A. Hanson et al.   SCIENCE

Identification of the GPR55 Agonist Binding Site Using a Novel Set of High-Potency GPR55 Selective Ligands

(2011) Evangelia Kotsikorou et al.   BIOCHEMISTRY

Ligand binding sensitivity of the extracellular loop two of the cannabinoid receptor 1

(2010) Alexander C. Bertalovitz et al.   DRUG DEVELOPMENT RESEARCH

Third Extracellular Loop (EC3)-N Terminus Interaction Is Important for Seven-transmembrane Domain Receptor Function

(2010) Soumendra Rana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Lipid Pathway for Ligand Binding Is Necessary for a Cannabinoid G Protein-coupled Receptor

(2010) Dow P. Hurst et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ligand-specific Conformation of Extracellular Loop-2 in the Angiotensin II Type 1 Receptor

(2010) Hamiyet Unal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An overview of the metabolic effects of rimonabant in randomized controlled trials: potential for other cannabinoid 1 receptor blockers in obesity

(2010) F. D. Christopoulou et al.   JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS

Allosteric modulation of G protein-coupled receptors: A pharmacological perspective

(2010) Peter Keov et al.   NEUROPHARMACOLOGY

Importance of the extracellular loops in G protein-coupled receptors for ligand recognition and receptor activation

(2010) M.C. Peeters et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Structural analysis of the human cannabinoid receptor one carboxyl-terminus identifies two amphipathic helices

(2009) Kwang H. Ahn et al.   BIOPOLYMERS

Emerging strategies for exploiting cannabinoid receptor agonists as medicines

(2009) Roger G Pertwee   BRITISH JOURNAL OF PHARMACOLOGY

Dual Role of the Second Extracellular Loop of the Cannabinoid Receptor 1: Ligand Binding and Receptor Localization

(2009) K. H. Ahn et al.   MOLECULAR PHARMACOLOGY

Helix movement is coupled to displacement of the second extracellular loop in rhodopsin activation

(2009) Shivani Ahuja et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural diversity of G protein-coupled receptors and significance for drug discovery

(2008) Malin C. Lagerström et al.   NATURE REVIEWS DRUG DISCOVERY

Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

(2008) P. Jeffrey Conn et al.   NATURE REVIEWS DRUG DISCOVERY

Heterologous GPCR Expression: A Bottleneck to Obtaining Crystal Structures

(2007) Emily C. McCusker et al.   BIOTECHNOLOGY PROGRESS