Platelets in Inflammation and Resolution

Neutrophil activation and NETosis are the major drivers of thrombosis in heparin-induced thrombocytopenia

(2019) José Perdomo et al.   Nature Communications

Challenging the concept of immunothrombosis

(2019) Raghavendra Palankar et al.   BLOOD

Human megakaryocytes possess intrinsic anti-viral immunity through regulated induction of IFITM3

(2019) Robert A. Campbell et al.   BLOOD

Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer

(2019) Mohsen Malehmir et al.   NATURE MEDICINE

The role of platelets in mediating a response to human influenza infection

(2019) Milka Koupenova et al.   Nature Communications

Modulation of megakaryopoiesis and platelet production during inflammation

(2019) Genevieve Couldwell et al.   THROMBOSIS RESEARCH

Regulation of Innate Immune Responses by Platelets

(2019) Lucas Secchim Ribeiro et al.   Frontiers in Immunology

Platelets play an essential role in murine lung development through Clec-2/podoplanin interaction

(2018) Nagaharu Tsukiji et al.   BLOOD

α-Toxin Induces Platelet Aggregation and Liver Injury during Staphylococcus aureus Sepsis

(2018) Bas G.J. Surewaard et al.   Cell Host & Microbe

NLRP3 regulates platelet integrin αIIbβ3 outside-in signaling, hemostasis and arterial thrombosis

(2018) Jianlin Qiao et al.   HAEMATOLOGICA

Platelet Munc13-4 regulates hemostasis, thrombosis and airway inflammation

(2018) Eduardo I. Cardenas et al.   HAEMATOLOGICA

Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators

(2018) Charles N. Serhan et al.   JOURNAL OF CLINICAL INVESTIGATION

Soluble CD40 ligand disrupts the blood–brain barrier and exacerbates inflammation in experimental autoimmune encephalomyelitis

(2018) Hiroki Masuda et al.   JOURNAL OF NEUROIMMUNOLOGY

Platelets kill bacteria by bridging innate and adaptive immunity via platelet factor 4 and FcγRIIA

(2018) R. Palankar et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Platelets release pathogenic serotonin and return to circulation after immune complex-mediated sequestration

(2018) Nathalie Cloutier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of IP6K1 suppresses neutrophil-mediated pulmonary damage in bacterial pneumonia

(2018) Qingming Hou et al.   Science Translational Medicine

Cathelicidins prime platelets to mediate arterial thrombosis and tissue inflammation

(2018) Joachim Pircher et al.   Nature Communications

Differential Interaction of Platelet-Derived Extracellular Vesicles with Leukocyte Subsets in Human Whole Blood

(2018) René Weiss et al.   Scientific Reports

NLRP3 regulates platelet integrin αIIbβ3 outside-in signaling, hemostasis and arterial thrombosis

(2018) Jianlin Qiao et al.   HAEMATOLOGICA

Platelet Munc13-4 regulates hemostasis, thrombosis and airway inflammation

(2018) Eduardo I. Cardenas et al.   HAEMATOLOGICA

Ability of Platelet-Derived Extracellular Vesicles to Promote Neutrophil-Endothelial Cell Interactions

(2018) Sahithi J. Kuravi et al.   INFLAMMATION

Platelet activation and prothrombotic properties in a mouse model of peritoneal sepsis

(2018) Fanny Vardon Bounes et al.   Scientific Reports

TLR4-dependent upregulation of the platelet NLRP3 inflammasome promotes platelet aggregation in a murine model of hindlimb ischemia

(2018) Sebastian Vogel et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Salmonella-induced thrombi in mice develop asynchronously in the spleen and liver and are not effective bacterial traps

(2018) Nonantzin Beristain-Covarrubias et al.   BLOOD

Regulatory T Cells Promote Macrophage Efferocytosis during Inflammation Resolution

(2018) Jonathan D. Proto et al.   IMMUNITY

Role of platelets and platelet receptors in cancer metastasis

(2018) Martin Schlesinger   Journal of Hematology & Oncology

Role of Platelets in Leukocyte Recruitment and Resolution of Inflammation

(2018) Jan Rossaint et al.   Frontiers in Immunology

Platelet rescue by macrophage depletion in obese ADAMTS-13-deficient mice at risk of thrombotic thrombocytopenic purpura

(2017) L. Geys et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Maresin 1 induces a novel pro-resolving phenotype in human platelets

(2017) K. L. Lannan et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Transient von Willebrand factor-mediated platelet influx stimulates liver regeneration after partial hepatectomy in mice

(2017) Marc Kirschbaum et al.   LIVER INTERNATIONAL

Activated Platelets Induce an Anti-Inflammatory Response of Monocytes/Macrophages through Cross-Regulation of PGE2 and Cytokines

(2017) Bona Linke et al.   MEDIATORS OF INFLAMMATION

The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors

(2017) Emma Lefrançais et al.   NATURE

New Concepts and Mechanisms of Platelet Activation Signaling

(2017) Brian Estevez et al.   PHYSIOLOGY

Endothelial Wnt/β-catenin signaling reduces immune cell infiltration in multiple sclerosis

(2017) Justin E. Lengfeld et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The podoplanin-CLEC-2 axis inhibits inflammation in sepsis

(2017) Julie Rayes et al.   Nature Communications

Leukocyte integrin Mac-1 regulates thrombosis via interaction with platelet GPIbα

(2017) Yunmei Wang et al.   Nature Communications

Effects of chronic inflammation on megakaryocyte and platelet function in a conditional mouse model

(2016) M. Salzmann et al.   ATHEROSCLEROSIS

Disulfide HMGB1 derived from platelets coordinates venous thrombosis in mice

(2016) K. Stark et al.   BLOOD

Thrombocytopenia is associated with a dysregulated host response in critically ill sepsis patients

(2016) T. A. M. Claushuis et al.   BLOOD

Resolution of Acute Inflammation and the Role of Resolvins in Immunity, Thrombosis, and Vascular Biology

(2016) Brian E. Sansbury et al.   CIRCULATION RESEARCH

Platelets Mediate Host Defense againstStaphylococcus aureusthrough Direct Bactericidal Activity and by Enhancing Macrophage Activities

(2016) Ramadan A. Ali et al.   JOURNAL OF IMMUNOLOGY

Platelet-borne complement proteins and their role in platelet-bacteria interactions

(2016) I. Arbesu et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The lectin complement pathway serine proteases (MASPs) represent a possible crossroad between the coagulation and complement systems in thromboinflammation

(2016) H. Kozarcanin et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Neutrophils are not required for resolution of acute gouty arthritis in mice

(2016) Laurent L Reber et al.   NATURE MEDICINE

Blockade of Thrombopoietin Reduces Organ Damage in Experimental Endotoxemia and Polymicrobial Sepsis

(2016) Alessandra Cuccurullo et al.   PLoS One

Blood coagulation in immunothrombosis—At the frontline of intravascular immunity

(2016) Florian Gaertner et al.   SEMINARS IN IMMUNOLOGY

Directed transport of neutrophil-derived extracellular vesicles enables platelet-mediated innate immune response

(2016) Jan Rossaint et al.   Nature Communications

Platelets Guide Leukocytes to Their Sites of Extravasation

(2016) Gabriele Zuchtriegel et al.   PLOS BIOLOGY

Topographic Cues Reveal Two Distinct Spreading Mechanisms in Blood Platelets

(2016) Rabea Sandmann et al.   Scientific Reports

Single platelets seal neutrophil-induced vascular breaches via GPVI during immune-complex-mediated inflammation in mice

(2015) A. Gros et al.   BLOOD

Fibrin activates GPVI in human and mouse platelets

(2015) O. M. Alshehri et al.   BLOOD

Platelet secretion: From haemostasis to wound healing and beyond

(2015) Ewelina M. Golebiewska et al.   BLOOD REVIEWS

Platelets convert peripheral blood circulating monocytes to regulatory cells via immunoglobulin G and activating-type Fcγ receptors

(2015) Masanori Inui et al.   BMC IMMUNOLOGY

Is enhanced platelet activation the missing link leading to increased cardiovascular risk in psoriasis?

(2015) Laxmisha Chandrashekar et al.   CLINICA CHIMICA ACTA

Imaging the dynamic platelet-neutrophil response in sterile liver injury and repair in mice

(2015) Ingrid Slaba et al.   HEPATOLOGY

Platelets modulate the immune response following trauma by interaction with CD4+ T regulatory cells in a mouse model

(2015) Christian B. Bergmann et al.   IMMUNOLOGIC RESEARCH

Platelet-derived HMGB1 is a critical mediator of thrombosis

(2015) Sebastian Vogel et al.   JOURNAL OF CLINICAL INVESTIGATION

HMGB1 binds to activated platelets via the receptor for advanced glycation end products and is present in platelet rich human coronary artery thrombi

(2015) Michael Bode et al.   THROMBOSIS AND HAEMOSTASIS

Desialylation is a mechanism of Fc-independent platelet clearance and a therapeutic target in immune thrombocytopenia

(2015) June Li et al.   Nature Communications

Age-related changes in platelet function are more profound in women than in men

(2015) Jonathan Cowman et al.   Scientific Reports

Elevated platelet activation in patients with chronic urticaria: a comparison between aspirin-intolerant and aspirin-tolerant groups

(2014) Sailesh Palikhe et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Platelet Glycoprotein Ib-IX as a Regulator of Systemic Inflammation

(2014) Adam Corken et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cellular thrust and parry in the leukemic niche

(2014) Y. Kfoury et al.   BLOOD

Platelets promote allergic asthma through the expression of CD154

(2014) Jun Tian et al.   Cellular & Molecular Immunology

Maresin-like Lipid Mediators Are Produced by Leukocytes and Platelets and Rescue Reparative Function of Diabetes-Impaired Macrophages

(2014) Song Hong et al.   CHEMISTRY & BIOLOGY

Platelets and allergic inflammation

(2014) C. Page et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Platelet count and aging

(2014) C. L. Balduini et al.   HAEMATOLOGICA

Platelets provoke distinct dynamics of immune responses by differentially regulating CD4+T-cell proliferation

(2014) L. Zhu et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Activated platelets present high mobility group box 1 to neutrophils, inducing autophagy and promoting the extrusion of neutrophil extracellular traps

(2014) N. Maugeri et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines

(2014) Christine Schauer et al.   NATURE MEDICINE

Maresin 1 biosynthesis during platelet–neutrophil interactions is organ-protective

(2014) Raja-Elie E. Abdulnour et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutrophils scan for activated platelets to initiate inflammation

(2014) Vinatha Sreeramkumar et al.   SCIENCE

Ectosomes released by platelets induce differentiation of CD4+ T cells into T regulatory cells

(2014) Ceylan Eken et al.   THROMBOSIS AND HAEMOSTASIS

Platelets induce a proinflammatory phenotype in monocytes via the CD147 pathway in rheumatoid arthritis

(2014) Meng-yao Rong et al.   ARTHRITIS RESEARCH & THERAPY

Production of Serotonin by Tryptophan Hydroxylase 1 and Release via Platelets Contribute to Allergic Airway Inflammation

(2013) Thorsten Dürk et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Platelets mediate increased endothelium permeability in dengue through NLRP3-inflammasome activation

(2013) E. D. Hottz et al.   BLOOD

Platelet endothelial cell adhesion molecule 1 deficiency misguides venous thrombus resolution

(2013) J. Kellermair et al.   BLOOD

Nucleation of platelets with blood-borne pathogens on Kupffer cells precedes other innate immunity and contributes to bacterial clearance

(2013) Connie H Y Wong et al.   NATURE IMMUNOLOGY

Platelet activation in chronic urticaria and its correlation with disease severity

(2013) Laxmisha Chandrashekar et al.   PLATELETS

Age- And Sex-Related Variations in Platelet Count in Italy: A Proposal of Reference Ranges Based on 40987 Subjects' Data

(2013) Ginevra Biino et al.   PLoS One

Platelets and matrix metalloproteinases

(2013) Peter Seizer et al.   THROMBOSIS AND HAEMOSTASIS

Platelet-derived PF4 reduces neutrophil apoptosis following arterial occlusion

(2013) Dirk Lievens et al.   THROMBOSIS AND HAEMOSTASIS

Platelet Activation, P-Selectin, and Eosinophil β1-Integrin Activation in Asthma

(2012) Mats W. Johansson et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Platelet Factor 4 Activity against P. falciparum and Its Translation to Nonpeptidic Mimics as Antimalarials

(2012) Melissa S. Love et al.   Cell Host & Microbe

Platelets Contribute to the Pathogenesis of Experimental Autoimmune Encephalomyelitis

(2012) Harald F. Langer et al.   CIRCULATION RESEARCH

Platelet Activation Receptor CLEC-2 Regulates Blood/Lymphatic Vessel Separation by Inhibiting Proliferation, Migration, and Tube Formation of Lymphatic Endothelial Cells

(2012) Makoto Osada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo

(2012) Marie-Luise von Brühl et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Platelets Present Antigen in the Context of MHC Class I

(2012) L. M. Chapman et al.   JOURNAL OF IMMUNOLOGY

Excess Soluble CD40L Contributes to Blood Brain Barrier Permeability In Vivo: Implications for HIV-Associated Neurocognitive Disorders

(2012) Donna C. Davidson et al.   PLoS One

Microtubule and cortical forces determine platelet size during vascular platelet production

(2012) Jonathan N Thon et al.   Nature Communications

Release of angiogenesis regulatory proteins from platelet alpha granules: modulation of physiologic and pathologic angiogenesis

(2011) E. M. Battinelli et al.   BLOOD

Microparticles (Ectosomes) Shed by Stored Human Platelets Downregulate Macrophages and Modify the Development of Dendritic Cells

(2011) S. Sadallah et al.   JOURNAL OF IMMUNOLOGY

Mannose-Binding Lectin-Associated Serine Protease-1 Is a Significant Contributor to Coagulation in a Murine Model of Occlusive Thrombosis

(2011) L. R. La Bonte et al.   JOURNAL OF IMMUNOLOGY

Platelet adhesion and activation mechanisms in arterial thrombosis and ischaemic stroke

(2011) B. NIESWANDT et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The Human Endogenous Circadian System Causes Greatest Platelet Activation during the Biological Morning Independent of Behaviors

(2011) Frank A. J. L. Scheer et al.   PLoS One

Monocyte-Platelet Interaction Induces a Pro-Inflammatory Phenotype in Circulating Monocytes

(2011) Gabriella Passacquale et al.   PLoS One

Normal range of mean platelet volume in healthy subjects: Insight from a large epidemiologic study

(2011) Hilmi Demirin et al.   THROMBOSIS RESEARCH

Resolvin E1 Regulates Adenosine Diphosphate Activation of Human Platelets

(2010) Gabrielle Fredman et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Platelet CD40L mediates thrombotic and inflammatory processes in atherosclerosis

(2010) D. Lievens et al.   BLOOD

Determinants of platelet count in humans

(2010) M. E. Daly   HAEMATOLOGICA

CD40 ligand shedding is regulated by interaction between matrix metalloproteinase-2 and platelet integrin αIIbβ3

(2010) W.-S. CHOI et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Platelet aggregation in severe sepsis

(2010) Gábor Woth et al.   JOURNAL OF THROMBOSIS AND THROMBOLYSIS

Platelet adhesion to collagen

(2010) Benedicte P. Nuyttens et al.   THROMBOSIS RESEARCH

Timed feeding of mice modulates light-entrained circadian rhythms of reticulated platelet abundance and plasma thrombopoietin and affects gene expression in megakaryocytes

(2009) Paul S. Hartley et al.   BRITISH JOURNAL OF HAEMATOLOGY

Platelets Kill Intraerythrocytic Malarial Parasites and Mediate Survival to Infection

(2009) B. J. McMorran et al.   SCIENCE

Resolvin E1, an EPA-derived mediator in whole blood, selectively counterregulates leukocytes and platelets

(2008) M. Dona et al.   BLOOD

Complement activation triggered by chondroitin sulfate released by thrombin receptor-activated platelets

(2008) O. A. HAMAD et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Allergen Induces the Migration of Platelets to Lung Tissue in Allergic Asthma

(2007) Simon C. Pitchford et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Role of metalloproteinases in platelet function

(2007) María José Santos-Martínez et al.   THROMBOSIS RESEARCH