Advances in the discovery of microRNA-based anticancer therapeutics: latest tools and developments

MicroRNA Delivery with Bioreducible Polyethylenimine as a Non-Viral Vector for Breast Cancer Gene Therapy

(2019) Yu Dai et al.   MACROMOLECULAR BIOSCIENCE

Mesyl phosphoramidate antisense oligonucleotides as an alternative to phosphorothioates with improved biochemical and biological properties

(2019) S. K. Miroshnichenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The functional synergism of microRNA clustering provides therapeutically relevant epigenetic interference in glioblastoma

(2019) Vivek Bhaskaran et al.   Nature Communications

Prediction of small molecule-microRNA associations by sparse learning and heterogeneous graph inference

(2019) Jun Yin et al.   MOLECULAR PHARMACEUTICS

The Potential for microRNA Therapeutics and Clinical Research

(2019) Johora Hanna et al.   Frontiers in Genetics

Identification and validation of microRNAs that synergize with miR-34a – a basis for combinatorial microRNA therapeutics

(2019) Esteban A. Orellana et al.   CELL CYCLE

Modulation of miRNA function by natural and synthetic RNA-binding proteins in cancer

(2019) Pascal D. Vos et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Systems biology-based investigation of cooperating microRNAs as monotherapy or adjuvant therapy in cancer

(2019) Xin Lai et al.   NUCLEIC ACIDS RESEARCH

Stimuli-Responsive Nanocarrier for Co-delivery of MiR-31 and Doxorubicin To Suppress High MtEF4 Cancer

(2018) Fang Wang et al.   ACS Applied Materials & Interfaces

Overcoming Chemoresistance in Cancer via Combined MicroRNA Therapeutics with Anti-Cancer Drugs using Multifunctional Magnetic Core-Shell Nanoparticles

(2018) Perry T. Yin et al.   ACS Applied Materials & Interfaces

Regulation of Memory CD8+ T Cell Differentiation by MicroRNAs

(2018) Zhen Zhang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Non-viral based miR delivery and recent developments

(2018) Annalise Elizabeth Labatut et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

A regulatory circuitry between miR-193a/miR-600 and WT1 enhances leukemogenesis in acute myeloid leukemia

(2018) Haiying Li et al.   EXPERIMENTAL HEMATOLOGY

Epigenetics and MicroRNAs in Cancer

(2018) Alice Ramassone et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Treating cancer with microRNA replacement therapy: A literature review

(2018) Nayer Hosseinahli et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Angubindin-1 opens the blood–brain barrier in vivo for delivery of antisense oligonucleotide to the central nervous system

(2018) Satoshi Zeniya et al.   JOURNAL OF CONTROLLED RELEASE

miRNAs as Potential Treatment Targets and Treatment Options in Cancer

(2018) Nina Petrovic et al.   Molecular Diagnosis & Therapy

Cell Death Pathways Associated with Photodynamic Therapy: An Update

(2018) David Kessel et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Anti-miRNA oligonucleotides: A comprehensive guide for design

(2018) Joana Filipa Lima et al.   RNA Biology

MicroRNAs in the prognosis and therapy of colorectal cancer: From bench to bedside

(2018) Kenneth KW To et al.   WORLD JOURNAL OF GASTROENTEROLOGY

MicroRNA miR-4779 suppresses tumor growth by inducing apoptosis and cell cycle arrest through direct targeting of PAK2 and CCND3

(2018) Kyung Hee Koo et al.   Cell Death & Disease

Efficient RNA drug delivery using red blood cell extracellular vesicles

(2018) Waqas Muhammad Usman et al.   Nature Communications

Inferring potential small molecule–miRNA association based on triple layer heterogeneous network

(2018) Jia Qu et al.   Journal of Cheminformatics

Targeted nanoparticle delivery of therapeutic antisense microRNAs presensitizes glioblastoma cells to lower effective doses of temozolomide in vitro and in a mouse model

(2018) Meenakshi Malhotra et al.   Oncotarget

MiR-205-5p and miR-342-3p cooperate in the repression of the E2F1 transcription factor in the context of anticancer chemotherapy resistance

(2018) Xin Lai et al.   Theranostics

MiR-634 sensitizes glioma cells to temozolomide by targeting CYR61 through Raf-ERK signaling pathway

(2018) Zhigang Tan et al.   Cancer Medicine

Therapeutic Prospects of Extracellular Vesicles in Cancer Treatment

(2018) Daria S. Chulpanova et al.   Frontiers in Immunology

Screen for MicroRNA and Drug Interactions in Breast Cancer Cell Lines Points to miR-126 as a Modulator of CDK4/6 and PIK3CA Inhibitors

(2018) Federica Baldassari et al.   Frontiers in Genetics

Cobomarsen, an oligonucleotide inhibitor of miR-155, co-ordinately regulates multiple survival pathways to reduce cellular proliferation and survival in cutaneous T-cell lymphoma

(2018) Anita G. Seto et al.   BRITISH JOURNAL OF HAEMATOLOGY

Exosomal transfer of miR-151a enhances chemosensitivity to temozolomide in drug-resistant glioblastoma

(2018) Ailiang Zeng et al.   CANCER LETTERS

MicroRNAs in cancer drug resistance: Basic evidence and clinical applications

(2018) Mehri Ghasabi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Capturing intracellular oncogenic microRNAs with self-assembled DNA nanostructures for microRNA-based cancer therapy

(2018) Q. Liu et al.   Chemical Science

Peptide-oligonucleotide conjugates exhibiting pyrimidine-X cleavage specificity efficiently silence miRNA target acting synergistically with RNase H

(2018) O. A. Patutina et al.   Scientific Reports

miR-370-3p is a therapeutic tool in anti-glioblastoma therapy, but is not an intratumoral or cell-free circulating biomarker

(2018) Arulraj Nadaradjane et al.   Molecular Therapy-Nucleic Acids

RNA Micelles for the Systemic Delivery of Anti-miRNA for Cancer Targeting and Inhibition without Ligand

(2018) Hongran Yin et al.   ACS Nano

Up-regulation of miR-383-5p suppresses proliferation and enhances chemosensitivity in ovarian cancer cells by targeting TRIM27

(2018) Jing Jiang et al.   BIOMEDICINE & PHARMACOTHERAPY

Regulatory network of miRNA on its target: coordination between transcriptional and post-transcriptional regulation of gene expression

(2018) Mengfan Pu et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Exosome-mediated delivery of functionally active miRNA-142-3p inhibitor reduces tumorigenicity of breast cancer in vitro and in vivo

(2018) Zahra Naseri et al.   International Journal of Nanomedicine

Dual delivery nanoscale device for miR-345 and gemcitabine co-delivery to treat pancreatic cancer

(2018) Metin Uz et al.   JOURNAL OF CONTROLLED RELEASE

MicroRNA therapeutics: design of single-stranded miR-216b mimics to target KRAS in pancreatic cancer cells

(2018) Annalisa Ferino et al.   RNA Biology

Extracellular vesicles produced in B cells deliver tumor suppressor miR-335 to breast cancer cells disrupting oncogenic programming in vitro and in vivo

(2018) Gonzalo Almanza et al.   Scientific Reports

Gene Editing of HIV-1 Co-receptors to Prevent and/or Cure Virus Infection

(2018) Alexander G. Allen et al.   Frontiers in Microbiology

Engineering CAR-T Cells for Improved Function Against Solid Tumors

(2018) Michael A. Morgan et al.   Frontiers in Immunology

MicroRNA-365 targets multiple oncogenes to inhibit proliferation, invasion, and self-renewal of aggressive endometrial cancer cells

(2018) Chunfang Wang et al.   Cancer Management and Research

In Silico Prediction of Small Molecule-miRNA Associations Based on the HeteSim Algorithm

(2018) Jia Qu et al.   Molecular Therapy-Nucleic Acids

Bioengineered miRNA-1291 prodrug therapy in pancreatic cancer cells and patient-derived xenograft mouse models

(2018) Mei-Juan Tu et al.   CANCER LETTERS

miR-30a inhibits the biological function of breast cancer cells by targeting Notch1

(2017) He-Da Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Development of Novel Therapeutic Agents by Inhibition of Oncogenic MicroRNAs

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MiR-198 enhances temozolomide sensitivity in glioblastoma by targeting MGMT

(2017) Er Nie et al.   JOURNAL OF NEURO-ONCOLOGY

MiR-181b modulates chemosensitivity of glioblastoma multiforme cells to temozolomide by targeting the epidermal growth factor receptor

(2017) Yunxiang Chen et al.   JOURNAL OF NEURO-ONCOLOGY

Safety and activity of microRNA-loaded minicells in patients with recurrent malignant pleural mesothelioma: a first-in-man, phase 1, open-label, dose-escalation study

(2017) Nico van Zandwijk et al.   LANCET ONCOLOGY

A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis

(2017) Thomas Treiber et al.   MOLECULAR CELL

EGFR-Targeted Cationic Polymeric Mixed Micelles for Codelivery of Gemcitabine and miR-205 for Treating Advanced Pancreatic Cancer

(2017) Goutam Mondal et al.   MOLECULAR PHARMACEUTICS

Genome Editing Reveals Glioblastoma Addiction to MicroRNA-10b

(2017) Rachid El Fatimy et al.   MOLECULAR THERAPY

RNA Nanoparticle-Based Targeted Therapy for Glioblastoma through Inhibition of Oncogenic miR-21

(2017) Tae Jin Lee et al.   MOLECULAR THERAPY

Three-layered polyplex as a microRNA targeted delivery system for breast cancer gene therapy

(2017) Yan Li et al.   NANOTECHNOLOGY

MicroRNA therapeutics: towards a new era for the management of cancer and other diseases

(2017) Rajesha Rupaimoole et al.   NATURE REVIEWS DRUG DISCOVERY

Selective targeting of point-mutated KRAS through artificial microRNAs

(2017) Mario Acunzo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of microRNA-500 has anti-cancer effect through its conditional downstream target of TFPI in human prostate cancer

(2017) Bing Cai et al.   PROSTATE

CRISPR/Cas9-mediated noncoding RNA editing in human cancers

(2017) Jie Yang et al.   RNA Biology

MicroRNA-27b functions as a new inhibitor of ovarian cancer-mediated vasculogenic mimicry through suppression of VE-cadherin expression

(2017) Wenming Liu et al.   RNA

Simultaneous overexpression of miR-126 and miR-34a induces a superior antitumor efficacy in pancreatic adenocarcinoma

(2017) Shu-De Feng et al.   OncoTargets and Therapy

Small RNA zippers lock miRNA molecules and block miRNA function in mammalian cells

(2017) Lingyu Meng et al.   Nature Communications

Suppressive role exerted by microRNA-29b-1-5p in triple negative breast cancer through SPIN1 regulation

(2017) Rosa Drago-Ferrante et al.   Oncotarget

Lentiviral CRISPR/Cas9 vector mediated miR-21 gene editing inhibits the epithelial to mesenchymal transition in ovarian cancer cells

(2017) Wenying Huo et al.   Journal of Cancer

Preclinical and Clinical Advances of GalNAc-Decorated Nucleic Acid Therapeutics

(2017) Yuanyu Huang   Molecular Therapy-Nucleic Acids

Locked nucleic acid anti-miR-21 inhibits cell growth and invasive behaviors of a colorectal adenocarcinoma cell line: LNA-anti-miR as a novel approach

(2016) R Nedaeinia et al.   CANCER GENE THERAPY

Safe and Effective Treatment of Experimental Neuroblastoma and Glioblastoma Using Systemically Delivered Triple MicroRNA-Detargeted Oncolytic Semliki Forest Virus

(2016) Mohanraj Ramachandran et al.   CLINICAL CANCER RESEARCH

Vesicle-MaNiA: extracellular vesicles in liquid biopsy and cancer

(2016) Veronica Torrano et al.   CURRENT OPINION IN PHARMACOLOGY

Sponges against miR-19 and miR-155 reactivate the p53-Socs1 axis in hematopoietic cancers

(2016) Lian Mignacca et al.   CYTOKINE

Therapeutic potential of targeting microRNA-10b in established intracranial glioblastoma: first steps toward the clinic

(2016) N. M. Teplyuk et al.   EMBO Molecular Medicine

A new plasmid-based microRNA inhibitor system that inhibits microRNA families in transgenic mice and cells: a potential new therapeutic reagent

(2016) H Cao et al.   GENE THERAPY

EZH2 coupled with HOTAIR to silence MicroRNA-34a by the induction of heterochromatin formation in human pancreatic ductal adenocarcinoma

(2016) Chi-Han Li et al.   INTERNATIONAL JOURNAL OF CANCER

Phase I study of MRX34, a liposomal miR-34a mimic, administered twice weekly in patients with advanced solid tumors

(2016) Muhammad S. Beg et al.   INVESTIGATIONAL NEW DRUGS

Exploiting Nanotechnology for the Development of MicroRNA-Based Cancer Therapeutics

(2016) Nikhil Tyagi et al.   Journal of Biomedical Nanotechnology

Reducible self-assembling cationic polypeptide-based micelles mediate co-delivery of doxorubicin and microRNA-34a for androgen-independent prostate cancer therapy

(2016) Chong Yao et al.   JOURNAL OF CONTROLLED RELEASE

Targeted inhibition of oncogenic miR-21 maturation with designed RNA-binding proteins

(2016) Yu Chen et al.   Nature Chemical Biology

The delivery of therapeutic oligonucleotides

(2016) Rudolph L. Juliano   NUCLEIC ACIDS RESEARCH

Identification of miR-34 regulatory networks in settings of disease and antimiR-therapy: Implications for treating cardiac pathology and other diseases

(2016) Jenny Y.Y. Ooi et al.   RNA Biology

Enhancing adoptive T cell immunotherapy with microRNA therapeutics

(2016) Yun Ji et al.   SEMINARS IN IMMUNOLOGY

The effect of antisense inhibitor of miRNA 106b∼25 on the proliferation, invasion, migration, and apoptosis of gastric cancer cell

(2016) Rupeng Zhang et al.   TUMOR BIOLOGY

Knockdown of LMP1-induced miR-155 sensitizes nasopharyngeal carcinoma cells to radiotherapy in vitro

(2016) YUSHENG WANG et al.   Oncology Letters

Downregulation of miR-221/222 by a microRNA sponge promotes apoptosis in oral squamous cell carcinoma cells through upregulation of PTEN

(2016) Lijie Zhou et al.   Oncology Letters

Identification of associations between small molecule drugs and miRNAs based on functional similarity

(2016) Jing Wang et al.   Oncotarget

Psmir: a database of potential associations between small molecules and miRNAs

(2016) Fanlin Meng et al.   Scientific Reports

Downregulation of miR-522 suppresses proliferation and metastasis of non-small cell lung cancer cells by directly targeting DENN/MADD domain containing 2D

(2016) Tianze Zhang et al.   Scientific Reports

Up- regulation of miR-328-3p sensitizes non-small cell lung cancer to radiotherapy

(2016) Wei Ma et al.   Scientific Reports

Lipid Nanovectors to Deliver RNA Oligonucleotides in Cancer

(2016) Virginia Campani et al.   Nanomaterials

microRNA Therapeutics in Cancer — An Emerging Concept

(2016) Maitri Y. Shah et al.   EBioMedicine

Cooperative Effect of miR-141-3p and miR-145-5p in the Regulation of Targets in Clear Cell Renal Cell Carcinoma

(2016) Julia Liep et al.   PLoS One

CRISPR/cas9, a novel genomic tool to knock down microRNA in vitro and in vivo

(2016) Hong Chang et al.   Scientific Reports

miRNAsong: a web-based tool for generation and testing of miRNA sponge constructs in silico

(2016) Tomas Barta et al.   Scientific Reports

In vivo delivery of miRNAs for cancer therapy: Challenges and strategies

(2015) Yunching Chen et al.   ADVANCED DRUG DELIVERY REVIEWS

Antisense oligonucleotides in therapy for neurodegenerative disorders

(2015) Melvin M. Evers et al.   ADVANCED DRUG DELIVERY REVIEWS

The regulatory and predictive functions of miR-17 and miR-92 families on cisplatin resistance of non-small cell lung cancer

(2015) Jian Zhao et al.   BMC CANCER

Combinatorial Action of MicroRNAslet-7and miR-34 Effectively Synergizes with Erlotinib to Suppress Non-small Cell Lung Cancer Cell Proliferation

(2015) Carlos Stahlhut et al.   CELL CYCLE

miR-137 and miR-197 Induce Apoptosis and Suppress Tumorigenicity by Targeting MCL-1 in Multiple Myeloma

(2015) Y. Yang et al.   CLINICAL CANCER RESEARCH

The Role of miR-21 in Cancer

(2015) Susan R. Pfeffer et al.   DRUG DEVELOPMENT RESEARCH

High levels of apoptosis are induced in human glioma cell lines by co-administration of peptide nucleic acids targeting miR-221 and miR-222

(2015) ELEONORA BROGNARA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

LO7 : A single subcutaneous dose of 2mg/kg or 4mg/kg of RG-101, a GalNAc-conjugated oligonucleotide with antagonist activity against MIR-122, results in significant viral load reductions in chronic hepatitis C patients

(2015) M. Van Der Ree et al.   JOURNAL OF HEPATOLOGY

Pharmacological targeting of miR-155 via the NEDD8-activating enzyme inhibitor MLN4924 (Pevonedistat) in FLT3-ITD acute myeloid leukemia

(2015) J Khalife et al.   LEUKEMIA

Combinational treatment with microRNA-133b and cetuximab has increased inhibitory effects on the growth and invasion of colorectal cancer cells by regulating EGFR

(2015) JIANYU ZHOU et al.   Molecular Medicine Reports

Let-7 Sensitizes KRAS Mutant Tumor Cells to Chemotherapy

(2015) Xin Dai et al.   PLoS One

Genome-wide pharmacologic unmasking identifies tumor suppressive microRNAs in multiple myeloma

(2015) Chonglei Bi et al.   Oncotarget

miR-497 and miR-34a retard lung cancer growth by co-inhibiting cyclin E1 (CCNE1)

(2015) Zhiyuan Han et al.   Oncotarget

Temozolomide resistance in glioblastoma occurs by miRNA-9-targeted PTCH1, independent of sonic hedgehog level

(2015) Jessian L. Munoz et al.   Oncotarget

Simultaneous inhibition of multiple oncogenic miRNAs by a multi-potent microRNA sponge

(2015) Jaeyun Jung et al.   Oncotarget

Targeting of RUNX3 by miR-130a and miR-495 cooperatively increases cell proliferation and tumor angiogenesis in gastric cancer cells

(2015) Sun Hee Lee et al.   Oncotarget

MicroRNA-21 links epithelial-to-mesenchymal transition and inflammatory signals to confer resistance to neoadjuvant trastuzumab and chemotherapy in HER2-positive breast cancer patients

(2015) Leticia De Mattos-Arruda et al.   Oncotarget

In Vivo Delivery of miR-34a Sensitizes Lung Tumors to Radiation Through RAD51 Regulation

(2015) Maria Angelica Cortez et al.   Molecular Therapy-Nucleic Acids

Transfection of microRNA Mimics Should Be Used with Caution

(2015) Hyun Yong Jin et al.   Frontiers in Genetics

MicroRNA-183/182/96 cooperatively regulates the proliferation of colon cancer cells

(2015) QINGQUAN ZHANG et al.   Molecular Medicine Reports

Long chain microRNA conjugates in calcium phosphate nanoparticles for efficient formulation and delivery

(2014) Hyosook Jung et al.   ARCHIVES OF PHARMACAL RESEARCH

Higher LRRFIP1 expression in glioblastoma multiforme is associated with better response to teniposide, a type II topoisomerase inhibitor

(2014) Wei-Qing Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

NRF2-driven miR-125B1 and miR-29B1 transcriptional regulation controls a novel anti-apoptotic miRNA regulatory network for AML survival

(2014) N M Shah et al.   CELL DEATH AND DIFFERENTIATION

A Free-Blockage Controlled Release System Based on the Hydrophobic/Hydrophilic Conversion of Mesoporous Silica Nanopores

(2014) Wenqian Wang et al.   CHEMISTRY-A EUROPEAN JOURNAL

A Mini Review of Biodegradable Calcium Phosphate Nanoparticles for Gene Delivery

(2014) Ying Xie et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

A microRNA 221– and 222–Mediated Feedback Loop Maintains Constitutive Activation of NFκB and STAT3 in Colorectal Cancer Cells

(2014) Sanhong Liu et al.   GASTROENTEROLOGY

miR-181b increases drug sensitivity in acute myeloid leukemia via targeting HMGB1 and Mcl-1

(2014) FEI LU et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

MicroRNA silencing for cancer therapy targeted to the tumour microenvironment

(2014) Christopher J. Cheng et al.   NATURE

miR-Synth: a computational resource for the design of multi-site multi-target synthetic miRNAs

(2014) Alessandro Laganà et al.   NUCLEIC ACIDS RESEARCH

A combinatorial microRNA therapeutics approach to suppressing non-small cell lung cancer

(2014) A L Kasinski et al.   ONCOGENE

MiR-143 and MiR-145 Regulate IGF1R to Suppress Cell Proliferation in Colorectal Cancer

(2014) Jiaojiao Su et al.   PLoS One

Star-branched amphiphilic PLA-b-PDMAEMA copolymers for co-delivery of miR-21 inhibitor and doxorubicin to treat glioma

(2013) Xiaomin Qian et al.   BIOMATERIALS

Locked nucleic acid: tighter is different

(2013) Jonathan K. Watts   CHEMICAL COMMUNICATIONS

Genome-based cancer therapeutics: targets, kinase drug resistance and future strategies for precision oncology

(2013) Paul Workman et al.   CURRENT OPINION IN PHARMACOLOGY

MicroRNAs Cooperatively Inhibit a Network of Tumor Suppressor Genes to Promote Pancreatic Tumor Growth and Progression

(2013) Adam E. Frampton et al.   GASTROENTEROLOGY

Polycation liposomes as a vector for potential intracellular delivery of microRNA

(2013) Hidenori Ando et al.   JOURNAL OF GENE MEDICINE

Comprehensive analysis of alterations in the miRNome in response to photodynamic treatment

(2013) Doris Bach et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

miR-9 is a tumor suppressor in pediatric AML with t(8;21)

(2013) S Emmrich et al.   LEUKEMIA

Inorganic Nanoparticle-Based Drug Codelivery Nanosystems To Overcome the Multidrug Resistance of Cancer Cells

(2013) Yu Chen et al.   MOLECULAR PHARMACEUTICS

First microRNA mimic enters clinic

(2013) Aaron Bouchie   NATURE BIOTECHNOLOGY

Photofrin Based Photodynamic Therapy and miR-99a Transfection Inhibited FGFR3 and PI3K/Akt Signaling Mechanisms to Control Growth of Human Glioblastoma In Vitro and In Vivo

(2013) Mrinmay Chakrabarti et al.   PLoS One

Growth-Promoting Role of the miR-106a∼363 Cluster in Ewing Sarcoma

(2013) Layne Dylla et al.   PLoS One

Critical role of miR-9 in myelopoiesis and EVI1-induced leukemogenesis

(2013) V. Senyuk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

miR-9 is an essential oncogenic microRNA specifically overexpressed in mixed lineage leukemia-rearranged leukemia

(2013) P. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression of miR-17-92 enhances anti-tumor activity of T-cells transduced with the anti-EGFRvIII chimeric antigen receptor in mice bearing human GBM xenografts

(2013) Masasuke Ohno et al.   Journal for ImmunoTherapy of Cancer

Ecological photodynamic therapy: New trend to disrupt the intricate networks within tumor ecosystem

(2012) N. Belén Rumie Vittar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

SM2miR: a database of the experimentally validated small molecules' effects on microRNA expression

(2012) X. Liu et al.   BIOINFORMATICS

Meta-analysis of human lung cancer microRNA expression profiling studies comparing cancer tissues with normal tissues

(2012) Peng Guan et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Exploiting microRNA regulation for genetic engineering

(2012) B. Gentner et al.   TISSUE ANTIGENS

Identification of links between small molecules and miRNAs in human cancers based on transcriptional responses

(2012) Wei Jiang et al.   Scientific Reports

A MicroRNA196a2* and TP63 Circuit Regulated by Estrogen Receptor-α and ERK2 that Controls Breast Cancer Proliferation and Invasiveness Properties

(2012) Kyuri Kim et al.   Hormones & Cancer

MicroRNA expression is differentially altered by xenobiotic drugs in different human cell lines

(2011) Alice C. Rodrigues et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

MicroRNA-21: A novel therapeutic target in human cancer

(2011) Xuan Pan et al.   CANCER BIOLOGY & THERAPY

Inhibition of hypoxia-induced miR-155 radiosensitizes hypoxic lung cancer cells

(2011) Imran A. Babar et al.   CANCER BIOLOGY & THERAPY

The targeted delivery of multicomponent cargos to cancer cells by nanoporous particle-supported lipid bilayers

(2011) Carlee E. Ashley et al.   NATURE MATERIALS

The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect

(2010) Jun Fang et al.   ADVANCED DRUG DELIVERY REVIEWS

Target specific tumor treatment by VEGF siRNA complexed with reducible polyethyleneimine–hyaluronic acid conjugate

(2010) Kitae Park et al.   BIOMATERIALS

The Promise of MicroRNA Replacement Therapy

(2010) A. G. Bader et al.   CANCER RESEARCH

Targeting MicroRNAs With Small Molecules: From Dream to Reality

(2010) S Zhang et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma

(2010) Pedro P. Medina et al.   NATURE

miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis

(2010) Li Ma et al.   NATURE CELL BIOLOGY

A Direct Comparison of Anti-microRNA Oligonucleotide Potency

(2010) Kim A. Lennox et al.   PHARMACEUTICAL RESEARCH

Differential effects of STAT5 and PI3K/AKT signaling on effector and memory CD8 T-cell survival

(2010) T. W. Hand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AngiomiRs—Key regulators of angiogenesis

(2009) Shusheng Wang et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

A single anti-microRNA antisense oligodeoxyribonucleotide (AMO) targeting multiple microRNAs offers an improved approach for microRNA interference

(2009) Yanjie Lu et al.   NUCLEIC ACIDS RESEARCH

Vectors expressing efficient RNA decoys achieve the long-term suppression of specific microRNA activity in mammalian cells

(2009) Takeshi Haraguchi et al.   NUCLEIC ACIDS RESEARCH

MicroRNA-21 Targets a Network of Key Tumor-Suppressive Pathways in Glioblastoma Cells

(2008) T. Papagiannakopoulos et al.   CANCER RESEARCH

Viral Vectors in Cancer Immunotherapy: Which Vector for Which Strategy?

(2008) Sara Collins et al.   CURRENT GENE THERAPY

MicroRNAs modulate the chemosensitivity of tumor cells

(2008) P. E. Blower et al.   MOLECULAR CANCER THERAPEUTICS

LNA-mediated microRNA silencing in non-human primates

(2008) Joacim Elmén et al.   NATURE