The Role of Berberine in the Prevention of HIF-1α Activation to Alleviate Adipose Tissue Fibrosis in High-Fat-Diet-Induced Obese Mice

Berberine Reverses Hypoxia-induced Chemoresistance in Breast Cancer through the Inhibition of AMPK- HIF-1α

(2017) Yue Pan et al.   International Journal of Biological Sciences

Health Effects of Overweight and Obesity in 195 Countries over 25 Years

(2017)   NEW ENGLAND JOURNAL OF MEDICINE

Advances in the study of berberine and its derivatives: a focus on anti-inflammatory and anti-tumor effects in the digestive system

(2016) Kun Zou et al.   ACTA PHARMACOLOGICA SINICA

HIF-1 Mediates Renal Fibrosis in OVE26 Type 1 Diabetic Mice

(2016) Bijaya K. Nayak et al.   DIABETES

HIF-1α in Myeloid Cells Promotes Adipose Tissue Remodeling Toward Insulin Resistance

(2016) Akiko Takikawa et al.   DIABETES

Berberine Inhibition of Fibrogenesis in a Rat Model of Liver Fibrosis and in Hepatic Stellate Cells

(2016) Ning Wang et al.   Evidence-based Complementary and Alternative Medicine

An obligatory role for neurotensin in high-fat-diet-induced obesity

(2016) Jing Li et al.   NATURE

Adipose tissue fibrosis, hypertrophy, and hyperplasia: Correlations with diabetes in human obesity

(2016) Lindsey A. Muir et al.   Obesity

Renoprotective effect of berberine on type 2 diabetic nephropathy in rats

(2015) Si-Fan Sun et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Increased Adipocyte O2 Consumption Triggers HIF-1α, Causing Inflammation and Insulin Resistance in Obesity

(2014) Yun Sok Lee et al.   CELL

What We Talk About When We Talk About Fat

(2014) Evan D. Rosen et al.   CELL

Deletion of Hypoxia-Inducible Factor-1α in Adipocytes Enhances Glucagon-Like Peptide-1 Secretion and Reduces Adipose Tissue Inflammation

(2014) Yoshitaka Kihira et al.   PLoS One

Immune Cell Toll-like Receptor 4 Mediates the Development of Obesity- and Endotoxemia-Associated Adipose Tissue Fibrosis

(2014) Isabelle K. Vila et al.   Cell Reports

Fibrosis and Adipose Tissue Dysfunction

(2013) Kai Sun et al.   Cell Metabolism

Hypoxia and Adipose Tissue Function and Dysfunction in Obesity

(2013) Paul Trayhurn   PHYSIOLOGICAL REVIEWS

Dietary obesity-associated Hif1  activation in adipocytes restricts fatty acid oxidation and energy expenditure via suppression of the Sirt2-NAD+ system

(2012) J. Krishnan et al.   GENES & DEVELOPMENT

Adipose tissue macrophages in insulin-resistant subjects are associated with collagen VI and fibrosis and demonstrate alternative activation

(2010) Michael Spencer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Atrogin-1 Affects Muscle Protein Synthesis and Degradation When Energy Metabolism Is Impaired by the Antidiabetes Drug Berberine

(2010) Huiling Wang et al.   DIABETES

Hypoxia-Inducible Factor 1  Induces Fibrosis and Insulin Resistance in White Adipose Tissue

(2009) N. Halberg et al.   MOLECULAR AND CELLULAR BIOLOGY

Mechanisms of Fibrogenesis

(2008) Tatiana Kisseleva et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Emerging role of adipose tissue hypoxia in obesity and insulin resistance

(2008) J Ye   INTERNATIONAL JOURNAL OF OBESITY

Treatment of Type 2 Diabetes and Dyslipidemia with the Natural Plant Alkaloid Berberine

(2008) Yifei Zhang et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Metabolic Dysregulation and Adipose Tissue Fibrosis: Role of Collagen VI

(2008) T. Khan et al.   MOLECULAR AND CELLULAR BIOLOGY