HMGB1-triggered inflammation inhibition of notoginseng leaf triterpenes against cerebral ischemia and reperfusion injury via MAPK and NF-κB signaling pathways

Ginsenoside Rb1 as an Anti-Diabetic Agent and Its Underlying Mechanism Analysis

(2019) Ping Zhou et al.   Cells

Notoginsenoside R1 Ameliorates Diabetic Retinopathy through PINK1-Dependent Activation of Mitophagy

(2019) Ping Zhou et al.   Cells

Folic acid deficiency enhanced microglial immune response via the Notch1/nuclear factor kappa B p65 pathway in hippocampus following rat brain I/R injury and BV2 cells

(2019) Man Cheng et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The effects of epothilone D on microtubule degradation and delayed neuronal death in the hippocampus following transient global ischemia

(2019) Tian-Qing Xiong et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Rapid Intramitochondrial Zn2+ Accumulation in CA1 Hippocampal Pyramidal Neurons After Transient Global Ischemia: A Possible Contributor to Mitochondrial Disruption and Cell Death

(2019) Hong Z Yin et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Spatial T-maze identifies cognitive deficits in piglets 1 month after hypoxia-ischemia in a model of hippocampal pyramidal neuron loss and interneuron attrition

(2019) Rashmi Singh et al.   BEHAVIOURAL BRAIN RESEARCH

The diabetes drug semaglutide reduces infarct size, inflammation, and apoptosis, and normalizes neurogenesis in a rat model of stroke

(2019) Xiaoyan Yang et al.   NEUROPHARMACOLOGY

Global profiling combined with predicted metabolites screening for discovery of natural compounds: Characterization of ginsenosides in the leaves of Panax notoginseng as a case study

(2018) Chang-liang Yao et al.   JOURNAL OF CHROMATOGRAPHY A

Lentivirus-mediated overexpression of OTULIN ameliorates microglia activation and neuroinflammation by depressing the activation of the NF-κB signaling pathway in cerebral ischemia/reperfusion rats

(2018) Hongbei Xu et al.   Journal of Neuroinflammation

JM-20 Treatment After MCAO Reduced Astrocyte Reactivity and Neuronal Death on Peri-infarct Regions of the Rat Brain

(2018) Jeney Ramírez-Sánchez et al.   MOLECULAR NEUROBIOLOGY

Panax Notoginseng Saponins: A Review of Its Mechanisms of Antidepressant or Anxiolytic Effects and Network Analysis on Phytochemistry and Pharmacology

(2018) Weijie Xie et al.   MOLECULES

Notoginsenoside R1 ameliorates diabetic encephalopathy by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome activation

(2018) Yadong Zhai et al.   Oncotarget

Antidepressant Effect of Fraxinus rhynchophylla Hance Extract in a Mouse Model of Chronic Stress-Induced Depression

(2018) Yu Ri Kim et al.   Biomed Research International

Systemic Inflammation and Cardiovascular Comorbidity in Psoriasis Patients: Causes and Consequences

(2018) Wolf-Henning Boehncke   Frontiers in Immunology

Neuroprotective Effects of Radix Scrophulariae on Cerebral Ischemia and Reperfusion Injury via MAPK Pathways

(2018) Xiaobo Meng et al.   MOLECULES

Protective Effects of Total Saponins of Aralia elata (Miq.) on Endothelial Cell Injury Induced by TNF-α via Modulation of the PI3K/Akt and NF-κB Signalling Pathways

(2018) Ping Zhou et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inhibitory Effects of Ginsenoside Rb1 on Early Atherosclerosis in ApoE-/- Mice via Inhibition of Apoptosis and Enhancing Autophagy

(2018) Ping Zhou et al.   MOLECULES

From Analysis of Ischemic Mouse Brain Proteome to Identification of Human Serum Clusterin as a Potential Biomarker for Severity of Acute Ischemic Stroke

(2018) Hailong Song et al.   Translational Stroke Research

Protective Effects and Target Network Analysis of Ginsenoside Rg1 in Cerebral Ischemia and Reperfusion Injury: A Comprehensive Overview of Experimental Studies

(2018) Weijie Xie et al.   Cells

Ginsenoside Rb1 and mitochondria: A short review of the literature

(2018) Ping Zhou et al.   MOLECULAR AND CELLULAR PROBES

HMGB1 translocation and release mediate cigarette smoke–induced pulmonary inflammation in mice through a TLR4/MyD88-dependent signaling pathway

(2017) Yao Cheng et al.   MOLECULAR BIOLOGY OF THE CELL

Attenuation of TNF-α-Induced Inflammatory Injury in Endothelial Cells by Ginsenoside Rb1 via Inhibiting NF-κB, JNK and p38 Signaling Pathways

(2017) Ping Zhou et al.   Frontiers in Pharmacology

Dammarane-type saponins from the leaves of Panax notoginseng and their neuroprotective effects on damaged SH-SY5Y cells

(2017) Xin-Yi Liu et al.   PHYTOCHEMISTRY

Neuroprotective effects of penehyclidine hydrochloride against cerebral ischemia/reperfusion injury in mice

(2016) Ya Shu et al.   BRAIN RESEARCH BULLETIN

The Mitogen-Activated Protein Kinase (MAPK) Signaling Pathway as a Discovery Target in Stroke

(2016) Jing Sun et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Beneficial Effects of a CaMKIIα Inhibitor TatCN21 Peptide in Global Cerebral Ischemia

(2016) Mohammad Ejaz Ahmed et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Dioscin ameliorates cerebral ischemia/reperfusion injury through the downregulation of TLR4 signaling via HMGB-1 inhibition

(2015) Xufeng Tao et al.   FREE RADICAL BIOLOGY AND MEDICINE

DAMP Signaling is a Key Pathway Inducing Immune Modulation after Brain Injury

(2015) A. Liesz et al.   JOURNAL OF NEUROSCIENCE

Ameliorating effects of traditional Chinese medicine preparation, Chinese materia medica and active compounds on ischemia/reperfusion-induced cerebral microcirculatory disturbances and neuron damage

(2015) Kai Sun et al.   Acta Pharmaceutica Sinica B

The PTEN/PI3K/Akt signaling pathway mediates HMGB1-induced cell proliferation by regulating the NF-κB/cyclin D1 pathway in mouse mesangial cells

(2014) Xiao-Juan Feng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

FIP200 is Involved in Murine Pseudomonas Infection by Regulating HMGB1 Intracellular Translocation

(2014) Yi Li et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Protective Effects of Panax Notoginseng Saponins on Cardiovascular Diseases: A Comprehensive Overview of Experimental Studies

(2014) Xiaochen Yang et al.   Evidence-based Complementary and Alternative Medicine

Treatment with ginseng total saponins improves the neurorestoration of rat after traumatic brain injury

(2014) Bao-Ying Hu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Neuroprotective effects of bilobalide on cerebral ischemia and reperfusion injury are associated with inhibition of pro-inflammatory mediator production and down-regulation of JNK1/2 and p38 MAPK activation

(2014) Mingjin Jiang et al.   Journal of Neuroinflammation

Pseudoginsenoside-F11 (PF11) exerts anti-neuroinflammatory effects on LPS-activated microglial cells by inhibiting TLR4-mediated TAK1/IKK/NF-κB, MAPKs and Akt signaling pathways

(2014) Xiaoxiao Wang et al.   NEUROPHARMACOLOGY

Antioxidative effects of Panax notoginseng saponins in brain cells

(2014) Ningna Zhou et al.   PHYTOMEDICINE

Perspectives of drug-based neuroprotection targeting mitochondria

(2014) V. Procaccio et al.   REVUE NEUROLOGIQUE

High mobility group box protein-1 promotes cerebral edema after traumatic brain injury via activation of toll-like receptor 4

(2013) Melissa D. Laird et al.   GLIA

Intracellular Signaling MAPK Pathway After Cerebral Ischemia–Reperfusion Injury

(2012) Maria Kovalska et al.   NEUROCHEMICAL RESEARCH

Ischemia and reperfusion—from mechanism to translation

(2011) Holger K Eltzschig et al.   NATURE MEDICINE

Involvement of oxidative stress-mediated ERK1/2 and p38 activation regulated mitochondria-dependent apoptotic signals in methylmercury-induced neuronal cell injury

(2011) Tien-Hui Lu et al.   TOXICOLOGY LETTERS

Protective effects and mechanism of Panax Notoginseng saponins on oxidative stress-induced damage and apoptosis of rabbit bone marrow stromal cells

(2010) Hui Qiang et al.   Chinese Journal of Integrative Medicine

Effects of clinical and laboratory variables and of pretreatment with cardiovascular drugs in acute ischaemic stroke: A retrospective chart review from the GIFA study

(2010) Antonino Tuttolomondo et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Acute Stroke Therapy 1981–2009*

(2009) Bernd Eckert   CLINICAL NEURORADIOLOGY

Raloxifene analogue LY117018 suppresses oxidative stress-induced endothelial cell apoptosis through activation of ERK1/2 signaling pathway

(2008) Jing Yu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY