The Length of the Expressed 3′ UTR Is an Intermediate Molecular Phenotype Linking Genetic Variants to Complex Diseases
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Title
The Length of the Expressed 3′ UTR Is an Intermediate Molecular Phenotype Linking Genetic Variants to Complex Diseases
Authors
Keywords
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Journal
Frontiers in Genetics
Volume 10, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2019-08-16
DOI
10.3389/fgene.2019.00714
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Note: Only part of the references are listed.- Chromatin three-dimensional interactions mediate genetic effects on gene expression
- (2019) O. Delaneau et al. SCIENCE
- Sequence, Structure, and Context Preferences of Human RNA Binding Proteins
- (2018) Daniel Dominguez et al. MOLECULAR CELL
- Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights
- (2018) Alexander Gusev et al. NATURE GENETICS
- A brave new world of RNA-binding proteins
- (2018) Matthias W. Hentze et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- VIRMA mediates preferential m6A mRNA methylation in 3′UTR and near stop codon and associates with alternative polyadenylation
- (2018) Yanan Yue et al. Cell Discovery
- Integrative transcriptome analyses of the aging brain implicate altered splicing in Alzheimer’s disease susceptibility
- (2018) Towfique Raj et al. NATURE GENETICS
- What Are 3′ UTRs Doing?
- (2018) Christine Mayr Cold Spring Harbor Perspectives in Biology
- The immunogenetics of neurological disease
- (2017) Maneesh K. Misra et al. IMMUNOLOGY
- Posttranscriptional Regulation of HLA-A Protein Expression by Alternative Polyadenylation Signals Involving the RNA-Binding Protein Syncrip
- (2017) Smita Kulkarni et al. JOURNAL OF IMMUNOLOGY
- Genetic effects on gene expression across human tissues
- (2017) François Aguet et al. NATURE
- Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes
- (2017) James D McKay et al. NATURE GENETICS
- A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci
- (2017) Diana Chang et al. NATURE GENETICS
- Overexpression of the Cytokine BAFF and Autoimmunity Risk
- (2017) Maristella Steri et al. NEW ENGLAND JOURNAL OF MEDICINE
- OUP accepted manuscript
- (2017) NUCLEIC ACIDS RESEARCH
- Ensembl 2018
- (2017) Daniel R Zerbino et al. NUCLEIC ACIDS RESEARCH
- Genome-wide identification of splicing QTLs in the human brain and their enrichment among schizophrenia-associated loci
- (2017) Atsushi Takata et al. Nature Communications
- Roar: detecting alternative polyadenylation with standard mRNA sequencing libraries
- (2016) Elena Grassi et al. BMC BIOINFORMATICS
- A comprehensive analysis of 3′ end sequencing data sets reveals novel polyadenylation signals and the repressive role of heterogeneous ribonucleoprotein C on cleavage and polyadenylation
- (2016) Andreas J. Gruber et al. GENOME RESEARCH
- HLA-F coding and regulatory segments variability determined by massively parallel sequencing procedures in a Brazilian population sample
- (2016) Thálitta Hetamaro Ayala Lima et al. HUMAN IMMUNOLOGY
- Integrative approaches for large-scale transcriptome-wide association studies
- (2016) Alexander Gusev et al. NATURE GENETICS
- Alternative polyadenylation of mRNA precursors
- (2016) Bin Tian et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Regulation of disease-associated gene expression in the 3D genome
- (2016) Peter Hugo Lodewijk Krijger et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- The roles of RNA processing in translating genotype to phenotype
- (2016) Kassie S. Manning et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- The new NHGRI-EBI Catalog of published genome-wide association studies (GWAS Catalog)
- (2016) Jacqueline MacArthur et al. NUCLEIC ACIDS RESEARCH
- Translational control by 5'-untranslated regions of eukaryotic mRNAs
- (2016) A. G. Hinnebusch et al. SCIENCE
- Tunable protein synthesis by transcript isoforms in human cells
- (2016) Stephen N Floor et al. eLife
- Sam68 promotes self-renewal and glycolytic metabolism in mouse neural progenitor cells by modulating Aldh1a3 pre-mRNA 3'-end processing
- (2016) Piergiorgio La Rosa et al. eLife
- Sequence variation between 462 human individuals fine-tunes functional sites of RNA processing
- (2016) Pedro G. Ferreira et al. Scientific Reports
- The end of the message: multiple protein–RNA interactions define the mRNA polyadenylation site
- (2015) Yongsheng Shi et al. GENES & DEVELOPMENT
- HLA-E coding and 3′ untranslated region variability determined by next-generation sequencing in two West-African population samples
- (2015) Erick C. Castelli et al. HUMAN IMMUNOLOGY
- ELAV Links Paused Pol II to Alternative Polyadenylation in the Drosophila Nervous System
- (2015) Katarzyna Oktaba et al. MOLECULAR CELL
- Alternative 3′ UTRs act as scaffolds to regulate membrane protein localization
- (2015) Binyamin D. Berkovits et al. NATURE
- A global reference for human genetic variation
- (2015) Richard A. Gibbs et al. NATURE
- A gene-based association method for mapping traits using reference transcriptome data
- (2015) Eric R Gamazon et al. NATURE GENETICS
- The role of regulatory variation in complex traits and disease
- (2015) Frank W. Albert et al. NATURE REVIEWS GENETICS
- Reference sequence (RefSeq) database at NCBI: current status, taxonomic expansion, and functional annotation
- (2015) Nuala A. O'Leary et al. NUCLEIC ACIDS RESEARCH
- The Ro60 autoantigen binds endogenous retroelements and regulates inflammatory gene expression
- (2015) T. Hung et al. SCIENCE
- The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans
- (2015) et al. SCIENCE
- Predicting effective microRNA target sites in mammalian mRNAs
- (2015) Vikram Agarwal et al. eLife
- Second-generation PLINK: rising to the challenge of larger and richer datasets
- (2015) Christopher C Chang et al. GigaScience
- Altered Gene Expression Associated with microRNA Binding Site Polymorphisms
- (2015) Urmo Võsa et al. PLoS One
- IRF5-mediated signaling and implications for SLE
- (2014) Elisa Lazzari et al. CLINICAL IMMUNOLOGY
- CFIm25 links alternative polyadenylation to glioblastoma tumour suppression
- (2014) Chioniso P. Masamha et al. NATURE
- APASdb: a database describing alternative poly(A) sites and selection of heterogeneous cleavage sites downstream of poly(A) signals
- (2014) Leiming You et al. NUCLEIC ACIDS RESEARCH
- The human splicing code reveals new insights into the genetic determinants of disease
- (2014) H. Y. Xiong et al. SCIENCE
- Identification of genetic variants associated with alternative splicing using sQTLseekeR
- (2014) Jean Monlong et al. Nature Communications
- Genetic determinants of amidating enzyme activity and its relationship with metal cofactors in human serum
- (2014) Eric D Gaier et al. BMC Endocrine Disorders
- 3' UTR-isoform choice has limited influence on the stability and translational efficiency of most mRNAs in mouse fibroblasts
- (2013) N. Spies et al. GENOME RESEARCH
- A compendium of RNA-binding motifs for decoding gene regulation
- (2013) Debashish Ray et al. NATURE
- Transcriptome and genome sequencing uncovers functional variation in humans
- (2013) Tuuli Lappalainen et al. NATURE
- Alternative cleavage and polyadenylation: extent, regulation and function
- (2013) Ran Elkon et al. NATURE REVIEWS GENETICS
- DeepSAGE Reveals Genetic Variants Associated with Alternative Polyadenylation and Expression of Coding and Non-coding Transcripts
- (2013) Daria V. Zhernakova et al. PLoS Genetics
- Using eQTL weights to improve power for genome-wide association studies: a genetic study of childhood asthma
- (2013) Lin Li et al. Frontiers in Genetics
- Matrix eQTL: ultra fast eQTL analysis via large matrix operations
- (2012) A. A. Shabalin BIOINFORMATICS
- Ccr4-Not complex: the control freak of eukaryotic cells
- (2012) Jason E. Miller et al. CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
- Shortening of 3′UTRs Correlates with Poor Prognosis in Breast and Lung Cancer
- (2012) Antonio Lembo et al. PLoS One
- Single Nucleotide Polymorphisms Can Create Alternative Polyadenylation Signals and Affect Gene Expression through Loss of MicroRNA-Regulation
- (2012) Laurent F. Thomas et al. PLoS Computational Biology
- Genetics and Regulatory Impact of Alternative Polyadenylation in Human B-Lymphoblastoid Cells
- (2012) Oh Kyu Yoon et al. PLoS Genetics
- The variant call format and VCFtools
- (2011) P. Danecek et al. BIOINFORMATICS
- FIMO: scanning for occurrences of a given motif
- (2011) Charles E. Grant et al. BIOINFORMATICS
- Differential genome-wide profiling of tandem 3' UTRs among human breast cancer and normal cells by high-throughput sequencing
- (2011) Y. Fu et al. GENOME RESEARCH
- Toward molecular trait-based ecology through integration of biogeochemical, geographical and metagenomic data
- (2011) J. Raes et al. Molecular Systems Biology
- Mapping and analysis of chromatin state dynamics in nine human cell types
- (2011) Jason Ernst et al. NATURE
- Genetic variants and disease-associated factors contribute to enhanced IRF-5 expression in blood cells of systemic lupus erythematosus patients
- (2010) Di Feng et al. ARTHRITIS AND RHEUMATISM
- LocusZoom: regional visualization of genome-wide association scan results
- (2010) R. J. Pruim et al. BIOINFORMATICS
- Modeling sample variables with an Experimental Factor Ontology
- (2010) James Malone et al. BIOINFORMATICS
- The Sequence Read Archive
- (2010) R. Leinonen et al. NUCLEIC ACIDS RESEARCH
- TopHat: discovering splice junctions with RNA-Seq
- (2009) Cole Trapnell et al. BIOINFORMATICS
- 118 SNPs of folate-related genes and risks of spina bifida and conotruncal heart defects
- (2009) Gary M Shaw et al. BMC Medical Genetics
- Widespread Shortening of 3′UTRs by Alternative Cleavage and Polyadenylation Activates Oncogenes in Cancer Cells
- (2009) Christine Mayr et al. CELL
- Mapping identifiers for the integration of genomic datasets with the R/Bioconductor package biomaRt
- (2009) Steffen Durinck et al. Nature Protocols
- Mapping complex disease traits with global gene expression
- (2009) William Cookson et al. NATURE REVIEWS GENETICS
- A physical and functional link between splicing factors promotes pre-mRNA 3′ end processing
- (2009) Stefania Millevoi et al. NUCLEIC ACIDS RESEARCH
- Progressive lengthening of 3' untranslated regions of mRNAs by alternative polyadenylation during mouse embryonic development
- (2009) Z. Ji et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Ultrafast and memory-efficient alignment of short DNA sequences to the human genome
- (2009) Ben Langmead et al. GENOME BIOLOGY
- Long-Range LD Can Confound Genome Scans in Admixed Populations
- (2008) Alkes L. Price et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Distinct Role of Long 3′ UTR BDNF mRNA in Spine Morphology and Synaptic Plasticity in Hippocampal Neurons
- (2008) Juan Ji An et al. CELL
- Genes mirror geography within Europe
- (2008) John Novembre et al. NATURE
- Genome-wide analysis of transcript isoform variation in humans
- (2008) Tony Kwan et al. NATURE GENETICS
- Proliferating Cells Express mRNAs with Shortened 3' Untranslated Regions and Fewer MicroRNA Target Sites
- (2008) R. Sandberg et al. SCIENCE
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