Neuroprotective Effects of Flavonoid Compounds on Neuronal Death Associated to Alzheimer’s Disease

Autophagy impairment by caspase-1-dependent inflammation mediates memory loss in response to β-Amyloid peptide accumulation

(2017) Lourdes Álvarez-Arellano et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Plaque formation and the intraneuronal accumulation of β-amyloid in Alzheimer's disease

(2017) Reisuke H. Takahashi et al.   PATHOLOGY INTERNATIONAL

Amyloid β1-42 (Aβ1-42) Induces the CDK2-Mediated Phosphorylation of Tau through the Activation of the mTORC1 Signaling Pathway While Promoting Neuronal Cell Death

(2017) Ki Hoon Lee et al.   Frontiers in Molecular Neuroscience

A Flavonol Glycoside, Isolated From Roots of Panax notoginseng, Reduces Amyloid-β-Induced Neurotoxicity in Cultured Neurons: Signaling Transduction and Drug Development for Alzheimer's Disease

(2017) Roy C.Y. Choi et al.   JOURNAL OF ALZHEIMERS DISEASE

The role of metabolism (and the microbiome) in defining the clinical efficacy of dietary flavonoids

(2016) Aedín Cassidy et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

The flavonoid baicalein rescues synaptic plasticity and memory deficits in a mouse model of Alzheimer’s disease

(2016) Xun-Hu Gu et al.   BEHAVIOURAL BRAIN RESEARCH

Microglial response to LPS increases in wild-type mice during aging but diminishes in an Alzheimer's mouse model: Implication of TLR4 signaling in disease progression

(2016) Michelle Go et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Flavonoids and Their Glycosides as Anti-amyloidogenic Compounds: Aβ1-42 Interaction Studies to Gain New Insights into Their Potential for Alzheimer's Disease Prevention and Therapy

(2016) Cinzia Guzzi et al.   Chemistry-An Asian Journal

Neuroprotective effects of liquiritin on cognitive deficits induced by soluble amyloid-β1–42oligomers injected into the hippocampus

(2016) Shi-Liang Jia et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

Tribbles Pseudokinase 3 Induces Both Apoptosis and Autophagy in Amyloid-β-induced Neuronal Death

(2016) Suraiya Saleem et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disposition of flavonoids via recycling: Direct biliary excretion of enterically or extrahepatically derived flavonoid glucuronides

(2016) Min Zeng et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Protective effects of a Chotosan Fraction and its active components on β-amyloid-induced neurotoxicity

(2016) Menglin Wei et al.   NEUROSCIENCE LETTERS

Green Tea Polyphenols Attenuated Glutamate Excitotoxicity via Antioxidative and Antiapoptotic Pathway in the Primary Cultured Cortical Neurons

(2016) Lin Cong et al.   Oxidative Medicine and Cellular Longevity

Pratensein attenuates Aβ-induced cognitive deficits in rats: Enhancement of synaptic plasticity and cholinergic function

(2015) Ling Wei et al.   FITOTERAPIA

Identification of 5-Methoxyflavone as a Novel DNA Polymerase-Beta Inhibitor and Neuroprotective Agent against Beta-Amyloid Toxicity

(2015) Sara Merlo et al.   JOURNAL OF NATURAL PRODUCTS

Protective effects of flavonoids against microbes and toxins: The cases of hesperidin and hesperetin

(2015) Mehrdad Iranshahi et al.   LIFE SCIENCES

Orientin alleviates cognitive deficits and oxidative stress in Aβ1–42-induced mouse model of Alzheimer's disease

(2015) Linjie Yu et al.   LIFE SCIENCES

Physiology of the Alzheimer’s disease

(2015) Jung Y. Hahr   MEDICAL HYPOTHESES

Compromised autophagy and neurodegenerative diseases

(2015) Fiona M. Menzies et al.   NATURE REVIEWS NEUROSCIENCE

Protective effects of Anthocyanins against Amyloid beta-induced neurotoxicity in vivo and in vitro

(2015) Haroon Badshah et al.   NEUROCHEMISTRY INTERNATIONAL

Neuroprotective Effect ofBrassica oleraceaSprouts Crude Juice in a Cellular Model of Alzheimer’s Disease

(2015) Alessandra Masci et al.   Oxidative Medicine and Cellular Longevity

Protective effect of centipedegrass against Aβoligomerization and Aβ-mediated cell death in PC12 cells

(2015) Yuno Song et al.   PHARMACEUTICAL BIOLOGY

Icariin, a major constituent of flavonoids from Epimedium brevicornum, protects against cognitive deficits induced by chronic brain hypoperfusion via its anti-amyloidogenic effect in rats

(2015) Wen-Xian Li et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Metabolism of Flavonoids in Human: A Comprehensive Review

(2014) Zhongjian Chen et al.   CURRENT DRUG METABOLISM

Effect of troxerutin on synaptic plasticity of hippocampal dentate gyrus neurons in a β-amyloid model of Alzheimer׳s disease: An electrophysiological study

(2014) Shirin Babri et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Longitudinal follow-up of autophagy and inflammation in brain of APPswePS1dE9 transgenic mice

(2014) Arnaud François et al.   Journal of Neuroinflammation

Structure-Activity Association of Flavonoids in Lung Diseases

(2014) João Lago et al.   MOLECULES

Apoptosis in Alzheimer’s Disease: An Understanding of the Physiology, Pathology and Therapeutic Avenues

(2014) M. Obulesu et al.   NEUROCHEMICAL RESEARCH

Neuroprotective effect of purple rice extract and its constituent against amyloid beta-induced neuronal cell death in SK-N-SH cells

(2014) Sarinthorn Thummayot et al.   NEUROTOXICOLOGY

Antioxidant and Anti-Inflammatory Properties of the Citrus Flavonoids Hesperidin and Hesperetin: An Updated Review of their Molecular Mechanisms and Experimental Models

(2014) Hamideh Parhiz et al.   PHYTOTHERAPY RESEARCH

Kaempferol attenuates the glutamate-induced oxidative stress in mouse-derived hippocampal neuronal HT22 cells

(2014) Eun-Ju Yang et al.   Food & Function

The neuroprotective effects of ipriflavone against H2O2 and amyloid beta induced toxicity in human neuroblastoma SH-SY5Y cells

(2013) Zhimin Xiao et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Alzheimer's disease: Review of hormone therapy trials and implications for treatment and prevention after menopause

(2013) Victor W. Henderson   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Neuroprotective, Anti-Amyloidogenic and Neurotrophic Effects of Apigenin in an Alzheimer’s Disease Mouse Model

(2013) Le Zhao et al.   MOLECULES

Prevention of LPS-Induced Microglia Activation, Cytokine Production and Sickness Behavior with TLR4 Receptor Interfering Peptides

(2013) Dustin J. Hines et al.   PLoS One

The Ubiquitin-Proteasome System and the Autophagic-Lysosomal System in Alzheimer Disease

(2013) Y. Ihara et al.   Cold Spring Harbor Perspectives in Medicine

Pinocembrin protects against β-amyloid-induced toxicity in neurons through inhibiting receptor for advanced glycation end products (RAGE)-independent signaling pathways and regulating mitochondrion-mediated apoptosis

(2012) Rui Liu et al.   BMC Medicine

Apigenin attenuates copper-mediated β-amyloid neurotoxicity through antioxidation, mitochondrion protection and MAPK signal inactivation in an AD cell model

(2012) Le Zhao et al.   BRAIN RESEARCH

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Protective effect of ε-viniferin on β-amyloid peptide aggregation investigated by electrospray ionization mass spectrometry

(2011) Tristan Richard et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Protective Effects of Anthocyanins against Amyloid β-Peptide-Induced Damage in Neuro-2A Cells

(2011) Ping-Hsiao Shih et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Autophagy failure in Alzheimer's disease—locating the primary defect

(2011) Ralph A. Nixon et al.   NEUROBIOLOGY OF DISEASE

Role of Cell Cycle Re-Entry in Neurons: A Common Apoptotic Mechanism of Neuronal Cell Death

(2011) Jaume Folch et al.   NEUROTOXICITY RESEARCH

Inducing Autophagy by Rapamycin Before, but Not After, the Formation of Plaques and Tangles Ameliorates Cognitive Deficits

(2011) Smita Majumder et al.   PLoS One

Amyloid β oligomers induce Ca2+ dysregulation and neuronal death through activation of ionotropic glutamate receptors

(2010) Elena Alberdi et al.   CELL CALCIUM

Tau in Alzheimer Disease and Related Tauopathies

(2010) K. Iqbal et al.   Current Alzheimer Research

Puerarin attenuates amyloid-beta-induced cognitive impairment through suppression of apoptosis in rat hippocampus in vivo

(2010) Jiaming Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Puerarin protects Alzheimer's disease neuronal cybrids from oxidant-stress induced apoptosis by inhibiting pro-death signaling pathways

(2010) Haiying Zhang et al.   EXPERIMENTAL GERONTOLOGY

Bioavailability of dietary flavonoids and phenolic compounds

(2010) Alan Crozier et al.   MOLECULAR ASPECTS OF MEDICINE

Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

(2010) Patricia Spilman et al.   PLoS One

Autophagy protects neuron from Aβ-induced cytotoxicity

(2009) Shih-Ya Hung et al.   Autophagy

Cocoa procyanidins attenuate 4-hydroxynonenal-induced apoptosis of PC12 cells by directly inhibiting mitogen-activated protein kinase kinase 4 activity

(2009) Eun Sun Cho et al.   FREE RADICAL BIOLOGY AND MEDICINE

Three distinct neuroprotective functions of myricetin against glutamate-induced neuronal cell death: Involvement of direct inhibition of caspase-3

(2008) Yoshiari Shimmyo et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Protective effect of quercetin in primary neurons against Aβ(1–42): relevance to Alzheimer's disease

(2008) Mubeen Ahmad Ansari et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY