Journal
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
Volume 75, Issue 5, Pages 1403-1410Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.saa.2010.01.008
Keywords
In situ monitoring; Salicylic acid; Paracetamol; Acidity constants; Multiwavelength spectroscopy; Nonlinear least squares; Raman spectroscopy
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Funding
- Libyan Government
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Molecular speciation of organic compounds in solution is essential for the understanding of ionic complexation. The Raman technique was chosen because it allows the identification of compounds in different states, and it can give information about the molecular geometry from the analysis of the vibrational spectra. The effect of pH on organic compounds can give information about the ionisation of molecule species. In this study the ionisation steps of salicylic acid and paracetamol have been studied by means of potentiometry coupled with Raman spectroscopy at 30.0 degrees C in a solution of ionic strength 0.96 mol dm(-3) (KNO3) and 0.04 mol dm(-3) (HNO3). The protonation and deprotonation behaviour of the molecules were studied in different pH regions. The abundance of the three different species in the Raman spectra of aqueous salicylic acid have been identified satisfactorily, characterised, and determined by numeric treatment of the data using a multiwavelength curve-fitting program and confirmed with the observed spectral information. (C) 2010 Elsevier BM. All rights reserved.
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