Sulphoxythiocarbamates modify cysteine residues in HSP90 causing degradation of client proteins and inhibition of cancer cell proliferation

Hsp90 inhibitors in breast cancer: A systematic review

(2013) Flora Zagouri et al.   BREAST

Regulation of Organismal Proteostasis by Transcellular Chaperone Signaling

(2013) Patricija van Oosten-Hawle et al.   CELL

NMS-E973, a Novel Synthetic Inhibitor of Hsp90 with Activity against Multiple Models of Drug Resistance to Targeted Agents, Including Intracranial Metastases

(2013) G. Fogliatto et al.   CLINICAL CANCER RESEARCH

Inhibition of HSP90 molecular chaperones: moving into the clinic

(2013) Rocio Garcia-Carbonero et al.   LANCET ONCOLOGY

The HSP90 Inhibitor NVP-AUY922 Potently Inhibits Non-Small Cell Lung Cancer Growth

(2013) E. B. Garon et al.   MOLECULAR CANCER THERAPEUTICS

Inhibition of Wee1, AKT, and CDK4 Underlies the Efficacy of the HSP90 Inhibitor XL888 in an In Vivo Model of NRAS-Mutant Melanoma

(2013) H. E. Haarberg et al.   MOLECULAR CANCER THERAPEUTICS

Novobiocin analogues with second-generation noviose surrogates

(2012) Huiping Zhao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Low-dose Hsp90 inhibitors tumor-selectively sensitize bladder cancer cells to chemoradiotherapy

(2012) Soichiro Yoshida et al.   CELL CYCLE

The yeast Hsp70 Ssa1 is a sensor for activation of the heat shock response by thiol-reactive compounds

(2012) Yanyu Wang et al.   MOLECULAR BIOLOGY OF THE CELL

Using the Heat-Shock Response To Discover Anticancer Compounds that Target Protein Homeostasis

(2011) Sandro Santagata et al.   ACS Chemical Biology

Advances in the clinical development of heat shock protein 90 (Hsp90) inhibitors in cancers

(2011) Komal Jhaveri et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The ‘active life’ of Hsp90 complexes

(2011) Chrisostomos Prodromou   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Post-translational modifications of Hsp90 and their contributions to chaperone regulation

(2011) Mehdi Mollapour et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Overview of lipid peroxidation products and hepatic protein modification in alcoholic liver disease

(2011) Rebecca L. Smathers et al.   CHEMICO-BIOLOGICAL INTERACTIONS

HSF1-Dependent Upregulation of Hsp70 by Sulfhydryl-Reactive Inducers of the KEAP1/NRF2/ARE Pathway

(2011) Ying Zhang et al.   CHEMISTRY & BIOLOGY

Effective Targeting of Triple-Negative Breast Cancer Cells by PF-4942847, a Novel Oral Inhibitor of Hsp 90

(2011) Pramod P. Mehta et al.   CLINICAL CANCER RESEARCH

Molecular Chaperone Hsp90 as a Target for Oxidant-Based Anticancer Therapies

(2011) R. Beck et al.   CURRENT MEDICINAL CHEMISTRY

Expression and prognostic role of pan-Ras, Raf-1, pMEK1 and pERK1/2 in patients with hepatocellular carcinoma

(2011) L. Chen et al.   EJSO

Transthiocarbamoylation of Proteins by Thiolated Isothiocyanates

(2011) Takahiro Shibata et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hormesis, cellular stress response and vitagenes as critical determinants in aging and longevity

(2011) Vittorio Calabrese et al.   MOLECULAR ASPECTS OF MEDICINE

Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90

(2011) Kamalika Moulick et al.   Nature Chemical Biology

Small-molecule proteostasis regulators for protein conformational diseases

(2011) Barbara Calamini et al.   Nature Chemical Biology

Systems Analysis of Protein Modification and Cellular Responses Induced by Electrophile Stress

(2010) Aaron T. Jacobs et al.   ACCOUNTS OF CHEMICAL RESEARCH

Macrocyclic Inhibitors of Hsp90

(2010) Victoria A. Johnson et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Hsp90 Interaction with INrf2(Keap1) Mediates Stress-induced Nrf2 Activation

(2010) Suryakant K. Niture et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HSP90 at the hub of protein homeostasis: emerging mechanistic insights

(2010) Mikko Taipale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Electrophilic tuning of the chemoprotective natural product sulforaphane

(2010) Y.-H. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hsp90 is regulated by a switch point in the C-terminal domain

(2009) Marco Retzlaff et al.   EMBO REPORTS

Modeling Signal Propagation Mechanisms and Ligand-Based Conformational Dynamics of the Hsp90 Molecular Chaperone Full-Length Dimer

(2009) Giulia Morra et al.   PLoS Computational Biology

Identification of Protein Targets of 4-Hydroxynonenal Using Click Chemistry for ex Vivo Biotinylation of Azido and Alkynyl Derivatives

(2008) Andrew Vila et al.   CHEMICAL RESEARCH IN TOXICOLOGY