Host Factor SAMHD1 Restricts DNA Viruses in Non-Dividing Myeloid Cells

Protein Kinase C Overexpression Does Not Enhance Immune-Stimulatory Surface Markers of Vaccinia-Infected Dendritic Cells and DC Cell Lines

(2013) Hartwig P. Huemer et al.   IMMUNOLOGICAL INVESTIGATIONS

Tetramerization of SAMHD1 Is Required for Biological Activity and Inhibition of HIV Infection

(2013) Junpeng Yan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic pathways as regulators of HIV infection

(2013) Marco Craveiro et al.   Current Opinion in HIV and AIDS

Ribonucleotide Reductase Activity Is Coupled to DNA Synthesis via Proliferating Cell Nuclear Antigen

(2012) Israel Salguero et al.   CURRENT BIOLOGY

Efficient transduction of myeloid cells by an HIV-1-derived lentiviral vector that packages the Vpx accessory protein

(2012) S Bobadilla et al.   GENE THERAPY

Tight Interplay among SAMHD1 Protein Level, Cellular dNTP Levels, and HIV-1 Proviral DNA Synthesis Kinetics in Human Primary Monocyte-derived Macrophages

(2012) Baek Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The interaction of metabolic factors with HCV infection: Does it matter?

(2012) Elisabetta Bugianesi et al.   JOURNAL OF HEPATOLOGY

SAMHD1 Restricts HIV-1 Cell-to-Cell Transmission and Limits Immune Detection in Monocyte-Derived Dendritic Cells

(2012) I. Puigdomenech et al.   JOURNAL OF VIROLOGY

The Vpx Lentiviral Accessory Protein Targets SAMHD1 for Degradation in the Nucleus

(2012) H. Hofmann et al.   JOURNAL OF VIROLOGY

SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates

(2012) Hichem Lahouassa et al.   NATURE IMMUNOLOGY

SAMHD1 restricts HIV-1 infection in resting CD4+ T cells

(2012) Hanna-Mari Baldauf et al.   NATURE MEDICINE

SAMHD1 restricts HIV-1 infection in dendritic cells (DCs) by dNTP depletion, but its expression in DCs and primary CD4+ T-lymphocytes cannot be upregulated by interferons

(2012) Corine St Gelais et al.   Retrovirology

SAMHD1 restricts HIV-1 reverse transcription in quiescent CD4+ T-cells

(2012) Benjamin Descours et al.   Retrovirology

Contribution of SAM and HD domains to retroviral restriction mediated by human SAMHD1

(2012) Tommy E. White et al.   VIROLOGY

Intracellular nucleotide levels and the control of retroviral infections

(2012) Sarah M. Amie et al.   VIROLOGY

Leishmania Induces Survival, Proliferation and Elevated Cellular dNTP Levels in Human Monocytes Promoting Acceleration of HIV Co-Infection

(2012) David J. Mock et al.   PLoS Pathogens

Immunology in the Clinic Review Series; focus on host responses: T cell responses to herpes simplex viruses

(2011) K. J. Laing et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Innate immune recognition of poxviral vaccine vectors

(2011) Erin L Lousberg et al.   Expert Review of Vaccines

Vaccinia viruses: vaccines against smallpox and vectors against infectious diseases and tumors

(2011) Stephen R Walsh et al.   Expert Review of Vaccines

Aicardi-Goutières Syndrome Gene and HIV-1 Restriction Factor SAMHD1 Is a dGTP-regulated Deoxynucleotide Triphosphohydrolase

(2011) Rebecca D. Powell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nuclear delivery mechanism of herpes simplex virus type 1 genome

(2011) Ivan Liashkovich et al.   JOURNAL OF MOLECULAR RECOGNITION

How vaccinia virus has evolved to subvert the host immune response

(2011) Mohammad W. Bahar et al.   JOURNAL OF STRUCTURAL BIOLOGY

The Virion Host Shutoff Protein of Herpes Simplex Virus 1 Blocks the Replication-Independent Activation of NF- B in Dendritic Cells in the Absence of Type I Interferon Signaling

(2011) C. R. Cotter et al.   JOURNAL OF VIROLOGY

HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase

(2011) David C. Goldstone et al.   NATURE

SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx

(2011) Nadine Laguette et al.   NATURE

Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein

(2011) Kasia Hrecka et al.   NATURE

A simple, versatile and efficient method to genetically modify human monocyte-derived dendritic cells with HIV-1–derived lentiviral vectors

(2011) Grégory Berger et al.   Nature Protocols

Stunned Silence: Gene Expression Programs in Human Cells Infected with Monkeypox or Vaccinia Virus

(2011) Kathleen H. Rubins et al.   PLoS One

SAMHD1: a new insight into HIV-1 restriction in myeloid cells

(2011) Corine St Gelais et al.   Retrovirology

Restricted Access to Myeloid Cells Explained

(2011) Vicente Planelles   Viruses-Basel

Induction of Noxa-Mediated Apoptosis by Modified Vaccinia Virus Ankara Depends on Viral Recognition by Cytosolic Helicases, Leading to IRF-3/IFN-β-Dependent Induction of Pro-Apoptotic Noxa

(2011) Pedro Eitz Ferrer et al.   PLoS Pathogens

SAMHD1-Deficient CD14+ Cells from Individuals with Aicardi-Goutières Syndrome Are Highly Susceptible to HIV-1 Infection

(2011) André Berger et al.   PLoS Pathogens

Chromatin dynamics during herpes simplex virus-1 lytic infection

(2010) Brandon J. Placek et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Ribonucleoside Triphosphates as Substrate of Human Immunodeficiency Virus Type 1 Reverse Transcriptase in Human Macrophages

(2010) Edward M. Kennedy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enzymatic Regulation of Cytosolic Thymidine Kinase 1 and Mitochondrial Thymidine Kinase 2: A Mini Review

(2010) B. Munch-Petersen   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

Vaccinia Virus–Encoded Ribonucleotide Reductase Subunits Are Differentially Required for Replication and Pathogenesis

(2010) Don B. Gammon et al.   PLoS Pathogens

The Human Immunodeficiency Virus Type 2 Vpx Protein Usurps the CUL4A-DDB1DCAF1 Ubiquitin Ligase To Overcome a Postentry Block in Macrophage Infection

(2009) A. Bergamaschi et al.   JOURNAL OF VIROLOGY

Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response

(2009) Gillian I Rice et al.   NATURE GENETICS

Characterization of Simian Immunodeficiency Virus SIVSM/Human Immunodeficiency Virus Type 2 Vpx Function in Human Myeloid Cells

(2008) C. Goujon et al.   JOURNAL OF VIROLOGY

Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for antiviral therapy

(2008) Joshua Munger et al.   NATURE BIOTECHNOLOGY