Notoginsenoside R1 Ameliorates Diabetic Retinopathy through PINK1-Dependent Activation of Mitophagy

Therapeutic targets for altering mitochondrial dysfunction associated with diabetic retinopathy

(2018) Renu A. Kowluru et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Diabetic retinopathy pathogenesis and the ameliorating effects of melatonin; involvement of autophagy, inflammation and oxidative stress

(2018) Ehsan Dehdashtian et al.   LIFE SCIENCES

Notoginsenoside R1 ameliorates diabetic encephalopathy by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome activation

(2018) Yadong Zhai et al.   Oncotarget

AKT signalling selectively regulates PINK1 mitophagy in SHSY5Y cells and human iPSC-derived neurons

(2018) Marc P. M. Soutar et al.   Scientific Reports

High concentration of branched-chain amino acids promotes oxidative stress, inflammation and migration of human peripheral blood mononuclear cells via mTORC1 activation

(2017) Olha Zhenyukh et al.   FREE RADICAL BIOLOGY AND MEDICINE

Functional changes in the neural retina occur in the absence of mitochondrial dysfunction in a rodent model of diabetic retinopathy

(2017) Dustin R. Masser et al.   JOURNAL OF NEUROCHEMISTRY

Chinese herbal drugs for the treatment of diabetic retinopathy

(2017) Tapan Behl et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Müller cells and diabetic retinopathy

(2017) Brandon A. Coughlin et al.   VISION RESEARCH

TXNIP regulates mitophagy in retinal Müller cells under high-glucose conditions: implications for diabetic retinopathy

(2017) Takhellambam Swornalata Devi et al.   Cell Death & Disease

The mitochondria-targeted antioxidant MitoQ ameliorated tubular injury mediated by mitophagy in diabetic kidney disease via Nrf2/PINK1

(2017) Li Xiao et al.   Redox Biology

Loss of VPS13C Function in Autosomal-Recessive Parkinsonism Causes Mitochondrial Dysfunction and Increases PINK1/Parkin-Dependent Mitophagy

(2016) Suzanne Lesage et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitophagy

(2016) Ming Chen et al.   Autophagy

UCP2 Regulates Mitochondrial Fission and Ventromedial Nucleus Control of Glucose Responsiveness

(2016) Chitoku Toda et al.   CELL

Epidemiology of diabetic retinopathy, diabetic macular edema and vision loss due to diabetes

(2016) Charumathi Sabanayagam   DIABETES RESEARCH AND CLINICAL PRACTICE

Development and Validation of a Deep Learning Algorithm for Detection of Diabetic Retinopathy in Retinal Fundus Photographs

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Enhanced endoplasmic reticulum stress in bone marrow angiogenic progenitor cells in a mouse model of long-term experimental type 2 diabetes

(2015) Maulasri Bhatta et al.   DIABETOLOGIA

Anti-VEGF Pharmacotherapy as an Alternative to Panretinal Laser Photocoagulation for Proliferative Diabetic Retinopathy

(2015) Timothy W. Olsen   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The effectiveness and safety of a danshen-containing Chinese herbal medicine for diabetic retinopathy: A randomized, double-blind, placebo-controlled multicenter clinical trial

(2015) Fengmei Lian et al.   JOURNAL OF ETHNOPHARMACOLOGY

Retinal Neurodegeneration in db/db Mice at the Early Period of Diabetes

(2015) Qin Yang et al.   Journal of Ophthalmology

NRF2 Regulates PINK1 Expression under Oxidative Stress Conditions

(2015) Hitoshi Murata et al.   PLoS One

Mitophagy of damaged mitochondria occurs locally in distal neuronal axons and requires PINK1 and Parkin

(2014) Ghazaleh Ashrafi et al.   JOURNAL OF CELL BIOLOGY

Ubiquitin is phosphorylated by PINK1 to activate parkin

(2014) Fumika Koyano et al.   NATURE

VEGF Secreted by Hypoxic Muller Cells Induces MMP-2 Expression and Activity in Endothelial Cells to Promote Retinal Neovascularization in Proliferative Diabetic Retinopathy

(2013) M. Rodrigues et al.   DIABETES

An Aqueous Extract of Radix Astragali,Angelica sinensis, andPanax notoginsengIs Effective in Preventing Diabetic Retinopathy

(2013) Dehong Gao et al.   Evidence-based Complementary and Alternative Medicine

Drosophila ref(2)P is required for the parkin-mediated suppression of mitochondrial dysfunction in pink1 mutants

(2013) I P de Castro et al.   Cell Death & Disease

Mitochondria: In Sickness and in Health

(2012) Jodi Nunnari et al.   CELL

Activation of Endoplasmic Reticulum Stress by Hyperglycemia Is Essential for Muller Cell-Derived Inflammatory Cytokine Production in Diabetes

(2012) Y. Zhong et al.   DIABETES

Mitochondrial biogenesis and the development of diabetic retinopathy

(2011) Julia M. Santos et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hypoxia-induced upregulation of pigment epithelium-derived factor by retinal glial (Müller) cells

(2011) Xiu Mei Yang et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Therapeutic Target Achievement in Type 2 Diabetic Patients after Hyperglycemia, Hypertension, Dyslipidemia Management

(2011) Ah Young Kang et al.   Diabetes & Metabolism Journal

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE