TRIM32, but not its muscular dystrophy-associated mutant, positively regulates and is targeted to autophagic degradation by p62/SQSTM1

Altered myogenesis and premature senescence underlie human TRIM32-related myopathy

(2019) E. Servián-Morilla et al.   Acta Neuropathologica Communications

The Small Non-coding Vault RNA1-1 Acts as a Riboregulator of Autophagy

(2019) Rastislav Horos et al.   CELL

ATG8-Binding UIM Proteins Define a New Class of Autophagy Adaptors and Receptors

(2019) Richard S. Marshall et al.   CELL

Autophagy induction in atrophic muscle cells requires ULK1 activation by TRIM32 through unanchored K63-linked polyubiquitin chains

(2019) M. Di Rienzo et al.   Science Advances

Phasing out the bad—How SQSTM1/p62 sequesters ubiquitinated proteins for degradation by autophagy

(2018) Gabriele Zaffagnini et al.   Autophagy

TRIM50 regulates Beclin 1 proautophagic activity

(2018) Carmela Fusco et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Polyubiquitin chain-induced p62 phase separation drives autophagic cargo segregation

(2018) Daxiao Sun et al.   CELL RESEARCH

Starvation induces rapid degradation of selective autophagy receptors by endosomal microautophagy

(2018) Jakob Mejlvang et al.   JOURNAL OF CELL BIOLOGY

TIA1 variant drives myodegeneration in multisystem proteinopathy with SQSTM1 mutations

(2018) YouJin Lee et al.   JOURNAL OF CLINICAL INVESTIGATION

Blocking p62-dependent SMN degradation ameliorates spinal muscular atrophy disease phenotypes

(2018) Natalia Rodriguez-Muela et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanism and medical implications of mammalian autophagy

(2018) Ivan Dikic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TRIM32 promotes proliferation and confers chemoresistance to breast cancer cells through activation of the NF-κB pathway

(2018) Ting-Ting Zhao et al.   Journal of Cancer

TRIM Proteins and Their Roles in Antiviral Host Defenses

(2018) Michiel van Gent et al.   Annual Review of Virology

TRIM32 promotes cell proliferation and invasion by activating β-catenin signalling in gastric cancer

(2018) Changming Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Expression and the potential functions of TRIM32 in lung cancer tumorigenesis

(2018) Hongmei Yin et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The Autophagy-Lysosomal Pathways and Their Emerging Roles in Modulating Proteostasis in Tumors

(2018) Zhen Dong et al.   Cells

The HECT E3 ubiquitin ligase NEDD4 interacts with and ubiquitylates SQSTM1 for inclusion body autophagy

(2017) Qiong Lin et al.   JOURNAL OF CELL SCIENCE

TRIM Family Proteins: Roles in Autophagy, Immunity, and Carcinogenesis

(2017) Shigetsugu Hatakeyama   TRENDS IN BIOCHEMICAL SCIENCES

Keap1/Cullin3 Modulates p62/SQSTM1 Activity via UBA Domain Ubiquitination

(2017) YouJin Lee et al.   Cell Reports

Enhanced Degradation of Misfolded Proteins Promotes Tumorigenesis

(2017) Liang Chen et al.   Cell Reports

TRIM32-TAX1BP1-dependent selective autophagic degradation of TRIF negatively regulates TLR3/4-mediated innate immune responses

(2017) Qing Yang et al.   PLoS Pathogens

TRIM23 mediates virus-induced autophagy via activation of TBK1

(2017) Konstantin M. J. Sparrer et al.   Nature Microbiology

Types of Ubiquitin Ligases

(2016) Francesca Ester Morreale et al.   CELL

An ER-Associated Pathway Defines Endosomal Architecture for Controlled Cargo Transport

(2016) Marlieke L.M. Jongsma et al.   CELL

TRIMs and Galectins Globally Cooperate and TRIM16 and Galectin-3 Co-direct Autophagy in Endomembrane Damage Homeostasis

(2016) Santosh Chauhan et al.   DEVELOPMENTAL CELL

Dedicated SNAREs and specialized TRIM cargo receptors mediate secretory autophagy

(2016) Tomonori Kimura et al.   EMBO JOURNAL

TRIM32 ubiquitin E3 ligase, one enzyme for several pathologies: From muscular dystrophy to tumours

(2016) Elisa Lazzari et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Precision autophagy directed by receptor regulators – emerging examples within the TRIM family

(2016) Tomonori Kimura et al.   JOURNAL OF CELL SCIENCE

TRIM17 contributes to autophagy of midbodies while actively sparing other targets from degradation

(2016) Michael A. Mandell et al.   JOURNAL OF CELL SCIENCE

TRIM21 Ubiquitylates SQSTM1/p62 and Suppresses Protein Sequestration to Regulate Redox Homeostasis

(2016) Ji-An Pan et al.   MOLECULAR CELL

TRIM31 promotes Atg5/Atg7-independent autophagy in intestinal cells

(2016) Eun A. Ra et al.   Nature Communications

RNF166 Determines Recruitment of Adaptor Proteins during Antibacterial Autophagy

(2016) Robert J. Heath et al.   Cell Reports

TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity

(2015) Tomonori Kimura et al.   JOURNAL OF CELL BIOLOGY

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

(2015) Michael Lazarou et al.   NATURE

TRIM-NHL proteins in development and disease

(2015) Cristina Tocchini et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

TRIM proteins regulate autophagy: TRIM5 is a selective autophagy receptor mediating HIV-1 restriction

(2015) Michael A Mandell et al.   Autophagy

E3 ubiquitin ligase TRIM32 negatively regulates tumor suppressor p53 to promote tumorigenesis

(2014) Ju Liu et al.   CELL DEATH AND DIFFERENTIATION

Interactions between Autophagy Receptors and Ubiquitin-like Proteins Form the Molecular Basis for Selective Autophagy

(2014) Vladimir Rogov et al.   MOLECULAR CELL

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

MURF2B, a Novel LC3-Binding Protein, Participates with MURF2A in the Switch between Autophagy and Ubiquitin Proteasome System during Differentiation of C2C12 Muscle Cells

(2013) Véronique Pizon et al.   PLoS One

ATG8 Family Proteins Act as Scaffolds for Assembly of the ULK Complex

(2012) Endalkachew Ashenafi Alemu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquitylation by Trim32 causes coupled loss of desmin, Z-bands, and thin filaments in muscle atrophy

(2012) Shenhav Cohen et al.   JOURNAL OF CELL BIOLOGY

Satellite cell senescence underlies myopathy in a mouse model of limb-girdle muscular dystrophy 2H

(2012) Elena Kudryashova et al.   JOURNAL OF CLINICAL INVESTIGATION

TRIM32 Regulates Skeletal Muscle Stem Cell Differentiation and Is Necessary for Normal Adult Muscle Regeneration

(2012) Sarah Nicklas et al.   PLoS One

The E3-Ubiquitin Ligase TRIM50 Interacts with HDAC6 and p62, and Promotes the Sequestration and Clearance of Ubiquitinated Proteins into the Aggresome

(2012) Carmela Fusco et al.   PLoS One

Selective autophagy mediated by autophagic adapter proteins

(2011) Terje Johansen et al.   Autophagy

TRIM13 regulates ER stress induced autophagy and clonogenic ability of the cells

(2011) Dhanendra Tomar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

The common missense mutation D489N in TRIM32 causing limb girdle muscular dystrophy 2H leads to loss of the mutated protein in knock-in mice resulting in a Trim32-null phenotype

(2011) E. Kudryashova et al.   HUMAN MOLECULAR GENETICS

Crystal Structure of the Ubiquitin-associated (UBA) Domain of p62 and Its Interaction with Ubiquitin

(2011) Shin Isogai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p62 targeting to the autophagosome formation site requires self-oligomerization but not LC3 binding

(2011) Eisuke Itakura et al.   JOURNAL OF CELL BIOLOGY

A reporter cell system to monitor autophagy based on p62/SQSTM1

(2010) Kenneth Bowitz Larsen et al.   Autophagy

Chaperone-Assisted Selective Autophagy Is Essential for Muscle Maintenance

(2010) Verena Arndt et al.   CURRENT BIOLOGY

p62/SQSTM1Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription

(2010) Ashish Jain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRIM32 is an E3 ubiquitin ligase for dysbindin

(2009) Matthew Locke et al.   HUMAN MOLECULAR GENETICS

Dimerisation of the UBA Domain of p62 Inhibits Ubiquitin Binding and Regulates NF-κB Signalling

(2009) Jed Long et al.   JOURNAL OF MOLECULAR BIOLOGY

Dynamics and diversity in autophagy mechanisms: lessons from yeast

(2009) Hitoshi Nakatogawa et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY