The Multifaceted p21 (Cip1/Waf1/CDKN1A) in Cell Differentiation, Migration and Cancer Therapy
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
The Multifaceted p21 (Cip1/Waf1/CDKN1A) in Cell Differentiation, Migration and Cancer Therapy
Authors
Keywords
-
Journal
Cancers
Volume 11, Issue 9, Pages 1220
Publisher
MDPI AG
Online
2019-08-21
DOI
10.3390/cancers11091220
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- CRISPR–Cas9 a boon or bane: the bumpy road ahead to cancer therapeutics
- (2019) Debarati Ghosh et al. Cancer Cell International
- Thr55 phosphorylation of p21 by MPK38/MELK ameliorates defects in glucose, lipid, and energy metabolism in diet-induced obese mice
- (2019) Hyun-A. Seong et al. Cell Death & Disease
- Function of p21 (Cip1/Waf1/CDKN1A) in Migration and Invasion of Cancer and Trophoblastic Cells
- (2019) Kreis et al. Cancers
- Ironing out the role of the cyclin-dependent kinase inhibitor, p21 in cancer: Novel iron chelating agents to target p21 expression and activity
- (2018) Rayan S. Moussa et al. FREE RADICAL BIOLOGY AND MEDICINE
- Alteration of Epigenetic Regulation by Long Noncoding RNAs in Cancer
- (2018) Mariangela Morlando et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Epigenetic silencing of tumor suppressor gene CDKN1A by oncogenic long non-coding RNA SNHG1 in cholangiocarcinoma
- (2018) Yang Yu et al. Cell Death & Disease
- Senescence and senotherapeutics: a new field in cancer therapy
- (2018) Vassilios Myrianthopoulos et al. PHARMACOLOGY & THERAPEUTICS
- The Senescence–Stemness Alliance – A Cancer-Hijacked Regeneration Principle
- (2018) Maja Milanovic et al. TRENDS IN CELL BIOLOGY
- Molecular signatures for CCN1, p21 and p27 in progressive mantle cell lymphoma
- (2018) Afak Rasheed Salman Zaidi et al. Journal of Cell Communication and Signaling
- Cytoplasmic p21 Mediates 5-Fluorouracil Resistance by Inhibiting Pro-Apoptotic Chk2
- (2018) Arnatchai Maiuthed et al. Cancers
- Revisiting epithelial-mesenchymal transition in cancer metastasis: the connection between epithelial plasticity and stemness
- (2017) Tsai-Tsen Liao et al. Molecular Oncology
- Senescence-associated reprogramming promotes cancer stemness
- (2017) Maja Milanovic et al. NATURE
- p21: A Two-Faced Genome Guardian
- (2017) Alexandros G. Georgakilas et al. TRENDS IN MOLECULAR MEDICINE
- Long non-coding RNA SNHG20 promotes non-small cell lung cancer cell proliferation and migration by epigenetically silencing of P21 expression
- (2017) Zhenyao Chen et al. Cell Death & Disease
- p16Ink4a and p21Cip1/Waf1 promote tumour growth by enhancing myeloid-derived suppressor cells chemotaxis
- (2017) Atsushi Okuma et al. Nature Communications
- DNA damage during S-phase mediates the proliferation-quiescence decision in the subsequent G1 via p21 expression
- (2017) Alexis R. Barr et al. Nature Communications
- The Cell Cycle Inhibitors p21 Cip1 and p27 Kip1 Control Proliferation but Enhance DNA Damage Resistance of Glioma Stem Cells
- (2017) Olivia Morris-Hanon et al. NEOPLASIA
- p21(WAF1) Mediates Cell-Cycle Inhibition, Relevant to Cancer Suppression and Therapy
- (2016) Wafik S. El-Deiry CANCER RESEARCH
- Coordinating cell proliferation and differentiation: Antagonism between cell cycle regulators and cell type-specific gene expression
- (2016) Suzan Ruijtenberg et al. CELL CYCLE
- p21 shapes cancer evolution
- (2016) Vasily S. Romanov et al. NATURE CELL BIOLOGY
- Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing
- (2016) Panagiotis Galanos et al. NATURE CELL BIOLOGY
- Mitotic p21Cip1/CDKN1A is regulated by cyclin-dependent kinase 1 phosphorylation
- (2016) Nina-Naomi Kreis et al. Oncotarget
- Increased levels of p21(CIP1/WAF1) correlate with decreased chondrogenic differentiation potential in synovial membrane progenitor cells.
- (2015) Anand Oliveira Masson et al. MECHANISMS OF AGEING AND DEVELOPMENT
- P21 Deficiency Delays Regeneration of Skeletal Muscular Tissue
- (2015) Nobuaki Chinzei et al. PLoS One
- Battle of the eternal rivals: restoring functional p53 and inhibiting Polo-like kinase 1 as cancer therapy
- (2015) Frank Louwen et al. Oncotarget
- Loss of p21Cip1/CDKN1A renders cancer cells susceptible to Polo-like kinase 1 inhibition
- (2015) Nina-Naomi Kreis et al. Oncotarget
- Mislocalization of p27 to the cytoplasm of breast cancer cells confers resistance to anti-HER2 targeted therapy
- (2015) Hui Zhao et al. Oncotarget
- Biology of the cell cycle inhibitor p21CDKN1A: molecular mechanisms and relevance in chemical toxicology
- (2014) Ilaria Dutto et al. ARCHIVES OF TOXICOLOGY
- SOX9 accelerates ESC differentiation to three germ layer lineages by repressing SOX2 expression through P21 (WAF1/CIP1)
- (2014) K. Yamamizu et al. DEVELOPMENT
- Cooperative actions of p21WAF1 and p53 induce Slug protein degradation and suppress cell invasion
- (2014) J. Kim et al. EMBO REPORTS
- Less understood issues: p21Cip1 in mitosis and its therapeutic potential
- (2014) N-N Kreis et al. ONCOGENE
- Differential Expression of STAT1 and p21 Proteins Predicts Pancreatic Cancer Progression and Prognosis
- (2014) Yu Sun et al. PANCREAS
- Cytoplasmic Localization of p21 Protects Trophoblast Giant Cells from DNA Damage Induced Apoptosis
- (2014) Christelle de Renty et al. PLoS One
- A novel p21 attenuator which is structurally related to sorafenib
- (2013) Hiromi I. Wettersten et al. CANCER BIOLOGY & THERAPY
- Small-molecule inhibitors of p21 as novel therapeutics for chemotherapy-resistant kidney cancer
- (2013) Ruiwu Liu et al. Future Medicinal Chemistry
- Lats2 phosphorylates p21/CDKN1A after UV irradiation and regulates apoptosis
- (2013) H. Suzuki et al. JOURNAL OF CELL SCIENCE
- The opposite prognostic significance of nuclear and cytoplasmic p21 expression in resectable gastric cancer patients
- (2013) Yefei Huang et al. JOURNAL OF GASTROENTEROLOGY
- Aberrant promoter hypermethylation of p21 (WAF1/CIP1) gene and its impact on expression and role of polymorphism in the risk of breast cancer
- (2013) Marjan Askari et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- A p21-ZEB1 Complex Inhibits Epithelial-Mesenchymal Transition through the MicroRNA 183-96-182 Cluster
- (2013) X. L. Li et al. MOLECULAR AND CELLULAR BIOLOGY
- Cancer stem cells: The challenges ahead
- (2013) Jan Paul Medema NATURE CELL BIOLOGY
- p21Waf1/Cip1 deficiency causes multiple mitotic defects in tumor cells
- (2013) N-N Kreis et al. ONCOGENE
- PUMA Cooperates with p21 to Regulate Mammary Epithelial Morphogenesis and Epithelial-To-Mesenchymal Transition
- (2013) Yanhong Zhang et al. PLoS One
- p53 Efficiently Suppresses Tumor Development in the Complete Absence of Its Cell-Cycle Inhibitory and Proapoptotic Effectors p21, Puma, and Noxa
- (2013) Liz J. Valente et al. Cell Reports
- Cell cycle regulation by the intrinsically disordered proteins p21 and p27
- (2012) Mi-Kyung Yoon et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- CDK inhibitors (p16/p19/p21) induce senescence and autophagy in cancer-associated fibroblasts, “fueling” tumor growth via paracrine interactions, without an increase in neo-angiogenesis
- (2012) Claudia Capparelli et al. CELL CYCLE
- The Cyclin-Dependent Kinase Inhibitor p21CDKN1A as a Target of Anti-Cancer Drugs
- (2012) L. A. Stivala et al. CURRENT CANCER DRUG TARGETS
- p21WAF1 and tumourigenesis
- (2012) Noel A. Warfel et al. CURRENT OPINION IN ONCOLOGY
- Cellular senescence and cancer chemotherapy resistance
- (2012) Ryan R. Gordon et al. DRUG RESISTANCE UPDATES
- Cytoplasmic translocation of p21 mediates NUPR1-induced chemoresistance
- (2012) Andrew J. Vincent et al. FEBS LETTERS
- Identification of Small Molecule Proliferating Cell Nuclear Antigen (PCNA) Inhibitor That Disrupts Interactions with PIP-box Proteins and Inhibits DNA Replication
- (2012) Chandanamali Punchihewa et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Genetic variants of p27 and p21 as predictors for risk of second primary malignancy in patients with index squamous cell carcinoma of head and neck
- (2012) Zhongqiu Wang et al. Molecular Cancer
- p21 promotes error-free replication-coupled DNA double-strand break repair
- (2012) Maurizio Mauro et al. NUCLEIC ACIDS RESEARCH
- p21CIP1 mediates reciprocal switching between proliferation and invasion during metastasis
- (2012) X Qian et al. ONCOGENE
- Quinacrine-Mediated Autophagy and Apoptosis in Colon Cancer Cells Is Through a p53- and p21-Dependent Mechanism
- (2012) Purusottam Mohapatra et al. ONCOLOGY RESEARCH
- p21 as a Transcriptional Co-Repressor of S-Phase and Mitotic Control Genes
- (2012) Nuria Ferrándiz et al. PLoS One
- Therapeutic targeting of cancer cell cycle using proteasome inhibitors
- (2012) Namrata Rastogi et al. Cell Division
- Knockdown of p21Cip1/Waf1 enhances proliferation, the expression of stemness markers, and osteogenic potential in human mesenchymal stem cells
- (2011) Tu-Lai Yew et al. AGING CELL
- Polo-Box Domain Inhibitor Poloxin Activates the Spindle Assembly Checkpoint and Inhibits Tumor Growth in Vivo
- (2011) Juping Yuan et al. AMERICAN JOURNAL OF PATHOLOGY
- Current progress of siRNA/shRNA therapeutics in clinical trials
- (2011) John C. Burnett et al. Biotechnology Journal
- Cytoplasmic p21 is a potential predictor for cisplatin sensitivity in ovarian cancer
- (2011) Xi Xia et al. BMC CANCER
- Sorafenib attenuates p21 in kidney cancer cells and augments cell death in combination with DNA-damaging chemotherapy
- (2011) Hiromi Inoue et al. CANCER BIOLOGY & THERAPY
- Long-term downregulation of Polo-like kinase 1 increases the cyclin-dependent kinase inhibitor p21WAF1/CIP1
- (2011) Nina-Naomi Kreis et al. CELL CYCLE
- Pharmacologic Activation of p53 by Small-Molecule MDM2 Antagonists
- (2011) Hong Shen et al. CURRENT PHARMACEUTICAL DESIGN
- Four faces of cellular senescence
- (2011) Francis Rodier et al. JOURNAL OF CELL BIOLOGY
- A Perspective on Cancer Cell Metastasis
- (2011) C. L. Chaffer et al. SCIENCE
- Multiple degradation pathways regulate versatile CIP/KIP CDK inhibitors
- (2011) Natalia G. Starostina et al. TRENDS IN CELL BIOLOGY
- Association between p21 Ser31Arg polymorphism and cancer risk: a meta-analysis
- (2011) Hongxia Ma et al. Chinese Journal of Cancer
- p21 Waf1/Cip1 Polymorphisms and Risk of Esophageal Cancer
- (2010) Wenjun Yang et al. ANNALS OF SURGICAL ONCOLOGY
- Activation of p21(CIP1/WAF1) in mammary epithelium accelerates mammary tumorigenesis and promotes lung metastasis
- (2010) Xiaoyun Cheng et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- High throughput screening of a small molecule one-bead-one-compound combinatorial library to identify attenuators of p21 as chemotherapy sensitizers
- (2010) See-Hyoung Park et al. CANCER BIOLOGY & THERAPY
- GATA-1 directly regulates p21 gene expression during erythroid differentiation
- (2010) Michael Papetti et al. CELL CYCLE
- Examination of the expanding pathways for the regulation of p21 expression and activity
- (2010) Yong-Sam Jung et al. CELLULAR SIGNALLING
- CRL2LRR-1 Targets a CDK Inhibitor for Cell Cycle Control in C. elegans and Actin-Based Motility Regulation in Human Cells
- (2010) Natalia G. Starostina et al. DEVELOPMENTAL CELL
- Restoring p53 tumor suppressor activity as an anticancer therapeutic strategy
- (2010) Jesse D Martinez Future Oncology
- Cytoplasmic p21 expression levels determine cisplatin resistance in human testicular cancer
- (2010) Roelof Koster et al. JOURNAL OF CLINICAL INVESTIGATION
- Replicative senescence of human bone marrow and umbilical cord derived mesenchymal stem cells and their differentiation to adipocytes and osteoblasts
- (2010) HuanChen Cheng et al. MOLECULAR BIOLOGY REPORTS
- Multiple roles of the cell cycle inhibitor p21CDKN1A in the DNA damage response
- (2010) Ornella Cazzalini et al. MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
- p21WAF1/CIP1and cancer: A shifting paradigm?
- (2009) Andrei L. Gartel BIOFACTORS
- The role of p53 in limiting somatic cell reprogramming
- (2009) Yan Liu et al. CELL RESEARCH
- Extracellular Signal-Regulated Kinase 2-Dependent Phosphorylation Induces Cytoplasmic Localization and Degradation of p21Cip1
- (2009) C. Y. Hwang et al. MOLECULAR AND CELLULAR BIOLOGY
- Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells
- (2009) Andrea Viale et al. NATURE
- Linking the p53 tumour suppressor pathway to somatic cell reprogramming
- (2009) Teruhisa Kawamura et al. NATURE
- Suppression of induced pluripotent stem cell generation by the p53–p21 pathway
- (2009) Hyenjong Hong et al. NATURE
- p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug
- (2009) Shu-Ping Wang et al. NATURE CELL BIOLOGY
- p21CIP1attenuates Ras- and c-Myc-dependent breast tumor epithelial mesenchymal transition and cancer stem cell-like gene expression in vivo
- (2009) Manran Liu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- CDK Inhibitors: Cell Cycle Regulators and Beyond
- (2008) Arnaud Besson et al. DEVELOPMENTAL CELL
- p21 and p27: roles in carcinogenesis and drug resistance
- (2008) Abde M. Abukhdeir et al. EXPERT REVIEWS IN MOLECULAR MEDICINE
- Cyclin-dependent Kinase Inhibitor, p21WAF1/CIP1, Is Involved in Adipocyte Differentiation and Hypertrophy, Linking to Obesity, and Insulin Resistance
- (2008) Noriyuki Inoue et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- p21 differentially regulates DNA replication and DNA-repair-associated processes after UV irradiation
- (2008) G. Soria et al. JOURNAL OF CELL SCIENCE
- Antisense Attenuation of p21 Sensitizes Kidney Cancer to Apoptosis in Response to Conventional DNA Damaging Chemotherapy Associated With Enhancement of Phospho-p53
- (2008) See-Hyoung Park et al. JOURNAL OF UROLOGY
- MicroRNAs in the miR-106b Family Regulate p21/CDKN1A and Promote Cell Cycle Progression
- (2008) I. Ivanovska et al. MOLECULAR AND CELLULAR BIOLOGY
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now