Platelet adhesion and activation mechanisms in arterial thrombosis and ischaemic stroke

Dividing VI by X(a)

(2011) B. Nieswandt et al.   BLOOD

Coagulation-induced shedding of platelet glycoprotein VI mediated by factor Xa

(2011) M. Al-Tamimi et al.   BLOOD

Mechanisms underlying FeCl3-induced arterial thrombosis

(2011) A. ECKLY et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Genetic and antibody-induced glycoprotein VI deficiency equally protects mice from mechanically and FeCl3-induced thrombosis

(2011) M. BENDER et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Combating innate inflammation: a new paradigm for acute treatment of stroke?

(2010) Guido Stoll et al.   Annals of the New York Academy of Sciences

Acute anti-inflammatory approaches to ischemic stroke

(2010) Gregory J. Del Zoppo   Annals of the New York Academy of Sciences

Platelets

(2010) Cara C. Bertozzi et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Binding of von Willebrand Factor to Collagen and Glycoprotein Ibα, But Not to Glycoprotein IIb/IIIa, Contributes to Ischemic Stroke in Mice—Brief Report

(2010) Simon F. De Meyer et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Dissolution of arterial platelet thrombi in vivo with a bifunctional platelet GPIIIa49-66 ligand which specifically targets the platelet thrombus

(2010) W. Zhang et al.   BLOOD

Novel function for blood platelets and podoplanin in developmental separation of blood and lymphatic circulation

(2010) P. Uhrin et al.   BLOOD

Differentially regulated GPVI ectodomain shedding by multiple platelet-expressed proteinases

(2010) M. Bender et al.   BLOOD

Multiple alterations of platelet functions dominated by increased secretion in mice lacking Cdc42 in platelets

(2010) I. Pleines et al.   BLOOD

ADF/n-cofilin-dependent actin turnover determines platelet formation and sizing

(2010) M. Bender et al.   BLOOD

Early detrimental T-cell effects in experimental cerebral ischemia are neither related to adaptive immunity nor thrombus formation

(2010) C. Kleinschnitz et al.   BLOOD

CLEC-2 activates Syk through dimerization

(2010) C. E. Hughes et al.   BLOOD

Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling

(2010) C. C. Bertozzi et al.   BLOOD

Factor XIIa Inhibitor Recombinant Human Albumin Infestin-4 Abolishes Occlusive Arterial Thrombus Formation Without Affecting Bleeding

(2010) Ina Hagedorn et al.   CIRCULATION

Essentialin VivoRoles of the C-type Lectin Receptor CLEC-2

(2010) Katsue Suzuki-Inoue et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Syk-dependent Phosphorylation of CLEC-2

(2010) Sonia Séverin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GPVI and CLEC-2 in hemostasis and vascular integrity

(2010) S. P. WATSON et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

CLEC-2 is not required for platelet aggregation at arteriolar shear

(2010) C. E. HUGHES et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The final steps of integrin activation: the end game

(2010) Sanford J. Shattil et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

G Protein Subunit G 13 Binds to Integrin  IIb 3 and Mediates Integrin "Outside-In" Signaling

(2010) H. Gong et al.   SCIENCE

Platelets Amplify Inflammation in Arthritis via Collagen-Dependent Microparticle Production

(2010) E. Boilard et al.   SCIENCE

Impaired  IIb 3 Integrin Activation and Shear-Dependent Thrombus Formation in Mice Lacking Phospholipase D1

(2010) M. Elvers et al.   Science Signaling

Soluble Glycoprotein VI Is Raised in the Plasma of Patients With Acute Ischemic Stroke

(2010) Mohammad Al-Tamimi et al.   STROKE

RACK1 associates with CLEC-2 and promotes its ubiquitin–proteasome degradation

(2009) Yuanyuan Ruan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Platelet Receptor CLEC-2 Is Active as a Dimer

(2009) Aleksandra A. Watson et al.   BIOCHEMISTRY

Absence of collagen-induced platelet activation caused by compound heterozygous GPVI mutations

(2009) B. Dumont et al.   BLOOD

von Willebrand factor-cleaving protease ADAMTS13 reduces ischemic brain injury in experimental stroke

(2009) B.-Q. Zhao et al.   BLOOD

Deficiency of von Willebrand factor protects mice from ischemic stroke

(2009) C. Kleinschnitz et al.   BLOOD

ADAMTS13 gene deletion aggravates ischemic brain damage: a possible neuroprotective role of ADAMTS13 by ameliorating postischemic hypoperfusion

(2009) M. Fujioka et al.   BLOOD

CLEC-2 is an essential platelet-activating receptor in hemostasis and thrombosis

(2009) F. May et al.   BLOOD

Platelet Polyphosphates Are Proinflammatory and Procoagulant Mediators In Vivo

(2009) Felicitas Müller et al.   CELL

Expression of platelet glycoprotein VI is associated with transient ischemic attack and stroke

(2009) B. Bigalke et al.   EUROPEAN JOURNAL OF NEUROLOGY

Platelet receptors and signaling in the dynamics of thrombus formation

(2009) J. Rivera et al.   HAEMATOLOGICA

Calcium signaling in platelets

(2009) D. VARGA-SZABO et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Novel molecules in calcium signaling in platelets

(2009) W. BERGMEIER et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Endothelial cell specific adhesion molecule (ESAM) localizes to platelet–platelet contacts and regulates thrombus formationin vivo

(2009) T. J. STALKER et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Integrins in platelet activation

(2009) B. NIESWANDT et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

A compound heterozygous mutation in glycoprotein VI in a patient with a bleeding disorder

(2009) C. HERMANS et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Arterial thrombosis: relevance of a model with two levels of severity assessed by histologic, ultrastructural and functional characterization

(2009) B. HECHLER et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans

(2009) Nikolay L Malinin et al.   NATURE MEDICINE

Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation

(2009) Lena Svensson et al.   NATURE MEDICINE

A shear gradient–dependent platelet aggregation mechanism drives thrombus formation

(2009) Warwick S Nesbitt et al.   NATURE MEDICINE

When Recanalization Does Not Improve Clinical Outcomes

(2009) Shelagh B. Coutts et al.   STROKE

Novel Therapeutic Targets at the Platelet Vascular Interface

(2008) Lawrence F. Brass et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Molecular characterization of two novel isoforms and a soluble form of mouse CLEC-2

(2008) Jianhui Xie et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Orai1 (CRACM1) is the platelet SOC channel and essential for pathological thrombus formation

(2008) A. Braun et al.   BLOOD

Kindlin-3: a new gene involved in the pathogenesis of LAD-III

(2008) A. Mory et al.   BLOOD

Molecular mechanisms of thrombus formation in ischemic stroke: novel insights and targets for treatment

(2008) G. Stoll et al.   BLOOD

Novel roles for factor XII-driven plasma contact activation system

(2008) Felicitas Müller et al.   CURRENT OPINION IN HEMATOLOGY

Thrombomodulation via CLEC-2 targeting

(2008) Chris A O’Callaghan   CURRENT OPINION IN PHARMACOLOGY

RIAM Activates Integrins by Linking Talin to Ras GTPase Membrane-targeting Sequences

(2008) Ho-Sup Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endothelial cell O-glycan deficiency causes blood/lymphatic misconnections and consequent fatty liver disease in mice

(2008) Jianxin Fu et al.   JOURNAL OF CLINICAL INVESTIGATION

The calcium sensor STIM1 is an essential mediator of arterial thrombosis and ischemic brain infarction

(2008) David Varga-Szabo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ex vivo inhibition of thrombus formation by an anti-glycoprotein VI Fab fragment in non-human primates without modification of glycoprotein VI expression

(2008) P. OHLMANN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Critical Role of FcR γ-Chain, LAT, PLCγ2 and Thrombin in Arteriolar Thrombus Formation upon Mild, Laser-Induced Endothelial InjuryIn Vivo

(2008) Neena Kalia et al.   MICROCIRCULATION

Kindlin-3 is essential for integrin activation and platelet aggregation

(2008) Markus Moser et al.   NATURE MEDICINE

Rac1 is essential for phospholipase C-γ2 activation in platelets

(2008) Irina Pleines et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Store-operated Ca2+ entry in platelets occurs independently of transient receptor potential (TRP) C1

(2008) David Varga-Szabo et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Blockade of Bradykinin Receptor B1 but Not Bradykinin Receptor B2 Provides Protection From Cerebral Infarction and Brain Edema

(2008) Madeleine Austinat et al.   STROKE

Emergency Administration of Abciximab for Treatment of Patients With Acute Ischemic Stroke: Results of an International Phase III Trial

(2007) Harold P. Adams et al.   STROKE