Molecular Mechanisms Associated with ROR1-Mediated Drug Resistance: Crosstalk with Hippo-YAP/TAZ and BMI-1 Pathways

Wnt5a and ROR1 activate non-canonical Wnt signaling via RhoA in TCF3-PBX1 acute lymphoblastic leukemia and highlight new treatment strategies via Bcl-2 co-targeting

(2019) Hanna Karvonen et al.   ONCOGENE

Inhibition of chemotherapy resistant breast cancer stem cells by a ROR1 specific antibody

(2019) Suping Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ovarian Cancer Stem Cells with High ROR1 Expression Serve as a New Prophylactic Vaccine for Ovarian Cancer

(2019) Di Wu et al.   Journal of Immunology Research

Prospects for pharmacological targeting of pseudokinases

(2019) Jennifer E. Kung et al.   NATURE REVIEWS DRUG DISCOVERY

Glucocorticoids promote breast cancer metastasis

(2019) Milan M. S. Obradović et al.   NATURE

Genetic interactions between Ror2 and Wnt9a, Ror1 and Wnt9a and Ror2 and Ror1: Phenotypic analysis of the limb skeleton and palate in compound mutants

(2019) Martina Weissenböck et al.   GENES TO CELLS

YAP1‐LATS2 feedback loop dictates senescent or malignant cell fate to maintain tissue homeostasis

(2019) Chunbo He et al.   EMBO REPORTS

Novel ROR1 Inhibitor ARI-1 Suppresses the Development of Non-Small Cell Lung Cancer

(2019) Xuesha Liu et al.   CANCER LETTERS

Prognostic value of receptor tyrosine kinase-like orphan receptor (ROR) family in cancer: A meta-analysis

(2019) Ramy R. Saleh et al.   CANCER TREATMENT REVIEWS

Wnt5a induces ROR1 and ROR2 to activate RhoA in esophageal squamous cell carcinoma cells

(2019) Xuping Wu et al.   Cancer Management and Research

Antibody-drug conjugate T-DM1 treatment for HER2+ breast cancer induces ROR1 and confers resistance through activation of Hippo transcriptional coactivator YAP1

(2019) Syed S. Islam et al.   EBioMedicine

HDAC Inhibition Enhances the In Vivo Efficacy of MEK Inhibitor Therapy in Uveal Melanoma

(2019) Fernanda Faião-Flores et al.   CLINICAL CANCER RESEARCH

The WNT receptor ROR2 drives the interaction of multiple myeloma cells with the microenvironment through AKT activation

(2019) M. Frenquelli et al.   LEUKEMIA

Hippo Signaling in Cancer: Lessons From Drosophila Models

(2019) Kirti Snigdha et al.   Frontiers in Cell and Developmental Biology

Phase I Trial: Cirmtuzumab Inhibits ROR1 Signaling and Stemness Signatures in Patients with Chronic Lymphocytic Leukemia

(2018) Michael Y. Choi et al.   Cell Stem Cell

Targeting Wnt signaling pseudokinases in hematological cancers

(2018) Hanna Karvonen et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

ROR1 and ROR2 play distinct and opposing roles in endometrial cancer

(2018) C.E. Henry et al.   GYNECOLOGIC ONCOLOGY

Inhibition of tumor growth by mouse ROR1 specific antibody in a syngeneic mouse tumor model

(2018) Hadi Hassannia et al.   IMMUNOLOGY LETTERS

Potent and selective antitumor activity of a T cell-engaging bispecific antibody targeting a membrane-proximal epitope of ROR1

(2018) Junpeng Qi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Twist promotes tumor metastasis in basal-like breast cancer by transcriptionally upregulating ROR1

(2018) Jingying Cao et al.   Theranostics

Commonly Occurring Cell Subsets in High-Grade Serous Ovarian Tumors Identified by Single-Cell Mass Cytometry

(2018) Veronica D. Gonzalez et al.   Cell Reports

YAP and TAZ in Lung Cancer: Oncogenic Role and Clinical Targeting

(2018) Federica Lo Sardo et al.   Cancers

Pseudokinases: update on their functions and evaluation as new drug targets

(2017) Dominic P Byrne et al.   Future Medicinal Chemistry

Molecular genetics and targeted therapy of WNT-related human diseases (Review)

(2017) Masuko Katoh et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Canonical and non-canonical WNT signaling in cancer stem cells and their niches: Cellular heterogeneity, omics reprogramming, targeted therapy and tumor plasticity (Review)

(2017) Masaru Katoh   INTERNATIONAL JOURNAL OF ONCOLOGY

MicroRNAdysregulation to identify therapeutic target combinations for chronic lymphocytic leukemia

(2017) Laura Z. Rassenti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Wnt5a Receptor, Receptor Tyrosine Kinase-Like Orphan Receptor 2, Is a Predictive Cell Surface Marker of Human Mesenchymal Stem Cells with an Enhanced Capacity for Chondrogenic Differentiation

(2017) Sally C. Dickinson et al.   STEM CELLS

Antiproliferative and Apoptotic Effects of Novel Anti-ROR1 Single-Chain Antibodies in Hematological Malignancies

(2017) Leili Aghebati-Maleki et al.   SLAS Discovery

High-level ROR1 associates with accelerated disease progression in chronic lymphocytic leukemia

(2016) B. Cui et al.   BLOOD

Cirmtuzumab inhibits Wnt5a-induced Rac1 activation in chronic lymphocytic leukemia treated with ibrutinib

(2016) J Yu et al.   LEUKEMIA

ROR1 sustains caveolae and survival signalling as a scaffold of cavin-1 and caveolin-1

(2016) Tomoya Yamaguchi et al.   Nature Communications

Alternative Wnt Signaling Activates YAP/TAZ

(2015) Hyun Woo Park et al.   CELL

Actin remodeling confers BRAF inhibitor resistance to melanoma cells through YAP/TAZ activation

(2015) M. H. Kim et al.   EMBO JOURNAL

The Hippo/YAP pathway interacts with EGFR signaling and HPV oncoproteins to regulate cervical cancer progression

(2015) Chunbo He et al.   EMBO Molecular Medicine

Wnt5a induces ROR1/ROR2 heterooligomerization to enhance leukemia chemotaxis and proliferation

(2015) Jian Yu et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting Polycomb systems to regulate gene expression: modifications to a complex story

(2015) Neil P. Blackledge et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ror2 as a Therapeutic Target in Cancer

(2015) Zufan Debebe et al.   PHARMACOLOGY & THERAPEUTICS

Cancer Stem Cells: The Promise and the Potential

(2015) Jaffer A. Ajani et al.   SEMINARS IN ONCOLOGY

BMI-1, a promising therapeutic target for human cancer

(2015) MIN-CONG WANG et al.   Oncology Letters

Functional genomics screen identifies YAP1 as a key determinant to enhance treatment sensitivity in lung cancer cells

(2015) Haiying Cheng et al.   Oncotarget

Targeting the ROR1 and ROR2 receptors in epithelial ovarian cancer inhibits cell migration and invasion

(2015) Claire Henry et al.   Oncotarget

Disrupting the Interaction of BRD4 with Diacetylated Twist Suppresses Tumorigenesis in Basal-like Breast Cancer

(2014) Jian Shi et al.   CANCER CELL

The Hippo signaling pathway in stem cell biology and cancer

(2014) J.-S. Mo et al.   EMBO REPORTS

Yap1 Is Required for Endothelial to Mesenchymal Transition of the Atrioventricular Cushion

(2014) Hui Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ovarian cancer stem cells express ROR1, which can be targeted for anti–cancer-stem-cell therapy

(2014) Suping Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ROR1 expression correlated with poor clinical outcome in human ovarian cancer

(2014) Huilin Zhang et al.   Scientific Reports

ROR1, an embryonic protein with an emerging role in cancer biology

(2014) Nicholas Borcherding et al.   Protein & Cell

A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties

(2013) James M. Murphy et al.   BIOCHEMICAL JOURNAL

Receptor tyrosine kinases with intracellular pseudokinase domains

(2013) Jeannine M. Mendrola et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Dawn of the dead: protein pseudokinases signal new adventures in cell biology

(2013) Patrick A. Eyers et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Targeting ROR1 Inhibits Epithelial-Mesenchymal Transition and Metastasis

(2013) B. Cui et al.   CANCER RESEARCH

ROR1 can interact with TCL1 and enhance leukemogenesis in E -TCL1 transgenic mice

(2013) G. F. Widhopf et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling

(2012) Fa-Xing Yu et al.   CELL

Cancer stem cells

(2012) Zuoren Yu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Akt-mediated phosphorylation of Bmi1 modulates its oncogenic potential, E3 ligase activity, and DNA damage repair activity in mouse prostate cancer

(2012) Karim Nacerddine et al.   JOURNAL OF CLINICAL INVESTIGATION

The complex world of WNT receptor signalling

(2012) Christof Niehrs   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Akt Phosphorylates the Transcriptional Repressor Bmi1 to Block Its Effects on the Tumor-Suppressing Ink4a-Arf Locus

(2012) Y. Liu et al.   Science Signaling

Targeting Wnt Pathways in Disease

(2012) Z. F. Zimmerman et al.   Cold Spring Harbor Perspectives in Biology

The Hippo Transducer TAZ Confers Cancer Stem Cell-Related Traits on Breast Cancer Cells

(2011) Michelangelo Cordenonsi et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

BMI1 as a novel target for drug discovery in cancer

(2011) Liangxian Cao et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Bmi-1 Is a Crucial Regulator of Prostate Stem Cell Self-Renewal and Malignant Transformation

(2010) Rita U. Lukacs et al.   Cell Stem Cell

Towards an integrated view of Wnt signaling in development

(2009) R. van Amerongen et al.   DEVELOPMENT

BMI1 Sustains Human Glioblastoma Multiforme Stem Cell Renewal

(2009) M. Abdouh et al.   JOURNAL OF NEUROSCIENCE