Mesencephalic astrocyte-derived neurotrophic factor (MANF) protects against Aβ toxicity via attenuating Aβ-induced endoplasmic reticulum stress

MANF protects human pancreatic beta cells against stress-induced cell death

(2018) Elina Hakonen et al.   DIABETOLOGIA

XBP1 activation enhances MANF expression via binding to endoplasmic reticulum stress response elements within MANF promoter region in hepatitis B

(2018) Dong Wang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

XBP1 and PERK Have Distinct Roles in Aβ-Induced Pathology

(2018) Kuan-Chung Cheng et al.   MOLECULAR NEUROBIOLOGY

Amyloid toxicity in Alzheimer’s disease

(2018) Allison B. Reiss et al.   REVIEWS IN THE NEUROSCIENCES

Mesencephalic Astrocyte-Derived Neurotrophic Factor Prevents Traumatic Brain Injury in Rats by Inhibiting Inflammatory Activation and Protecting the Blood-Brain Barrier

(2018) Qing-Xin Li et al.   World Neurosurgery

Mesencephalic astrocyte-derived neurotrophic factor affords neuroprotection to early brain injury induced by subarachnoid hemorrhage via activating Akt-dependent prosurvival pathway and defending blood–brain barrier integrity

(2018) Tao Li et al.   FASEB JOURNAL

MANF Is Required for the Postnatal Expansion and Maintenance of Pancreatic β-Cell Mass in Mice

(2018) Tatiana Danilova et al.   DIABETES

Emerging Roles for Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) in Pancreatic Beta Cells and Diabetes

(2018) Tatiana Danilova et al.   Frontiers in Physiology

Mesencephalic astrocyte-derived neurotrophic factor alleviated 6-OHDA-induced cell damage via ROS-AMPK/mTOR mediated autophagic inhibition

(2017) Jingxing Zhang et al.   EXPERIMENTAL GERONTOLOGY

Long-term protective effects of AAV9-mesencephalic astrocyte-derived neurotrophic factor gene transfer in parkinsonian rats

(2017) Fei Hao et al.   EXPERIMENTAL NEUROLOGY

Emerging roles of ER stress in the etiology and pathogenesis of Alzheimer's disease

(2017) Yannis Gerakis et al.   FEBS Journal

Not just amyloid: physiological functions of the amyloid precursor protein family

(2017) Ulrike C. Müller et al.   NATURE REVIEWS NEUROSCIENCE

Unconventional neurotrophic factors CDNF and MANF: Structure, physiological functions and therapeutic potential

(2017) Maria Lindahl et al.   NEUROBIOLOGY OF DISEASE

The Cellular Phase of Alzheimer’s Disease

(2016) Bart De Strooper et al.   CELL

Alzheimer's disease

(2016) Philip Scheltens et al.   LANCET

Immune modulation by MANF promotes tissue repair and regenerative success in the retina

(2016) J. Neves et al.   SCIENCE

Mesencephalic astrocyte-derived neurotrophic factor and cerebral dopamine neurotrophic factor: New endoplasmic reticulum stress response proteins

(2015) Hao Liu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Mesencephalic Astrocyte-Derived Neurotrophic Factor Is Involved in Inflammation by Negatively Regulating the NF-κB Pathway

(2015) Lijian Chen et al.   Scientific Reports

Mesencephalic astrocyte-derived neurotrophic factor prevents neuron loss via inhibiting ischemia-induced apoptosis

(2014) Wen Yang et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

The amyloid state and its association with protein misfolding diseases

(2014) Tuomas P. J. Knowles et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Endoplasmic reticulum stress as a novel neuronal mediator in Alzheimer’s disease

(2014) Han-Chang Huang et al.   NEUROLOGICAL RESEARCH

MANF Is Indispensable for the Proliferation and Survival of Pancreatic β Cells

(2014) Maria Lindahl et al.   Cell Reports

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

(2013) Jaeseok Han et al.   NATURE CELL BIOLOGY

The unfolded protein response in Alzheimer’s disease

(2013) Víctor Hugo Cornejo et al.   Seminars in Immunopathology

Mesencephalic Astrocyte-derived Neurotrophic Factor Protects the Heart from Ischemic Damage and Is Selectively Secreted upon Sarco/endoplasmic Reticulum Calcium Depletion

(2012) Christopher C. Glembotski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Upregulation of mesencephalic astrocyte-derived neurotrophic factor in glial cells is associated with ischemia-induced glial activation

(2012) Yujun Shen et al.   Journal of Neuroinflammation

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

(2011) Ira Tabas et al.   NATURE CELL BIOLOGY

Amyloid β-induced ER stress is enhanced under mitochondrial dysfunction conditions

(2011) Rui O. Costa et al.   NEUROBIOLOGY OF AGING

Widespread cortical expression of MANF by AAV serotype 7: Localization and protection against ischemic brain injury

(2010) Mikko Airavaara et al.   EXPERIMENTAL NEUROLOGY

Chronic infusion of CDNF prevents 6-OHDA-induced deficits in a rat model of Parkinson's disease

(2010) Merja H. Voutilainen et al.   EXPERIMENTAL NEUROLOGY

Solution structure and dynamics of mouse ARMET

(2010) Jun Hoseki et al.   FEBS LETTERS

Mesencephalic Astrocyte-derived Neurotrophic Factor (MANF) Has a Unique Mechanism to Rescue Apoptotic Neurons

(2010) Maarit Hellman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alzheimer's disease: strategies for disease modification

(2010) Martin Citron   NATURE REVIEWS DRUG DISCOVERY

Activation of PERK Signaling Attenuates Aβ-Mediated ER Stress

(2010) Do Yeon Lee et al.   PLoS One

Induction Profile of MANF/ARMET by Cerebral Ischemia and its Implication for Neuron Protection

(2009) Yong-Qiang Yu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Mesencephalic astrocyte-derived neurotrophic factor reduces ischemic brain injury and promotes behavioral recovery in rats

(2009) Mikko Airavaara et al.   JOURNAL OF COMPARATIVE NEUROLOGY

ER stress in Alzheimer's disease: a novel neuronal trigger for inflammation and Alzheimer's pathology

(2009) Antero Salminen et al.   Journal of Neuroinflammation

Mesencephalic Astrocyte-Derived Neurotrophic Factor Is Neurorestorative in Rat Model of Parkinson's Disease

(2009) M. H. Voutilainen et al.   JOURNAL OF NEUROSCIENCE

Divergent Effects of PERK and IRE1 Signaling on Cell Viability

(2009) Jonathan H. Lin et al.   PLoS One

Mesencephalic Astrocyte-Derived Neurotrophic Factor Is an Ischemia-Inducible Secreted Endoplasmic Reticulum Stress Response Protein in the Heart

(2008) Archana Tadimalla et al.   CIRCULATION RESEARCH

Armet, a UPR-upregulated protein, inhibits cell proliferation and ER stress-induced cell death

(2008) A APOSTOLOU et al.   EXPERIMENTAL CELL RESEARCH

Amyloid Precursor Protein Trafficking, Processing, and Function

(2008) Gopal Thinakaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

E2-25K/Hip-2 regulates caspase-12 in ER stress–mediated Aβ neurotoxicity

(2008) Sungmin Song et al.   JOURNAL OF CELL BIOLOGY

MANF is widely expressed in mammalian tissues and differently regulated after ischemic and epileptic insults in rodent brain

(2008) Päivi Lindholm et al.   MOLECULAR AND CELLULAR NEUROSCIENCE