Revisiting epithelial-mesenchymal transition in cancer metastasis: the connection between epithelial plasticity and stemness

The EMT-activator Zeb1 is a key factor for cell plasticity and promotes metastasis in pancreatic cancer

(2017) Angela M. Krebs et al.   NATURE CELL BIOLOGY

EMT: 2016

(2016) M. Angela Nieto et al.   CELL

let-7 Modulates Chromatin Configuration and Target Gene Repression through Regulation of the ARID3B Complex

(2016) Tsai-Tsen Liao et al.   Cell Reports

OVOL2 Maintains the Transcriptional Program of Human Corneal Epithelium by Suppressing Epithelial-to-Mesenchymal Transition

(2016) Koji Kitazawa et al.   Cell Reports

Plasticity between Epithelial and Mesenchymal States Unlinks EMT from Metastasis-Enhancing Stem Cell Capacity

(2016) Evelyne Beerling et al.   Cell Reports

Vitamin D and the Epithelial to Mesenchymal Transition

(2016) María Jesús Larriba et al.   Stem Cells International

Adoptive T-cell therapy of prostate cancer targeting the cancer stem cell antigen EpCAM

(2015) Zhenling Deng et al.   BMC IMMUNOLOGY

Tracking and Functional Characterization of Epithelial-Mesenchymal Transition and Mesenchymal Tumor Cells during Prostate Cancer Metastasis

(2015) M. Ruscetti et al.   CANCER RESEARCH

Different Levels of Twist1 Regulate Skin Tumor Initiation, Stemness, and Progression

(2015) Benjamin Beck et al.   Cell Stem Cell

Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer

(2015) Xiaofeng Zheng et al.   NATURE

miR-200 promotes the mesenchymal to epithelial transition by suppressing multiple members of the Zeb2 and Snail1 transcriptional repressor complexes

(2015) R Perdigão-Henriques et al.   ONCOGENE

Stem-Cell-like Properties and Epithelial Plasticity Arise as Stable Traits after Transient Twist1 Activation

(2015) Johanna M. Schmidt et al.   Cell Reports

An Ovol2-Zeb1 Mutual Inhibitory Circuit Governs Bidirectional and Multi-step Transition between Epithelial and Mesenchymal States

(2015) Tian Hong et al.   PLoS Computational Biology

Let-7d microRNA affects mesenchymal phenotypic properties of lung fibroblasts

(2014) Luai Huleihel et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Acetylation of Snail Modulates the Cytokinome of Cancer Cells to Enhance the Recruitment of Macrophages

(2014) Dennis Shin-Shian Hsu et al.   CANCER CELL

CD44v6 Is a Marker of Constitutive and Reprogrammed Cancer Stem Cells Driving Colon Cancer Metastasis

(2014) Matilde Todaro et al.   Cell Stem Cell

Mammary Morphogenesis and Regeneration Require the Inhibition of EMT at Terminal End Buds by Ovol2 Transcriptional Repressor

(2014) Kazuhide Watanabe et al.   DEVELOPMENTAL CELL

miR-181a mediates TGF-β-induced hepatocyte EMT and is dysregulated in cirrhosis and hepatocellular cancer

(2014) Jennifer Brockhausen et al.   LIVER INTERNATIONAL

MicroRNA-146a directs the symmetric division of Snail-dominant colorectal cancer stem cells

(2014) Wei-Lun Hwang et al.   NATURE CELL BIOLOGY

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Oct4 is a critical regulator of stemness in head and neck squamous carcinoma cells

(2014) B S Koo et al.   ONCOGENE

Epithelial–mesenchymal transition and cancer stemness: the Twist1–Bmi1 connection

(2013) Kou‑Juey Wu et al.   BIOSCIENCE REPORTS

Connective Tissue Growth Factor Activates Pluripotency Genes and Mesenchymal–Epithelial Transition in Head and Neck Cancer Cells

(2013) Cheng-Chi Chang et al.   CANCER RESEARCH

Regulation of epithelial–mesenchymal and mesenchymal–epithelial transitions by microRNAs

(2013) Samy Lamouille et al.   CURRENT OPINION IN CELL BIOLOGY

Down-Regulation of Vitamin D Receptor in Mammospheres: Implications for Vitamin D Resistance in Breast Cancer and Potential for Combination Therapy

(2013) Shehla Pervin et al.   PLoS One

Transcription Factors OVOL1 and OVOL2 Induce the Mesenchymal to Epithelial Transition in Human Cancer

(2013) Hernan Roca et al.   PLoS One

Epithelial Plasticity: A Common Theme in Embryonic and Cancer Cells

(2013) M. A. Nieto   SCIENCE

Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition

(2013) M. Yu et al.   SCIENCE

TGF-β-Id1 Signaling Opposes Twist1 and Promotes Metastatic Colonization via a Mesenchymal-to-Epithelial Transition

(2013) Marko Stankic et al.   Cell Reports

Cancer Stem Cell Markers in Head and Neck Squamous Cell Carcinoma

(2013) Aidan G. Major et al.   Stem Cells International

Metastatic Colonization Requires the Repression of the Epithelial-Mesenchymal Transition Inducer Prrx1

(2012) Oscar H. Ocaña et al.   CANCER CELL

Spatiotemporal Regulation of Epithelial-Mesenchymal Transition Is Essential for Squamous Cell Carcinoma Metastasis

(2012) Jeff H. Tsai et al.   CANCER CELL

Slug and Sox9 Cooperatively Determine the Mammary Stem Cell State

(2012) Wenjun Guo et al.   CELL

Sal-like protein 4 (SALL4), a stem cell biomarker in liver cancers

(2012) Tsunekazu Oikawa et al.   HEPATOLOGY

The p65 subunit of NF-κB and PARP1 assist Snail1 in activating fibronectin transcription

(2012) Jelena Stanisavljevic et al.   JOURNAL OF CELL SCIENCE

Epithelial-mesenchymal transition can suppress major attributes of human epithelial tumor-initiating cells

(2012) Toni Celià-Terrassa et al.   JOURNAL OF CLINICAL INVESTIGATION

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(2012) Rikke Leth-Larsen et al.   MOLECULAR MEDICINE

Defining the mode of tumour growth by clonal analysis

(2012) Gregory Driessens et al.   NATURE

A restricted cell population propagates glioblastoma growth after chemotherapy

(2012) Jian Chen et al.   NATURE

RAC1 activation mediates Twist1-induced cancer cell migration

(2012) Wen-Hao Yang et al.   NATURE CELL BIOLOGY

Characterization of the SNAG and SLUG Domains of Snail2 in the Repression of E-Cadherin and EMT Induction: Modulation by Serine 4 Phosphorylation

(2012) Patricia Molina-Ortiz et al.   PLoS One

Lineage Tracing Reveals Lgr5+ Stem Cell Activity in Mouse Intestinal Adenomas

(2012) A. G. Schepers et al.   SCIENCE

Monoclonal Antibodies Against Lgr5 Identify Human Colorectal Cancer Stem Cells

(2012) Kristel Kemper et al.   STEM CELLS

EMT Inducers Catalyze Malignant Transformation of Mammary Epithelial Cells and Drive Tumorigenesis towards Claudin-Low Tumors in Transgenic Mice

(2012) Anne-Pierre Morel et al.   PLoS Genetics

Epithelial-mesenchymal transition and stemness features in circulating tumor cells from breast cancer patients

(2011) Cristina Raimondi et al.   BREAST CANCER RESEARCH AND TREATMENT

Detection of circulating tumour cells with a hybrid (epithelial/mesenchymal) phenotype in patients with metastatic non-small cell lung cancer

(2011) A Lecharpentier et al.   BRITISH JOURNAL OF CANCER

The EMT regulator slug and lung carcinogenesis

(2011) J.-Y. Shih et al.   CARCINOGENESIS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Linkage between Twist1 and Bmi1: Molecular mechanism of cancer metastasis/stemness and clinical implications

(2011) Chung-Yin Wu et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

SNAIL Regulates Interleukin-8 Expression, Stem Cell–Like Activity, and Tumorigenicity of Human Colorectal Carcinoma Cells

(2011) Wei–Lun Hwang et al.   GASTROENTEROLOGY

Functional Cooperation between Snail1 and Twist in the Regulation ofZEB1Expression during Epithelial to Mesenchymal Transition

(2011) Natàlia Dave et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An autocrine TGF-β/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition

(2011) Philip A. Gregory et al.   MOLECULAR BIOLOGY OF THE CELL

Mechanism of the Mesenchymal-Epithelial Transition and Its Relationship with Metastatic Tumor Formation

(2011) D. Yao et al.   MOLECULAR CANCER RESEARCH

Circulating Tumor Cells from Patients with Advanced Prostate and Breast Cancer Display Both Epithelial and Mesenchymal Markers

(2011) A. J. Armstrong et al.   MOLECULAR CANCER RESEARCH

Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization

(2011) Manav Korpal et al.   NATURE MEDICINE

A dynamic in vivo model of epithelial-to-mesenchymal transitions in circulating tumor cells and metastases of breast cancer

(2011) A Bonnomet et al.   ONCOGENE

Sox2 expression in breast tumours and activation in breast cancer stem cells

(2011) O Leis et al.   ONCOGENE

Analysis of Epithelial and Mesenchymal Markers in Ovarian Cancer Reveals Phenotypic Heterogeneity and Plasticity

(2011) Robert Strauss et al.   PLoS One

Epithelial and Mesenchymal Subpopulations Within Normal Basal Breast Cell Lines Exhibit Distinct Stem Cell/Progenitor Properties

(2011) David Sarrio et al.   STEM CELLS

Inhibition and Role of let-7d in Idiopathic Pulmonary Fibrosis

(2010) Kusum V. Pandit et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Epidermal Growth Factor Receptor and Mutant p53 Expand an Esophageal Cellular Subpopulation Capable of Epithelial-to-Mesenchymal Transition through ZEB Transcription Factors

(2010) S. Ohashi et al.   CANCER RESEARCH

Endothelial Cell-Initiated Signaling Promotes the Survival and Self-Renewal of Cancer Stem Cells

(2010) S. Krishnamurthy et al.   CANCER RESEARCH

A MicroRNA Targeting Dicer for Metastasis Control

(2010) Graziano Martello et al.   CELL

A Mesenchymal-to-Epithelial Transition Initiates and Is Required for the Nuclear Reprogramming of Mouse Fibroblasts

(2010) Ronghui Li et al.   Cell Stem Cell

Functional Genomics Reveals a BMP-Driven Mesenchymal-to-Epithelial Transition in the Initiation of Somatic Cell Reprogramming

(2010) Payman Samavarchi-Tehrani et al.   Cell Stem Cell

Regulation of Excision Repair Cross-Complementation Group 1 by Snail Contributes to Cisplatin Resistance in Head and Neck Cancer

(2010) D. S.-S. Hsu et al.   CLINICAL CANCER RESEARCH

The Role of Notch Signaling Pathway in Epithelial-Mesenchymal Transition (EMT) During Development and Tumor Aggressiveness

(2010) Zhiwei Wang et al.   CURRENT DRUG TARGETS

The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine-specific demethylase 1

(2010) Yiwei Lin et al.   EMBO JOURNAL

Bmi1 is essential in Twist1-induced epithelial–mesenchymal transition

(2010) Muh-Hwa Yang et al.   NATURE CELL BIOLOGY

Requirement of the histone demethylase LSD1 in Snai1-mediated transcriptional repression during epithelial-mesenchymal transition

(2010) T Lin et al.   ONCOGENE

Epithelial to Mesenchymal Transition Is Mechanistically Linked with Stem Cell Signatures in Prostate Cancer Cells

(2010) Dejuan Kong et al.   PLoS One

High expression of CXCR4 may predict poor survival in resected pancreatic adenocarcinoma

(2009) R Maréchal et al.   BRITISH JOURNAL OF CANCER

Circulating tumor cells with a putative stem cell phenotype in peripheral blood of patients with breast cancer

(2009) Panayiotis A. Theodoropoulos et al.   CANCER LETTERS

The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs

(2009) Ulrich Wellner et al.   NATURE CELL BIOLOGY

p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug

(2009) Shu-Ping Wang et al.   NATURE CELL BIOLOGY

Expression of standard CD44 in human colorectal carcinoma: Association with prognosis

(2009) Jung Wook Huh et al.   PATHOLOGY INTERNATIONAL

miR-200 Enhances Mouse Breast Cancer Cell Colonization to Form Distant Metastases

(2009) Derek M. Dykxhoorn et al.   PLoS One

In vivo binding to and functional repression of the VDR gene promoter by SLUG in human breast cells

(2008) Mukul K. Mittal et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

CD44+CD24− prostate cells are early cancer progenitor/stem cells that provide a model for patients with poor prognosis

(2008) E M Hurt et al.   BRITISH JOURNAL OF CANCER

Induction of EMT by Twist Proteins as a Collateral Effect of Tumor-Promoting Inactivation of Premature Senescence

(2008) Stéphane Ansieau et al.   CANCER CELL

A Double-Negative Feedback Loop between ZEB1-SIP1 and the microRNA-200 Family Regulates Epithelial-Mesenchymal Transition

(2008) C. P. Bracken et al.   CANCER RESEARCH

The Role of CD133 in Normal Human Prostate Stem Cells and Malignant Cancer-Initiating Cells

(2008) D. J. Vander Griend et al.   CANCER RESEARCH

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

CD44 is of Functional Importance for Colorectal Cancer Stem Cells

(2008) L. Du et al.   CLINICAL CANCER RESEARCH

The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2

(2008) S.-M. Park et al.   GENES & DEVELOPMENT

The miR-200 Family Inhibits Epithelial-Mesenchymal Transition and Cancer Cell Migration by Direct Targeting of E-cadherin Transcriptional RepressorsZEB1andZEB2

(2008) Manav Korpal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Slug is a direct Notch target required for initiation of cardiac cushion cellularization

(2008) Kyle Niessen et al.   JOURNAL OF CELL BIOLOGY

Polycomb Complex 2 Is Required for E-cadherin Repression by the Snail1 Transcription Factor

(2008) N. Herranz et al.   MOLECULAR AND CELLULAR BIOLOGY

Aldehyde Dehydrogenase Discriminates the CD133 Liver Cancer Stem Cell Populations

(2008) S. Ma et al.   MOLECULAR CANCER RESEARCH

A hypoxic twist in metastasis

(2008) Héctor Peinado et al.   NATURE CELL BIOLOGY

Direct regulation of TWIST by HIF-1α promotes metastasis

(2008) Muh-Hwa Yang et al.   NATURE CELL BIOLOGY

The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1

(2008) Philip A. Gregory et al.   NATURE CELL BIOLOGY

Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity

(2008) L. Vermeulen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA