A pharmaceutical model for the molecular evolution of microbial natural products

Evolutionary Trajectories for the Functional Diversification of Anthracycline Methyltransferases

(2019) Thadée Grocholski et al.   ACS Chemical Biology

Identification of the Formycin A Biosynthetic Gene Cluster from Streptomyces kaniharaensis Illustrates the Interplay between Biological Pyrazolopyrimidine Formation and de Novo Purine Biosynthesis

(2019) Shao-An Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Emulating evolutionary processes to morph aureothin-type modular polyketide synthases and associated oxygenases

(2019) Huiyun Peng et al.   Nature Communications

Metabolite–Enzyme Coevolution: From Single Enzymes to Metabolic Pathways and Networks

(2018) Lianet Noda-Garcia et al.   Annual Review of Biochemistry

Engineering chemical interactions in microbial communities

(2018) Douglas J. Kenny et al.   CHEMICAL SOCIETY REVIEWS

Ironing out siderophore biosynthesis: a review of non-ribosomal peptide synthetase (NRPS)-independent siderophore synthetases

(2018) Cassandra S. Carroll et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

RiPP antibiotics: biosynthesis and engineering potential

(2018) Graham A Hudson et al.   CURRENT OPINION IN MICROBIOLOGY

Roles of 2-oxoglutarate oxygenases and isopenicillin N synthase in β-lactam biosynthesis

(2018) Patrick Rabe et al.   NATURAL PRODUCT REPORTS

Amazing Diversity in Biochemical Roles of Fe(II)/2-Oxoglutarate Oxygenases

(2018) Caitlyn Q Herr et al.   TRENDS IN BIOCHEMICAL SCIENCES

Novofumigatonin biosynthesis involves a non-heme iron-dependent endoperoxide isomerase for orthoester formation

(2018) Yudai Matsuda et al.   Nature Communications

Structure function and engineering of multifunctional non-heme iron dependent oxygenases in fungal meroterpenoid biosynthesis

(2018) Yu Nakashima et al.   Nature Communications

Enzymatic Synthesis of the C-Glycosidic Moiety of Nogalamycin R

(2018) Vilja Siitonen et al.   ACS Chemical Biology

Enzymatic Cascade Reactions in Biosynthesis

(2018) Christopher T. Walsh et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Reprogramming of the antimycin NRPS-PKS assembly lines inspired by gene evolution

(2018) Takayoshi Awakawa et al.   Nature Communications

N-Prenylation of Tryptophan by an Aromatic Prenyltransferase from the Cyanobactin Biosynthetic Pathway

(2018) Luca Dalponte et al.   BIOCHEMISTRY

Diversity of nature's assembly lines – recent discoveries in non-ribosomal peptide synthesis

(2017) Jennifer A. E. Payne et al.   Molecular BioSystems

Antibiotics and specialized metabolites from the human microbiota

(2017) Walaa K. Mousa et al.   NATURAL PRODUCT REPORTS

Structure and specificity of a permissive bacterial C-prenyltransferase

(2017) Sherif I Elshahawi et al.   Nature Chemical Biology

Evolution inspired engineering of antibiotic biosynthesis enzymes

(2017) M. Metsä-Ketelä   ORGANIC & BIOMOLECULAR CHEMISTRY

Hydroxyl regioisomerization of anthracycline catalyzed by a four-enzyme cascade

(2017) Zhuan Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Retrospective analysis of natural products provides insights for future discovery trends

(2017) Cameron R. Pye et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diversity oriented biosynthesis via accelerated evolution of modular gene clusters

(2017) Aleksandra Wlodek et al.   Nature Communications

A Unique Tryptophan C-Prenyltransferase from the Kawaguchipeptin Biosynthetic Pathway

(2016) Anirudra Parajuli et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structural Diversification of Lyngbyatoxin A by Host-Dependent Heterologous Expression of thetleABCBiosynthetic Gene Cluster

(2016) Lihan Zhang et al.   CHEMBIOCHEM

Gene Flow and Molecular Innovation in Bacteria

(2016) Antonio C. Ruzzini et al.   CURRENT BIOLOGY

Structure and mechanism of assembly line polyketide synthases

(2016) Thomas Robbins et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Natural Products as Sources of New Drugs from 1981 to 2014

(2016) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Discovery of Key Dioxygenases that Diverged the Paraherquonin and Acetoxydehydroaustin Pathways in Penicillium brasilianum

(2016) Yudai Matsuda et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bacterial terpene cyclases

(2016) Jeroen S. Dickschat   NATURAL PRODUCT REPORTS

Molecular insights into the enzyme promiscuity of an aromatic prenyltransferase

(2016) Ridao Chen et al.   Nature Chemical Biology

Divergent non-heme iron enzymes in the nogalamycin biosynthetic pathway

(2016) Vilja Siitonen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Natural Products and the Gene Cluster Revolution

(2016) Paul R. Jensen   TRENDS IN MICROBIOLOGY

Manipulation of prenylation reactions by structure-based engineering of bacterial indolactam prenyltransferases

(2016) Takahiro Mori et al.   Nature Communications

Structural Characterization of O- and C-Glycosylating Variants of the Landomycin Glycosyltransferase LanGT2

(2015) Heng Keat Tam et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structural Insight into MtmC, a Bifunctional Ketoreductase-Methyltransferase Involved in the Assembly of the Mithramycin Trisaccharide Chain

(2015) Jhong-Min Chen et al.   BIOCHEMISTRY

Genomic insights into the evolution of hybrid isoprenoid biosynthetic gene clusters in the MAR4 marine streptomycete clade

(2015) Kelley A. Gallagher et al.   BMC GENOMICS

Regioselective Acetylation of C21 Hydroxysteroids by the Bacterial Chloramphenicol Acetyltransferase I

(2015) Azzam Mosa et al.   CHEMBIOCHEM

Evolution of Efficient Modular Polyketide Synthases by Homologous Recombination

(2015) Joseph A. Chemler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Taxonomy, Physiology, and Natural Products of Actinobacteria

(2015) Essaid Ait Barka et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Mechanistic studies on the indole prenyltransferases

(2015) Martin E. Tanner   NATURAL PRODUCT REPORTS

The re-emergence of natural products for drug discovery in the genomics era

(2015) Alan L. Harvey et al.   NATURE REVIEWS DRUG DISCOVERY

Discovery of microbial natural products by activation of silent biosynthetic gene clusters

(2015) Peter J. Rutledge et al.   NATURE REVIEWS MICROBIOLOGY

Divergent evolution of an atypicalS-adenosyl-l-methionine–dependent monooxygenase involved in anthracycline biosynthesis

(2015) Thadée Grocholski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An evolutionary biochemist's perspective on promiscuity

(2015) Shelley D. Copley   TRENDS IN BIOCHEMICAL SCIENCES

Natural Product Biosynthetic Diversity and Comparative Genomics of the Cyanobacteria

(2015) Elke Dittmann et al.   TRENDS IN MICROBIOLOGY

Pseudoaeruginosins, Nonribosomal Peptides in Nodularia spumigena

(2014) Liwei Liu et al.   ACS Chemical Biology

High Divergence of the Precursor Peptides in Combinatorial Lanthipeptide Biosynthesis

(2014) Qi Zhang et al.   ACS Chemical Biology

Entropy is Key to the Formation of Pentacyclic Terpenoids by Enzyme-Catalyzed Polycyclization

(2014) Per-Olof Syrén et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Potential for Reduction of Streptogramin A Resistance Revealed by Structural Analysis of Acetyltransferase VatA

(2014) Peter J. Stogios et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Insights into Secondary Metabolism from a Global Analysis of Prokaryotic Biosynthetic Gene Clusters

(2014) Peter Cimermancic et al.   CELL

A Systematic Analysis of Biosynthetic Gene Clusters in the Human Microbiome Reveals a Common Family of Antibiotics

(2014) Mohamed S. Donia et al.   CELL

Structure-Based Engineering of Angucyclinone 6-Ketoreductases

(2014) Pekka Patrikainen et al.   CHEMISTRY & BIOLOGY

Mining the Metabiome: Identifying Novel Natural Products from Microbial Communities

(2014) Aleksandr Milshteyn et al.   CHEMISTRY & BIOLOGY

Squalene hopene cyclases are protonases for stereoselective Brønsted acid catalysis

(2014) Stephan C Hammer et al.   Nature Chemical Biology

Atlas of nonribosomal peptide and polyketide biosynthetic pathways reveals common occurrence of nonmodular enzymes

(2014) H. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Organic synthesis: the art and science of replicating the molecules of living nature and creating others like them in the laboratory

(2014) K. C. Nicolaou   PROCEEDINGS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

Tracing the Evolution of Angucyclinone Monooxygenases: Structural Determinants for C-12b Hydroxylation and Substrate Inhibition in PgaE

(2013) Pauli Kallio et al.   BIOCHEMISTRY

Structural and Functional Analysis of Angucycline C-6 Ketoreductase LanV Involved in Landomycin Biosynthesis

(2013) Pasi Paananen et al.   BIOCHEMISTRY

Synthesis of Heterocyclic Terpenoids by Promiscuous Squalene-Hopene Cyclases

(2013) Miriam Seitz et al.   CHEMBIOCHEM

The Genetic Basis for O-Acetylation of the Microcystin Toxin in Cyanobacteria

(2013) David P. Fewer et al.   CHEMISTRY & BIOLOGY

Multisite Prenylation of 4-Substituted Tryptophans by Dimethylallyltryptophan Synthase

(2013) Jeffrey D. Rudolf et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Spiro-Ring Formation is Catalyzed by a Multifunctional Dioxygenase in Austinol Biosynthesis

(2013) Yudai Matsuda et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Evolution and Distribution of Saxitoxin Biosynthesis in Dinoflagellates

(2013) Russell Orr et al.   Marine Drugs

Prokaryotic squalene-hopene cyclases can be converted to citronellal cyclases by single amino acid exchange

(2012) Gabriele Siedenburg et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Discovery of a Two-Component Monooxygenase SnoaW/SnoaL2 Involved in Nogalamycin Biosynthesis

(2012) Vilja Siitonen et al.   CHEMISTRY & BIOLOGY

Tailoring Enzymes Involved in the Biosynthesis of Angucyclines Contain Latent Context-Dependent Catalytic Activities

(2012) Pekka Patrikainen et al.   CHEMISTRY & BIOLOGY

Engineering specialized metabolic pathways—is there a room for enzyme improvements?

(2012) Arren Bar-Even et al.   CURRENT OPINION IN BIOTECHNOLOGY

Crystal structure of the glycosyltransferase SnogD from the biosynthetic pathway of nogalamycin inStreptomyces nogalater

(2012) Magnus Claesson et al.   FEBS Journal

Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010

(2012) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

The structural basis for substrate versatility of chloramphenicol acetyltransferase CATI

(2012) Tapan Biswas et al.   PROTEIN SCIENCE

Flavoprotein Hydroxylase PgaE Catalyzes Two Consecutive Oxygen-Dependent Tailoring Reactions in Angucycline Biosynthesis

(2011) Pauli Kallio et al.   BIOCHEMISTRY

The Moderately Efficient Enzyme: Evolutionary and Physicochemical Trends Shaping Enzyme Parameters

(2011) Arren Bar-Even et al.   BIOCHEMISTRY

Identification of Late-Stage Glycosylation Steps in the Biosynthetic Pathway of the Anthracycline Nogalamycin

(2011) Vilja Siitonen et al.   CHEMBIOCHEM

Rational Design of an Aryl-C-Glycoside Catalyst from a Natural Product O-Glycosyltransferase

(2011) Johannes Härle et al.   CHEMISTRY & BIOLOGY

Angucyclines: Biosynthesis, mode-of-action, new natural products, and synthesis

(2011) Madan K. Kharel et al.   NATURAL PRODUCT REPORTS

Microbial ultraviolet sunscreens

(2011) Qunjie Gao et al.   NATURE REVIEWS MICROBIOLOGY

Chemo-enzymatic syntheses of drimane-type sesquiterpenes and the fundamental core of hongoquercin meroterpenoid by recombinant squalene–hopene cyclase

(2011) Yukie Yonemura et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Evolutionary Relationships of Microbial Aromatic Prenyltransferases

(2011) Tobias Bonitz et al.   PLoS One

Natural Products as Chemical Probes

(2010) Erin E. Carlson   ACS Chemical Biology

Enzyme Promiscuity: A Mechanistic and Evolutionary Perspective

(2010) Olga Khersonsky and Dan S. Tawfik   Annual Review of Biochemistry

Characterization of JadH as an FAD- and NAD(P)H-Dependent Bifunctional Hydroxylase/Dehydrase in Jadomycin Biosynthesis

(2010) Yihua Chen  et al.   CHEMBIOCHEM

Biosynthesis of the Putative Siderophore Erythrochelin Requires Unprecedented Crosstalk between Separate Nonribosomal Peptide Gene Clusters

(2010) Orestis Lazos et al.   CHEMISTRY & BIOLOGY

Biochemical Characterization of a Novel Indole Prenyltransferase from Streptomyces sp. SN-593

(2010) S. Takahashi et al.   JOURNAL OF BACTERIOLOGY

Catalytic promiscuity in the biosynthesis of cyclic peptide secondary metabolites in planktonic marine cyanobacteria

(2010) B. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prenyl transfer to aromatic substrates: genetics and enzymology

(2009) Lutz Heide   CURRENT OPINION IN CHEMICAL BIOLOGY

Mechanism of Dimethylallyltryptophan Synthase: Evidence for a Dimethylallyl Cation Intermediate in an Aromatic Prenyltransferase Reaction

(2009) Louis Y. P. Luk et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The structure of dimethylallyl tryptophan synthase reveals a common architecture of aromatic prenyltransferases in fungi and bacteria

(2009) U. Metzger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The ABBA family of aromatic prenyltransferases: broadening natural product diversity

(2008) M. Tello et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

FtmPT2, anN-Prenyltransferase fromAspergillus fumigatus, Catalyses the Last Step in the Biosynthesis of Fumitremorgin B

(2008) Alexander Grundmann et al.   CHEMBIOCHEM

Turning a hobby into a job: How duplicated genes find new functions

(2008) Gavin C. Conant et al.   NATURE REVIEWS GENETICS

The evolution of gene collectives: How natural selection drives chemical innovation

(2008) M. A. Fischbach et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA