Recent Insights into Long Bone Development: Central Role of Hedgehog Signaling Pathway in Regulating Growth Plate

p.E95K mutation in Indian hedgehog causing brachydactyly type A1 impairs IHH/Gli1 downstream transcriptional regulation

(2019) Lu Shen et al.   BMC GENETICS

Activation of hedgehog signaling in mesenchymal stem cells induces cartilage and bone tumor formation via Wnt/β-Catenin

(2019) Qi Deng et al.   eLife

Mineralization pathways in the active murine epiphyseal growth plate

(2019) Heden Haimov et al.   BONE

A highlight on Sonic hedgehog pathway

(2018) Gabriela Basile Carballo et al.   Cell Communication and Signaling

Intracellular biosynthesis of lipids and cholesterol by Scap and Insig in mesenchymal cells regulates long bone growth and chondrocyte homeostasis

(2018) Hidetoshi Tsushima et al.   DEVELOPMENT

Growth plate-derived hedgehog-signal-responsive cells provide skeletal tissue components in growing bone

(2018) Ryuma Haraguchi et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Gli1 identifies osteogenic progenitors for bone formation and fracture repair

(2017) Yu Shi et al.   Nature Communications

Spatial regulation of bone morphogenetic proteins (BMPs) in postnatal articular and growth plate cartilage

(2017) Presley Garrison et al.   PLoS One

Chondrogenesis and osteogenesis are one continuous developmental and lineage defined biological process

(2017) Yan Jing et al.   Scientific Reports

Ihh and PTH1R signaling in limb mesenchyme is required for proper segmentation and subsequent formation and growth of digit bones

(2016) Katsuhiko Amano et al.   BONE

Cellular Cholesterol Directly Activates Smoothened in Hedgehog Signaling

(2016) Pengxiang Huang et al.   CELL

Hedgehog signalling

(2016) Raymond Teck Ho Lee et al.   DEVELOPMENT

Structural and mechanical properties of the proliferative zone of the developing murine growth plate cartilage assessed by atomic force microscopy

(2016) Carina Prein et al.   MATRIX BIOLOGY

BMP signalling in skeletal development, disease and repair

(2016) Valerie S. Salazar et al.   Nature Reviews Endocrinology

A pathway to bone: signaling molecules and transcription factors involved in chondrocyte development and maturation

(2015) E. Kozhemyakina et al.   DEVELOPMENT

Sufu and Kif7 in limb patterning and development

(2015) Olena Zhulyn et al.   DEVELOPMENTAL DYNAMICS

Conditional Deletion of Indian Hedgehog in Limb Mesenchyme Results in Complete Loss of Growth Plate Formation but Allows Mature Osteoblast Differentiation

(2015) Katsuhiko Amano et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The role of hedgehog signalling in skeletal health and disease

(2015) Benjamin A. Alman   Nature Reviews Rheumatology

Radiographic features of the skeleton in disorders of post-squalene cholesterol biosynthesis

(2015) Massimiliano Rossi et al.   PEDIATRIC RADIOLOGY

FGFR3 Deficiency Causes Multiple Chondroma-like Lesions by Upregulating Hedgehog Signaling

(2015) Siru Zhou et al.   PLoS Genetics

Regulation of Cholesterol Homeostasis by Hedgehog Signaling in Osteoarthritic Cartilage

(2015) Shabana Amanda Ali et al.   Arthritis & Rheumatology

Osteogenic fate of hypertrophic chondrocytes

(2014) Guan Yang et al.   CELL RESEARCH

Roles for Hedgehog signaling in adult organ homeostasis and repair

(2014) R. Petrova et al.   DEVELOPMENT

RECENT RESEARCH ON THE GROWTH PLATE: Advances in fibroblast growth factor signaling in growth plate development and disorders

(2014) Y. Xie et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

A subset of chondrogenic cells provides early mesenchymal progenitors in growing bones

(2014) Noriaki Ono et al.   NATURE CELL BIOLOGY

Hypertrophic chondrocytes can become osteoblasts and osteocytes in endochondral bone formation

(2014) L. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chondrocytes Transdifferentiate into Osteoblasts in Endochondral Bone during Development, Postnatal Growth and Fracture Healing in Mice

(2014) Xin Zhou et al.   PLoS Genetics

Histochemical aspects of the vascular invasion at the erosion zone of the epiphyseal cartilage in MMP-9-deficient mice

(2013) Taku KOJIMA et al.   BIOMEDICAL RESEARCH-TOKYO

Heparan sulfate in skeletal development, growth, and pathology: The case of hereditary multiple exostoses

(2013) Julianne Huegel et al.   DEVELOPMENTAL DYNAMICS

BMP Receptor 1A Determines the Cell Fate of the Postnatal Growth Plate

(2013) Junjun Jing et al.   International Journal of Biological Sciences

Ptpn11 deletion in a novel progenitor causes metachondromatosis by inducing hedgehog signalling

(2013) Wentian Yang et al.   NATURE

Activation of Hedgehog signaling by loss of GNAS causes heterotopic ossification

(2013) Jean B Regard et al.   NATURE MEDICINE

Development of the Endochondral Skeleton

(2013) F. Long et al.   Cold Spring Harbor Perspectives in Biology

A review of hedgehog signaling in cranial bone development

(2013) Angel Pan et al.   Frontiers in Physiology

Hedgehog Secretion and Signal Transduction in Vertebrates

(2012) Kaitlyn E. Ryan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic Regulation of the Growth Plate

(2012) Elham Karimian et al.   Frontiers in Endocrinology

Compound heterozygous loss of Ext1 and Ext2 is sufficient for formation of multiple exostoses in mouse ribs and long bones

(2011) Beverly M. Zak et al.   BONE

Indian hedgehog mutations causing brachydactyly type A1 impair Hedgehog signal transduction at multiple levels

(2011) Gang Ma et al.   CELL RESEARCH

Sixteen years and counting: The current understanding of fibroblast growth factor receptor 3 (FGFR3) signaling in skeletal dysplasias

(2011) Silvie Foldynova-Trantirkova et al.   HUMAN MUTATION

BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development

(2011) B. Shu et al.   JOURNAL OF CELL SCIENCE

Wnt/ -catenin signaling is differentially regulated by G  proteins and contributes to fibrous dysplasia

(2011) J. B. Regard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Benign bone tumors—recent developments

(2011) Roberto A. Garcia et al.   SEMINARS IN DIAGNOSTIC PATHOLOGY

Growth plate biology: new insights

(2011) Rose Marino   Current Opinion in Endocrinology Diabetes and Obesity

Loss-of-Function Mutations in PTPN11 Cause Metachondromatosis, but Not Ollier Disease or Maffucci Syndrome

(2011) Margot E. Bowen et al.   PLoS Genetics

Complementary interplay between matrix metalloproteinase-9, vascular endothelial growth factor and osteoclast function drives endochondral bone formation

(2010) N. Ortega et al.   Disease Models & Mechanisms

Inactivation ofPatched1in the Mouse Limb Has Novel Inhibitory Effects on the Chondrogenic Program

(2010) Stephen J. Bruce et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Whole-Genome Sequencing of a Single Proband Together with Linkage Analysis Identifies a Mendelian Disease Gene

(2010) Nara L. M. Sobreira et al.   PLoS Genetics

Benign Cartilaginous Tumors of Bone

(2009) Salvatore Romeo et al.   ADVANCES IN ANATOMIC PATHOLOGY

Partial rescue of postnatal growth plate abnormalities in Ihh mutants by expression of a constitutively active PTH/PTHrP receptor

(2009) Yukiko Maeda et al.   BONE

BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation

(2009) K. N. Retting et al.   DEVELOPMENT

Multiple osteochondromas: mutation update and description of the multiple osteochondromas mutation database (MOdb)

(2009) Ivy Jennes et al.   HUMAN MUTATION

A mutation in Ihh that causes digit abnormalities alters its signalling capacity and range

(2009) Bo Gao et al.   NATURE

Hedgehog: functions and mechanisms

(2008) M. Varjosalo et al.   GENES & DEVELOPMENT

Morphogenetic and Regulatory Mechanisms During Developmental Chondrogenesis: New Paradigms for Cartilage Tissue Engineering

(2008) Lluís Quintana et al.   TISSUE ENGINEERING PART B-REVIEWS