Monozygotic twins and triplets discordant for amyotrophic lateral sclerosis display differential methylation and gene expression

C8orf46 homolog encodes a novel protein Vexin that is required for neurogenesis in Xenopus laevis

(2018) Kathryn B. Moore et al.   DEVELOPMENTAL BIOLOGY

Clustering of RNA-Seq samples: Comparison study on cancer data

(2018) Pablo Andretta Jaskowiak et al.   METHODS

Clinical features and genetic characterization of two dizygotic twins with C9orf72 expansion

(2018) Francesca Luisa Conforti et al.   NEUROBIOLOGY OF AGING

Whole blood transcriptome analysis in amyotrophic lateral sclerosis: A biomarker study

(2018) Wouter van Rheenen et al.   PLoS One

Expression of ALS/FTD-linked mutant CCNF in zebrafish leads to increased cell death in the spinal cord and an aberrant motor phenotype

(2017) Alison L. Hogan et al.   HUMAN MOLECULAR GENETICS

Increase in DNA methylation in patients with amyotrophic lateral sclerosis carriers of not fully penetrant SOD1 mutations

(2017) Fabio Coppedè et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Characterization of Gene Expression Phenotype in Amyotrophic Lateral Sclerosis Monocytes

(2017) Weihua Zhao et al.   JAMA Neurology

Molecular Taxonomy of Sporadic Amyotrophic Lateral Sclerosis Using Disease-Associated Genes

(2017) Giovanna Morello et al.   Frontiers in Neurology

Epigenetic differences between monozygotic twins discordant for amyotrophic lateral sclerosis (ALS) provide clues to disease pathogenesis

(2017) Paul E. Young et al.   PLoS One

Epigenetic changes in T-cell and monocyte signatures and production of neurotoxic cytokines in ALS patients

(2016) Larry Lam et al.   FASEB JOURNAL

Genetic and epigenetic study of ALS-discordant identical twins with double mutations inSOD1andARHGEF28

(2016) Ming Zhang et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Epigenome-wide DNA methylation analysis in siblings and monozygotic twins discordant for sporadic Parkinson’s disease revealed different epigenetic patterns in peripheral blood mononuclear cells

(2016) Oliver Kaut et al.   NEUROGENETICS

Axonal Excitability in Amyotrophic Lateral Sclerosis

(2016) Susanna B. Park et al.   Neurotherapeutics

Expansion of the Gene Ontology knowledgebase and resources

(2016)   NUCLEIC ACIDS RESEARCH

PANTHER version 11: expanded annotation data from Gene Ontology and Reactome pathways, and data analysis tool enhancements

(2016) Huaiyu Mi et al.   NUCLEIC ACIDS RESEARCH

CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia

(2016) Kelly L. Williams et al.   Nature Communications

The C9orf72 repeat expansion itself is methylated in ALS and FTLD patients

(2015) Zhengrui Xi et al.   ACTA NEUROPATHOLOGICA

DNA methylation age is associated with mortality in a longitudinal Danish twin study

(2015) Lene Christiansen et al.   AGING CELL

The C9orf72 repeat size correlates with onset age of disease, DNA methylation and transcriptional downregulation of the promoter

(2015) I Gijselinck et al.   MOLECULAR PSYCHIATRY

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(2015) Fabio Coppedè et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

HISAT: a fast spliced aligner with low memory requirements

(2015) Daehwan Kim et al.   NATURE METHODS

C9orf72 promoter hypermethylation is neuroprotective: Neuroimaging and neuropathologic evidence

(2015) C. T. McMillan et al.   NEUROLOGY

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Up-regulation of neural and cell cycle-related microRNAs in brain of amyotrophic lateral sclerosis mice at late disease stage

(2015) Stefania Marcuzzo et al.   Molecular Brain

Hypermethylation of repeat expanded C9orf72 is a clinical and molecular disease modifier

(2014) Jenny Russ et al.   ACTA NEUROPATHOLOGICA

C9orf72 hypermethylation protects against repeat expansion-associated pathology in ALS/FTD

(2014) Elaine Y. Liu et al.   ACTA NEUROPATHOLOGICA

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(2014) S. Anders et al.   BIOINFORMATICS

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(2014) Martin J. Aryee et al.   BIOINFORMATICS

Trimmomatic: a flexible trimmer for Illumina sequence data

(2014) Anthony M. Bolger et al.   BIOINFORMATICS

Characterization of DNA hypermethylation in the cerebellum of c9FTD/ALS patients

(2014) Veronique V. Belzil et al.   BRAIN RESEARCH

Hypermethylation of the CpG-island near the C9orf72 G4C2-repeat expansion in FTLD patients

(2014) Zhengrui Xi et al.   HUMAN MOLECULAR GENETICS

Comprehensive analysis of DNA methylation data with RnBeads

(2014) Yassen Assenov et al.   NATURE METHODS

The phenotypic variability of amyotrophic lateral sclerosis

(2014) Bart Swinnen et al.   Nature Reviews Neurology

Identical twins with the C9orf72 repeat expansion are discordant for ALS

(2014) Z. Xi et al.   NEUROLOGY

Intrinsic Membrane Hyperexcitability of Amyotrophic Lateral Sclerosis Patient-Derived Motor Neurons

(2014) Brian J. Wainger et al.   Cell Reports

A major QTL on mouse chromosome 17 resulting in lifespan variability in SOD1-G93A transgenic mouse models of amyotrophic lateral sclerosis

(2014) Roger B. Sher et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

voom: precision weights unlock linear model analysis tools for RNA-seq read counts

(2014) Charity W Law et al.   GENOME BIOLOGY

Reduced C9orf72 gene expression in c9FTD/ALS is caused by histone trimethylation, an epigenetic event detectable in blood

(2013) Veronique V. Belzil et al.   ACTA NEUROPATHOLOGICA

Hypermethylation of the CpG Island Near the G4C2 Repeat in ALS with a C9orf72 Expansion

(2013) Zhengrui Xi et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A data-driven approach to preprocessing Illumina 450K methylation array data

(2013) Ruth Pidsley et al.   BMC GENOMICS

Discovery of cross-reactive probes and polymorphic CpGs in the Illumina Infinium HumanMethylation450 microarray

(2013) Yi-an Chen et al.   Epigenetics

Amyotrophic lateral sclerosis: an update on recent genetic insights

(2013) Yohei Iguchi et al.   JOURNAL OF NEUROLOGY

State of play in amyotrophic lateral sclerosis genetics

(2013) Alan E Renton et al.   NATURE NEUROSCIENCE

Additional annotation enhances potential for biologically-relevant analysis of the Illumina Infinium HumanMethylation450 BeadChip array

(2013) Magda E Price et al.   Epigenetics & Chromatin

Whole-blood global DNA methylation is increased in amyotrophic lateral sclerosis independently of age of onset

(2013) Lucio Tremolizzo et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

DNA methylation age of human tissues and cell types

(2013) Steve Horvath   GENOME BIOLOGY

Monozygotic twins affected with major depressive disorder have greater variance in methylation than their unaffected co-twin

(2013) E M Byrne et al.   Translational Psychiatry

DNA methylation arrays as surrogate measures of cell mixture distribution

(2012) Eugene Houseman et al.   BMC BIOINFORMATICS

Rad9B responds to nucleolar stress through ATR and JNK signalling, and delays the G1-S transition

(2012) A. J. Perez-Castro et al.   JOURNAL OF CELL SCIENCE

Association between DPP6 polymorphism and the risk of progressive multiple sclerosis in Northern and Southern Europeans

(2012) Paola Brambilla et al.   NEUROSCIENCE LETTERS

Identification of Epigenetically Altered Genes in Sporadic Amyotrophic Lateral Sclerosis

(2012) Claudia Figueroa-Romero et al.   PLoS One

Alterations of T cell subsets in ALS: a systemic immune activation?

(2011) M. Rentzos et al.   ACTA NEUROLOGICA SCANDINAVICA

Resequencing of 29 Candidate Genes in Patients With Familial and Sporadic Amyotrophic Lateral Sclerosis

(2011) Hussein Daoud et al.   ARCHIVES OF NEUROLOGY

Granzymes A and B levels in serum of patients with amyotrophic lateral sclerosis

(2011) Joanna Iłżecka   CLINICAL BIOCHEMISTRY

Global Methylation in Exposure Biology and Translational Medical Science

(2011) Heather H. Nelson et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder

(2011) Emma L. Dempster et al.   HUMAN MOLECULAR GENETICS

Comparison of Clustering Methods for Investigation of Genome-Wide Methylation Array Data

(2011) Harry Clifford et al.   Frontiers in Genetics

Increased SOD1 association with chromatin, DNA damage, p53 activation, and apoptosis in a cellular model of SOD1-linked ALS

(2010) Livea F. Barbosa et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Characterization of the kynurenine pathway in NSC-34 cell line: implications for amyotrophic lateral sclerosis

(2010) Yiquan Chen et al.   JOURNAL OF NEUROCHEMISTRY

An estimate of amyotrophic lateral sclerosis heritability using twin data

(2010) A. Al-Chalabi et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

A genome-wide analysis of brain DNA methylation identifies new candidate genes for sporadic amyotrophic lateral sclerosis

(2009) Julia M. Morahan et al.   Amyotrophic Lateral Sclerosis

Prognostic factors in ALS: A critical review

(2009) Adriano Chiò et al.   Amyotrophic Lateral Sclerosis

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus

(2009) B. M. Javierre et al.   GENOME RESEARCH

Immune system alterations in sporadic amyotrophic lateral sclerosis patients suggest an ongoing neuroinflammatory process

(2009) Stefania Mantovani et al.   JOURNAL OF NEUROIMMUNOLOGY

DPP6 IS ASSOCIATED WITH SUSCEPTIBILITY TO PROGRESSIVE SPINAL MUSCULAR ATROPHY

(2009) M. A. van Es et al.   NEUROLOGY

Epigenetic Differences in Cortical Neurons from a Pair of Monozygotic Twins Discordant for Alzheimer's Disease

(2009) Diego Mastroeni et al.   PLoS One

Kv4 Accessory Protein DPPX (DPP6) is a Critical Regulator of Membrane Excitability in Hippocampal CA1 Pyramidal Neurons

(2008) Jinhyun Kim et al.   JOURNAL OF NEUROPHYSIOLOGY