Clinical use of adjuvants in allergen-immunotherapy

Allergen-specific immunotherapy: is it vaccination against toxins after all?

(2016) M. F. Bachmann et al.   ALLERGY

Allergen-loaded strontium-doped hydroxyapatite spheres improve allergen-specific immunotherapy in mice

(2016) M. Garbani et al.   ALLERGY

New opportunities for allergen immunotherapy using synthetic peptide immuno-regulatory epitopes (SPIREs)

(2016) Ludger Klimek et al.   Expert Review of Clinical Immunology

The Use of Adjuvants for Enhancing Allergen Immunotherapy Efficacy

(2016) Julie Chesné et al.   IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA

Novel Delivery Routes for Allergy Immunotherapy

(2016) Gabriela Senti et al.   IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA

Investigation of peanut oral immunotherapy with CpG/peanut nanoparticles in a murine model of peanut allergy

(2016) Kamal D. Srivastava et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Short-term subcutaneous grass pollen immunotherapy under the umbrella of anti–IL-4: A randomized controlled trial

(2016) Adam M. Chaker et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Biodegradable antigen-associated PLG nanoparticles tolerize Th2-mediated allergic airway inflammation pre- and postsensitization

(2016) Charles B. Smarr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Fusion Protein Consisting of the Vaccine Adjuvant Monophosphoryl Lipid A and the Allergen Ovalbumin Boosts Allergen-Specific Th1, Th2, and Th17 ResponsesIn Vitro

(2016) Stefan Schülke et al.   Journal of Immunology Research

Insight into the cellular fate and toxicity of aluminium adjuvants used in clinically approved human vaccinations

(2016) Matthew Mold et al.   Scientific Reports

MPLA shows attenuated pro-inflammatory properties and diminished capacity to activate mast cells in comparison with LPS

(2015) S. Schülke et al.   ALLERGY

Administration of a probiotic with peanut oral immunotherapy: A randomized trial

(2015) Mimi L.K. Tang et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The adsorption of allergoids and 3-O-desacyl-4′-monophosphoryl lipid A (MPL®) to microcrystalline tyrosine (MCT) in formulations for use in allergy immunotherapy

(2015) A.J. Bell et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Vaccines, adjuvants and autoimmunity

(2015) Luísa Eça Guimarães et al.   PHARMACOLOGICAL RESEARCH

Nanoparticle conjugation enhances the immunomodulatory effects of intranasally delivered CpG in house dust mite-allergic mice

(2015) Marie Ballester et al.   Scientific Reports

Aluminium in Allergies and Allergen immunotherapy

(2015) Erika Jensen-Jarolim   World Allergy Organization Journal

Mechanisms of allergen-specific immunotherapy and immune tolerance to allergens

(2015) Cezmi A Akdis et al.   World Allergy Organization Journal

Development of a Poly (lactic-co-glycolic acid) Particle Vaccine to Protect Against House Dust Mite Induced Allergy

(2014) Vijaya B. Joshi et al.   AAPS Journal

Hydrogels and Scaffolds for Immunomodulation

(2014) Ankur Singh et al.   ADVANCED MATERIALS

Immunogenicity of Peanut Proteins Containing Poly(Anhydride) Nanoparticles

(2014) Juliana De S. Rebouças et al.   Clinical and Vaccine Immunology

Modified Allergens and their Potential to Treat Allergic Disease

(2014) Laurian Jongejan et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Immunotherapy of type-1 allergies with virus-like particles and CpG-motifs

(2014) Ludger Klimek et al.   Expert Review of Clinical Immunology

A promising CpG adjuvant-loaded nanoparticle-based vaccine for treatment of dust mite allergies

(2014) Aliasger K Salem   Immunotherapy

An allergen-polymeric nanoaggregate as a new tool for allergy vaccination

(2014) Mariano Licciardi et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Immunotherapy: What lies beyond

(2014) Thomas B. Casale et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Designing and building the next generation of improved vaccine adjuvants

(2014) Luis A. Brito et al.   JOURNAL OF CONTROLLED RELEASE

Cutting Edge: Alum Adjuvant Stimulates Inflammatory Dendritic Cells through Activation of the NALP3 Inflammasome

(2014) M. Kool et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Inflammasome Activation by Alum and Alum's Adjuvant Effect Are Mediated by NLRP3

(2014) H. Li et al.   JOURNAL OF IMMUNOLOGY

Aluminium in allergen-specific subcutaneous immunotherapy – A German perspective

(2014) Matthias F. Kramer et al.   VACCINE

A new adjuvanted nanoparticle-based H1N1 influenza vaccine induced antigen-specific local mucosal and systemic immune responses after administration into the lung

(2014) Vanessa Neuhaus et al.   VACCINE

Conformationally Constrained Lipid A Mimetics for Exploration of Structural Basis of TLR4/MD-2 Activation by Lipopolysaccharide

(2013) Daniel Artner et al.   ACS Chemical Biology

Immuntherapie der allergischen Rhinitis ohne Allergene?

(2013) L. Klimek et al.   HNO

Mechanisms of Allergen-Specific Immunotherapy and Novel Ways for Vaccine Development

(2013) Marek Jutel et al.   ALLERGOLOGY INTERNATIONAL

Mechanisms of Action of Adjuvants

(2013) Sunita Awate et al.   Frontiers in Immunology

REVIEWING AND IDENTIFYING AMINO ACIDS OF HUMAN, MURINE, CANINE AND EQUINE TLR4 / MD-2 RECEPTOR COMPLEXES CONFERRING ENDOTOXIC INNATE IMMUNITY ACTIVATION BY LPS/LIPID A, OR ANTAGONISTIC EFFECTS BY ERITORAN, IN CONTRAST TO SPECIES-DEPENDENT MODULATION BY LIPID IVA

(2013) Thomas Scior et al.   Computational and Structural Biotechnology Journal

Adjuvants for immunotherapy

(2012) Oliver Pfaar et al.   Current Opinion in Allergy and Clinical Immunology

Intralymphatic immunotherapy for cat allergy induces tolerance after only 3 injections

(2012) Gabriela Senti et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Nanoparticulate Adjuvants and Delivery Systems for Allergen Immunotherapy

(2012) Juliana De Souza Rebouças et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2

(2012) U. Ohto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adjuvants for allergy vaccines

(2012) Philippe Moingeon   Human Vaccines & Immunotherapeutics

New routes for allergen immunotherapy

(2012) Pål Johansen et al.   Human Vaccines & Immunotherapeutics

Ultrashort-specific immunotherapy successfully treats seasonal allergic rhinoconjunctivitis to grass pollen

(2011) Lawrence M. DuBuske et al.   ALLERGY AND ASTHMA PROCEEDINGS

Antigen depot is not required for alum adjuvanticity

(2011) Sharon Hutchison et al.   FASEB JOURNAL

Long-term tolerance after allergen immunotherapy is accompanied by selective persistence of blocking antibodies

(2011) Louisa K. James et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Vaccine adjuvants alum and MF59 induce rapid recruitment of neutrophils and monocytes that participate in antigen transport to draining lymph nodes

(2011) Samuele Calabro et al.   VACCINE

Sublingual Allergen-Specific Immunotherapy Adjuvanted with Monophosphoryl Lipid A: A Phase I/IIa Study

(2010) Oliver Pfaar et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Differential Induction of Innate Immune Responses by Synthetic Lipid A Derivatives

(2010) Jidnyasa Gaekwad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Administration routes affect the quality of immune responses: A cross-sectional evaluation of particulate antigen-delivery systems

(2010) Deepa Mohanan et al.   JOURNAL OF CONTROLLED RELEASE

Vaccines with Aluminum-containing Adjuvants: Optimizing Vaccine Efficacy and Thermal Stability

(2010) Tanya Clapp et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Targeting the allergen to oral dendritic cells with mucoadhesive chitosan particles enhances tolerance induction

(2009) N. Saint-Lu et al.   ALLERGY

Local Nasal Immunotherapy: Efficacy of Dermatophagoides farinae-Chitosan Vaccine in Murine Asthma

(2009) Zhigang Liu et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Alum Induces Innate Immune Responses through Macrophage and Mast Cell Sensors, But These Sensors Are Not Required for Alum to Act As an Adjuvant for Specific Immunity

(2009) A. S. McKee et al.   JOURNAL OF IMMUNOLOGY

Alum adjuvanticity: Unraveling a century old mystery

(2008) Ennio De Gregorio et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Nlrp3 inflammasome is critical for aluminium hydroxide-mediated IL-1β secretion but dispensable for adjuvant activity

(2008) Luigi Franchi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Molecular differences between the divergent responses of ovalbumin-specific CD4 T cells to alum-precipitated ovalbumin compared to ovalbumin expressed by Salmonella

(2008) Karine Serre et al.   MOLECULAR IMMUNOLOGY

Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants

(2008) Stephanie C. Eisenbarth et al.   NATURE