The Autophagy-Lysosomal Pathways and Their Emerging Roles in Modulating Proteostasis in Tumors

Targeting of stress response pathways in the prevention and treatment of cancer

(2018) Jaroslav Zelenka et al.   BIOTECHNOLOGY ADVANCES

Cancer chemoprevention via activation of proteostatic modules

(2018) Aimilia Sklirou et al.   CANCER LETTERS

CCPG1 Is a Non-canonical Autophagy Cargo Receptor Essential for ER-Phagy and Pancreatic ER Proteostasis

(2018) Matthew D. Smith et al.   DEVELOPMENTAL CELL

Targeting autophagy in lymphomas: a double-edged sword?

(2018) Han Zhang   INTERNATIONAL JOURNAL OF HEMATOLOGY

Mitochondrial Proteostasis in the Context of Cellular and Organismal Health and Aging

(2018) Erica A Moehle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein aggregates and proteostasis in aging: Amylin and β-cell function

(2018) Michaela Press et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Aqueous extracts of Paeonia suffruticosa modulates mitochondrial proteostasis by reactive oxygen species-induced endoplasmic reticulum stress in pancreatic cancer cells

(2018) Yu-Huei Liu et al.   PHYTOMEDICINE

Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis

(2018) Bernadette Carroll et al.   Nature Communications

Golgi Apparatus and Protein Trafficking in Alzheimer's Disease

(2018) Stavros J. Baloyannis   JOURNAL OF ALZHEIMERS DISEASE

ER homeostasis and autophagy

(2017) Matthew Smith et al.   Essays in Biochemistry

Pathways of cellular proteostasis in aging and disease

(2017) Courtney L. Klaips et al.   JOURNAL OF CELL BIOLOGY

BAG3-mediated proteostasis at a glance

(2017) Christina Klimek et al.   JOURNAL OF CELL SCIENCE

Mitophagy in maintaining skeletal muscle mitochondrial proteostasis and metabolic health with ageing

(2017) Joshua C. Drake et al.   JOURNAL OF PHYSIOLOGY-LONDON

Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity

(2017) Vincenzo Sorrentino et al.   NATURE

Progressing neurobiological strategies against proteostasis failure: Challenges in neurodegeneration

(2017) Ayeman Amanullah et al.   PROGRESS IN NEUROBIOLOGY

Withaferin A induced impaired autophagy and unfolded protein response in human breast cancer cell-lines MCF-7 and MDA-MB-231

(2017) Kamalini Ghosh et al.   TOXICOLOGY IN VITRO

Ampk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy

(2017) Rhianna C. Laker et al.   Nature Communications

Inactivation/deficiency of DHODH induces cell cycle arrest and programed cell death in melanoma

(2017) Lichao Liu et al.   Oncotarget

Simultaneous inhibition of the ubiquitin-proteasome system and autophagy enhances apoptosis induced by ER stress aggravators in human pancreatic cancer cells

(2016) Xu Li et al.   Autophagy

Autophagy regulation and its role in gastric cancer and colorectal cancer

(2016) Huangyan Zhou et al.   Cancer Biomarkers

Structural and Biological Interaction of hsc-70 Protein with Phosphatidylserine in Endosomal Microautophagy

(2016) Kateryna Morozova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy maintains stemness by preventing senescence

(2016) Laura García-Prat et al.   NATURE

CSN6 controls the proliferation and metastasis of glioblastoma by CHIP-mediated degradation of EGFR

(2016) J Hou et al.   ONCOGENE

Regulatory module involving FGF13, miR-504, and p53 regulates ribosomal biogenesis and supports cancer cell survival

(2016) Débora R. Bublik et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Autophagy–Lysosomal Pathway in Neurodegeneration: A TFEB Perspective

(2016) Heidi Martini-Stoica et al.   TRENDS IN NEUROSCIENCES

Role of exosomes in the protection of cellular homeostasis

(2016) Gabriela Desdín-Micó et al.   Cell Adhesion & Migration

Adapt, Recycle, and Move on: Proteostasis and Trafficking Mechanisms in Melanoma

(2016) Seyma Demirsoy et al.   Frontiers in Oncology

Protein synthesis as an integral quality control mechanism during ageing

(2015) Nikolaos Charmpilas et al.   AGEING RESEARCH REVIEWS

Endoplasmic Reticulum Stress in Immunity

(2015) Sarah E. Bettigole et al.   Annual Review of Immunology

A plastic SQSTM1/p62-dependent autophagic reserve maintains proteostasis and determines proteasome inhibitor susceptibility in multiple myeloma cells

(2015) Enrico Milan et al.   Autophagy

Review: Beta-thalassemia and molecular chaperones

(2015) Afshan Sumera et al.   BLOOD CELLS MOLECULES AND DISEASES

In Search of a Cure for Proteostasis-Addicted Cancer: A AAA Target Revealed

(2015) Di Xia et al.   CANCER CELL

Targeted therapy in cancer

(2015) Apostolia-Maria Tsimberidou   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Protein trafficking in colorectal carcinogenesis--targeting and bypassing resistance to currently applied treatments

(2015) A. N. Gargalionis et al.   CARCINOGENESIS

mTORC1 signaling activates NRF1 to increase cellular proteasome levels

(2015) Yinan Zhang et al.   CELL CYCLE

Drugs acting on homeostasis: challenging cancer cell adaptation

(2015) Maria Moschovi et al.   Expert Review of Anticancer Therapy

Oxidative stress, mitochondrial and proteostasis malfunction in adrenoleukodystrophy: A paradigm for axonal degeneration

(2015) Stéphane Fourcade et al.   FREE RADICAL BIOLOGY AND MEDICINE

Proteomic Analysis Identifies Ribosome Reduction as an Effective Proteotoxic Stress Response

(2015) Angel Guerra-Moreno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role for autophagy in cancer

(2015) Eileen White   JOURNAL OF CLINICAL INVESTIGATION

Melatonin and endoplasmic reticulum stress: relation to autophagy and apoptosis

(2015) Anna Fernández et al.   JOURNAL OF PINEAL RESEARCH

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

(2015) Michael Lazarou et al.   NATURE

MitoCarta2.0: an updated inventory of mammalian mitochondrial proteins

(2015) Sarah E. Calvo et al.   NUCLEIC ACIDS RESEARCH

Anthocyanin Vacuolar Inclusions Form by a Microautophagy Mechanism

(2015) Alexandra Chanoca et al.   PLANT CELL

ER proteostasis addiction in cancer biology: Novel concepts

(2015) Estefanie Dufey et al.   SEMINARS IN CANCER BIOLOGY

Molecular Chaperones ofLeishmania: Central Players in Many Stress-Related and -Unrelated Physiological Processes

(2015) Jose M. Requena et al.   Biomed Research International

Autophagy in colorectal cancer: An important switch from physiology to pathology

(2015) Florin Burada   World Journal of Gastrointestinal Oncology

The measurement of protein synthesis for assessing proteostasis in studies of slowed aging

(2014) Benjamin F. Miller et al.   AGEING RESEARCH REVIEWS

Hypoxia disrupts proteostasis inCaenorhabditis elegans

(2014) Emily M. Fawcett et al.   AGING CELL

Mechanisms of Cellular Proteostasis: Insights from Single-Molecule Approaches

(2014) Carlos J. Bustamante et al.   Annual Review of Biophysics

Dynamics and function of PtdIns(3)Pin autophagy

(2014) Keisuke Obara et al.   Autophagy

Structural insights into E2–E3 interaction for LC3 lipidation

(2014) Zoltan Metlagel et al.   Autophagy

Proteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy

(2014) Raymond J Deshaies   BMC BIOLOGY

Mitochondrial Proteostasis in the Control of Aging and Longevity

(2014) Martin Borch Jensen et al.   Cell Metabolism

Molecular chaperones are nanomachines that catalytically unfold misfolded and alternatively folded proteins

(2014) Rayees U. H. Mattoo et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Interrelation Between Protein Synthesis, Proteostasis and Life Span

(2014) Kristin Arnsburg et al.   CURRENT GENOMICS

Unfolded protein response-induced ERdj3 secretion links ER stress to extracellular proteostasis

(2014) J. C. Genereux et al.   EMBO JOURNAL

Multiple myeloma proteostasis can be targeted via translation initiation factor eIF4E

(2014) VICTORIA ZISMANOV et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Emerging therapies targeting the ubiquitin proteasome system in cancer

(2014) Nathaniel M. Weathington et al.   JOURNAL OF CLINICAL INVESTIGATION

Proteostasis and the Aging Proteome in Health and Disease

(2014) R. I. Morimoto et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Dysregulation of protein trafficking in neurodegeneration

(2014) Xin Wang et al.   Molecular Neurodegeneration

Potential pharmacological chaperones targeting cancer-associated MCL-1 and Parkinson disease-associated  -synuclein

(2014) M. Oh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Celastrol targets proteostasis and acts synergistically with a heat-shock protein 90 inhibitor to kill human glioblastoma cells

(2014) S Boridy et al.   Cell Death & Disease

The role of protein clearance mechanisms in organismal ageing and age-related diseases

(2014) David Vilchez et al.   Nature Communications

Cellular Stress Responses in Cancer and Cancer Therapy

(2014) Megan Chircop et al.   Frontiers in Oncology

Molecular Chaperone Functions in Protein Folding and Proteostasis

(2013) Yujin E. Kim et al.   Annual Review of Biochemistry

Targeting the ubiquitin–proteasome system for cancer therapy

(2013) Min Shen et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Molecular effects of advanced glycation end products on cell signalling pathways, ageing and pathophysiology

(2013) O. Nedić et al.   FREE RADICAL RESEARCH

14-3-3 protein targets misfolded chaperone-associated proteins to aggresomes

(2013) Z. Xu et al.   JOURNAL OF CELL SCIENCE

Biophysical Characterization of Two Different Stable Misfolded Monomeric Polypeptides That Are Chaperone-Amenable Substrates

(2013) Antonino Natalello et al.   JOURNAL OF MOLECULAR BIOLOGY

SirT3 Regulates the Mitochondrial Unfolded Protein Response

(2013) L. Papa et al.   MOLECULAR AND CELLULAR BIOLOGY

Autophagosomes form at ER–mitochondria contact sites

(2013) Maho Hamasaki et al.   NATURE

SQSTM1/p62 Interacts with HDAC6 and Regulates Deacetylase Activity

(2013) Jin Yan et al.   PLoS One

Cancer Genome Landscapes

(2013) B. Vogelstein et al.   SCIENCE

Bypass Mechanisms of Resistance to Receptor Tyrosine Kinase Inhibition in Lung Cancer

(2013) M. J. Niederst et al.   Science Signaling

The Hairpin-type Tail-Anchored SNARE Syntaxin 17 Targets to Autophagosomes for Fusion with Endosomes/Lysosomes

(2012) Eisuke Itakura et al.   CELL

Heat shock proteins in cancer: targeting the ‘chaperones’

(2012) Z Nahleh et al.   Future Medicinal Chemistry

Development of proteasome inhibitors as research tools and cancer drugs

(2012) Alfred L. Goldberg   JOURNAL OF CELL BIOLOGY

The Ubiquitin-Proteasome System Meets Angiogenesis

(2012) N. Rahimi   MOLECULAR CANCER THERAPEUTICS

The E3-Ubiquitin Ligase TRIM50 Interacts with HDAC6 and p62, and Promotes the Sequestration and Clearance of Ubiquitinated Proteins into the Aggresome

(2012) Carmela Fusco et al.   PLoS One

Chaperone-mediated autophagy: a unique way to enter the lysosome world

(2012) Susmita Kaushik et al.   TRENDS IN CELL BIOLOGY

Delivery of endosomes to lysosomes via microautophagy in the visceral endoderm of mouse embryos

(2012) Nobuyuki Kawamura et al.   Nature Communications

Protein Folding at the Exit Tunnel

(2011) Daria V. Fedyukina et al.   Annual Review of Biophysics

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Proteostasis regulation at the endoplasmic reticulum: a new perturbation site for targeted cancer therapy

(2011) Yanfen Liu et al.   CELL RESEARCH

Microautophagy of Cytosolic Proteins by Late Endosomes

(2011) Ranjit Sahu et al.   DEVELOPMENTAL CELL

BAG3 mediates chaperone-based aggresome-targeting and selective autophagy of misfolded proteins

(2011) Martin Gamerdinger et al.   EMBO REPORTS

Proteostasis of tau. Tau overexpression results in its secretion via membrane vesicles

(2011) Diana Simón et al.   FEBS LETTERS

Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) Associates with Huntingtin Protein and Promotes Its Atypical Ubiquitination to Enhance Aggregate Formation

(2011) Silvia Zucchelli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Aggregates Are Recruited to Aggresome by Histone Deacetylase 6 via Unanchored Ubiquitin C Termini

(2011) Hui Ouyang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein kinase CK2 regulates the formation and clearance of aggresomes in response to stress

(2011) M. Watabe et al.   JOURNAL OF CELL SCIENCE

Protein localization in disease and therapy

(2011) M.-C. Hung et al.   JOURNAL OF CELL SCIENCE

Molecular chaperones in mammary cancer growth and breast tumor therapy

(2011) Stuart K. Calderwood et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Role of AMPK-mTOR-Ulk1/2 in the Regulation of Autophagy: Cross Talk, Shortcuts, and Feedbacks

(2011) S. Alers et al.   MOLECULAR AND CELLULAR BIOLOGY

The Role of Autophagy in Cancer: Therapeutic Implications

(2011) Z. J. Yang et al.   MOLECULAR CANCER THERAPEUTICS

Chaperonopathies of senescence and the scrambling of interactions between the chaperoning and the immune systems

(2010) Alberto J. L. Macario et al.   Annals of the New York Academy of Sciences

The Golgi as a potential membrane source for autophagy

(2010) Jiefei Geng et al.   Autophagy

Targeting heat shock proteins in cancer

(2010) Gaëtan Jego et al.   CANCER LETTERS

Identification of Aneuploidy-Tolerating Mutations

(2010) Eduardo M. Torres et al.   CELL

Mitochondria Supply Membranes for Autophagosome Biogenesis during Starvation

(2010) Dale W. Hailey et al.   CELL

The Aging Stress Response

(2010) Marcia C. Haigis et al.   MOLECULAR CELL

Plasma membrane contributes to the formation of pre-autophagosomal structures

(2010) Brinda Ravikumar et al.   NATURE CELL BIOLOGY

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

(2010) Sven Geisler et al.   NATURE CELL BIOLOGY

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

Biological and Chemical Approaches to Diseases of Proteostasis Deficiency

(2009) Evan T. Powers et al.   Annual Review of Biochemistry

The structure of Atg4B–LC3 complex reveals the mechanism of LC3 processing and delipidation during autophagy

(2009) Kenji Satoo et al.   EMBO JOURNAL

Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging

(2008) R. I. Morimoto   GENES & DEVELOPMENT

The ubiquitin-like modifier FAT10 interacts with HDAC6 and localizes to aggresomes under proteasome inhibition

(2008) B. Kalveram et al.   JOURNAL OF CELL SCIENCE

Small molecule enhancers of autophagy for neurodegenerative diseases

(2008) Sovan Sarkar et al.   Molecular BioSystems

Aneuploidy Affects Proliferation and Spontaneous Immortalization in Mammalian Cells

(2008) B. R. Williams et al.   SCIENCE

Adapting Proteostasis for Disease Intervention

(2008) William E. Balch et al.   SCIENCE