Intracellular Signals Activated by Canonical Wnt Ligands Independent of GSK3 Inhibition and β-Catenin Stabilization

Src and Fyn define a new signaling cascade activated by canonical and non-canonical Wnt ligands and required for gene transcription and cell invasion

(2019) Aida Villarroel et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Hippo Signaling Pathway in Development and Disease

(2019) Yonggang Zheng et al.   DEVELOPMENTAL CELL

DeSUMOylation switches Kaiso from activator to repressor upon hyperosmotic stress

(2018) Svetlana Zhenilo et al.   CELL DEATH AND DIFFERENTIATION

Multiprotein complexes governing Wnt signal transduction

(2018) Melissa Gammons et al.   CURRENT OPINION IN CELL BIOLOGY

CK1ε and p120-catenin control Ror2 function in noncanonical Wnt signaling

(2018) Josué Curto et al.   Molecular Oncology

TMEM59 potentiates Wnt signaling by promoting signalosome formation

(2018) Jan P. Gerlach et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dishevelled has a YAP nuclear export function in a tumor suppressor context-dependent manner

(2018) Yoonmi Lee et al.   Nature Communications

Wnt, RSPO and Hippo Signalling in the Intestine and Intestinal Stem Cells

(2018) Vitezslav Kriz et al.   Genes

The SIAH E3 ubiquitin ligases promote Wnt/β-catenin signaling through mediating Wnt-induced Axin degradation

(2017) Lei Ji et al.   GENES & DEVELOPMENT

Wnt5a promotes Frizzled-4 signalosome assembly by stabilizing cysteine-rich domain dimerization

(2017) Zachary J. DeBruine et al.   GENES & DEVELOPMENT

A CK1 FRET biosensor reveals that DDX3X is an essential activator of CK1ε

(2017) Christine Dolde et al.   JOURNAL OF CELL SCIENCE

Unsaturated fatty acyl recognition by Frizzled receptors mediates dimerization upon Wnt ligand binding

(2017) Aaron H. Nile et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Daple Coordinates Planar Polarized Microtubule Dynamics in Ependymal Cells and Contributes to Hydrocephalus

(2017) Maki Takagishi et al.   Cell Reports

SETD7 Controls Intestinal Regeneration and Tumorigenesis by Regulating Wnt/β-Catenin and Hippo/YAP Signaling

(2016) Menno J. Oudhoff et al.   DEVELOPMENTAL CELL

YAP1 and TAZ Control Pancreatic Cancer Initiation in Mice by Direct Up-regulation of JAK–STAT3 Signaling

(2016) Ralph Gruber et al.   GASTROENTEROLOGY

Hippo signaling interactions with Wnt/β-catenin and Notch signaling repress liver tumorigenesis

(2016) Wantae Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Activation of CK1ɛ by PP2A/PR61ɛ is required for the initiation of Wnt signaling

(2016) M Vinyoles et al.   ONCOGENE

β-Catenin-Independent Roles of Wnt/LRP6 Signaling

(2016) Sergio P. Acebron et al.   TRENDS IN CELL BIOLOGY

Alternative Wnt Signaling Activates YAP/TAZ

(2015) Hyun Woo Park et al.   CELL

FOXKs Promote Wnt/β-Catenin Signaling by Translocating DVL into the Nucleus

(2015) Wenqi Wang et al.   DEVELOPMENTAL CELL

β-Catenin destruction complex-independent regulation of Hippo–YAP signaling by APC in intestinal tumorigenesis

(2015) Jing Cai et al.   GENES & DEVELOPMENT

Systematic Mapping of WNT-FZD Protein Interactions Reveals Functional Selectivity by Distinct WNT-FZD Pairs

(2015) Jacomijn P. Dijksterhuis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rac1 augments Wnt signaling by stimulating  -catenin-lymphoid enhancer factor-1 complex assembly independent of  -catenin nuclear import

(2015) C. Jamieson et al.   JOURNAL OF CELL SCIENCE

An ancient Pygo-dependent Wnt enhanceosome integrated by Chip/LDB-SSDP

(2015) Marc Fiedler et al.   eLife

Mutant Gq/11 Promote Uveal Melanoma Tumorigenesis by Activating YAP

(2014) Fa-Xing Yu et al.   CANCER CELL

YAP/TAZ Incorporation in the β-Catenin Destruction Complex Orchestrates the Wnt Response

(2014) Luca Azzolin et al.   CELL

A Noncanonical Frizzled2 Pathway Regulates Epithelial-Mesenchymal Transition and Metastasis

(2014) Taranjit S. Gujral et al.   CELL

Tyrosine phosphorylation of LRP6 by Src and Fer inhibits Wnt/ -catenin signalling

(2014) Q. Chen et al.   EMBO REPORTS

p120-catenin regulates REST and CoREST, and modulates mouse embryonic stem cell differentiation

(2014) M. Lee et al.   JOURNAL OF CELL SCIENCE

Multivesicular GSK3 Sequestration upon Wnt Signaling Is Controlled by p120-Catenin/Cadherin Interaction with LRP5/6

(2014) Meritxell Vinyoles et al.   MOLECULAR CELL

Mitotic Wnt Signaling Promotes Protein Stabilization and Regulates Cell Size

(2014) Sergio P. Acebron et al.   MOLECULAR CELL

Hypoxia regulates Hippo signalling through the SIAH2 ubiquitin E3 ligase

(2014) Biao Ma et al.   NATURE CELL BIOLOGY

Clathrin and AP2 are required for PtdIns(4,5)P2-mediated formation of LRP6 signalosomes

(2013) Ingyu Kim et al.   JOURNAL OF CELL BIOLOGY

IQGAP1 Functions as a Modulator of Dishevelled Nuclear Localization in Wnt Signaling

(2013) Toshiyasu Goto et al.   PLoS One

Wnt Stabilization of  -Catenin Reveals Principles for Morphogen Receptor-Scaffold Assemblies

(2013) S.-E. Kim et al.   SCIENCE

RNA Helicase DDX3 Is a Regulatory Subunit of Casein Kinase 1 in Wnt- -Catenin Signaling

(2013) C.-M. Cruciat et al.   SCIENCE

Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling

(2012) Fa-Xing Yu et al.   CELL

Wnt Signaling through Inhibition of β-Catenin Degradation in an Intact Axin1 Complex

(2012) Vivian S.W. Li et al.   CELL

β-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis

(2012) Joseph Rosenbluh et al.   CELL

Role of TAZ as Mediator of Wnt Signaling

(2012) Luca Azzolin et al.   CELL

Disabled-2 (Dab2) inhibits Wnt/β-catenin signalling by binding LRP6 and promoting its internalization through clathrin

(2012) Yong Jiang et al.   EMBO JOURNAL

A molecular mechanism that links Hippo signalling to the inhibition of Wnt/β-catenin signalling

(2012) Masamichi Imajo et al.   EMBO JOURNAL

The many faces and functions of β-catenin

(2012) Tomas Valenta et al.   EMBO JOURNAL

DrosophilaCK1-γ,gilgamesh, controls PCP-mediated morphogenesis through regulation of vesicle trafficking

(2012) William J. Gault et al.   JOURNAL OF CELL BIOLOGY

Upon Wnt stimulation, Rac1 activation requires Rac1 and Vav2 binding to p120-catenin

(2012) Gabriela Valls et al.   JOURNAL OF CELL SCIENCE

Tiam1 Regulates the Wnt/Dvl/Rac1 Signaling Pathway and the Differentiation of Midbrain Dopaminergic Neurons

(2012) L. Cajanek et al.   MOLECULAR AND CELLULAR BIOLOGY

Restriction of intestinal stem cell expansion and the regenerative response by YAP

(2012) Evan R. Barry et al.   NATURE

β-catenin confers resistance to PI3K and AKT inhibitors and subverts FOXO3a to promote metastasis in colon cancer

(2012) Stephan P Tenbaum et al.   NATURE MEDICINE

The Wnt/β-Catenin Pathway Cross-Talks with STAT3 Signaling to Regulate Survival of Retinal Pigment Epithelium Cells

(2012) Miryam A. Fragoso et al.   PLoS One

Wnt/ -catenin signaling requires interaction of the Dishevelled DEP domain and C terminus with a discontinuous motif in Frizzled

(2012) D. V. F. Tauriello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amer1/WTX couples Wnt-induced formation of PtdIns(4,5)P2to LRP6 phosphorylation

(2011) Kristina Tanneberger et al.   EMBO JOURNAL

Wnt controls the transcriptional activity of Kaiso through CK1 -dependent phosphorylation of p120-catenin

(2011) B. del Valle-Perez et al.   JOURNAL OF CELL SCIENCE

Coordinated Action of CK1 Isoforms in Canonical Wnt Signaling

(2011) B. del Valle-Perez et al.   MOLECULAR AND CELLULAR BIOLOGY

A Rac1/PAK1 cascade controls β-catenin activation in colon cancer cells

(2011) G Zhu et al.   ONCOGENE

Wnt/ -catenin signaling is differentially regulated by G  proteins and contributes to fibrous dysplasia

(2011) J. B. Regard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dishevelled interacts with the DIX domain polymerization interface of Axin to interfere with its function in down-regulating β-catenin

(2011) Marc Fiedler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural and Energetic Mechanisms of Cooperative Autoinhibition and Activation of Vav1

(2010) Bingke Yu et al.   CELL

Wnt Signaling Requires Sequestration of Glycogen Synthase Kinase 3 inside Multivesicular Endosomes

(2010) Vincent F. Taelman et al.   CELL

Dishevelled interacts with p65 and acts as a repressor of NF-κB-mediated transcription

(2010) Ning Deng et al.   CELL RESEARCH

Shared molecular mechanisms regulate multiple catenin proteins: canonical Wnt signals and components modulate p120-catenin isoform-1 and additional p120 subfamily members

(2010) J. Y. Hong et al.   JOURNAL OF CELL SCIENCE

A p120-catenin-CK1  complex regulates Wnt signaling

(2010) D. Casagolda et al.   JOURNAL OF CELL SCIENCE

A Two-Step Model for Colon Adenoma Initiation and Progression Caused by APC Loss

(2009) Reid A. Phelps et al.   CELL

The non-methylated DNA-binding function of Kaiso is not required in early Xenopus laevis development

(2009) A. Ruzov et al.   DEVELOPMENT

The interaction of xKaiso with xTcf3: a revised model for integration of epigenetic and Wnt signalling pathways

(2009) A. Ruzov et al.   DEVELOPMENT

Dishevelled-2 docks and activates Src in a Wnt-dependent manner

(2009) Noriko Yokoyama et al.   JOURNAL OF CELL SCIENCE

Inhibition of GSK3 Phosphorylation of β-Catenin via Phosphorylated PPPSPXS Motifs of Wnt Coreceptor LRP6

(2009) Geng Wu et al.   PLoS One

Rac1 Activation Controls Nuclear Localization of β-catenin during Canonical Wnt Signaling

(2008) Ximei Wu et al.   CELL

Wnt3a and Dkk1 Regulate Distinct Internalization Pathways of LRP6 to Tune the Activation of β-Catenin Signaling

(2008) Hideki Yamamoto et al.   DEVELOPMENTAL CELL

Nuclear Dvl, c-Jun, β-catenin, and TCF form a complex leading to stabiLization of β-catenin–TCF interaction

(2008) Xiao-qing Gan et al.   JOURNAL OF CELL BIOLOGY

The Deleted in Brachydactyly B Domain of ROR2 Is Required for Receptor Activation by Recruitment of Src

(2008) Shiva Akbarzadeh et al.   PLoS One

Direct Inhibition of GSK3β by the Phosphorylated Cytoplasmic Domain of LRP6 in Wnt/β-Catenin Signaling

(2008) Shunfu Piao et al.   PLoS One

LRP6 transduces a canonical Wnt signal independently of Axin degradation by inhibiting GSK3's phosphorylation of  -catenin

(2008) C. S. Cselenyi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wnt3a-Mediated Formation of Phosphatidylinositol 4,5-Bisphosphate Regulates LRP6 Phosphorylation

(2008) W. Pan et al.   SCIENCE