CRISPR/Cas9-mediated genome editing in nonhuman primates

Generating mouse models for biomedical research: technological advances

(2019) Channabasavaiah B. Gurumurthy et al.   Disease Models & Mechanisms

Robust and efficient knock-in in embryonic stem cells and early-stage embryos of the common marmoset using the CRISPR-Cas9 system

(2019) Sho Yoshimatsu et al.   Scientific Reports

Gene Delivery to Nonhuman Primate Preimplantation Embryos Using Recombinant Adeno‐Associated Virus

(2019) Dan Wang et al.   Advanced Science

Efficient generation of Knock-in/Knock-out marmoset embryo via CRISPR/Cas9 gene editing

(2019) Wakako Kumita et al.   Scientific Reports

Cloning of Macaque Monkeys by Somatic Cell Nuclear Transfer

(2018) Zhen Liu et al.   CELL

Generation of a precise Oct4-hrGFP knockin cynomolgus monkey model via CRISPR/Cas9-assisted homologous recombination

(2018) Yiqiang Cui et al.   CELL RESEARCH

Generation of knock-in cynomolgus monkey via CRISPR/Cas9 editing

(2018) Xuan Yao et al.   CELL RESEARCH

Genetically engineered pigs as models for human disease

(2018) Carolin Perleberg et al.   Disease Models & Mechanisms

No off-target mutations in functional genome regions of a CRISPR/Cas9-generated monkey model of muscular dystrophy

(2018) Shuang Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Meganuclease targeting of PCSK9 in macaque liver leads to stable reduction in serum cholesterol

(2018) Lili Wang et al.   NATURE BIOTECHNOLOGY

CRISPR off-target analysis in genetically engineered rats and mice

(2018) Keith R. Anderson et al.   NATURE METHODS

SIRT6 deficiency results in developmental retardation in cynomolgus monkeys

(2018) Weiqi Zhang et al.   NATURE

In vivo CRISPR editing with no detectable genome-wide off-target mutations

(2018) Pinar Akcakaya et al.   NATURE

Directed evolution of CRISPR-Cas9 to increase its specificity

(2018) Jungjoon K. Lee et al.   Nature Communications

Genetic engineering a large animal model of human hypophosphatasia in sheep

(2018) Diarra K. Williams et al.   Scientific Reports

Quantitative assessment of timing, efficiency, specificity and genetic mosaicism of CRISPR/Cas9-mediated gene editing of hemoglobin beta gene in rhesus monkey embryos

(2017) Uros Midic et al.   HUMAN MOLECULAR GENETICS

Genetic engineering in nonhuman primates for human disease modeling

(2017) Kenya Sato et al.   JOURNAL OF HUMAN GENETICS

CRISPR/Cas9-mediated gene editing in human zygotes using Cas9 protein

(2017) Lichun Tang et al.   MOLECULAR GENETICS AND GENOMICS

Pseudotyped Lentiviral Vectors: One Vector, Many Guises

(2017) Alok V. Joglekar et al.   Human Gene Therapy Methods

Promoting Cas9 degradation reduces mosaic mutations in non-human primate embryos

(2017) Zhuchi Tu et al.   Scientific Reports

Generation of GGTA1 Mutant Pigs by Direct Pronuclear Microinjection of CRISPR/Cas9 Plasmid Vectors

(2016) Chin-Kai Chuang et al.   ANIMAL BIOTECHNOLOGY

Generation of a Nonhuman Primate Model of Severe Combined Immunodeficiency Using Highly Efficient Genome Editing

(2016) Kenya Sato et al.   Cell Stem Cell

High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects

(2016) Benjamin P. Kleinstiver et al.   NATURE

Use of PRECIS ratings in the National Institutes of Health (NIH) Health Care Systems Research Collaboratory

(2016) Karin E. Johnson et al.   Trials

Multiplex gene editing via CRISPR/Cas9 exhibits desirable muscle hypertrophy without detectable off-target effects in sheep

(2016) Xiaolong Wang et al.   Scientific Reports

Identification and characterization of rabbit ROSA26 for gene knock-in and stable reporter gene expression

(2016) Dongshan Yang et al.   Scientific Reports

Rosa26-targeted sheep gene knock-in via CRISPR-Cas9 system

(2016) Mingming Wu et al.   Scientific Reports

CRISPR/Cas9-mediatedDax1knockout in the monkey recapitulates human AHC-HH

(2015) Yu Kang et al.   HUMAN MOLECULAR GENETICS

Functional disruption of the dystrophin gene in rhesus monkey using CRISPR/Cas9

(2015) Yongchang Chen et al.   HUMAN MOLECULAR GENETICS

A genome-wide analysis of Cas9 binding specificity using ChIP-seq and targeted sequence capture

(2015) Henriette O'Geen et al.   NUCLEIC ACIDS RESEARCH

Rationally engineered Cas9 nucleases with improved specificity

(2015) I. M. Slaymaker et al.   SCIENCE

CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes

(2015) Puping Liang et al.   Protein & Cell

Cas-OFFinder: a fast and versatile algorithm that searches for potential off-target sites of Cas9 RNA-guided endonucleases

(2014) S. Bae et al.   BIOINFORMATICS

Generation of Gene-Modified Cynomolgus Monkey via Cas9/RNA-Mediated Gene Targeting in One-Cell Embryos

(2014) Yuyu Niu et al.   CELL

One-step generation of p53 gene biallelic mutant Cynomolgus monkey via the CRISPR/Cas system

(2014) Haifeng Wan et al.   CELL RESEARCH

Somatic mosaicism and allele complexity induced by CRISPR/Cas9 RNA injections in mouse zygotes

(2014) Shuo-Ting Yen et al.   DEVELOPMENTAL BIOLOGY

Highly efficient RNA-guided genome editing in human cells via delivery of purified Cas9 ribonucleoproteins

(2014) S. Kim et al.   GENOME RESEARCH

Improving CRISPR-Cas nuclease specificity using truncated guide RNAs

(2014) Yanfang Fu et al.   NATURE BIOTECHNOLOGY

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Transgenic rhesus monkeys produced by gene transfer into early-cleavage–stage embryos using a simian immunodeficiency virus-based vector

(2010) Yuyu Niu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Generation of transgenic non-human primates with germline transmission

(2009) Erika Sasaki et al.   NATURE

Towards a transgenic model of Huntington’s disease in a non-human primate

(2008) Shang-Hsun Yang et al.   NATURE