Hemagglutinin Cleavability, Acid Stability, and Temperature Dependence Optimize Influenza B Virus for Replication in Human Airways

Influenza virus entry via the GM3 ganglioside-mediated platelet-derived growth factor receptor β signalling pathway

(2019) Pieter Vrijens et al.   JOURNAL OF GENERAL VIROLOGY

European all-cause excess and influenza-attributable mortality in the 2017/18 season: should the burden of influenza B be reconsidered?

(2019) Jens Nielsen et al.   CLINICAL MICROBIOLOGY AND INFECTION

Tmprss2 knock-out mice are resistant to H10 influenza A virus pathogenesis

(2019) Ruth L. O. Lambertz et al.   JOURNAL OF GENERAL VIROLOGY

Influenza virus with increased pH of HA activation has improved replication in cell culture but at the cost of infectivity in human airway epithelium

(2019) Anika Singanayagam et al.   JOURNAL OF VIROLOGY

TMPRSS2 is the major activating protease of influenza A virus in primary human airway cells and influenza B virus in human type II pneumocytes

(2019) Hannah Limburg et al.   JOURNAL OF VIROLOGY

Kallikrein-related peptidase 5 and seasonal influenza viruses, limitations of the experimental models for activating proteases

(2018) Mélia Magnen et al.   BIOLOGICAL CHEMISTRY

Direct Visualization of the Conformational Dynamics of Single Influenza Hemagglutinin Trimers

(2018) Dibyendu Kumar Das et al.   CELL

New Threats from H7N9 Influenza Virus: Spread and Evolution of High- and Low-Pathogenicity Variants with High Genomic Diversity in Wave Five

(2018) Chuansong Quan et al.   JOURNAL OF VIROLOGY

Estimates of global seasonal influenza-associated respiratory mortality: a modelling study

(2018) A Danielle Iuliano et al.   LANCET

Influenza Hemagglutinin Protein Stability, Activation, and Pandemic Risk

(2018) Charles J. Russell et al.   TRENDS IN MICROBIOLOGY

Enterokinase Enhances Influenza A Virus Infection by Activating Trypsinogen in Human Cell Lines

(2018) Hideki Hayashi et al.   Frontiers in Cellular and Infection Microbiology

Host and viral determinants of influenza A virus species specificity

(2018) Jason S. Long et al.   NATURE REVIEWS MICROBIOLOGY

Gene correlation network analysis to identify regulatory factors in idiopathic pulmonary fibrosis

(2018) John E McDonough et al.   THORAX

Back to the Future: Lessons Learned From the 1918 Influenza Pandemic

(2018) Kirsty R. Short et al.   Frontiers in Cellular and Infection Microbiology

The Interplay between the Host Receptor and Influenza Virus Hemagglutinin and Neuraminidase

(2017) Lauren Byrd-Leotis et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

pH Optimum of Hemagglutinin-Mediated Membrane Fusion Determines Sensitivity of Influenza A Viruses to the Interferon-Induced Antiviral State and IFITMs

(2017) Thomas Gerlach et al.   JOURNAL OF VIROLOGY

Airway proteases: an emerging drug target for influenza and other respiratory virus infections

(2017) Manon Laporte et al.   Current Opinion in Virology

Kallikreins – The melting pot of activity and function

(2016) Magdalena Kalinska et al.   BIOCHIMIE

Knowns and unknowns of influenza B viruses

(2016) Marios Koutsakos et al.   Future Microbiology

Molecular requirements for a pandemic influenza virus: An acid-stable hemagglutinin protein

(2016) Marion Russier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intravirion cohesion of matrix protein M1 with ribonucleocapsid is a prerequisite of influenza virus infectivity

(2016) O.P. Zhirnov et al.   VIROLOGY

TMPRSS2 Independency for Haemagglutinin Cleavage In Vivo Differentiates Influenza B Virus from Influenza A Virus

(2016) Kouji Sakai et al.   Scientific Reports

Protease inhibitors targeting coronavirus and filovirus entry

(2015) Yanchen Zhou et al.   ANTIVIRAL RESEARCH

Influenza virus activating host proteases: Identification, localization and inhibitors as potential therapeutics

(2015) Wolfgang Garten et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Identification ofTMPRSS2as a Susceptibility Gene for Severe 2009 Pandemic A(H1N1) Influenza and A(H7N9) Influenza

(2015) Zhongshan Cheng et al.   JOURNAL OF INFECTIOUS DISEASES

A Mutant H3N2 Influenza Virus Uses an Alternative Activation Mechanism in TMPRSS2 Knockout Mice by Loss of an Oligosaccharide in the Hemagglutinin Stalk Region

(2015) Kouji Sakai et al.   JOURNAL OF VIROLOGY

H1N1 Swine Influenza Viruses Differ from Avian Precursors by a Higher pH Optimum of Membrane Fusion

(2015) Jan Baumann et al.   JOURNAL OF VIROLOGY

Mammalian adaptation of influenza A(H7N9) virus is limited by a narrow genetic bottleneck

(2015) Hassan Zaraket et al.   Nature Communications

The contrasting phylodynamics of human influenza B viruses

(2015) Dhanasekaran Vijaykrishna et al.   eLife

Identification, Characterization, and Natural Selection of Mutations Driving Airborne Transmission of A/H5N1 Virus

(2014) Martin Linster et al.   CELL

Estimates of mortality attributable to influenza and RSV in the United States during 1997-2009 by influenza type or subtype, age, cause of death, and risk status

(2014) Gonçalo Matias et al.   Influenza and Other Respiratory Viruses

TMPRSS2 Is a Host Factor That Is Essential for Pneumotropism and Pathogenicity of H7N9 Influenza A Virus in Mice

(2014) C. Tarnow et al.   JOURNAL OF VIROLOGY

DESC1 and MSPL Activate Influenza A Viruses and Emerging Coronaviruses for Host Cell Entry

(2014) P. Zmora et al.   JOURNAL OF VIROLOGY

The Host Protease TMPRSS2 Plays a Major Role in In Vivo Replication of Emerging H7N9 and Seasonal Influenza Viruses

(2014) K. Sakai et al.   JOURNAL OF VIROLOGY

The Burden of Influenza B: A Structured Literature Review

(2013) W. Paul Glezen et al.   AMERICAN JOURNAL OF PUBLIC HEALTH

Egg- or cell culture-derived hemagglutinin mutations impair virus stability and antigen content of inactivated influenza vaccines

(2013) Sabine Nakowitsch et al.   Biotechnology Journal

Cleavage Activation of Human-adapted Influenza Virus Subtypes by Kallikrein-related Peptidases 5 and 12

(2013) Brian S. Hamilton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

1918 Influenza Virus Hemagglutinin (HA) and the Viral RNA Polymerase Complex Enhance Viral Pathogenicity, but Only HA Induces Aberrant Host Responses in Mice

(2013) T. Watanabe et al.   JOURNAL OF VIROLOGY

Matriptase Proteolytically Activates Influenza Virus and Promotes Multicycle Replication in the Human Airway Epithelium

(2013) A. Beaulieu et al.   JOURNAL OF VIROLOGY

The pH of Activation of the Hemagglutinin Protein Regulates H5N1 Influenza Virus Replication and Pathogenesis in Mice

(2013) H. Zaraket et al.   JOURNAL OF VIROLOGY

Heterogeneity of the MDCK Cell Line and Its Applicability for Influenza Virus Research

(2013) Vladimir Y. Lugovtsev et al.   PLoS One

Structural basis for the divergent evolution of influenza B virus hemagglutinin

(2013) Fengyun Ni et al.   VIROLOGY

Tmprss2 Is Essential for Influenza H1N1 Virus Pathogenesis in Mice

(2013) Bastian Hatesuer et al.   PLoS Pathogens

Influenza HA Subtypes Demonstrate Divergent Phenotypes for Cleavage Activation and pH of Fusion: Implications for Host Range and Adaptation

(2013) Summer E. Galloway et al.   PLoS Pathogens

TMPRSS4 is a type II transmembrane serine protease involved in cancer and viral infections

(2012) Anke Ohler et al.   BIOLOGICAL CHEMISTRY

Altered receptor specificity and fusion activity of the haemagglutinin contribute to high virulence of a mouse-adapted influenza A virus

(2012) I. Koerner et al.   JOURNAL OF GENERAL VIROLOGY

Intrinsic Temperature Sensitivity of Influenza C Virus Hemagglutinin-Esterase-Fusion Protein

(2012) E. Takashita et al.   JOURNAL OF VIROLOGY

Cleavage Activation of the Human-Adapted Influenza Virus Subtypes by Matriptase Reveals both Subtype and Strain Specificities

(2012) B. S. Hamilton et al.   JOURNAL OF VIROLOGY

Matriptase, HAT, and TMPRSS2 Activate the Hemagglutinin of H9N2 Influenza A Viruses

(2012) Joanna Baron et al.   JOURNAL OF VIROLOGY

Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets

(2012) Masaki Imai et al.   NATURE

Hemagglutinin activating host cell proteases provide promising drug targets for the treatment of influenza A and B virus infections

(2012) Eva Böttcher-Friebertshäuser et al.   VACCINE

Influenza Virus-Mediated Membrane Fusion: Determinants of Hemagglutinin Fusogenic Activity and Experimental Approaches for Assessing Virus Fusion

(2012) Brian S. Hamilton et al.   Viruses-Basel

An unbiased approach for analysis of protein glycosylation and application to influenza vaccine hemagglutinin

(2011) Yanming An et al.   ANALYTICAL BIOCHEMISTRY

Biochemical Impact of the Host Adaptation-associated PB2 E627K Mutation on the Temperature-dependent RNA Synthesis Kinetics of Influenza A Virus Polymerase Complex

(2011) Shilpa Aggarwal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Influenza Hemagglutinin and Neuraminidase Membrane Glycoproteins

(2010) Steven J. Gamblin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel Inhibitors of Influenza Virus Fusion: Structure-Activity Relationship and Interaction with the Viral Hemagglutinin

(2010) E. Vanderlinden et al.   JOURNAL OF VIROLOGY

TMPRSS2 and TMPRSS4 Facilitate Trypsin-Independent Spread of Influenza Virus in Caco-2 Cells

(2010) S. Bertram et al.   JOURNAL OF VIROLOGY

The Low-pH Stability Discovered in Neuraminidase of 1918 Pandemic Influenza A Virus Enhances Virus Replication

(2010) Tadanobu Takahashi et al.   PLoS One

Proteolytic Activation of the 1918 Influenza Virus Hemagglutinin

(2009) C. Chaipan et al.   JOURNAL OF VIROLOGY

Avian Influenza Virus Glycoproteins Restrict Virus Replication and Spread through Human Airway Epithelium at Temperatures of the Proximal Airways

(2009) Margaret A. Scull et al.   PLoS Pathogens

Hepatocyte growth factor activator inhibitor-1 has a complex subcellular itinerary

(2008) Sine Godiksen et al.   BIOCHEMICAL JOURNAL

Molecular studies of temperature-sensitive replication of the cold-adapted B/Ann Arbor/1/66, the master donor virus for live attenuated influenza FluMist® vaccines

(2008) Zhongying Chen et al.   VIROLOGY