ORP5 localizes to ER–lipid droplet contacts and regulates the level of PI(4)P on lipid droplets

The biogenesis of lipid droplets: Lipids take center stage

(2019) Mingming Gao et al.   PROGRESS IN LIPID RESEARCH

The Oxysterol-Binding Protein Cycle: Burning Off PI(4)P to Transport Cholesterol

(2018) Bruno Antonny et al.   Annual Review of Biochemistry

Bridging the molecular and biological functions of the oxysterol-binding protein family

(2018) Antonietta Pietrangelo et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A Proximity Labeling Strategy Provides Insights into the Composition and Dynamics of Lipid Droplet Proteomes

(2018) Kirill Bersuker et al.   DEVELOPMENTAL CELL

Mechanism and Determinants of Amphipathic Helix-Containing Protein Targeting to Lipid Droplets

(2018) Coline Prévost et al.   DEVELOPMENTAL CELL

Oxysterol-binding protein–related protein 5 (ORP5) promotes cell proliferation by activation of mTORC1 signaling

(2018) Ximing Du et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PI(4,5)P2controls plasma membrane PI4P and PS levels via ORP5/8 recruitment to ER–PM contact sites

(2018) Mira Sohn et al.   JOURNAL OF CELL BIOLOGY

Rab18 promotes lipid droplet (LD) growth by tethering the ER to LDs through SNARE and NRZ interactions

(2018) Dijin Xu et al.   JOURNAL OF CELL BIOLOGY

VPS13A and VPS13C are lipid transport proteins differentially localized at ER contact sites

(2018) Nikit Kumar et al.   JOURNAL OF CELL BIOLOGY

A Membraneless Organelle Associated with the Endoplasmic Reticulum Enables 3′UTR-Mediated Protein-Protein Interactions

(2018) Weirui Ma et al.   CELL

ORP2 Delivers Cholesterol to the Plasma Membrane in Exchange for Phosphatidylinositol 4, 5-Bisphosphate (PI(4,5)P2)

(2018) Huan Wang et al.   MOLECULAR CELL

Lipid transfer proteins: the lipid commute via shuttles, bridges and tubes

(2018) Louise H. Wong et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dynamics and functions of lipid droplets

(2018) James A. Olzmann et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ORP2 interacts with phosphoinositides and controls the subcellular distribution of cholesterol

(2018) Annika Koponen et al.   BIOCHIMIE

Oxysterol-binding protein recruitment and activity at the endoplasmic reticulum-Golgi interface are independent of Sac1

(2017) Mark Charman et al.   TRAFFIC

ORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5)P 2) and regulate its level at the plasma membrane

(2017) Rajesh Ghai et al.   Nature Communications

ORP5/ORP8 localize to endoplasmic reticulum–mitochondria contacts and are involved in mitochondrial function

(2016) Romain Galmes et al.   EMBO REPORTS

Conserved Amphipathic Helices Mediate Lipid Droplet Targeting of Perilipins 1–3

(2016) Emily R. Rowe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting Fat: Mechanisms of Protein Localization to Lipid Droplets

(2016) Nora Kory et al.   TRENDS IN CELL BIOLOGY

Novel mechanisms of intracellular cholesterol transport: oxysterol-binding proteins and membrane contact sites

(2015) Ximing Du et al.   CURRENT OPINION IN CELL BIOLOGY

Modular Detection of GFP-Labeled Proteins for Rapid Screening by Electron Microscopy in Cells and Organisms

(2015) Nicholas Ariotti et al.   DEVELOPMENTAL CELL

Phosphatidylinositol 4-kinases: Function, structure, and inhibition

(2015) Evzen Boura et al.   EXPERIMENTAL CELL RESEARCH

Complementary probes reveal that phosphatidylserine is required for the proper transbilayer distribution of cholesterol

(2015) M. Maekawa et al.   JOURNAL OF CELL SCIENCE

Phosphatidylserine transport by ORP/Osh proteins is driven by phosphatidylinositol 4-phosphate

(2015) J. Moser von Filseck et al.   SCIENCE

PI4P/phosphatidylserine countertransport at ORP5- and ORP8-mediated ER-plasma membrane contacts

(2015) J. Chung et al.   SCIENCE

Itraconazole Inhibits Enterovirus Replication by Targeting the Oxysterol-Binding Protein

(2015) Jeroen R.P.M. Strating et al.   Cell Reports

Structure of the Legionella Virulence Factor, SidC Reveals a Unique PI(4)P-Specific Binding Domain Essential for Its Targeting to the Bacterial Phagosome

(2015) Xi Luo et al.   PLoS Pathogens

The brown adipocyte protein CIDEA promotes lipid droplet fusion via a phosphatidic acid-binding amphipathic helix

(2015) David Barneda et al.   eLife

A novel probe for phosphatidylinositol 4-phosphate reveals multiple pools beyond the Golgi

(2014) Gerald R.V. Hammond et al.   JOURNAL OF CELL BIOLOGY

A phosphatidylinositol transfer protein integrates phosphoinositide signaling with lipid droplet metabolism to regulate a developmental program of nutrient stress–induced membrane biogenesis

(2014) Jihui Ren et al.   MOLECULAR BIOLOGY OF THE CELL

Comparative proteomic study reveals 17 -HSD13 as a pathogenic protein in nonalcoholic fatty liver disease

(2014) W. Su et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Four-Step Cycle Driven by PI(4)P Hydrolysis Directs Sterol/PI(4)P Exchange by the ER-Golgi Tether OSBP

(2013) Bruno Mesmin et al.   CELL

Insights into the mechanisms of sterol transport between organelles

(2013) Bruno Mesmin et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Acyl-CoA synthetase 3 promotes lipid droplet biogenesis in ER microdomains

(2013) Adam Kassan et al.   JOURNAL OF CELL BIOLOGY

Interactome map uncovers phosphatidylserine transport by oxysterol-binding proteins

(2013) Kenji Maeda et al.   NATURE

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation

(2013) Tamas Balla   PHYSIOLOGICAL REVIEWS

Oxysterol-binding proteins: Sterol and phosphoinositide sensors coordinating transport, signaling and metabolism

(2013) Vesa M. Olkkonen et al.   PROGRESS IN LIPID RESEARCH

Feedback Regulation of Receptor-Induced Ca2+ Signaling Mediated by E-Syt1 and Nir2 at Endoplasmic Reticulum-Plasma Membrane Junctions

(2013) Chi-Lun Chang et al.   Cell Reports

Phospholipids and lipid droplets

(2012) Anke Penno et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Controlling the size of lipid droplets: lipid and protein factors

(2012) Hongyuan Yang et al.   CURRENT OPINION IN CELL BIOLOGY

Mammalian Atg2 proteins are essential for autophagosome formation and important for regulation of size and distribution of lipid droplets

(2012) Anoop Kumar G. Velikkakath et al.   MOLECULAR BIOLOGY OF THE CELL

Phosphatidylcholine Synthesis for Lipid Droplet Expansion Is Mediated by Localized Activation of CTP:Phosphocholine Cytidylyltransferase

(2011) Natalie Krahmer et al.   Cell Metabolism

Phosphatidylserine is a critical modulator for Akt activation

(2011) Bill X. Huang et al.   JOURNAL OF CELL BIOLOGY

A role for oxysterol-binding protein–related protein 5 in endosomal cholesterol trafficking

(2011) Ximing Du et al.   JOURNAL OF CELL BIOLOGY

Osh4p exchanges sterols for phosphatidylinositol 4-phosphate between lipid bilayers

(2011) Maud de Saint-Jean et al.   JOURNAL OF CELL BIOLOGY

Fsp27 promotes lipid droplet growth by lipid exchange and transfer at lipid droplet contact sites

(2011) Jingyi Gong et al.   JOURNAL OF CELL BIOLOGY

Intracellular phosphatidylserine is essential for retrograde membrane traffic through endosomes

(2011) Y. Uchida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Role for Phosphatidic Acid in the Formation of “Supersized” Lipid Droplets

(2011) Weihua Fei et al.   PLoS Genetics

The Distribution and Function of Phosphatidylserine in Cellular Membranes

(2010) Peter A. Leventis et al.   Annual Review of Biophysics

Immunocytochemical techniques reveal multiple, distinct cellular pools of PtdIns4Pand PtdIns(4,5)P2

(2009) Gerald R. V. Hammond et al.   BIOCHEMICAL JOURNAL

Lipid Droplets Finally Get a Little R-E-S-P-E-C-T

(2009) Robert V. Farese et al.   CELL

OSBP-related protein 2 is a sterol receptor on lipid droplets that regulates the metabolism of neutral lipids

(2009) Riikka Hynynen et al.   JOURNAL OF LIPID RESEARCH

The antiviral protein, viperin, localizes to lipid droplets via its N-terminal amphipathic  -helix

(2009) E. R. Hinson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA