COX‐2/sEH dual inhibitor PTUPB alleviates bleomycin‐induced pulmonary fibrosis in mice via inhibiting senescence

Suppression of chemotherapy-induced cytokine/lipid mediator surge and ovarian cancer by a dual COX-2/sEH inhibitor

(2019) Allison Gartung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular Senescence as a Mechanism and Target in Chronic Lung Diseases

(2019) Peter J Barnes et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Cellular Senescence: The Trojan Horse in Chronic Lung Diseases

(2019) Shruthi Hamsanathan et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Cellular Senescence: Aging, Cancer, and Injury

(2019) Arianna Calcinotto et al.   PHYSIOLOGICAL REVIEWS

Endothelium-specific CYP2J2 overexpression attenuates age-related insulin resistance

(2018) Yan Yang et al.   AGING CELL

Fibroblast senescence in the pathology of idiopathic pulmonary fibrosis

(2018) David W Waters et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Safer anti-inflammatory therapy through dual COX-2/5-LOX inhibitors: A structure-based approach

(2018) Jaismy Jacob P et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Vasoactive intestinal peptide overexpression mediated by lentivirus attenuates lipopolysaccharide-induced acute lung injury in mice by inhibiting inflammation

(2018) Guo-Ying Sun et al.   MOLECULAR IMMUNOLOGY

Celecoxib Does Not Protect against Fibrosis and Inflammation in a Carbon Tetrachloride–Induced Model of Liver Injury

(2018) Todd R. Harris et al.   MOLECULAR PHARMACOLOGY

Soluble epoxide hydrolase plays a key role in the pathogenesis of Parkinson’s disease

(2018) Qian Ren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacological Inhibition of Soluble Epoxide Hydrolase Ameliorates Chronic Ethanol-Induced Cardiac Fibrosis by Restoring Autophagic Flux

(2018) Chi Zhou et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Regional vulnerability to lipoxidative damage and inflammation in normal human brain aging

(2018) Mayelín Domínguez-González et al.   EXPERIMENTAL GERONTOLOGY

Inhibition of glycolysis alleviates lipopolysaccharide-induced acute lung injury in a mouse model

(2018) Wen-Jing Zhong et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Senescence of bone marrow-derived mesenchymal stem cells from patients with idiopathic pulmonary fibrosis

(2018) Nayra Cárdenes et al.   Stem Cell Research & Therapy

Humble beginnings with big goals: Small molecule soluble epoxide hydrolase inhibitors for treating CNS disorders

(2018) Sydney Zarriello et al.   PROGRESS IN NEUROBIOLOGY

Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosisex vivo

(2017) Mareike Lehmann et al.   EUROPEAN RESPIRATORY JOURNAL

Aucubin Alleviates Bleomycin-Induced Pulmonary Fibrosis in a Mouse Model

(2017) Yong Zhou et al.   INFLAMMATION

Inhibition of Bcl-2/xl With ABT-263 Selectively Kills Senescent Type II Pneumocytes and Reverses Persistent Pulmonary Fibrosis Induced by Ionizing Radiation in Mice

(2017) Jin Pan et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

CYP2J2 metabolites, epoxyeicosatrienoic acids, attenuate Ang II-induced cardiac fibrotic response by targeting Gα 12/13

(2017) Zuowen He et al.   JOURNAL OF LIPID RESEARCH

Pharmacological inhibition of soluble epoxide hydrolase or genetic deletion reduces diclofenac-induced gastric ulcers

(2017) Sumanta Kumar Goswami et al.   LIFE SCIENCES

COX-2/sEH Dual Inhibitor PTUPB Potentiates the Antitumor Efficacy of Cisplatin

(2017) Fuli Wang et al.   MOLECULAR CANCER THERAPEUTICS

Emerging therapies for idiopathic pulmonary fibrosis, a progressive age-related disease

(2017) Ana L. Mora et al.   NATURE REVIEWS DRUG DISCOVERY

Inhibition of soluble epoxide hydrolase lowers portal hypertension in cirrhotic rats by ameliorating endothelial dysfunction and liver fibrosis

(2017) Wensheng Deng et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Soluble Epoxide Hydrolase Inhibitor Attenuates Lipopolysaccharide-Induced Acute Lung Injury and Improves Survival in Mice

(2017) Yong Zhou et al.   SHOCK

Cellular senescence mediates fibrotic pulmonary disease

(2017) Marissa J. Schafer et al.   Nature Communications

Epoxyeicosatrienoic Acid Analog Decreases Renal Fibrosis by Reducing Epithelial-to-Mesenchymal Transition

(2017) Melissa Skibba et al.   Frontiers in Pharmacology

Soluble Epoxide Hydrolase Inhibitor Suppresses the Expression of Triggering Receptor Expressed on Myeloid Cells-1 by Inhibiting NF-kB Activation in Murine Macrophage

(2016) Liang Dong et al.   INFLAMMATION

Hippocampal Astrocyte Cultures from Adult and Aged Rats Reproduce Changes in Glial Functionality Observed in the Aging Brain

(2016) Bruna Bellaver et al.   MOLECULAR NEUROBIOLOGY

A dual COX-2/sEH inhibitor improves the metabolic profile and reduces kidney injury in Zucker diabetic fatty rat

(2016) Md. Abdul Hye Khan et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Tissue damage and senescence provide critical signals for cellular reprogramming in vivo

(2016) Lluc Mosteiro et al.   SCIENCE

Soluble epoxide hydrolase inhibitor 1-trifluoromethoxyphenyl-3- (1-propionylpiperidin-4-yl) urea attenuates bleomycin-induced pulmonary fibrosis in mice

(2015) Yong Zhou et al.   CELL AND TISSUE RESEARCH

Bleomycin in the setting of lung fibrosis induction: From biological mechanisms to counteractions

(2015) Veronica Della Latta et al.   PHARMACOLOGICAL RESEARCH

Breakdown of Epithelial Barrier Integrity and Overdrive Activation of Alveolar Epithelial Cells in the Pathogenesis of Acute Respiratory Distress Syndrome and Lung Fibrosis

(2015) Shigehisa Yanagi et al.   Biomed Research International

The role of lipoxygenases in pathophysiology; new insights and future perspectives

(2015) Ryuichi Mashima et al.   Redox Biology

Inhibition of 5-LOX, COX-1, and COX-2 Increases Tendon Healing and Reduces Muscle Fibrosis and Lipid Accumulation After Rotator Cuff Repair

(2014) Nikhil R. Oak et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

The role of senescent cells in ageing

(2014) Jan M. van Deursen   NATURE

Premature lung aging and cellular senescence in the pathogenesis of idiopathic pulmonary fibrosis and COPD/emphysema

(2013) Marco Chilosi et al.   Translational Research

Prostaglandins and Inflammation

(2011) Emanuela Ricciotti et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Synthesis and Structure−Activity Relationship Studies of Urea-Containing Pyrazoles as Dual Inhibitors of Cyclooxygenase-2 and Soluble Epoxide Hydrolase

(2011) Sung Hee Hwang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Prostaglandin F2α receptor signaling facilitates bleomycin-induced pulmonary fibrosis independently of transforming growth factor-β

(2009) Toru Oga et al.   NATURE MEDICINE

Application of Metabolomics to Cardiovascular Biomarker and Pathway Discovery

(2008) Gregory D. Lewis et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY