Apoptosis in Alzheimer’s Disease: An Understanding of the Physiology, Pathology and Therapeutic Avenues

2-Cyclopropylimino-3-methyl-1,3-thiazoline Hydrochloride Protects Against Beta-amyloid-induced Activation of the Apoptotic Cascade in Cultured Cortical Neurons

(2014) Eun-A Kim et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Apoptosis Signal Regulating Kinase 1 (ASK1): Potential as a Therapeutic Target for Alzheimer’s Disease

(2014) Juhyun Song et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Retinoic Acids Are Potent Inhibitors of Spontaneous Human Eosinophil Apoptosis

(2014) S. Ueki et al.   JOURNAL OF IMMUNOLOGY

Humanins, the neuroprotective and cytoprotective peptides with antiapoptotic and anti-inflammatory properties

(2014) Barbara Zapała et al.   Pharmacological Reports

The effect of Ginkgo biloba extract on scopolamine-induced apoptosis in the hippocampus of rats

(2013) M. Jahanshahi et al.   ANATOMICAL SCIENCE INTERNATIONAL

Ethyl acetate extract of germinated brown rice attenuates hydrogen peroxide-induced oxidative stress in human SH-SY5Y neuroblastoma cells: role of anti-apoptotic, pro-survival and antioxidant genes

(2013) Nur Hanisah Azmi et al.   BMC Complementary and Alternative Medicine

Protective effects of Peroxiredoxin 6 overexpression on amyloid β-induced apoptosis in PC12 cells

(2013) I. K. Kim et al.   FREE RADICAL RESEARCH

Neuroinflammation in Alzheimer's disease: an understanding of physiology and pathology

(2013) M. Obulesu et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

IL-1β and TNF-α induce neurotoxicity through glutamate production: a potential role for neuronal glutaminase

(2013) Ling Ye et al.   JOURNAL OF NEUROCHEMISTRY

Chronic noise exposure and Alzheimer disease: Is there an etiological association?

(2013) Bo Cui et al.   MEDICAL HYPOTHESES

Food, Nutrigenomics, and Neurodegeneration—Neuroprotection by What You Eat!

(2013) Ashraf Virmani et al.   MOLECULAR NEUROBIOLOGY

C-Terminal Peptide of γ-Enolase Impairs Amyloid-β-Induced Apoptosis Through p75NTR Signaling

(2013) Anja Hafner Pišlar et al.   NEUROMOLECULAR MEDICINE

Zinc homeostasis and neurodegenerative disorders

(2013) Bernadeta Szewczyk   Frontiers in Aging Neuroscience

Overcoming Cell Death and Tau Phosphorylation Mediated by PI3KInhibition: A Cell Assay to Measure Neuroprotection

(2012) D. Simon et al.   CNS & Neurological Disorders-Drug Targets

Ryanodine Receptor Blockade Reduces Amyloid-  Load and Memory Impairments in Tg2576 Mouse Model of Alzheimer Disease

(2012) B. Oules et al.   JOURNAL OF NEUROSCIENCE

Protective Effects of the Key Compounds Isolated from Corni fructus against β-Amyloid-Induced Neurotoxicity in PC12 Cells

(2012) Seung-Young Hong et al.   MOLECULES

Mesoporous Silica Nanoparticle-based H2O2 Responsive Controlled-Release System Used for Alzheimer's Disease Treatment

(2012) Jie Geng et al.   Advanced Healthcare Materials

Lipid peroxidation in Alzheimer’s Disease: emphasis on metal-mediated neurotoxicity

(2011) M. Obulesu et al.   ACTA NEUROLOGICA SCANDINAVICA

Interaction between 24-hydroxycholesterol, oxidative stress, and amyloid-β in amplifying neuronal damage in Alzheimer’s disease: three partners in crime

(2011) Paola Gamba et al.   AGING CELL

YAP accelerates Aβ25–35-induced apoptosis through upregulation of Bax expression by interaction with p73

(2011) Heng Zhang et al.   APOPTOSIS

Possible roles of amyloid intracellular domain of amyloid precursor protein

(2011) Keun-A Chang et al.   BMB Reports

Troxerutin protects against high cholesterol-induced cognitive deficits in mice

(2011) J. Lu et al.   BRAIN

Activation and Control of CNS Innate Immune Responses in Health and Diseases: A Balancing Act Finely Tuned by Neuroimmune Regulators (NIReg)

(2011) Jean-Jacques Hoarau et al.   CNS & Neurological Disorders-Drug Targets

Astrocytes: Implications for Neuroinflammatory Pathogenesis of Alzheimers Disease

(2011) Chuanyu Li et al.   Current Alzheimer Research

Matter of Life and Death: the Pharmacological Approaches Targeting Apoptosis in Brain Diseases

(2011) Virve Cavallucci et al.   CURRENT PHARMACEUTICAL DESIGN

Immunotherapy for Alzheimer's Disease: Rational Basis in Ongoing Clinical Trials

(2011) Manuel Menendez-Gonzalez et al.   CURRENT PHARMACEUTICAL DESIGN

Antiapoptotic Drugs: A Therapautic Strategy for the Prevention of Neurodegenerative Diseases

(2011) Francesc X. Sureda et al.   CURRENT PHARMACEUTICAL DESIGN

Neuroprotective effect of preadministration with Ganoderma lucidum spore on rat hippocampus

(2011) Yan Zhou et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Genetics of Alzheimer's Disease: An Insight Into Presenilins and Apolipoprotein E Instigated Neurodegeneration

(2011) M. Obulesu et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Regulator of Calcineurin 1 (RCAN1) Facilitates Neuronal Apoptosis through Caspase-3 Activation

(2011) Xiulian Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuroprotective effect of SuHeXiang Wan in Drosophila models of Alzheimer's disease

(2011) Yoon Ki Hong et al.   JOURNAL OF ETHNOPHARMACOLOGY

Icariin inhibits hydrogen peroxide-induced toxicity through inhibition of phosphorylation of JNK/p38 MAPK and p53 activity

(2011) Wei-Wei Li et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

A Novel Approach for Characterization of Cathepsin D Protease and Its Effect on Tau and β-Amyloid Proteins

(2011) Mazhar Malik et al.   NEUROCHEMICAL RESEARCH

Tau Mediated Neurodegeneration: An Insight into Alzheimer’s Disease Pathology

(2011) M. Obulesu et al.   NEUROCHEMICAL RESEARCH

Carotenoids and Alzheimer’s Disease: An insight into therapeutic role of retinoids in animal models

(2011) M. Obulesu et al.   NEUROCHEMISTRY INTERNATIONAL

Further Evidence on Mitochondrial Targeting of β-Amyloid and Specificity of β-Amyloid-Induced Mitotoxicity in Neurons

(2011) Laurent Tillement et al.   Neurodegenerative Diseases

Endocannabinoid 2-arachidonoylglycerol protects neurons against β-amyloid insults

(2011) X. Chen et al.   NEUROSCIENCE

Microarray Analysis on Human Neuroblastoma Cells Exposed to Aluminum, β1–42-Amyloid or the β1–42-Amyloid Aluminum Complex

(2011) Valentina Gatta et al.   PLoS One

TNF-α Contributes to Caspase-3 Independent Apoptosis in Neuroblastoma Cells: Role of NFAT

(2011) Susana Álvarez et al.   PLoS One

Proteomic Identification of Protein Targets for 15-Deoxy-Δ12,14-Prostaglandin J2 in Neuronal Plasma Membrane

(2011) Yasuhiro Yamamoto et al.   PLoS One

Regulation of Forkhead Transcription Factor FoxO3a Contributes to Calorie Restriction-induced Prevention of Alzheimer's Disease-type Amyloid Neuropathology and Spatial Memory Deterioration

(2010) Weiping Qin et al.   Annals of the New York Academy of Sciences

Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson’s, Huntington’s, Alzheimer’s, prions, bactericides, chemical toxicology and others as examples

(2010) Douglas B. Kell   ARCHIVES OF TOXICOLOGY

Baicalein protects HT22 murine hippocampal neuronal cells against endoplasmic reticulum stress-induced apoptosis through inhibition of reactive oxygen species production and CHOP induction

(2010) Ji Hyun Choi et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Animal Models of Alzheimer's Disease: An Understanding of Pathology and Therapeutic Avenues

(2010) M. Obulesu et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

DNA Damage and Impairment of DNA Repair in Alzheimer's Disease

(2010) M. Obulesu et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

P60TRP interferes with the GPCR/secretase pathway to mediate neuronal survival and synaptogenesis

(2010) Manisha Mishra et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

GD3 Accumulation in Cell Surface Lipid Rafts Prior to Mitochondrial Targeting Contributes to Amyloid-β-induced Apoptosis

(2010) Jong-Kook Kim et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

Psychopharmacological Neuroprotection in Neurodegenerative Disease: Assessing the Preclinical Data

(2010) E. C. Lauterbach et al.   JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES

Association of AICD and Fe65 with Hirano bodies reduces transcriptional activation and initiation of apoptosis

(2010) Sangdeuk Ha et al.   NEUROBIOLOGY OF AGING

Amyloid-β Triggers the Release of Neuronal Hexokinase 1 from Mitochondria

(2010) Leonardo M. Saraiva et al.   PLoS One

Induction of apoptosis by the retinoid inducible growth regulator RIG1 depends on the NC motif in HtTA cervical cancer cells

(2009) Fu-Ming Tsai et al.   BMC CELL BIOLOGY

The brain RAS and Alzheimer's disease

(2009) John W. Wright et al.   EXPERIMENTAL NEUROLOGY

All-transretinoic acid as a novel therapeutic strategy for Alzheimer’s disease

(2009) Hyun-Pil Lee et al.   Expert Review of Neurotherapeutics

c-Abl modulates AICD dependent cellular responses: Transcriptional induction and apoptosis

(2009) Mary C. Vázquez et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Humanin Inhibits Neuronal Cell Death by Interacting with a Cytokine Receptor Complex or Complexes Involving CNTF Receptor α/WSX-1/gp130

(2009) Yuichi Hashimoto et al.   MOLECULAR BIOLOGY OF THE CELL

Transcription Factors in Long-Term Memory and Synaptic Plasticity

(2009) Cristina M. Alberini   PHYSIOLOGICAL REVIEWS

Cdk5 phosphorylates Cdh1 and modulates cyclin B1 stability in excitotoxicity

(2008) Carolina Maestre et al.   EMBO JOURNAL

Sirtuin 1 Reduction Parallels the Accumulation of Tau in Alzheimer Disease

(2008) Carl Julien et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Sirtuins — novel therapeutic targets to treat age-associated diseases

(2008) Siva Lavu et al.   NATURE REVIEWS DRUG DISCOVERY

Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities

(2008) Inki Kim et al.   NATURE REVIEWS DRUG DISCOVERY

The intracellular domain of amyloid precursor protein induces neuron-specific apoptosis

(2008) Kohzo Nakayama et al.   NEUROSCIENCE LETTERS