Podocyte Injury in Lupus Nephritis

Integration of Genetic Testing and Pathology for the Diagnosis of Adults with FSGS

(2019) Tony Yao et al.   Clinical Journal of the American Society of Nephrology

A20 overexpression exerts protective effects on podocyte injury in lupus nephritis by downregulating UCH-L1

(2019) Ling Sun et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Pathogenesis of lupus nephritis: RIP3 dependent necroptosis and NLRP3 inflammasome activation

(2019) Chaohuan Guo et al.   JOURNAL OF AUTOIMMUNITY

CaMK4 compromises podocyte function in autoimmune and nonautoimmune kidney disease

(2018) Kayaho Maeda et al.   JOURNAL OF CLINICAL INVESTIGATION

The Crescentic Implication of Renal Outcomes in Proliferative Lupus Nephritis

(2018) Fanghao Cai et al.   JOURNAL OF RHEUMATOLOGY

Actin dynamics at focal adhesions: a common endpoint and putative therapeutic target for proteinuric kidney diseases

(2018) Sanja Sever et al.   KIDNEY INTERNATIONAL

CD44 is required for the pathogenesis of experimental crescentic glomerulonephritis and collapsing focal segmental glomerulosclerosis

(2018) Jennifer Eymael et al.   KIDNEY INTERNATIONAL

APOL1: The Balance Imposed by Infection, Selection, and Kidney Disease

(2018) Pazit Beckerman et al.   TRENDS IN MOLECULAR MEDICINE

CXCL12 blockade preferentially regenerates lost podocytes in cortical nephrons by targeting an intrinsic podocyte-progenitor feedback mechanism

(2018) Simone Romoli et al.   KIDNEY INTERNATIONAL

Expression of CMIP in podocytes is restricted to specific classes of lupus nephritis

(2018) Khedidja Bouachi et al.   PLoS One

Activated ERK1/2 increases CD44 in glomerular parietal epithelial cells leading to matrix expansion

(2017) Sebastian S. Roeder et al.   KIDNEY INTERNATIONAL

Potential relevance of shear stress for slit diaphragm and podocyte function

(2017) Wilhelm Kriz et al.   KIDNEY INTERNATIONAL

Mesangial proliferative lupus nephritis with podocytopathy: a special entity of lupus nephritis

(2017) S F Wang et al.   LUPUS

Transgenic expression of human APOL1 risk variants in podocytes induces kidney disease in mice

(2017) Pazit Beckerman et al.   NATURE MEDICINE

A tripartite complex of suPAR, APOL1 risk variants and αvβ3 integrin on podocytes mediates chronic kidney disease

(2017) Salim S Hayek et al.   NATURE MEDICINE

Redefining lupus nephritis: clinical implications of pathophysiologic subtypes

(2017) Feng Yu et al.   Nature Reviews Nephrology

Bi-nucleation of podocytes is uniformly accompanied by foot processes widening in renal disease

(2017) Johanna Mühldorfer et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Genetic and pharmacological inhibition of microRNA-92a maintains podocyte cell cycle quiescence and limits crescentic glomerulonephritis

(2017) Carole Henique et al.   Nature Communications

Podocyte Activation of NLRP3 Inflammasomes Contributes to the Development of Proteinuria in Lupus Nephritis

(2017) Rong Fu et al.   Arthritis & Rheumatology

Etiology and Outcome of Crescentic Glomerulonephritis From a Single Center in China: A 10-Year Review

(2016) Shasha Chen et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Personalized Immunomonitoring Uncovers Molecular Networks that Stratify Lupus Patients

(2016) Romain Banchereau et al.   CELL

Lupus Podocytopathy: A Distinct Entity

(2016) A. S. Bomback et al.   Clinical Journal of the American Society of Nephrology

Update on Lupus Nephritis

(2016) Salem Almaani et al.   Clinical Journal of the American Society of Nephrology

Clinical-Morphological Features and Outcomes of Lupus Podocytopathy

(2016) W. Hu et al.   Clinical Journal of the American Society of Nephrology

Podocyte injury and its consequences

(2016) Michio Nagata   KIDNEY INTERNATIONAL

The costimulatory receptor B7-1 is not induced in injured podocytes

(2016) Emilie Baye et al.   KIDNEY INTERNATIONAL

Podocyte–actin dynamics in health and disease

(2016) Luca Perico et al.   Nature Reviews Nephrology

Next generation sequencing and functional analysis of patient urine renal progenitor-derived podocytes to unravel the diagnosis underlying refractory lupus nephritis

(2016) Paola Romagnani et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Urinary dedifferentiated podocytes as a non-invasive biomarker of lupus nephritis

(2016) Javier Perez-Hernandez et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Is there a role for urinary podocyte excretion assessment in lupus nephritis?

(2016) Juliana B. Mansur et al.   RENAL FAILURE

Lupus Nephritis IgG Induction of Calcium/Calmodulin-Dependent Protein Kinase IV Expression in Podocytes and Alteration of Their Function

(2016) Kunihiro Ichinose et al.   Arthritis & Rheumatology

Risk of End-Stage Renal Disease in Patients With Lupus Nephritis, 1971-2015: A Systematic Review and Bayesian Meta-Analysis

(2016) Maria G. Tektonidou et al.   Arthritis & Rheumatology

Prediction of Renal Outcomes in Patients With Crescentic Lupus Nephritis

(2015) Shasha Chen et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Glomerular parietal epithelial cells contribute to adult podocyte regeneration in experimental focal segmental glomerulosclerosis

(2015) Diana G. Eng et al.   KIDNEY INTERNATIONAL

What is damaging the kidney in lupus nephritis?

(2015) Anne Davidson   Nature Reviews Rheumatology

Tacrolimus Protects Podocytes from Injury in Lupus Nephritis Partly by Stabilizing the Cytoskeleton and Inhibiting Podocyte Apoptosis

(2015) Ruyi Liao et al.   PLoS One

Glomerular Autoimmune Multicomponents of Human Lupus Nephritis In Vivo:  -Enolase and Annexin AI

(2014) M. Bruschi et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The emergence of the glomerular parietal epithelial cell

(2014) Stuart J. Shankland et al.   Nature Reviews Nephrology

Prevalence of CD44-Positive Glomerular Parietal Epithelial Cells Reflects Podocyte Injury in Adriamycin Nephropathy

(2014) Takayuki Okamoto et al.   NEPHRON EXPERIMENTAL NEPHROLOGY

Podocyte involvement in lupus nephritis based on the 2003 ISN/RPS system: a large cohort study from a single centre

(2014) Yan Wang et al.   RHEUMATOLOGY

Update on crescentic glomerulonephritis

(2014) Carole Hénique et al.   Seminars in Immunopathology

Treatment of Lupus Nephritis With Abatacept: The Abatacept and Cyclophosphamide Combination Efficacy and Safety Study

(2014)   Arthritis & Rheumatology

The regulation of the UCH-L1 gene by transcription factor NF-κB in podocytes

(2013) Hongxia Zhang et al.   CELLULAR SIGNALLING

suPAR: The Molecular Crystal Ball

(2013) Maria Thunø et al.   DISEASE MARKERS

Apolipoprotein L1 Risk Variants Associate with Systemic Lupus Erythematosus-Associated Collapsing Glomerulopathy

(2013) C. P. Larsen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Podocytes Are Nonhematopoietic Professional Antigen-Presenting Cells

(2013) A. Goldwich et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Aberrant Notch1-dependent effects on glomerular parietal epithelial cells promotes collapsing focal segmental glomerulosclerosis with progressive podocyte loss

(2013) Toshiharu Ueno et al.   KIDNEY INTERNATIONAL

Podocyte-specific deletion of signal transducer and activator of transcription 3 attenuates nephrotoxic serum–induced glomerulonephritis

(2013) Yan Dai et al.   KIDNEY INTERNATIONAL

Upregulation of c-mip is closely related to podocyte dysfunction in membranous nephropathy

(2013) Kelhia Sendeyo et al.   KIDNEY INTERNATIONAL

Expression patterns of RelA and c-mip are associated with different glomerular diseases following anti-VEGF therapy

(2013) Hassan Izzedine et al.   KIDNEY INTERNATIONAL

Podocyte injury in pure membranous and proliferative lupus nephritis: distinct underlying mechanisms of proteinuria?

(2013) GM Rezende et al.   LUPUS

Proteinuria in membranous lupus nephritis: the pathology is in the podocyte

(2013) N Desai et al.   LUPUS

End-Stage Renal Disease in African Americans With Lupus Nephritis Is Associated WithAPOL1

(2013) Barry I. Freedman et al.   Arthritis & Rheumatology

Efficacy and Safety of Abatacept in Lupus Nephritis: A Twelve-Month, Randomized, Double-Blind Study

(2013) Richard Furie et al.   Arthritis & Rheumatology

Podocyte Mitosis - A Catastrophe

(2012) L. Lasagni et al.   CURRENT MOLECULAR MEDICINE

Anti-DNA autoantibodies initiate experimental lupus nephritis by binding directly to the glomerular basement membrane in mice

(2012) Meera R. Krishnan et al.   KIDNEY INTERNATIONAL

Long- and short-term treatment with imatinib attenuates the development of chronic kidney disease in experimental anti-glomerular basement membrane nephritis

(2012) Masayuki Iyoda et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Novel target in the treatment of RPGN: the activated parietal cell

(2012) Marcus J. Moeller et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

MYH9 and APOL1 are both associated with sickle cell disease nephropathy

(2011) Allison E. Ashley-Koch et al.   BRITISH JOURNAL OF HAEMATOLOGY

APOL1 Genetic Variants in Focal Segmental Glomerulosclerosis and HIV-Associated Nephropathy

(2011) J. B. Kopp et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Podocyte main slit diaphragm proteins, nephrin and podocin, are affected at early stages of lupus nephritis and correlate with disease histology

(2011) GS Perysinaki et al.   LUPUS

Epidermal growth factor receptor promotes glomerular injury and renal failure in rapidly progressive crescentic glomerulonephritis

(2011) Guillaume Bollée et al.   NATURE MEDICINE

Anti-dsDNA Antibodies Bind to Mesangial Annexin II in Lupus Nephritis

(2010) S. Yung et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Expression of Toll-like receptor 9 in renal podocytes in childhood-onset active and inactive lupus nephritis

(2010) H. Machida et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Association of Trypanolytic ApoL1 Variants with Kidney Disease in African Americans

(2010) G. Genovese et al.   SCIENCE

c-mip Impairs Podocyte Proximal Signaling and Induces Heavy Proteinuria

(2010) S. y. Zhang et al.   Science Signaling

Notch Activation Differentially Regulates Renal Progenitors Proliferation and Differentiation Toward the Podocyte Lineage in Glomerular Disorders

(2010) Laura Lasagni et al.   STEM CELLS

Tracing the Origin of Glomerular Extracapillary Lesions from Parietal Epithelial Cells

(2009) B. Smeets et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Preventive and therapeutic effects of imatinib in Wistar-Kyoto rats with anti-glomerular basement membrane glomerulonephritis

(2009) Masayuki Iyoda et al.   KIDNEY INTERNATIONAL

UCH-L1 expression of podocytes in diseased glomeruli andin vitro

(2008) Yuan Liu et al.   JOURNAL OF PATHOLOGY

A new role for the neuronal ubiquitin C-terminal hydrolase-L1 (UCH-L1) in podocyte process formation and podocyte injury in human glomerulopathies

(2008) C Meyer-Schwesinger et al.   JOURNAL OF PATHOLOGY

Podocytes Contribute to the Formation of Glomerular Crescents

(2008) P. S. Thorner et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The actin cytoskeleton of kidney podocytes is a direct target of the antiproteinuric effect of cyclosporine A

(2008) Christian Faul et al.   NATURE MEDICINE

Activation of signal transducer and activator of transcription 3 correlates with cell proliferation and renal injury in human glomerulonephritis

(2008) T. Arakawa et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION