Heparan sulfate in skeletal development, growth, and pathology: The case of hereditary multiple exostoses

Perichondrium phenotype and border function are regulated by Ext1 and heparan sulfate in developing long bones: A mechanism likely deranged in Hereditary Multiple Exostoses

(2013) Julianne Huegel et al.   DEVELOPMENTAL BIOLOGY

Intronic deletion and duplication proximal of theEXT1gene: A novel causative mechanism for multiple osteochondromas

(2013) Cathelijn J. F. Waaijer et al.   GENES CHROMOSOMES & CANCER

Loss of β-Catenin Induces Multifocal Periosteal Chondroma-Like Masses in Mice

(2012) Leslie Cantley et al.   AMERICAN JOURNAL OF PATHOLOGY

20 novel point mutations and one large deletion in EXT1 and EXT2 genes: Report of diagnostic screening in a large Italian cohort of patients affected by hereditary multiple exostosis

(2012) Michele Ciavarella et al.   GENE

Pain, Physical and Social Functioning, and Quality of Life in Individuals with Multiple Hereditary Exostoses in the Netherlands

(2012) A L Goud et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Craniomaxillofacial Features in Hereditary Multiple Exostosis

(2012) Laura Pacheco Ruiz et al.   JOURNAL OF CRANIOFACIAL SURGERY

Toward an understanding of the short bone phenotype associated with multiple osteochondromas

(2012) Kevin B. Jones et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

HSPG-Deficient Zebrafish Uncovers Dental Aspect of Multiple Osteochondromas

(2012) Malgorzata I. Wiweger et al.   PLoS One

Compound heterozygous loss of Ext1 and Ext2 is sufficient for formation of multiple exostoses in mouse ribs and long bones

(2011) Beverly M. Zak et al.   BONE

Cell Surface Heparan Sulfate Chains Regulate Local Reception of FGF Signaling in the Mouse Embryo

(2011) Kayo Shimokawa et al.   DEVELOPMENTAL CELL

Genotype-Phenotype Correlation Study in 529 Patients with Multiple Hereditary Exostoses: Identification of “Protective” and “Risk” Factors

(2011) Elena Pedrini et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Glycobiology and the Growth Plate

(2011) Kevin B. Jones   JOURNAL OF PEDIATRIC ORTHOPAEDICS

Outcome and Prognosis of Myelopathy and Radiculopathy From Osteochondroma in the Mobile Spine

(2011) Lin Zaijun et al.   JOURNAL OF SPINAL DISORDERS & TECHNIQUES

Potent inhibition of heterotopic ossification by nuclear retinoic acid receptor-γ agonists

(2011) Kengo Shimono et al.   NATURE MEDICINE

Three Faces of Costal Exostoses

(2011) Dagnachew Assefa et al.   PEDIATRIC EMERGENCY CARE

Biosynthesis of heparan sulfate inEXT1-deficient cells

(2010) Megumi Okada et al.   BIOCHEMICAL JOURNAL

Bone morphogenetic protein and growth differentiation factor cytokine families and their protein antagonists

(2010) Christopher C. Rider et al.   BIOCHEMICAL JOURNAL

MicroRNA profiling of multiple osteochondromas: identification of disease-specific and normal cartilage signatures

(2010) M Zuntini et al.   CLINICAL GENETICS

Synovial joint formation requires local Ext1 expression and heparan sulfate production in developing mouse embryo limbs and spine

(2010) Christina Mundy et al.   DEVELOPMENTAL BIOLOGY

Conditional Ablation of the Heparan Sulfate-synthesizing EnzymeExt1Leads to Dysregulation of Bone Morphogenic Protein Signaling and Severe Skeletal Defects

(2010) Yoshihiro Matsumoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sulfotransferase Ndst1 is Needed for Mandibular and TMJ Development

(2010) T. Yasuda et al.   JOURNAL OF DENTAL RESEARCH

A splice-site mutation leads to haploinsufficiency of EXT2 mRNA for a dominant trait in a large family with multiple osteochondromas

(2010) Liu Yang et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Cartilage ultrastructure in proteoglycan-deficient zebrafish mutants brings to light new candidate genes for human skeletal disorders

(2010) Malgorzata I Wiweger et al.   JOURNAL OF PATHOLOGY

Primary cilia organization reflects polarity in the growth plate and implies loss of polarity and mosaicism in osteochondroma

(2010) Carlos E de Andrea et al.   LABORATORY INVESTIGATION

Extracellular sulfatases support cartilage homeostasis by regulating BMP and FGF signaling pathways

(2010) S. Otsuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transient Activation of Wnt/β-Catenin Signaling Induces Abnormal Growth Plate Closure and Articular Cartilage Thickening in Postnatal Mice

(2009) Takahito Yuasa et al.   AMERICAN JOURNAL OF PATHOLOGY

The extracellular regulation of bone morphogenetic protein signaling

(2009) D. Umulis et al.   DEVELOPMENT

Multiple osteochondromas: mutation update and description of the multiple osteochondromas mutation database (MOdb)

(2009) Ivy Jennes et al.   HUMAN MUTATION

Mutation in the Heparan Sulfate Biosynthesis Enzyme EXT1 Influences Growth Factor Signaling and Fibroblast Interactions with the Extracellular Matrix

(2009) Cecilia Österholm et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A mouse model of osteochondromagenesis from clonal inactivation of Ext1 in chondrocytes

(2009) K. B. Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heparanase: busy at the cell surface

(2009) Liat Fux et al.   TRENDS IN BIOCHEMICAL SCIENCES

Heparanase expression and activity influences chondrogenic and osteogenic processes during endochondral bone formation

(2008) A.J. Brown et al.   BONE

Extracellular regulation of developmental cell signaling by XtSulf1

(2008) Stephen D. Freeman et al.   DEVELOPMENTAL BIOLOGY

The molecular and cellular basis of exostosis formation in hereditary multiple exostoses

(2008) Meirav Trebicz-Geffen et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Surfen, a small molecule antagonist of heparan sulfate

(2008) M. Schuksz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Zebrafish Skeletogenesis by ext2/dackel and papst1/pinscher

(2008) Aurélie Clément et al.   PLoS Genetics