Engineering orthogonal signalling pathways reveals the sparse occupancy of sequence space

Global Analysis of the E. coli Toxin MazF Reveals Widespread Cleavage of mRNA and the Inhibition of rRNA Maturation and Ribosome Biogenesis

(2018) Peter H. Culviner et al.   MOLECULAR CELL

Engineering bacteria for diagnostic and therapeutic applications

(2018) David T. Riglar et al.   NATURE REVIEWS MICROBIOLOGY

Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes

(2018) Jonathan T. Sockolosky et al.   SCIENCE

The genetic landscape of a physical interaction

(2018) Guillaume Diss et al.   eLife

Alternative evolutionary histories in the sequence space of an ancient protein

(2017) Tyler N. Starr et al.   NATURE

Engineering Customized Cell Sensing and Response Behaviors Using Synthetic Notch Receptors

(2016) Leonardo Morsut et al.   CELL

De novo design of protein homo-oligomers with modular hydrogen-bond network-mediated specificity

(2016) S. E. Boyken et al.   SCIENCE

Genetic circuit design automation

(2016) A. A. K. Nielsen et al.   SCIENCE

Library-Aided Probing of Linker Determinants in Hybrid Photoreceptors

(2016) Robert Ohlendorf et al.   ACS Synthetic Biology

Unmasking Determinants of Specificity in the Human Kinome

(2015) Pau Creixell et al.   CELL

Pervasive degeneracy and epistasis in a protein-protein interface

(2015) A. I. Podgornaia et al.   SCIENCE

Activation and Inhibition of the Receptor Histidine Kinase AgrC Occurs through Opposite Helical Transduction Motions

(2014) Boyuan Wang et al.   MOLECULAR CELL

Deep mutational scanning: a new style of protein science

(2014) Douglas M Fowler et al.   NATURE METHODS

ForceAtlas2, a Continuous Graph Layout Algorithm for Handy Network Visualization Designed for the Gephi Software

(2014) Mathieu Jacomy et al.   PLoS One

Helix Bundle Loops Determine Whether Histidine Kinases Autophosphorylate in cis or in trans

(2013) Orr Ashenberg et al.   JOURNAL OF MOLECULAR BIOLOGY

Precise and reliable gene expression via standard transcription and translation initiation elements

(2013) Vivek K Mutalik et al.   NATURE METHODS

CD19-Targeted T Cells Rapidly Induce Molecular Remissions in Adults with Chemotherapy-Refractory Acute Lymphoblastic Leukemia

(2013) R. J. Brentjens et al.   Science Translational Medicine

Evolution of Two-Component Signal Transduction Systems

(2012) Emily J. Capra et al.   Annual Review of Microbiology

Adaptive Mutations that Prevent Crosstalk Enable the Expansion of Paralogous Signaling Protein Families

(2012) Emily J. Capra et al.   CELL

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

SYNZIP Protein Interaction Toolbox: in Vitro and in Vivo Specifications of Heterospecific Coiled-Coil Interaction Domains

(2012) Kenneth Evan Thompson et al.   ACS Synthetic Biology

Accelerated Profile HMM Searches

(2011) Sean R. Eddy   PLoS Computational Biology

A Synthetic Coiled-Coil Interactome Provides Heterospecific Modules for Molecular Engineering

(2010) Aaron W. Reinke et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Learning generative models for protein fold families

(2010) Sivaraman Balakrishnan et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Systematic Dissection and Trajectory-Scanning Mutagenesis of the Molecular Interface That Ensures Specificity of Two-Component Signaling Pathways

(2010) Emily J. Capra et al.   PLoS Genetics

Structural Insight into Partner Specificity and Phosphoryl Transfer in Two-Component Signal Transduction

(2009) Patricia Casino et al.   CELL

Kinetic Buffering of Cross Talk between Bacterial Two-Component Sensors

(2009) Eli S. Groban et al.   JOURNAL OF MOLECULAR BIOLOGY

Enzymatic assembly of DNA molecules up to several hundred kilobases

(2009) Daniel G Gibson et al.   NATURE METHODS

Rewiring the Specificity of Two-Component Signal Transduction Systems

(2008) Jeffrey M. Skerker et al.   CELL

Cross-talk suppression between the CpxA-CpxR and EnvZ-OmpR two-component systems inE. coli

(2008) Albert Siryaporn et al.   MOLECULAR MICROBIOLOGY

Using Engineered Scaffold Interactions to Reshape MAP Kinase Pathway Signaling Dynamics

(2008) C. J. Bashor et al.   SCIENCE