Biological, chemical, and biochemical strategies for modifying glycopeptide antibiotics

Toward Single-Peak Dalbavancin Analogs through Biology and Chemistry

(2019) Silke Alt et al.   ACS Chemical Biology

Kistamicin biosynthesis reveals the biosynthetic requirements for production of highly crosslinked glycopeptide antibiotics

(2019) Anja Greule et al.   Nature Communications

Vancomycin–Arginine Conjugate Inhibits Growth of Carbapenem-Resistant E. coli and Targets Cell-Wall Synthesis

(2019) Alexandra Antonoplis et al.   ACS Chemical Biology

Modular click chemistry libraries for functional screens using a diazotizing reagent

(2019) Genyi Meng et al.   NATURE

Enzymatic Cascade To Evaluate the Tricyclization of Glycopeptide Antibiotic Precursor Peptides as a Prequel to Biosynthetic Redesign

(2019) Julien Tailhades et al.   ORGANIC LETTERS

In Vitro Reconstitution of OxyC Activity Enables Total Chemoenzymatic Syntheses of Vancomycin Aglycone Variants

(2018) Clarissa C. Forneris et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A route to diastereomerically pure phenylglycine thioester peptides: crucial intermediates for investigating glycopeptide antibiotic biosynthesis

(2018) Julien Tailhades et al.   CHEMICAL COMMUNICATIONS

Precursor Manipulation in Glycopeptide Antibiotic Biosynthesis: Are β-Amino Acids Compatible with the Oxidative Cyclization Cascade?

(2018) Melanie Schoppet et al.   JOURNAL OF ORGANIC CHEMISTRY

Unrivalled diversity: the many roles and reactions of bacterial cytochromes P450 in secondary metabolism

(2018) Anja Greule et al.   NATURAL PRODUCT REPORTS

Protein-inspired antibiotics active against vancomycin- and daptomycin-resistant bacteria

(2018) Mark A. T. Blaskovich et al.   Nature Communications

Emergence of Vancomycin-Resistant Enterococcus faecium at an Australian Hospital: A Whole Genome Sequencing Analysis

(2018) Kelvin W. C. Leong et al.   Scientific Reports

Developments in Glycopeptide Antibiotics

(2018) Mark A. T. Blaskovich et al.   ACS Infectious Diseases

A Dual-Function Antibiotic-Transporter Conjugate Exhibits Superior Activity in Sterilizing MRSA Biofilms and Killing Persister Cells

(2018) Alexandra Antonoplis et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A chemoselective strategy for late-stage functionalization of complex small molecules with polypeptides and proteins

(2018) Daniel T. Cohen et al.   Nature Chemistry

Synthetic biology, genome mining, and combinatorial biosynthesis of NRPS-derived antibiotics: a perspective

(2017) Richard H. Baltz   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Diversity of nature's assembly lines – recent discoveries in non-ribosomal peptide synthesis

(2017) Jennifer A. E. Payne et al.   Molecular BioSystems

Halogenation of glycopeptide antibiotics occurs at the amino acid level during non-ribosomal peptide synthesis

(2017) Tiia Kittilä et al.   Chemical Science

New Structural Data Reveal the Motion of Carrier Proteins in Nonribosomal Peptide Synthesis

(2016) Tiia Kittilä et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A stepwise dechlorination/cross-coupling strategy to diversify the vancomycin ‘in-chloride’

(2016) Tyler J. Wadzinski et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Catalytic promiscuity of glycopeptide N-methyltransferases enables bio-orthogonal labelling of biosynthetic intermediates

(2016) Clara Brieke et al.   CHEMICAL COMMUNICATIONS

Understanding the crucial interactions between Cytochrome P450s and non-ribosomal peptide synthetases during glycopeptide antibiotic biosynthesis

(2016) Madeleine Peschke et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Antimicrobial Peptides Under Clinical Trials

(2016) Katarzyna E. Greber et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Regulation of the P450 Oxygenation Cascade Involved in Glycopeptide Antibiotic Biosynthesis

(2016) Madeleine Peschke et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Understanding the mechanisms and drivers of antimicrobial resistance

(2016) Alison H Holmes et al.   LANCET

How To Make a Glycopeptide: A Synthetic Biology Approach To Expand Antibiotic Chemical Diversity

(2016) Grace Yim et al.   ACS Infectious Diseases

Sequential In Vitro Cyclization by Cytochrome P450 Enzymes of Glycopeptide Antibiotic Precursors Bearing the X-Domain from Nonribosomal Peptide Biosynthesis

(2015) Clara Brieke et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structure Diversification of Vancomycin through Peptide-Catalyzed, Site-Selective Lipidation: A Catalysis-Based Approach To Combat Glycopeptide-Resistant Pathogens

(2015) Sabesan Yoganathan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural aspects of phenylglycines, their biosynthesis and occurrence in peptide natural products

(2015) Rashed S. Al Toma et al.   NATURAL PRODUCT REPORTS

X-domain of peptide synthetases recruits oxygenases crucial for glycopeptide biosynthesis

(2015) Kristina Haslinger et al.   NATURE

Investigation into the functional impact of the vancomycin C-ring aryl chloride

(2013) Joseph R. Pinchman et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of 1,5-triazole bridged vancomycin CDE-ring bicyclic mimics using RuAAC macrocyclization

(2013) Jinqiang Zhang et al.   CHEMICAL COMMUNICATIONS

Glycopeptide antibiotic biosynthesis

(2013) Grace Yim et al.   JOURNAL OF ANTIBIOTICS

Probing the Role of the Vancomycin E-Ring Aryl Chloride: Selective Divergent Synthesis and Evaluation of Alternatively Substituted E-Ring Analogues

(2013) Joseph R. Pinchman et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chemical Tailoring of Teicoplanin with Site-Selective Reactions

(2013) Tejas P. Pathak et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric Catalysis at a Distance: Catalytic, Site-Selective Phosphorylation of Teicoplanin

(2013) Sunkyu Han et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Identifying producers of antibacterial compounds by screening for antibiotic resistance

(2013) Maulik N Thaker et al.   NATURE BIOTECHNOLOGY

Oritavancin: Mechanism of Action

(2012) George G. Zhanel et al.   CLINICAL INFECTIOUS DISEASES

Combining biocatalysis and chemoselective chemistries for glycopeptide antibiotics modification

(2012) Tsung-Lin Li et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Site-Selective Bromination of Vancomycin

(2012) Tejas P. Pathak et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Silver(I)-Promoted Conversion of Thioamides to Amidines: Divergent Synthesis of a Key Series of Vancomycin Aglycon Residue 4 Amidines That Clarify Binding Behavior to Model Ligands

(2012) Akinori Okano et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic Site-Selective Thiocarbonylations and Deoxygenations of Vancomycin Reveal Hydroxyl-Dependent Conformational Effects

(2012) Brandon S. Fowler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Combinatorial Biosynthesis of Cyclic Lipopeptide Antibiotics: A Model for Synthetic Biology To Accelerate the Evolution of Secondary Metabolite Biosynthetic Pathways

(2012) Richard H. Baltz   ACS Synthetic Biology

Opportunities for Synthetic Biology in Antibiotics: Expanding Glycopeptide Chemical Diversity

(2012) Maulik N. Thaker et al.   ACS Synthetic Biology

Recent advances in the synthesis of new glycopeptide antibiotics

(2011) Polly-Anna Ashford et al.   CHEMICAL SOCIETY REVIEWS

A Redesigned Vancomycin Engineered for Duald-Ala-d-Ala andd-Ala-d-Lac Binding Exhibits Potent Antimicrobial Activity Against Vancomycin-Resistant Bacteria

(2011) Jian Xie et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total Synthesis of [Ψ[C(═S)NH]Tpg4]Vancomycin Aglycon, [Ψ[C(═NH)NH]Tpg4]Vancomycin Aglycon, and Related Key Compounds: Reengineering Vancomycin for Dual d-Ala-d-Ala and d-Ala-d-Lac Binding

(2011) Jian Xie et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Interception of teicoplanin oxidation intermediates yields new antimicrobial scaffolds

(2011) Yu-Chen Liu et al.   Nature Chemical Biology

Cu(I)- and Ru(II)-Mediated “Click” Cyclization of Tripeptides Toward Vancomycin-Inspired Mimics

(2011) Jinqiang Zhang et al.   ORGANIC LETTERS

Glycopeptide biosynthesis in the context of basic cellular functions

(2010) Evi Stegmann et al.   CURRENT OPINION IN MICROBIOLOGY

Discovery of a Novel Series of Semisynthetic Vancomycin Derivatives Effective against Vancomycin-Resistant Bacteria

(2010) Yuki Nakama et al.   JOURNAL OF MEDICINAL CHEMISTRY

Origins and Evolution of Antibiotic Resistance

(2010) J. Davies et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

VanA-Type Vancomycin-Resistant Staphylococcus aureus

(2009) B. Perichon et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Synthesis and Evaluation of Vancomycin Aglycon Analogues That Bear Modifications in the N-Terminald-Leucyl Amino Acid

(2009) Christine M. Crane et al.   JOURNAL OF MEDICINAL CHEMISTRY

Vancomycin and Oritavancin Have Different Modes of Action in Enterococcus faecium

(2009) Gary J. Patti et al.   JOURNAL OF MOLECULAR BIOLOGY

Catalytic Turnover-Based Phage Selection for Engineering the Substrate Specificity of Sfp Phosphopantetheinyl Transferase

(2009) Murat Sunbul et al.   JOURNAL OF MOLECULAR BIOLOGY

Telavancin

(2009) G. Ralph Corey et al.   NATURE REVIEWS DRUG DISCOVERY

Federal Funding for the Study of Antimicrobial Resistance in Nosocomial Pathogens: No ESKAPE

(2008) Louis B. Rice   JOURNAL OF INFECTIOUS DISEASES