Anything You Can Do, I Can Do Better: Can Aptamers Replace Antibodies in Clinical Diagnostic Applications?

Recent Advances in Aptamer Discovery and Applications

(2019) Yang Zhang et al.   MOLECULES

Molecular Aptamer Beacons and Their Applications in Sensing, Imaging, and Diagnostics

(2019) Angeliki Moutsiopoulou et al.   Small

Recent developments of aptasensors expedient for point-of-care (POC) diagnostics

(2019) Marimuthu Citartan et al.   TALANTA

Application of Aptamers in Virus Detection and Antiviral Therapy

(2019) Xinran Zou et al.   Frontiers in Microbiology

Molecular affinity rulers: systematic evaluation of DNA aptamers for their applicabilities in ELISA

(2019) Michiko Kimoto et al.   NUCLEIC ACIDS RESEARCH

Implementation of an antibody characterization procedure and application to the major ALS/FTD disease gene C9ORF72

(2019) Carl Laflamme et al.   eLife

Serum Protein Changes in Pediatric Sepsis Patients Identified With an Aptamer-Based Multiplexed Proteomic Approach

(2019) Nicholas J. Shubin et al.   CRITICAL CARE MEDICINE

Nucleic acid aptamer-based methods for diagnosis of infections

(2018) Ki Soo Park   BIOSENSORS & BIOELECTRONICS

The path to VICTORy – a beginner's guide to success using commercial research antibodies

(2018) Simon L. Goodman   JOURNAL OF CELL SCIENCE

Oligonucleotide aptamers: promising and powerful diagnostic and therapeutic tools for infectious diseases

(2018) Qin Pan et al.   JOURNAL OF INFECTION

The global burden of paediatric and neonatal sepsis: a systematic review

(2018) Carolin Fleischmann-Struzek et al.   Lancet Respiratory Medicine

Epidemiology and Immune Pathogenesis of Viral Sepsis

(2018) Gu-Lung Lin et al.   Frontiers in Immunology

Developing slow-off dickkopf-1 aptamers for early-diagnosis of hepatocellular carcinoma

(2018) Yin Zhou et al.   TALANTA

Aptahistochemistry in diagnostic pathology: technical scrutiny and feasibility

(2017) Bakhtiar A. Bukari et al.   HISTOCHEMISTRY AND CELL BIOLOGY

The Importance of Epitope Density in Selecting a Sensitive Positive IHC Control

(2017) Kodela Vani et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Aptamer-based point-of-care diagnostic platforms

(2017) Abhijeet Dhiman et al.   SENSORS AND ACTUATORS B-CHEMICAL

Selection, characterization, and application of DNA aptamers for detection of Mycobacterium tuberculosis secreted protein MPT64

(2017) Marzhan Sypabekova et al.   TUBERCULOSIS

Best practices in performing flow cytometry in a regulated environment: feedback from experience within the European Bioanalysis Forum

(2017) Barry van der Strate et al.   Bioanalysis

Broadly reactive aptamers targeting bacteria belonging to different genera using a sequential toggle cell-SELEX

(2017) Min Young Song et al.   Scientific Reports

DNA Aptamers for the Characterization of Histological Structure of Lung Adenocarcinoma

(2017) Galina S. Zamay et al.   Molecular Therapy-Nucleic Acids

Diagnostic Evaluation of ELISA and Chemiluminescent Assays as Alternative Screening Tests to Indirect Immunofluorescence for the Detection of Antibodies to Cellular Antigens

(2016) Fabiano de Almeida Brito et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

[Letter to the Editor] The need for improved education and training in research antibody usage and validation practices

(2016) Leonard P. Freedman et al.   BIOTECHNIQUES

A proposal for validation of antibodies

(2016) Mathias Uhlen et al.   NATURE METHODS

Aptamers as targeted therapeutics: current potential and challenges

(2016) Jiehua Zhou et al.   NATURE REVIEWS DRUG DISCOVERY

Truncation and Mutation of a Transferrin Receptor Aptamer Enhances Binding Affinity

(2016) Joanna Macdonald et al.   Nucleic Acid Therapeutics

The Application of Aptamers for Immunohistochemistry

(2016) Michelle Bauer et al.   Nucleic Acid Therapeutics

Host Biomarkers for Distinguishing Bacterial from Non-Bacterial Causes of Acute Febrile Illness: A Comprehensive Review

(2016) Anokhi J. Kapasi et al.   PLoS One

Aptamers as a replacement for antibodies in enzyme-linked immunosorbent assay

(2015) Saw Yi Toh et al.   BIOSENSORS & BIOELECTRONICS

Biomarkers for the diagnosis of bacterial infections: in pursuit of the ′Holy Grail′

(2015) Alladi Mohan et al.   INDIAN JOURNAL OF MEDICAL RESEARCH

Predicting the Uncertain Future of Aptamer-Based Diagnostics and Therapeutics

(2015) John Bruno   MOLECULES

Antibody anarchy: A call to order

(2015) Monya Baker   NATURE

Reproducibility crisis: Blame it on the antibodies

(2015) Monya Baker   NATURE

Reproducibility: Standardize antibodies used in research

(2015) Andrew Bradbury et al.   NATURE

Getting to reproducible antibodies: the rationale for sequenced recombinant characterized reagents

(2015) Andrew R.M. Bradbury et al.   PROTEIN ENGINEERING DESIGN & SELECTION

The Economics of Reproducibility in Preclinical Research

(2015) Leonard P. Freedman et al.   PLOS BIOLOGY

CFP10 and ESAT6 aptamers as effective Mycobacterial antigen diagnostic reagents

(2014) Xiao-Lei Tang et al.   JOURNAL OF INFECTION

One-step antibody immobilization-based rapid and highly-sensitive sandwich ELISA procedure for potential in vitro diagnostics

(2014) Sandeep Kumar Vashist et al.   Scientific Reports

Aptamer cocktails: Enhancement of sensing signals compared to single use of aptamers for detection of bacteria

(2013) Yeon Seok Kim et al.   BIOSENSORS & BIOELECTRONICS

Optimized flow cytometry protocol for analysis of surface expression of interleukin-1 receptor types I and II

(2013) Filipp Filippovich Vasilyev et al.   CYTOTECHNOLOGY

Finding the right antibody for the job

(2013) Vivien Marx   NATURE METHODS

Calling the next generation of affinity reagents

(2013) Vivien Marx   NATURE METHODS

The Use of Sensitive Chemical Antibodies for Diagnosis: Detection of Low Levels of Epcam in Breast Cancer

(2013) Sarah Shigdar et al.   PLoS One

Aptamers as Theranostic Agents: Modifications, Serum Stability and Functionalisation

(2013) Sarah Shigdar et al.   SENSORS

Sepsis, severe sepsis and septic shock: changes in incidence, pathogens and outcomes

(2012) Greg S Martin   Expert Review of Anti-Infective Therapy

Raise standards for preclinical cancer research

(2012) C. Glenn Begley et al.   NATURE

Clinical applications of aptamers and nucleic acid therapeutics in haematological malignancies

(2011) Sarah Shigdar et al.   BRITISH JOURNAL OF HAEMATOLOGY

RNA aptamer against a cancer stem cell marker epithelial cell adhesion molecule

(2011) Sarah Shigdar et al.   CANCER SCIENCE

Rapid Histochemistry Using Slow Off-rate Modified Aptamers With Anionic Competition

(2011) Shashi Gupta et al.   APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY

Where Are All the Aptamers?

(2010) Geoffrey S. Baird   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

Antibody validation

(2010) Jennifer Bordeaux et al.   BIOTECHNIQUES

Using oligonucleotide aptamer probes for immunostaining of formalin-fixed and paraffin-embedded tissues

(2010) Zihua Zeng et al.   MODERN PATHOLOGY

From Lateral Flow Devices to a Novel Nano-Color Microfluidic Assay

(2009) Saied Assadollahi et al.   SENSORS

Assessment of Three Commercially Available Serologic Assays for Detection of Antibodies to Mycobacterium tuberculosis and Identification of Active Tuberculosis

(2008) B. L. Anderson et al.   Clinical and Vaccine Immunology

A Guide to the Perplexed on the Specificity of Antibodies

(2008) Clifford B. Saper   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

A Genecentric Human Protein Atlas for Expression Profiles Based on Antibodies

(2008) Lisa Berglund et al.   MOLECULAR & CELLULAR PROTEOMICS

Bringing diagnostic technologies to the clinical laboratory: Rigor, regulation, and reality

(2008) Gordon Whiteley   Proteomics Clinical Applications

Aptamer-based biosensors

(2007) Shiping Song et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY