Griffithsin, a Highly Potent Broad-Spectrum Antiviral Lectin from Red Algae: From Discovery to Clinical Application

In vitro antiviral activity of Griffithsin against porcine epidemic diarrhea virus

(2019) Lan Li et al.   VIRUS GENES

Design of Poly(lactic-co-glycolic Acid) (PLGA) Nanoparticles for Vaginal Co-Delivery of Griffithsin and Dapivirine and Their Synergistic Effect for HIV Prophylaxis

(2019) Haitao Yang et al.   Pharmaceutics

A Caulobacter crescentus microbicide protects from vaginal infection with HIV-1JR-CSF in Humanized Bone Marrow-Liver-Thymus Mice

(2019) Christina Farr Zuend et al.   JOURNAL OF VIROLOGY

pH-responsive delivery of Griffithsin from electrospun fibers

(2018) Kevin M. Tyo et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Engineering Lactobacillus rhamnosus GG and GR-1 to express HIV-inhibiting griffithsin

(2018) Mariya I. Petrova et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Development of a Vaginal Fast-Dissolving Insert Combining Griffithsin and Carrageenan for Potential Use Against Sexually Transmitted Infections

(2018) Manjari Lal et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Bioengineered intravaginal isolate of Lactobacillus plantarum expresses algal lectin scytovirin demonstrating anti-HIV-1 activity

(2018) Essam Mohammed Ahmed Janahi et al.   MICROBIAL PATHOGENESIS

Characterization of the hypersensitive response-like cell death phenomenon induced by targeting antiviral lectin griffithsin to the secretory pathway

(2018) Bo Min Kim et al.   PLANT BIOTECHNOLOGY JOURNAL

High-level expression of the HIV entry inhibitor griffithsin from the plastid genome and retention of biological activity in dried tobacco leaves

(2018) Matthijs Hoelscher et al.   PLANT MOLECULAR BIOLOGY

Generation of a Dual-Target, Safe, Inexpensive Microbicide that Protects Against HIV-1 and HSV-2 Disease

(2018) Christina Farr Zuend et al.   Scientific Reports

Impact of the griffithsin anti-HIV microbicide and placebo gels on the rectal mucosal proteome and microbiome in non-human primates

(2018) Lauren Girard et al.   Scientific Reports

Unexpected synergistic HIV neutralization by a triple microbicide produced in rice endosperm

(2018) Evangelia Vamvaka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Griffithsin carrageenan fast dissolving inserts prevent SHIV HSV-2 and HPV infections in vivo

(2018) Nina Derby et al.   Nature Communications

Griffithsin-Modified Electrospun Fibers as a Delivery Scaffold To Prevent HIV Infection

(2016) Tiffany N. Grooms et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Middle East respiratory syndrome coronavirus infection is inhibited by griffithsin

(2016) Jean K. Millet et al.   ANTIVIRAL RESEARCH

Rice endosperm is cost-effective for the production of recombinant griffithsin with potent activity against HIV

(2016) Evangelia Vamvaka et al.   PLANT BIOTECHNOLOGY JOURNAL

Hepatitis C Virus Resistance to Carbohydrate-Binding Agents

(2016) Laure Izquierdo et al.   PLoS One

Griffithsin binds to the glycosylated proteins (E and prM) of Japanese encephalitis virus and inhibit its infection

(2016) Hassan Z.A. Ishag et al.   VIRUS RESEARCH

Pharmacokinetics of the Antiviral Lectin Griffithsin Administered by Different Routes Indicates Multiple Potential Uses

(2016) Christopher Barton et al.   Viruses-Basel

Studies in a Murine Model Confirm the Safety of Griffithsin and Advocate Its Further Development as a Microbicide Targeting HIV-1 and Other Enveloped Viruses

(2016) Joseph Kouokam et al.   Viruses-Basel

Griffithsin: An Antiviral Lectin with Outstanding Therapeutic Potential

(2016) Sabrina Lusvarghi et al.   Viruses-Basel

Binding Site Geometry and Subdomain Valency Control Effects of Neutralizing Lectins on HIV-1 Viral Particles

(2016) Sabrina Lusvarghi et al.   ACS Infectious Diseases

Griffithsin and Carrageenan Combination To Target Herpes Simplex Virus 2 and Human Papillomavirus

(2015) Keith Levendosky et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Improving the large scale purification of the HIV microbicide, griffithsin

(2015) Joshua L Fuqua et al.   BMC BIOTECHNOLOGY

Sensitivity of transmitted and founder human immunodeficiency virus type 1 envelopes to carbohydrate-binding agents griffithsin, cyanovirin-N and Galanthus nivalis agglutinin

(2015) Bodan Hu et al.   JOURNAL OF GENERAL VIROLOGY

Griffithsin tandemers: flexible and potent lectin inhibitors of the human immunodeficiency virus

(2015) Tinoush Moulaei et al.   Retrovirology

A novel and fully scalableAgrobacteriumspray-based process for manufacturing cellulases and other cost-sensitive proteins in plants

(2014) Simone Hahn et al.   PLANT BIOTECHNOLOGY JOURNAL

The Griffithsin Dimer Is Required for High-Potency Inhibition of HIV-1: Evidence for Manipulation of the Structure of gp120 as Part of the Griffithsin Dimer Mechanism

(2013) Jie Xue et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Activity of and Effect of Subcutaneous Treatment with the Broad-Spectrum Antiviral Lectin Griffithsin in Two Laboratory Rodent Models

(2013) Christopher Barton et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Griffithsin Protects Mice from Genital Herpes by Preventing Cell-to-Cell Spread

(2013) B. Nixon et al.   JOURNAL OF VIROLOGY

Antiviral Lectins from Red and Blue-Green Algae Show Potent In Vitro and In Vivo Activity against Hepatitis C Virus

(2013) Yutaka Takebe et al.   PLoS One

Role of the Carbohydrate-Binding Sites of Griffithsin in the Prevention of DC-SIGN-Mediated Capture and Transmission of HIV-1

(2013) Bart Hoorelbeke et al.   PLoS One

Mechanisms of HIV-1 subtype C resistance to GRFT, CV-N and SVN

(2013) Kabamba B. Alexandre et al.   VIROLOGY

Combinations of Griffithsin with Other Carbohydrate-Binding Agents Demonstrate Superior Activity Against HIV Type 1, HIV Type 2, and Selected Carbohydrate-Binding Agent-Resistant HIV Type 1 Strains

(2012) Geoffrey Férir et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Griffithsin inhibits Japanese encephalitis virus infection in vitro and in vivo

(2012) Hassan Z. A. Ishag et al.   ARCHIVES OF VIROLOGY

Global epidemiology of HIV infection in men who have sex with men

(2012) Chris Beyrer et al.   LANCET

The Role of Individual Carbohydrate-Binding Sites in the Function of the Potent Anti-HIV Lectin Griffithsin

(2012) Jie Xue et al.   MOLECULAR PHARMACEUTICS

Occluding the Mannose Moieties on Human Immunodeficiency Virus Type 1 gp120 with Griffithsin Improves the Antibody Responses to Both Proteins in Mice

(2011) Kaustuv Banerjee et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Griffithsin Has Antiviral Activity against Hepatitis C Virus

(2011) Philip Meuleman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Removal of two high-mannose N-linked glycans on gp120 renders human immunodeficiency virus 1 largely resistant to the carbohydrate-binding agent griffithsin

(2011) X. Huang et al.   JOURNAL OF GENERAL VIROLOGY

Binding of the Mannose-Specific Lectin, Griffithsin, to HIV-1 gp120 Exposes the CD4-Binding Site

(2011) K. B. Alexandre et al.   JOURNAL OF VIROLOGY

Investigation of Griffithsin's Interactions with Human Cells Confirms Its Outstanding Safety and Efficacy Profile as a Microbicide Candidate

(2011) Joseph Calvin Kouokam et al.   PLoS One

Synergistic activity profile of griffithsin in combination with tenofovir, maraviroc and enfuvirtide against HIV-1 clade C

(2011) Geoffrey Férir et al.   VIROLOGY

The lectins griffithsin, cyanovirin-N and scytovirin inhibit HIV-1 binding to the DC-SIGN receptor and transfer to CD4+ cells

(2011) Kabamba B. Alexandre et al.   VIROLOGY

Potent Strategy To Inhibit HIV-1 by Binding both gp120 and gp41

(2010) Ioannis Kagiampakis et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A Lectin Isolated from Bananas Is a Potent Inhibitor of HIV Replication

(2010) Michael D. Swanson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microvirin, a Novel α(1,2)-Mannose-specific Lectin Isolated fromMicrocystis aeruginosa, Has Anti-HIV-1 Activity Comparable with That of Cyanovirin-N but a Much Higher Safety Profile

(2010) Dana Huskens et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Grifonin-1: A Small HIV-1 Entry Inhibitor Derived from the Algal Lectin, Griffithsin

(2010) Ewa D. Micewicz et al.   PLoS One

Effectiveness and Safety of Tenofovir Gel, an Antiretroviral Microbicide, for the Prevention of HIV Infection in Women

(2010) Q. Abdool Karim et al.   SCIENCE

Monomerization of Viral Entry Inhibitor Griffithsin Elucidates the Relationship between Multivalent Binding to Carbohydrates and anti-HIV Activity

(2010) Tinoush Moulaei et al.   STRUCTURE

Mannose-rich glycosylation patterns on HIV-1 subtype C gp120 and sensitivity to the lectins, Griffithsin, Cyanovirin-N and Scytovirin

(2010) Kabamba B. Alexandre et al.   VIROLOGY

Broad-Spectrum In Vitro Activity and In Vivo Efficacy of the Antiviral Protein Griffithsin against Emerging Viruses of the Family Coronaviridae

(2009) B. R. O'Keefe et al.   JOURNAL OF VIROLOGY

Scaleable manufacture of HIV-1 entry inhibitor griffithsin and validation of its safety and efficacy as a topical microbicide component

(2009) B. R. O'Keefe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA