New Structural Data Reveal the Motion of Carrier Proteins in Nonribosomal Peptide Synthesis

Probing the selectivity of β-hydroxylation reactions in non-ribosomal peptide synthesis using analytical ultracentrifugation

(2016) Bashkim Kokona et al.   ANALYTICAL BIOCHEMISTRY

Online Pyrophosphate Assay for Analyzing Adenylation Domains of Nonribosomal Peptide Synthetases

(2016) Tiia Kittilä et al.   CHEMBIOCHEM

Regulation of the P450 Oxygenation Cascade Involved in Glycopeptide Antibiotic Biosynthesis

(2016) Madeleine Peschke et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Recent advances in engineering nonribosomal peptide assembly lines

(2016) M. Winn et al.   NATURAL PRODUCT REPORTS

A structural model for multimodular NRPS assembly lines

(2016) Mohamed A. Marahiel   NATURAL PRODUCT REPORTS

Structures of two distinct conformations of holo-non-ribosomal peptide synthetases

(2016) Eric J. Drake et al.   NATURE

Synthetic cycle of the initiation module of a formylating nonribosomal peptide synthetase

(2016) Janice M. Reimer et al.   NATURE

A Peptidyl-Transesterifying Type I Thioesterase in Salinamide Biosynthesis

(2015) Lauren Ray et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Nuclear Magnetic Resonance Method for Probing Molecular Influences of Substrate Loading in Nonribosomal Peptide Synthetase Carrier Proteins

(2015) Andrew C. Goodrich et al.   BIOCHEMISTRY

High-resolution structures of thed-alanyl carrier protein (Dcp) DltC fromBacillus subtilisreveal equivalent conformations ofapo- andholo-forms

(2015) Stephan Zimmermann et al.   FEBS LETTERS

Structure and Substrate Sequestration in the Pyoluteorin Type II Peptidyl Carrier Protein PltL

(2015) Matt J. Jaremko et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Solution Structure of a Nonribosomal Peptide Synthetase Carrier Protein Loaded with Its Substrate Reveals Transient, Well-Defined Contacts

(2015) Andrew C. Goodrich et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

X-domain of peptide synthetases recruits oxygenases crucial for glycopeptide biosynthesis

(2015) Kristina Haslinger et al.   NATURE

β-Lactam formation by a non-ribosomal peptide synthetase during antibiotic biosynthesis

(2015) Nicole M. Gaudelli et al.   NATURE

Structure of the terminal PCP domain of the non-ribosomal peptide synthetase in teicoplanin biosynthesis

(2015) Kristina Haslinger et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Antimicrobial Peptide Resistance of Vibrio cholerae Results from an LPS Modification Pathway Related to Nonribosomal Peptide Synthetases

(2014) Jeremy C. Henderson et al.   ACS Chemical Biology

The Structure of a Transient Complex of a Nonribosomal Peptide Synthetase and a Cytochrome P450 Monooxygenase

(2014) Kristina Haslinger et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Visualizing the Chain-Flipping Mechanism in Fatty-Acid Biosynthesis

(2014) Joris Beld et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Crystal Structure of a PCP/Sfp Complex Reveals the Structural Basis for Carrier Protein Posttranslational Modification

(2014) Peter Tufar et al.   CHEMISTRY & BIOLOGY

Epimerization and substrate gating by a TE domain in β-lactam antibiotic biosynthesis

(2014) Nicole M Gaudelli et al.   Nature Chemical Biology

Analysis of the linker region joining the adenylation and carrier protein domains of the modular nonribosomal peptide synthetases

(2014) Bradley R. Miller et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Cytochrome P450sky Interacts Directly with the Nonribosomal Peptide Synthetase to Generate Three Amino Acid Precursors in Skyllamycin Biosynthesis

(2013) Stefanie Uhlmann et al.   ACS Chemical Biology

Nonproteinogenic Amino Acid Building Blocks for Nonribosomal Peptide and Hybrid Polyketide Scaffolds

(2013) Christopher T. Walsh et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Crystal Structures of the First Condensation Domain of CDA Synthetase Suggest Conformational Changes during the Synthetic Cycle of Nonribosomal Peptide Synthetases

(2013) Kristjan Bloudoff et al.   JOURNAL OF MOLECULAR BIOLOGY

The crystal structure of BlmI as a model for nonribosomal peptide synthetase peptidyl carrier proteins

(2013) Jeremy R. Lohman et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Introduction of a Non-Natural Amino Acid into a Nonribosomal Peptide Antibiotic by Modification of Adenylation Domain Specificity

(2012) Jenny Thirlway et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structure of PA1221, a Nonribosomal Peptide Synthetase Containing Adenylation and Peptidyl Carrier Protein Domains

(2012) Carter A. Mitchell et al.   BIOCHEMISTRY

Structural and Functional Investigation of the Intermolecular Interaction between NRPS Adenylation and Carrier Protein Domains

(2012) Jesse A. Sundlov et al.   CHEMISTRY & BIOLOGY

The structural role of the carrier protein – active controller or passive carrier

(2012) John Crosby et al.   NATURAL PRODUCT REPORTS

Explorations of catalytic domains in non-ribosomal peptide synthetase enzymology

(2012) Gene H. Hur et al.   NATURAL PRODUCT REPORTS

Structural Basis for Phosphopantetheinyl Carrier Domain Interactions in the Terminal Module of Nonribosomal Peptide Synthetases

(2011) Ye Liu et al.   CHEMISTRY & BIOLOGY

Conformational Dynamics in the Acyl-CoA Synthetases, Adenylation Domains of Non-ribosomal Peptide Synthetases, and Firefly Luciferase

(2009) Andrew M. Gulick   ACS Chemical Biology

Probing the Interactions of Early Polyketide Intermediates with the Actinorhodin ACP from S. coelicolor A3(2)

(2009) Simon E. Evans et al.   JOURNAL OF MOLECULAR BIOLOGY

Crystal Structure of DltA

(2008) Huma Yonus et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nonribosomal Peptide Synthetases Involved in the Production of Medically Relevant Natural Products

(2008) Elizabeth A. Felnagle et al.   MOLECULAR PHARMACEUTICS

Dynamic thiolation–thioesterase structure of a non-ribosomal peptide synthetase

(2008) Dominique P. Frueh et al.   NATURE

Crystal Structure of the Termination Module of a Nonribosomal Peptide Synthetase

(2008) A. Tanovic et al.   SCIENCE