Design of Poly(lactic-co-glycolic Acid) (PLGA) Nanoparticles for Vaginal Co-Delivery of Griffithsin and Dapivirine and Their Synergistic Effect for HIV Prophylaxis

Impact of the griffithsin anti-HIV microbicide and placebo gels on the rectal mucosal proteome and microbiome in non-human primates

(2018) Lauren Girard et al.   Scientific Reports

Efaverinz and nano-gold-loaded mannosylated niosomes: a host cell-targeted topical HIV-1 prophylaxis via thermogel system

(2017) Tanushree Malik et al.   Artificial Cells Nanomedicine and Biotechnology

Nanomedicine in the development of anti-HIV microbicides

(2016) José das Neves et al.   ADVANCED DRUG DELIVERY REVIEWS

Nanoparticles-in-film for the combined vaginal delivery of anti-HIV microbicide drugs

(2016) Cassilda Cunha-Reis et al.   JOURNAL OF CONTROLLED RELEASE

Safety and Efficacy of a Dapivirine Vaginal Ring for HIV Prevention in Women

(2016) Annalene Nel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Use of a Vaginal Ring Containing Dapivirine for HIV-1 Prevention in Women

(2016) Jared M. Baeten et al.   NEW ENGLAND JOURNAL OF MEDICINE

Precise engineering of dapivirine-loaded nanoparticles for the development of anti-HIV vaginal microbicides

(2015) José das Neves et al.   Acta Biomaterialia

The Sheep as a Model of Preclinical Safety and Pharmacokinetic Evaluations of Candidate Microbicides

(2015) Jonathon D. S. Holt et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Generation of antigen-specific Foxp3+ regulatory T-cells in vivo following administration of diabetes-reversing tolerogenic microspheres does not require provision of antigen in the formulation

(2015) Carl Engman et al.   CLINICAL IMMUNOLOGY

Correction: Nanoformulations of Rilpivirine for Topical Pericoital and Systemic Coitus-Independent Administration Efficiently Prevent HIV Transmission

(2015) Martina Kovarova et al.   PLoS Pathogens

Simulated Biological Fluids with Possible Application in Dissolution Testing

(2015) Margareth R. C. Marques et al.   DISSOLUTION TECHNOLOGIES

Long-acting HIV drugs advanced to overcome adherence challenge

(2014) Elie Dolgin   NATURE MEDICINE

Biodistribution and Pharmacokinetics of Dapivirine-Loaded Nanoparticles after Vaginal Delivery in Mice

(2014) José das Neves et al.   PHARMACEUTICAL RESEARCH

Oral and Vaginal Epithelial Cell Lines Bind and Transfer Cell-Free Infectious HIV-1 to Permissive Cells but Are Not Productively Infected

(2014) Arinder Kohli et al.   PLoS One

Long-Acting Integrase Inhibitor Protects Macaques from Intrarectal Simian/Human Immunodeficiency Virus

(2014) C. D. Andrews et al.   SCIENCE

Assessment of topical microbicides to prevent HIV-1 transmission: Concepts, testing, lessons learned

(2013) David R. Friend et al.   ANTIVIRAL RESEARCH

In Vitro and Ex Vivo Evaluation of Polymeric Nanoparticles for Vaginal and Rectal Delivery of the Anti-HIV Drug Dapivirine

(2013) José das Neves et al.   MOLECULAR PHARMACEUTICS

Drug Synergy of Tenofovir and Nanoparticle-Based Antiretrovirals for HIV Prophylaxis

(2013) Thanyanan Chaowanachan et al.   PLoS One

A Perspective on Progress and Gaps in HIV Prevention Science

(2012) Patrick F. Kiser et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Safety and efficacy of tenofovir/IQP-0528 combination gels – A dual compartment microbicide for HIV-1 prevention

(2012) Charlene S. Dezzutti et al.   ANTIVIRAL RESEARCH

Reformulated tenofovir gel for use as a dual compartment microbicide

(2012) C. S. Dezzutti et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Is Wetter Better? An Evaluation of Over-the-Counter Personal Lubricants for Safety and Anti-HIV-1 Activity

(2012) Charlene S. Dezzutti et al.   PLoS One

The mechanisms of drug release in poly(lactic-co-glycolic acid)-based drug delivery systems—A review

(2011) Susanne Fredenberg et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Binding of the Mannose-Specific Lectin, Griffithsin, to HIV-1 gp120 Exposes the CD4-Binding Site

(2011) K. B. Alexandre et al.   JOURNAL OF VIROLOGY

Polymeric Nanoparticles Affect the Intracellular Delivery, Antiretroviral Activity and Cytotoxicity of the Microbicide Drug Candidate Dapivirine

(2011) José das Neves et al.   PHARMACEUTICAL RESEARCH

Synergistic activity profile of griffithsin in combination with tenofovir, maraviroc and enfuvirtide against HIV-1 clade C

(2011) Geoffrey Férir et al.   VIROLOGY

Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier

(2011) Hirenkumar K. Makadia et al.   Polymers

DDSolver: An Add-In Program for Modeling and Comparison of Drug Dissolution Profiles

(2010) Yong Zhang et al.   AAPS Journal

Potent Strategy To Inhibit HIV-1 by Binding both gp120 and gp41

(2010) Ioannis Kagiampakis et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A modified double-emulsion method for the preparation of daunorubicin-loaded polymeric nanoparticle with enhancedin vitroanti-tumor activity

(2010) Jie Liu et al.   Biomedical Materials

Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method

(2010) T.-C. Chou   CANCER RESEARCH

Antiretroviral release from poly(DL-lactide-co-glycolide) nanoparticles in mice

(2010) C. J. Destache et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Influence of experimental parameters and the copolymer structure on the size control of nanospheres in double emulsion method

(2010) Bin Xu et al.   JOURNAL OF POLYMER RESEARCH

Effectiveness and Safety of Tenofovir Gel, an Antiretroviral Microbicide, for the Prevention of HIV Infection in Women

(2010) Q. Abdool Karim et al.   SCIENCE

Nanotechnology-based systems for the treatment and prevention of HIV/AIDS

(2009) José das Neves et al.   ADVANCED DRUG DELIVERY REVIEWS

Combination antiretroviral drugs in PLGA nanoparticle for HIV-1

(2009) Christopher J Destache et al.   BMC INFECTIOUS DISEASES

Novel self-assembled core–shell nanoparticles based on crystalline amorphous moieties of aliphatic copolyesters for efficient controlled drug release

(2009) Sofia Papadimitriou et al.   JOURNAL OF CONTROLLED RELEASE

Scaleable manufacture of HIV-1 entry inhibitor griffithsin and validation of its safety and efficacy as a topical microbicide component

(2009) B. R. O'Keefe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The superior folding of a RANTES analogue expressed in lactobacilli as compared to mammalian cells reveals a promising system to screen new RANTES mutants

(2009) Massimiliano Secchi et al.   PROTEIN EXPRESSION AND PURIFICATION

Biomedical interventions to prevent HIV infection: evidence, challenges, and way forward

(2008) Nancy S Padian et al.   LANCET

Acidic Microclimate pH Distribution in PLGA Microspheres Monitored by Confocal Laser Scanning Microscopy

(2008) Amy G. Ding et al.   PHARMACEUTICAL RESEARCH

Targeted Delivery of PSC-RANTES for HIV-1 Prevention using Biodegradable Nanoparticles

(2008) Anthony S. Ham et al.   PHARMACEUTICAL RESEARCH