Regulation of Cell Signaling Pathways by Berberine in Different Cancers: Searching for Missing Pieces of an Incomplete Jig-Saw Puzzle for an Effective Cancer Therapy

Berberine as a potential autophagy modulator

(2019) Reza Mohammadinejad et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Berberine and zinc oxide-based nanoparticles for the chemo-photothermal therapy of lung adenocarcinoma

(2018) Sungyun Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hyaluronate/lactoferrin layer-by-layer-coated lipid nanocarriers for targeted co-delivery of rapamycin and berberine to lung carcinoma

(2018) Dalia M. Kabary et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Inhalable multi-compartmental phospholipid enveloped lipid core nanocomposites for localized mTOR inhibitor/herbal combined therapy of lung carcinoma

(2018) Dalia M. Kabary et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Berberine Hydrochloride-Loaded Chitosan Nanoparticles Effectively Targets and Suppresses Human Nasopharyngeal Carcinoma

(2018) Yonghong Wang et al.   Journal of Biomedical Nanotechnology

Tumor control by hypoxia-specific chemotargeting of iron-oxide nanoparticle – Berberine complexes in a mouse model

(2018) S. Sreeja et al.   LIFE SCIENCES

Inhibition of mTOR/S6K1/4E-BP1 Signaling by Nutraceutical SIRT1 Modulators

(2018) Sara Bianchi et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Extracellular Vesicles As miRNA Nano-Shuttles: Dual Role in Tumor Progression

(2018) Marzia Pucci et al.   Targeted Oncology

Cell-specific pattern of berberine pleiotropic effects on different human cell lines

(2018) Alessandro Agnarelli et al.   Scientific Reports

mTOR Pathways in Cancer and Autophagy

(2018) Mathieu Paquette et al.   Cancers

Extracellular Vesicles Derived from Hypoxic Colorectal Cancer Cells Confer Metastatic Phenotype to Non-metastatic Cancer Cells

(2018) EDGARS ENDZELIŅŠ et al.   ANTICANCER RESEARCH

Role of mTOR Signaling in Tumor Microenvironment: An Overview

(2018) Fabiana Conciatori et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

SWATH-MS based quantitative proteomics analysis reveals that curcumin alters the metabolic enzyme profile of CML cells by affecting the activity of miR-22/IPO7/HIF-1α axis

(2018) Francesca Monteleone et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Systematic identification of non-coding pharmacogenomic landscape in cancer

(2018) Yue Wang et al.   Nature Communications

Involvement of AMP-activated protein kinase and Death Receptor 5 in TRAIL-Berberine-induced apoptosis of cancer cells

(2018) Rong Ke et al.   Scientific Reports

Synergistic effect of berberine and HMQ1611 impairs cell proliferation and migration by regulating Wnt signaling pathway in hepatocellular carcinoma

(2018) Bingling Dai et al.   PHYTOTHERAPY RESEARCH

Berberine Attenuated Proliferation, Invasion and Migration by Targeting the AMPK/HNF4α/WNT5A Pathway in Gastric Carcinoma

(2018) Qian Hu et al.   Frontiers in Pharmacology

Non-coding RNAs and Berberine: A new mechanism of its anti-diabetic activities

(2017) Wenguang Chang   EUROPEAN JOURNAL OF PHARMACOLOGY

Dendrimer encapsulated and conjugated delivery of berberine: A novel approach mitigating toxicity and improving in vivo pharmacokinetics

(2017) Lokesh Gupta et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Bioformulation of silver nanoparticles as berberine carrier cum anticancer agent against breast cancer

(2017) Ramasamy Bhanumathi et al.   NEW JOURNAL OF CHEMISTRY

Role of nutraceutical SIRT1 modulators in AMPK and mTOR pathway: Evidence of a synergistic effect

(2017) Luca Giovannini et al.   NUTRITION

Berberine binds RXRα to suppress β-catenin signaling in colon cancer cells

(2017) H Ruan et al.   ONCOGENE

MicroRNA-100 shuttled by mesenchymal stem cell-derived exosomes suppresses in vitro angiogenesis through modulating the mTOR/HIF-1α/VEGF signaling axis in breast cancer cells

(2017) Katayoon Pakravan et al.   CELLULAR ONCOLOGY

Berberine and cinnamaldehyde together prevent lung carcinogenesis

(2017) Mingjing Meng et al.   Oncotarget

Exosomes as diagnostic and predictive biomarkers in lung cancer

(2017) Pablo Reclusa et al.   Journal of Thoracic Disease

mTOR remains unchanged in diet-resistant (DR) rats despite impaired LKB1/AMPK cascade in adipose tissue

(2016) Jie Han et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Synergistic anti-cancer effects of galangin and berberine through apoptosis induction and proliferation inhibition in oesophageal carcinoma cells

(2016) Kewei Ren et al.   BIOMEDICINE & PHARMACOTHERAPY

Communication by Extracellular Vesicles: Where We Are and Where We Need to Go

(2016) Mercedes Tkach et al.   CELL

Onto better TRAILs for cancer treatment

(2016) D de Miguel et al.   CELL DEATH AND DIFFERENTIATION

Gadd45a is a heterochromatin relaxer that enhances iPS cell generation

(2016) Keshi Chen et al.   EMBO REPORTS

Berberine modulates cisplatin sensitivity of human gastric cancer cells by upregulation of miR-203

(2016) He-Yi You et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Silver Nanoparticles Exhibit the Dose-Dependent Anti-Proliferative Effect against Human Squamous Carcinoma Cells Attenuated in the Presence of Berberine

(2016) Arkadiusz Dziedzic et al.   MOLECULES

Curcumin modulates chronic myelogenous leukemia exosomes composition and affects angiogenic phenotype via exosomal miR-21

(2016) Simona Taverna et al.   Oncotarget

Berberine induces autophagy in glioblastoma by targeting the AMPK/mTOR/ULK1-pathway

(2016) Jiwei Wang et al.   Oncotarget

Berberine Attenuates Development of the Hepatic Gluconeogenesis and Lipid Metabolism Disorder in Type 2 Diabetic Mice and in Palmitate-Incubated HepG2 Cells through Suppression of the HNF-4α miR122 Pathway

(2016) Shengnan Wei et al.   PLoS One

Resveratrol induces autophagy by directly inhibiting mTOR through ATP competition

(2016) Dohyun Park et al.   Scientific Reports

Berberine Increases Doxorubicin Sensitivity by Suppressing STAT3 in Lung Cancer

(2015) Ting Zhu et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Berberine Sensitizes Human Ovarian Cancer Cells to Cisplatin Through miR-93/PTEN/Akt Signaling Pathway

(2015) Qiaoyun Chen et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Cellular and molecular effects of the mTOR inhibitor everolimus

(2015) U. Saran et al.   CLINICAL SCIENCE

GADD45a physically and functionally interacts with TET1

(2015) Sabine Kienhöfer et al.   DIFFERENTIATION

Berberine ameliorates nonalcoholic fatty liver disease by a global modulation of hepatic mRNA and lncRNA expression profiles

(2015) Xinlu Yuan et al.   Journal of Translational Medicine

Gadd45a promotes DNA demethylation through TDG

(2015) Zheng Li et al.   NUCLEIC ACIDS RESEARCH

Berberine and Curcumin Target Survivin and STAT3 in Gastric Cancer Cells and Synergize Actions of Standard Chemotherapeutic 5-Fluorouracil

(2015) Arvind Pandey et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Dendrosomal curcumin increases expression of the long non-coding RNA gene MEG3 via up-regulation of epi-miRs in hepatocellular cancer

(2015) Mina Zamani et al.   PHYTOMEDICINE

Systematic analysis of berberine-induced signaling pathway between miRNA clusters and mRNAs and identification of mir-99a∼125b cluster function by seed-targeting inhibitors in multiple myeloma cells

(2015) Maoxiao Feng et al.   RNA Biology

Inhibition of p38 mitogen-activated protein kinase potentiates the apoptotic effect of berberine/tumor necrosis factor-related apoptosis-inducing ligand combination therapy

(2015) ALAA REFAAT et al.   Oncology Letters

Berberine may rescue Fusobacterium nucleatum-induced colorectal tumorigenesis by modulating the tumor microenvironment

(2015) Ya-Nan Yu et al.   Oncotarget

Curcumin inhibits in vitro and in vivo chronic myelogenous leukemia cells growth: a possible role for exosomal disposal of miR-21

(2015) Simona Taverna et al.   Oncotarget

MicroRNAs and Chinese Medicinal Herbs: New Possibilities in Cancer Therapy

(2015) Ming Hong et al.   Cancers

Berberine Inhibits Invasion and Metastasis of Colorectal Cancer Cells via COX-2/PGE2 Mediated JAK2/STAT3 Signaling Pathway

(2015) Xuan Liu et al.   PLoS One

Enhancing the Antitumor Activity of Berberine Hydrochloride by Solid Lipid Nanoparticle Encapsulation

(2014) Lu Wang et al.   AAPS PHARMSCITECH

Integrative analysis of differential miRNA and functional study of miR-21 by seed-targeting inhibition in multiple myeloma cells in response to berberine

(2014) Xiaochuang Luo et al.   BMC Systems Biology

Getting TRAIL back on track for cancer therapy

(2014) J Lemke et al.   CELL DEATH AND DIFFERENTIATION

The anti-atherogenic effects of berberine on foam cell formation are mediated through the upregulation of sirtuin 1

(2014) LIYI CHI et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Palmatine inhibits growth and invasion in prostate cancer cell: Potential role for rpS6/NFκB/FLIP

(2014) Heather G. Hambright et al.   MOLECULAR CARCINOGENESIS

Berberine regulates AMP-activated protein kinase signaling pathways and inhibits colon tumorigenesis in mice

(2014) Weidong Li et al.   MOLECULAR CARCINOGENESIS

Long Noncoding RNA TARID Directs Demethylation and Activation of the Tumor Suppressor TCF21 via GADD45A

(2014) Khelifa Arab et al.   MOLECULAR CELL

Berberine sensitizes rapamycin-mediated human hepatoma cell death in vitro

(2014) NA GUO et al.   Molecular Medicine Reports

Berberine Promotes Glucose Consumption Independently of AMP-Activated Protein Kinase Activation

(2014) Miao Xu et al.   PLoS One

Exosomes from bone marrow mesenchymal stem cells contain a microRNA that promotes dormancy in metastatic breast cancer cells

(2014) M. Ono et al.   Science Signaling

Phosphorylation of sterol regulatory element-binding protein (SREBP)-1c by p38 kinases, ERK and JNK influences lipid metabolism and the secretome of human liver cell line HepG2

(2014) Birgit Knebel et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Berberine suppresses tumorigenicity and growth of nasopharyngeal carcinoma cells by inhibiting STAT3 activation induced by tumor associated fibroblasts

(2013) Chi Man Tsang et al.   BMC CANCER

Extracellular vesicles: Exosomes, microvesicles, and friends

(2013) Graça Raposo et al.   JOURNAL OF CELL BIOLOGY

Berberine potently attenuates intestinal polyps growth in ApcMin mice and familial adenomatous polyposis patients through inhibition of Wnt signalling

(2013) Junfang Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Berberine reverts hepatic mitochondrial dysfunction in high-fat fed rats: A possible role for SirT3 activation

(2013) João Soeiro Teodoro et al.   MITOCHONDRION

MicroRNA-21-3p, a Berberine-Induced miRNA, Directly Down-Regulates Human Methionine Adenosyltransferases 2A and 2B and Inhibits Hepatoma Cell Growth

(2013) Ting-Fang Lo et al.   PLoS One

TRAIL on trial: preclinical advances in cancer therapy

(2013) Daniel W. Stuckey et al.   TRENDS IN MOLECULAR MEDICINE

Berberine enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in breast cancer

(2013) ALAA REFAAT et al.   Oncology Letters

Set9, NF-κB and microRNA-21 mediate berberine-induced apoptosis of human multiple myeloma cells

(2012) Hai-yan Hu et al.   ACTA PHARMACOLOGICA SINICA

Berberine: New perspectives for old remedies

(2012) Micol Tillhon et al.   BIOCHEMICAL PHARMACOLOGY

Temsirolimus: a safety and efficacy review

(2012) Ronald M. Bukowski   Expert Opinion On Drug Safety

Berberine inhibits the proliferation of colon cancer cells by inactivating Wnt/β-catenin signaling

(2012) Baicheng He   INTERNATIONAL JOURNAL OF ONCOLOGY

Berberine sensitizes TRAIL-induced apoptosis through proteasome-mediated downregulation of c-FLIP and Mcl-1 proteins

(2010) Lee   INTERNATIONAL JOURNAL OF ONCOLOGY

Berberine induces autophagic cell death and mitochondrial apoptosis in liver cancer cells: The cellular mechanism

(2010) Ning Wang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Imatinib resistance associated with BCR-ABL upregulation is dependent on HIF-1α-induced metabolic reprograming

(2010) F Zhao et al.   ONCOGENE