Protective Effects of Total Saponins of Aralia elata (Miq.) on Endothelial Cell Injury Induced by TNF-α via Modulation of the PI3K/Akt and NF-κB Signalling Pathways

Comparison of chemical composition in the buds ofAralia elatafrom different geographical origins of China

(2018) Mingming Qi et al.   Royal Society Open Science

Cancer cells increase endothelial cell tube formation and survival by activating the PI3K/Akt signalling pathway

(2017) Hao-Wei Cheng et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Attenuation of TNF-α-Induced Inflammatory Injury in Endothelial Cells by Ginsenoside Rb1 via Inhibiting NF-κB, JNK and p38 Signaling Pathways

(2017) Ping Zhou et al.   Frontiers in Pharmacology

Endothelial cells, endoplasmic reticulum stress and oxysterols

(2017) F. Luchetti et al.   Redox Biology

Amorphous silica nanoparticles trigger vascular endothelial cell injury through apoptosis and autophagy via reactive oxygen species-mediated MAPK/Bcl-2 and PI3K/Akt/mTOR signaling

(2016) Caixia Guo et al.   International Journal of Nanomedicine

Simultaneous quantification of triterpenoid saponins in rat plasma by UHPLC-MS/MS and its application to a pharmacokinetic study after oral total saponin ofAralia elataleaves

(2016) Yichun Sun et al.   JOURNAL OF SEPARATION SCIENCE

Expression of Apoptosis-regulating Proteins Bcl-2 and Bax in Lymph Node Aspirates from Dogs with Lymphoma

(2016) K. Meichner et al.   JOURNAL OF VETERINARY INTERNAL MEDICINE

Hericium erinaceusInhibits TNF-α-Induced Angiogenesis and ROS Generation through Suppression of MMP-9/NF-κB Signaling and Activation of Nrf2-Mediated Antioxidant Genes in Human EA.hy926 Endothelial Cells

(2016) Hebron C. Chang et al.   Oxidative Medicine and Cellular Longevity

Extracts from Aralia elata (Miq) Seem alleviate hepatosteatosis via improving hepatic insulin sensitivity

(2015) Kyung-A Hwang et al.   BMC Complementary and Alternative Medicine

In vivoluminescent imaging of NF-κB activity and NF-κB-related serum cytokine levels predict pain sensitivities in a rodent model of peripheral neuropathy

(2015) R.D. Bowles et al.   EUROPEAN JOURNAL OF PAIN

Determination and pharmacokinetic study of two triterpenoid saponins in rat plasma after oral administration of the extract of Aralia elata leaves by UHPLC–ESI–MS/MS

(2015) Zhibin Wang et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Total aralosides of aralia elata (Miq) seem (TASAES) ameliorate nonalcoholic steatohepatitis by modulating IRE1α-mediated JNK and NF-κB pathways in ApoE–/– mice

(2015) Yun Luo et al.   JOURNAL OF ETHNOPHARMACOLOGY

Rapid mitochondrial dysfunction mediates TNF-alpha-induced neurotoxicity

(2015) Danielle N. Doll et al.   JOURNAL OF NEUROCHEMISTRY

Protective effect of total saponins of Aralia elata (Miq) Seem on lipopolysaccharide-induced cardiac dysfunction via down-regulation of inflammatory signaling in mice

(2015) Rong-Chang Chen et al.   RSC Advances

Identification of novel molecular regulators of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in breast cancer cells by RNAi screening

(2014) Sireesha V Garimella et al.   BREAST CANCER RESEARCH

Effect of the total saponins of Aralia elata (Miq) Seem on cardiac contractile function and intracellular calcium cycling regulation

(2014) Min Wang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Generation and functional analysis of human TNF-α/iNOS-producing dendritic cells (Tip-DC)

(2013) D. Wilsmann-Theis et al.   ALLERGY

P90RSK and Nrf2 Activation via MEK1/2-ERK1/2 Pathways Mediated by Notoginsenoside R2 to Prevent 6-Hydroxydopamine-Induced Apoptotic Death in SH-SY5Y Cells

(2013) Xiang-Bao Meng et al.   Evidence-based Complementary and Alternative Medicine

Tetramethylpyrazine attenuates TNF-α-induced iNOS expression in human endothelial cells: Involvement of Syk-mediated activation of PI3K-IKK-IκB signaling pathways

(2013) Zhen Zheng et al.   EXPERIMENTAL CELL RESEARCH

Targeting factor Xa and thrombin: impact on coagulation and beyond

(2013) Charles T. Esmon   THROMBOSIS AND HAEMOSTASIS

Targeting Inflammation: Impact on Atherothrombosis

(2013) Maria Giulia Marini et al.   Journal of Cardiovascular Translational Research

Endothelial Nitric-oxide Synthase Activation Generates an Inducible Nitric-oxide Synthase-like Output of Nitric Oxide in Inflamed Endothelium

(2012) Jessica L. Lowry et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Resveratrol: A multitargeted agent for age-associated chronic diseases

(2011) Kuzhuvelil B. Harikumar et al.   CELL CYCLE

Protective effect of total aralosides of Aralia elata (Miq) Seem (TASAES) against diabetic cardiomyopathy in rats during the early stage, and possible mechanisms

(2009) Shugang Xi et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Inflammation in Atherosclerosis

(2009) Peter Libby et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Transforming growth factor-β prevents osteoblast apoptosis induced by skeletal unloading via PI3K/Akt, Bcl-2, and phospho-Bad signaling

(2008) Cécilie Dufour et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM