Alum impairs tolerogenic properties induced by allergoid‐mannan conjugates inhibiting mTOR and metabolic reprogramming in human DCs

Understanding differences in allergen immunotherapy products and practices in North America and Europe

(2019) Vera Mahler et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Therapeutic targeting of trained immunity

(2019) Willem J. M. Mulder et al.   NATURE REVIEWS DRUG DISCOVERY

Perspectives in allergen immunotherapy: 2017 and beyond

(2018) O. Pfaar et al.   ALLERGY

Oral myeloid cells uptake allergoids coupled to mannan driving Th1/Treg responses upon sublingual delivery in mice

(2018) I. Soria et al.   ALLERGY

Critical role of mammalian target of rapamycin for IL-10 dendritic cell induction by a flagellin A conjugate in preventing allergic sensitization

(2018) Stefan Schülke et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Reactive Oxygen Species: Involvement in T Cell Signaling and Metabolism

(2018) Davide G. Franchina et al.   TRENDS IN IMMUNOLOGY

Tolerogenic Dendritic Cells as a Promising Antigen-Specific Therapy in the Treatment of Multiple Sclerosis and Neuromyelitis Optica From Preclinical to Clinical Trials

(2018) Georgina Flórez-Grau et al.   Frontiers in Immunology

Toll-like Receptor 4–Induced Glycolytic Burst in Human Monocyte-Derived Dendritic Cells Results from p38-Dependent Stabilization of HIF-1α and Increased Hexokinase II Expression

(2018) Laure Perrin-Cocon et al.   JOURNAL OF IMMUNOLOGY

Recent developments and highlights in allergen immunotherapy

(2018) Oliver Pfaar et al.   ALLERGY

Targeting SHIP-1 in Myeloid Cells Enhances Trained Immunity and Boosts Response to Infection

(2018) Paula Saz-Leal et al.   Cell Reports

Trained Immunity-Based Vaccines: A New Paradigm for the Development of Broad-Spectrum Anti-infectious Formulations

(2018) Silvia Sánchez-Ramón et al.   Frontiers in Immunology

Clinical use of adjuvants in allergen-immunotherapy

(2017) Ludger Klimek et al.   Expert Review of Clinical Immunology

mTORC1 and mTORC2 as regulators of cell metabolism in immunity

(2017) Monika Linke et al.   FEBS LETTERS

Mechanisms of immune regulation in allergic diseases: the role of regulatory T and B cells

(2017) Oscar Palomares et al.   IMMUNOLOGICAL REVIEWS

Advances and highlights in allergen immunotherapy: On the way to sustained clinical and immunologic tolerance

(2017) Margot Berings et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mechanisms of allergen immunotherapy for inhaled allergens and predictive biomarkers

(2017) Mohamed H. Shamji et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

D-mannose induces regulatory T cells and suppresses immunopathology

(2017) Dunfang Zhang et al.   NATURE MEDICINE

Mite allergoids coupled to nonoxidized mannan from Saccharomyces cerevisae efficiently target canine dendritic cells for novel allergy immunotherapy in veterinary medicine

(2017) Irene Soria et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Reactive oxygen species are required for driving efficient and sustained aerobic glycolysis during CD4+ T cell activation

(2017) Dana M. Previte et al.   PLoS One

Acetylcholine polarizes dendritic cells toward a Th2-promoting profile

(2016) S. Gori et al.   ALLERGY

Novel vaccines targeting dendritic cells by coupling allergoids to nonoxidized mannan enhance allergen uptake and induce functional regulatory T cells through programmed death ligand 1

(2016) Sofía Sirvent et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Dendritic cell targeting with C-type lectins for improvement of allergen immunotherapy

(2016) Stefan Schülke et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

International Consensus on Allergen Immunotherapy II: Mechanisms, standardization, and pharmacoeconomics

(2016) Marek Jutel et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

mTOR-Mediated Regulation of Dendritic Cell Differentiation and Function

(2016) Nyamdelger Sukhbaatar et al.   TRENDS IN IMMUNOLOGY

Generation of Tolerogenic Dendritic Cells and Their Therapeutic Applications

(2016) Seungbo Yoo et al.   Immune Network

Mechanisms of development of multimorbidity in the elderly

(2015) Peter J. Barnes   EUROPEAN RESPIRATORY JOURNAL

Structural studies of novel glycoconjugates from polymerized allergens (allergoids) and mannans as allergy vaccines

(2015) Ana I. Manzano et al.   GLYCOCONJUGATE JOURNAL

Immunometabolism governs dendritic cell and macrophage function

(2015) Luke A.J. O’Neill et al.   JOURNAL OF EXPERIMENTAL MEDICINE

High Mitochondrial Respiration and Glycolytic Capacity Represent a Metabolic Phenotype of Human Tolerogenic Dendritic Cells

(2015) Frano Malinarich et al.   JOURNAL OF IMMUNOLOGY

Aluminium in Allergies and Allergen immunotherapy

(2015) Erika Jensen-Jarolim   World Allergy Organization Journal

Immunomodulatory properties of the vaccine adjuvant alum

(2014) Ewa Oleszycka et al.   CURRENT OPINION IN IMMUNOLOGY

Lung microbiota promotes tolerance to allergens in neonates via PD-L1

(2014) Eva S Gollwitzer et al.   NATURE MEDICINE

Staphylococcus aureusconvert neonatal conventional CD4+T cells into FOXP3+ CD25+ CD127lowT cells via the PD-1/PD-L1 axis

(2013) Hardis Rabe et al.   IMMUNOLOGY

Adjuvants for allergy vaccines

(2012) Philippe Moingeon   Human Vaccines & Immunotherapeutics

Critical role for programmed death 1 signaling and protein kinase B in augmented regulatory T-cell induction in cord blood

(2011) Sytze de Roock et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Alum adjuvant: some of the tricks of the oldest adjuvant

(2011) M. Kool et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Intracellular reactive oxygen species are essential for PI3K/Akt/mTOR-dependent IL-7-mediated viability of T-cell acute lymphoblastic leukemia cells

(2011) A Silva et al.   LEUKEMIA

DNA released from dying host cells mediates aluminum adjuvant activity

(2011) Thomas Marichal et al.   NATURE MEDICINE

Alum interaction with dendritic cell membrane lipids is essential for its adjuvanticity

(2011) Tracy L Flach et al.   NATURE MEDICINE

ROS-mediated amplification of AKT/mTOR signalling pathway leads to myeloproliferative syndrome in Foxo3−/− mice

(2010) Safak Yalcin et al.   EMBO JOURNAL

Aluminiumper seand in the anti-acid drug sucralfate promotes sensitization via the oral route

(2009) R. Brunner et al.   ALLERGY

SHIP limits immunoregulatory capacity in the T-cell compartment

(2009) M. M. Collazo et al.   BLOOD

PD-L1 regulates the development, maintenance, and function of induced regulatory T cells

(2009) Loise M. Francisco et al.   JOURNAL OF EXPERIMENTAL MEDICINE