Synergy of entry inhibitors with direct-acting antivirals uncovers novel combinations for prevention and treatment of hepatitis C

Curing Chronic Hepatitis C — The Arc of a Medical Triumph

(2014) Raymond T. Chung et al.   NEW ENGLAND JOURNAL OF MEDICINE

Human Monoclonal Antibody MBL-HCV1 Delays HCV Viral Rebound Following Liver Transplantation: A Randomized Controlled Study

(2013) R. T. Chung et al.   AMERICAN JOURNAL OF TRANSPLANTATION

HRas Signal Transduction Promotes Hepatitis C Virus Cell Entry by Triggering Assembly of the Host Tetraspanin Receptor Complex

(2013) Laetitia Zona et al.   Cell Host & Microbe

Combination therapies with NS5A, NS3 and NS5B inhibitors on different genotypes of hepatitis C virus in human hepatocyte chimeric mice

(2013) Niu Shi et al.   GUT

Epidermal growth factor receptor signaling impairs the antiviral activity of interferon-alpha

(2013) Joachim Lupberger et al.   HEPATOLOGY

In Vivo Emergence of a Novel Mutant L159F/L320F in the NS5B Polymerase Confers Low-Level Resistance to the HCV Polymerase Inhibitors Mericitabine and Sofosbuvir

(2013) Xiao Tong et al.   JOURNAL OF INFECTIOUS DISEASES

Sofosbuvir with pegylated interferon alfa-2a and ribavirin for treatment-naive patients with hepatitis C genotype-1 infection (ATOMIC): an open-label, randomised, multicentre phase 2 trial

(2013) Kris V Kowdley et al.   LANCET

Sofosbuvir in combination with peginterferon alfa-2a and ribavirin for non-cirrhotic, treatment-naive patients with genotypes 1, 2, and 3 hepatitis C infection: a randomised, double-blind, phase 2 trial

(2013) Eric Lawitz et al.   LANCET INFECTIOUS DISEASES

Future therapies for chronic hepatitis C

(2013) Noura M. Dabbouseh et al.   Nature Reviews Gastroenterology & Hepatology

Sofosbuvir for Hepatitis C Genotype 2 or 3 in Patients without Treatment Options

(2013) Ira M. Jacobson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Current and Future Therapies for Hepatitis C Virus Infection

(2013) T. Jake Liang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nucleotide Polymerase Inhibitor Sofosbuvir plus Ribavirin for Hepatitis C

(2013) Edward J. Gane et al.   NEW ENGLAND JOURNAL OF MEDICINE

Sofosbuvir for Previously Untreated Chronic Hepatitis C Infection

(2013) Eric Lawitz et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Novel Monoclonal Anti-CD81 Antibody Produced by Genetic Immunization Efficiently Inhibits Hepatitis C Virus Cell-Cell Transmission

(2013) Isabel Fofana et al.   PLoS One

HIV-1 entry inhibitors: recent development and clinical use

(2013) Timothy J Henrich et al.   Current Opinion in Virology

The kinase inhibitor Sorafenib impairs the antiviral effect of interferon α on hepatitis C virus replication

(2012) Kiyoshi Himmelsbach et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Persistence of HCV in Quiescent Hepatic Cells Under Conditions of an Interferon-Induced Antiviral Response

(2012) Oliver Bauhofer et al.   GASTROENTEROLOGY

Mutations That Alter Use of Hepatitis C Virus Cell Entry Factors Mediate Escape From Neutralizing Antibodies

(2012) Isabel Fofana et al.   GASTROENTEROLOGY

Viral Hepatitis in Liver Transplantation

(2012) Gonzalo Crespo et al.   GASTROENTEROLOGY

A Plant-Derived Flavonoid Inhibits Entry of All HCV Genotypes Into Human Hepatocytes

(2012) Sibylle Haid et al.   GASTROENTEROLOGY

The postbinding activity of scavenger receptor class B type I mediates initiation of hepatitis C virus infection and viral dissemination

(2012) Muhammad N. Zahid et al.   HEPATOLOGY

Antiviral strategies in hepatitis C virus infection

(2012) Christoph Sarrazin et al.   JOURNAL OF HEPATOLOGY

Novel human SR-BI antibodies prevent infection and dissemination of HCV in vitro and in humanized mice

(2012) Krzysztof Lacek et al.   JOURNAL OF HEPATOLOGY

Intravenous silibinin monotherapy shows significant antiviral activity in HCV-infected patients in the peri-transplantation period

(2012) Zoe Mariño et al.   JOURNAL OF HEPATOLOGY

Host-targeting agents for prevention and treatment of chronic hepatitis C – Perspectives and challenges

(2012) Mirjam B. Zeisel et al.   JOURNAL OF HEPATOLOGY

Identification of the Niemann-Pick C1–like 1 cholesterol absorption receptor as a new hepatitis C virus entry factor

(2012) Bruno Sainz et al.   NATURE MEDICINE

Preliminary Study of Two Antiviral Agents for Hepatitis C Genotype 1

(2012) Anna S. Lok et al.   NEW ENGLAND JOURNAL OF MEDICINE

Griffithsin Has Antiviral Activity against Hepatitis C Virus

(2011) Philip Meuleman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Effect of telaprevir on the pharmacokinetics of cyclosporine and tacrolimus

(2011) Varun Garg et al.   HEPATOLOGY

Telaprevir, boceprevir, cytochrome P450 and immunosuppressive agents - A potentially lethal cocktail

(2011) Michael Charlton   HEPATOLOGY

(−)-Epigallocatechin-3-gallate is a new inhibitor of hepatitis C virus entry

(2011) Noémie Calland et al.   HEPATOLOGY

Dual therapy with the nonstructural protein 5A inhibitor, daclatasvir, and the nonstructural protein 3 protease inhibitor, asunaprevir, in hepatitis C virus genotype 1b-infected null responders

(2011) Kazuaki Chayama et al.   HEPATOLOGY

EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy

(2011) Joachim Lupberger et al.   NATURE MEDICINE

Boceprevir for Untreated Chronic HCV Genotype 1 Infection

(2011) Fred Poordad et al.   NEW ENGLAND JOURNAL OF MEDICINE

Boceprevir for Previously Treated Chronic HCV Genotype 1 Infection

(2011) Bruce R. Bacon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Telaprevir for Retreatment of HCV Infection

(2011) Stefan Zeuzem et al.   NEW ENGLAND JOURNAL OF MEDICINE

Telaprevir for Previously Untreated Chronic Hepatitis C Virus Infection

(2011) Ira M. Jacobson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Treatment of Non–Small-Cell Lung Cancer with Erlotinib or Gefitinib

(2011) Vince D. Cataldo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Monoclonal Anti-Claudin 1 Antibodies Prevent Hepatitis C Virus Infection of Primary Human Hepatocytes

(2010) Isabel Fofana et al.   GASTROENTEROLOGY

Multiple effects of silymarin on the hepatitis C virus lifecycle

(2010) Jessica Wagoner et al.   HEPATOLOGY

Viral entry and escape from antibody-mediated neutralization influence hepatitis C virus reinfection in liver transplantation

(2010) Samira Fafi-Kremer et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Small molecule scavenger receptor BI antagonists are potent HCV entry inhibitors

(2010) Andrew J. Syder et al.   JOURNAL OF HEPATOLOGY

Oral combination therapy with a nucleoside polymerase inhibitor (RG7128) and danoprevir for chronic hepatitis C genotype 1 infection (INFORM-1): a randomised, double-blind, placebo-controlled, dose-escalation trial

(2010) Edward J Gane et al.   LANCET

Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect

(2010) Min Gao et al.   NATURE

Amphipathic DNA Polymers Inhibit Hepatitis C Virus Infection by Blocking Viral Entry

(2009) Takuya Matsumura et al.   GASTROENTEROLOGY

Rapid HCV-RNA Decline With Once Daily TMC435: A Phase I Study in Healthy Volunteers and Hepatitis C Patients

(2009) Henk W. Reesink et al.   GASTROENTEROLOGY

The cyclophilin inhibitor Debio 025 combined with PEG IFNα2a significantly reduces viral load in treatment-naïve hepatitis C patients

(2009) Robert Flisiak et al.   HEPATOLOGY

Production of Infectious Genotype 1b Virus Particles in Cell Culture and Impairment by Replication Enhancing Mutations

(2009) Thomas Pietschmann et al.   PLoS Pathogens

Anti-CD81 antibodies can prevent a hepatitis C virus infection in vivo

(2008) Philip Meuleman et al.   HEPATOLOGY